Results 121 to 130 of about 20,996,854 (289)
iLABMED, EarlyView.This article reviews the pivotal role of post‐translational modifications of proteins in the development and progression of hematologic malignancies, and explores their clinical translation potential as novel biomarkers and therapeutic targets. ABSTRACT Post‐translational modifications (PTMs) of proteins have emerged as critical regulators in the ...
Yuxuan Han +6 more
wiley +1 more source
Regional differences in mitochondrial DNA methylation in human post-mortem brain tissue
Clinical Epigenetics, 2017 Background DNA methylation is an important epigenetic mechanism involved in gene regulation, with alterations in DNA methylation in the nuclear genome being linked to numerous complex diseases.
Matthew Devall +8 more
doaj +1 more source
Variable presence of 5-methylcytosine in commercial RNA and DNA
, 2015 Variable presence of 5-methylcytosine in commercial RNA and ...
Antonia Ochel (430070) +5 more
core +1 more source
, 2022 Background: 5-methylcytosine has a profound impact on the development and progression of hepatocellular carcinoma. The aim of this study was to investigate the usefulness of 5-methylcytosine in determining the prognosis, tumor microenvironment, and ...
Haiying Wang (6869) +4 more
core +1 more source
Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials
iNew Medicine, EarlyView.ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong +5 more
wiley +1 more source
Genes and Environment, 2018 Environmental factors stimulate alteration of DNA methylation level. Investigation of the genome-wide DNA methylation status is important for environmental health studies.
Hisaka Kurita +3 more
doaj +1 more source
YTHDF2 Binds to 5-Methylcytosine in RNA and Modulates the Maturation of Ribosomal RNA
Analytical Chemistry, 2019 5-Methylcytosine is found in both DNA and RNA; although its functions in DNA are well established, the exact role of 5-methylcytidine (m5C) in RNA remains poorly defined.
X. Dai +14 more
semanticscholar +1 more source
Noncanonical Nucleotides in the Genome Around the Maternal‐Zygotic Transition
Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.In this paper, Kazzazi et al. provide a comprehensive review of the dynamics of nonconventional nucleotides in the genome during early developmental stages, hypothesizing a potential role for these nucleotides in the activation of the zygotic genome. ABSTRACT From the very moment of fertilization and throughout development, the cells of animal embryos ...
Latifa Kazzazy +7 more
wiley +1 more source
5-methylcytosine mediates nuclear export of mRNA [PDF]
Cell Research, 2017 5-methylcytosine was shown before to be an epitranscriptomic mark. Yang et al. now explored the unique topology of this mRNA modification, identified its writer and demonstrated its involvement in nuclear-cytoplasmic shuttling mediated by a specific reader.
Dan, Dominissini, Gideon, Rechavi
openaire +2 more sources
Genetic analysis of primary lung interdigitating dendritic cell sarcomas
The Journal of Pathology, EarlyView.Abstract Interdigitating dendritic cell sarcomas (IDCSs) are rare tumors that commonly arise in the hematopoietic system and rarely outside. The genetic drivers of IDCS carcinogenesis are unknown; therefore, therapeutic options are limited. We investigated somatic gene mutations and copy‐number alterations (CNAs) in nine IDCSs arising in the lung by ...
Mikhail S Ermakov +6 more
wiley +1 more source