Results 131 to 140 of about 44,474 (235)

Multi‐Omics Signatures of Organ Clocks in Biological Aging and Disease: A Conceptual Framework for Organ‐Specific Aging Clocks

Aging Cell, Volume 25, Issue 5, May 2026.
Organ‐specific aging clocks integrating genomics, epigenomics, transcriptomics, proteomics, and metabolomics offer a more accurate assessment of biological aging than single‐omics approaches. This review proposes a multi‐omics framework emphasizing tissue data, longitudinal study designs, and clinically meaningful training outcomes to advance the ...
Maria Vasileiou, Gabor Liposits, Bara Barakat, Nam P. Nguyen   +3 more
wiley   +1 more source

GPRC5B Identified by m5C meRIP‐Seq Suppresses Apoptosis in Osteosarcoma Through NSUN2‐Mediated RNA Methylation

Cancer Science, Volume 117, Issue 5, Page 1322-1332, May 2026.
We performed the first transcriptome‐wide profiling of m5C modifications in osteosarcoma, analyzing four pairs of tumor and adjacent normal tissues. We revealed that NSUN2 suppresses apoptosis in osteosarcoma cells by promoting GPRC5B m5C modification and expression.
Zhenyi Chen, Min Yang, Xiaoxiao Liang, Zhiqiang Yang, Wulan Mai, Yuyang Wang, Yushen Lu, Ruimin Wang, Yuanhang Han, Yuanlong Xie, Lin Cai   +10 more
wiley   +1 more source

Discovery and Evaluation of Cadmium‐Adapted Daphnia pulex Genotypes in a Region of Historical Mining Reveals Adaptation Protects the Germline From Cadmium‐Induced Mutations

Molecular Ecology, Volume 35, Issue 9, May 2026.
ABSTRACT Exposure to chemical pollutants can alter the rate and genome‐wide distribution of germline mutations. However, studies measuring the effects of chemical exposure on mutation rates and spectra have not considered the ecological and evolutionary backgrounds of the studied genotypes, which could influence the rates and patterns of germline ...
Nathan Keith, Stephen P. Glaholt, Craig E. Jackson, Kim Young, Karel De Schamphelaere, John K. Colbourne, Joseph R. Shaw   +6 more
wiley   +1 more source

Epigenetic regulation of mycorrhizal symbioses: from plastic responses to transgenerational legacies

New Phytologist, Volume 250, Issue 3, Page 1438-1452, May 2026.
Summary Mycorrhizal symbioses represent one of the most widespread and ecologically significant plant–microbe interactions, shaping plant nutrition, stress resilience, and ecosystem functioning. Beyond their role in nutrient exchange and systemic defense, growing evidence suggests that these symbioses also influence plant plasticity within and across ...
Gerson Beltrán‐Torres, Henry J. De La Cruz, Stéphane Maury, Martina Janoušková, Claire Veneault‐Fourrey, Vít Latzel, Pierre‐Emmanuel Courty, Harold Duruflé, Jörg Tost, Iris Sammarco   +9 more
wiley   +1 more source

Tet3 regulates synaptic transmission and homeostatic plasticity via DNA oxidation and repair. [PDF]

, 2015
Contrary to the long-held belief that DNA methylation of terminally differentiated cells is permanent and essentially immutable, post-mitotic neurons exhibit extensive DNA demethylation.
Coppola, Giovanni, Gao, Fuying, Geschwind, Daniel H, Guo, Junjie U, Ming, Guo-li, Shin, Jaehoon, Song, Hongjun, Su, Yijing, Weng, Yi-Lan, Yu, Huimei, Zhong, Chun   +10 more
core  

Quantification of cytosine modifications in the aged mouse brain

Neuropsychopharmacology Reports
Quantifying cytosine modifications in various brain regions provides important insights into the gene expression regulation and pathophysiology of neuropsychiatric disorders.
Hiroko Sugawara, Akitoshi Date, Satoshi Fuke, Yutaka Nakachi, Tadafumi Kato, Minoru Narita, Miki Bundo, Kazuya Iwamoto   +7 more
doaj   +1 more source

5-Methylcytosine [PDF]

, 2020
openaire   +1 more source

Analyses of pyrimidine and purine bases by a combination of paper chromatography and time of flight mass spectrometry [PDF]

Paper chromatography and mass spectrometry for analyses of pyrimidine and purine ...
Fuse, K., Hayatsu, R., Studier, M. H.
core   +1 more source

Unveiling the potential impact of RNA m5C methyltransferases NSUN2 and NSUN6 on cellular aging

Frontiers in Genetics
NSUN2 and NSUN6, two family members of NOL1/NSUN protein, are mainly responsible for catalyzing the formation of 5-methylcytosine (m5C) in RNA and highly involved in the physiological and pathological processes of many diseases.
Jiale Zhou, Jiale Zhou, Yang Han, Fuxi Ji, Renquan Zhang, Yuru Liang, Xudong Zhao, Ruizhe Hou   +7 more
doaj   +1 more source

Refeeding with different levels of dietary carbohydrate modulates epigenetic stability through global DNA (de)methylation and histone modifications in juvenile and adult Nile tilapia (Oreochromis niloticus)

Epigenetics
The Nile tilapia (Oreochromis niloticus) exhibits a strong metabolic response to dietary carbohydrates (CHO). Short-term refeeding after fasting with a high-carbohydrate (HC) diet has been shown to modulate CHO metabolism, but the role of epigenetic ...
Sirijanya Thongchaitriwat, Suksan Kumkhong, Cécile Heraud, Karine Dias, Stephane Panserat, Surintorn Boonanuntanasarn, Lucie Marandel   +6 more
doaj   +1 more source