Results 101 to 110 of about 171,203 (189)
Catalytic crosslinking-based methods for enzyme-specified profiling of RNA ribonucleotide modifications [PDF]
, 2019 Well over a hundred types of naturally occurring covalent modifications can be made to ribonucleotides in RNA molecules. Moreover, several types of such modifications are each known to be catalysed by multiple enzymes which largely appear to modify ...
Hussain, Shobbir
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Advanced Science, Volume 13, Issue 53, 24 September 2026.NSUN2‐mediated m5C modification cooperates with ALYREF to stabilize and export IP3R3 mRNA, increasing IP3R3 expression and Ca2 + overload in chondrocytes. This signaling promotes mitochondrial dysfunction, NLRP3 inflammasome activation, and senescence, thereby accelerating osteoarthritis progression.
Guping Mao +8 more
wiley +1 more source
M5C modulator mediated methylation pattern and TME cell infiltration in bladder cancer
, 2022 Abstract Background: In recent studies, the role of modification patterns of N6-methyladenosine (m6A) regulators in tumor microenvironment (TME) cell infiltration in the tumor microenvironment has been identified. However, the role of 5-methylcytosine (m5C) modification patterns in TME cell infiltration remains to be discovered.
Zhan Yang +12 more
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DNA Methylation Profiling Revealed Promoter Hypermethylation-induced Silencing of p16, DDAH2 and DUSP1 in Primary Oral Squamous Cell Carcinoma [PDF]
, 2014 Background: Hypermethylation in promoter regions of genes might lead to altered gene functions and result in malignant cellular transformation. Thus, biomarker identification for hypermethylated genes would be very useful for early diagnosis, prognosis ...
Zain, R. B. +8 more
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MedicineThe incidence of papillary thyroid carcinoma (PTC) has increased significantly in recent years, and for patients with metastatic and recurrent PTC, the options for treatment currently available are insufficient. To date, the exact molecular mechanism underlying PTC is still not fully understood. 5-Methylcytosine (m5C) RNA methylation is associated with
Furong Nie, Jiacheng Jiang, Jie Ning
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Apoptosis and DNA methylation [PDF]
, 2011 Epigenetic mechanisms assist in maintaining gene expression patterns and cellular properties in developing and adult tissues. The molecular pathology of disease states frequently includes perturbation of DNA and histone methylation patterns, which can ...
Meng, Huan X +19 more
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Abstract Glaucoma, one of the leading causes of blindness worldwide, is characterized by retinal ganglion cell (RGC) damage. NOP2/Sun RNA methyltransferase 4 (NSUN4), a known 5-methylcytosine (m5C) writer, is an essential dual-function mitochondrial protein that facilitates both the process of methylation and the coordination of mitoribosome ...
Yahong Li +4 more
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, 2017 Objective: Signal transducer and activator of transcription (STAT) 1 is a key tumor suppressor, which is always methylated in a variety of human cancers.
Chang, Ming-Cheng;Chiang, Ying-Cheng;Ho, Chih-Ming;Chen, Yu-Li;Chen, Chi-An;Cheng, Wen-Fang;Chou, Cheng-Yang +1 more
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SURVEY AND SUMMARY 5-methylcytosine in RNA: detection, enzymatic formation and biological functions
, 2009 The nucleobase modification 5-methylcytosine (m5C) is widespread both in DNA and different cellular RNAs. The functions and enzymatic mecha-nisms of DNA m5C-methylation were extensively studied during the last decades.
Frank Lyko, Mark Helm, Yuri Motorin
core
YebU is a m5C methyltransferase specific for 16 S rRNA nucleotide 1407
, 2006 The rRNAs in Escherichia coli contain methylations at 24 nucleotides, which collectively are important for ribosome function. Three of these methylations are m5C modifications located at nucleotides C967 and C1407 in 16S rRNA and at nucleotide C1962 in ...
Douthwaite, Stephen +1 more
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