Results 101 to 110 of about 5,629 (182)

NSUN2-mediated m5C modification of HBV RNA positively regulates HBV replication.

, 2023
Chronic hepatitis B virus (HBV) infection is a major cause of liver cirrhosis and liver cancer, despite strong prevention and treatment efforts.
Xianying Chen, Li Zhou, Miao He, Chengbao Ma, Yu Chen, Tianmo Xu, Zaichao Xu, Hongyun Wang, Huan Yan, Kun Yan, Jiali Li, Cong Zeng, Jiangpeng Feng, Yuchen Xia, Jiejie Liu, Peipei Yao, Shimin Yang   +16 more
core   +1 more source

Image_1_Prognostic Risk Model and Tumor Immune Environment Modulation of m5C-Related LncRNAs in Pancreatic Ductal Adenocarcinoma.tif

, 2021
RNA methylation modification is a key process in epigenetics that regulates posttranscriptional gene expression. With advances in next-generation sequencing technology, 5-methylcytosine (m5C) modification has also been found in multiple RNAs.
Shaoqing Fan (11807453), Hao Yuan (502114), Kuirong Jiang (530383), Bin Xiao (146435), Guosheng Chen (2803423), Taoyue Yang (10278501), Qun Chen (313764), Peng Shen (688111), Li Zhao (147498), Jinhui Liu (3692035), Pengfei Wu (3200082)   +10 more
core   +1 more source

Image_3_Prognostic Risk Model and Tumor Immune Environment Modulation of m5C-Related LncRNAs in Pancreatic Ductal Adenocarcinoma.tif

, 2021
RNA methylation modification is a key process in epigenetics that regulates posttranscriptional gene expression. With advances in next-generation sequencing technology, 5-methylcytosine (m5C) modification has also been found in multiple RNAs.
Shaoqing Fan (11807453), Hao Yuan (502114), Kuirong Jiang (530383), Bin Xiao (146435), Guosheng Chen (2803423), Taoyue Yang (10278501), Qun Chen (313764), Peng Shen (688111), Li Zhao (147498), Jinhui Liu (3692035), Pengfei Wu (3200082)   +10 more
core   +1 more source

NSUN2-Mediated M5c Dysregulation Promotes OSCC Ferroptosis

International Dental Journal
Aim or purpose: This study aimed to investigate the role of NSUN2-mediated 5-methylcytosine (m5C) methylation in regulating ferroptosis resistance and tumor progression in oral squamous cell carcinoma (OSCC), identifying potential epitranscriptomic ...
Yunyang Lu, Wei Zhao, Fangyang Shi, Jie Wu, Hui Gao, Hui Zhang, Jiajun Hu, Shiyu Lv, Weidong Du, Runze Li   +9 more
doaj   +1 more source

RNA m5C methylation mediated by Ybx1 ensures hematopoietic stem and progenitor cell expansion

Cell Reports
Hematopoietic stem and progenitor cells (HSPCs) undergo rapid transcriptional transitions among distinct cell states and functional properties during development, but the underlying molecular mechanism is largely unknown. Here, we characterize the mRNA m5C landscape of developing HSPCs in zebrafish and found that m5C modification is essential for HSPC ...
Fan Liu, Mengke Wang, Suwei Gao, Gege Song, Mengyao Liu, Ying Li, Piao Sun, Weiyi Lai, Hailin Wang, Yun-Gui Yang, Feng Liu, Ying Yang, Lu Wang   +12 more
openaire   +2 more sources

Image_2_Prognostic Risk Model and Tumor Immune Environment Modulation of m5C-Related LncRNAs in Pancreatic Ductal Adenocarcinoma.tif

, 2021
RNA methylation modification is a key process in epigenetics that regulates posttranscriptional gene expression. With advances in next-generation sequencing technology, 5-methylcytosine (m5C) modification has also been found in multiple RNAs.
Shaoqing Fan (11807453), Hao Yuan (502114), Kuirong Jiang (530383), Bin Xiao (146435), Guosheng Chen (2803423), Taoyue Yang (10278501), Qun Chen (313764), Peng Shen (688111), Li Zhao (147498), Jinhui Liu (3692035), Pengfei Wu (3200082)   +10 more
core   +1 more source

NSUN2-mediated RNA m5C modification drives multiple myeloma progression by enhancing the stability of HIP1 mRNA

Scientific Reports
RNA 5-methylcytosine (m5C) modification is a crucial epigenetic regulation, and aberrant m5C methylation is associated with the pathogenesis of certain cancers.
Yang Jiang, Jing Sun, Yuyan Chen, Lin Cheng, Saran Feng, Yan Wang, Congcong Sun   +6 more
doaj   +1 more source

Shikonin promotes ferroptosis though NSUN2-mediated m5C methylation modification of TFRC in acute myelocytic leukemia

Shikonin (SHK), extracted from the traditional Chinese herb Lithospermum erythrorhizon, demonstrates a wide range of pharmacological activities.
Shuyu Chen, Yiqun Huang, Yinhao Liu, Liuxuan Jiang, Yuqing Chen   +4 more
core   +1 more source

The RNA m5C methylase NSUN4 protects retinal ganglion cells by regulating m5C methylation in the Hedgehog signaling pathway

Abstract Glaucoma, one of the leading causes of blindness worldwide, is characterized by retinal ganglion cell (RGC) damage. NOP2/Sun RNA methyltransferase 4 (NSUN4), a known 5-methylcytosine (m5C) writer, is an essential dual-function mitochondrial protein that facilitates both the process of methylation and the coordination of mitoribosome ...
Yahong Li, Dian Li, Chao Geng, Ruihua Wei, Yajian Duan   +4 more
openaire   +1 more source

NSUN2-mediated m5C hypermethylation of hsa_circ_0004516 promotes breast cancer brain metastasis by activating AKT signaling

Non-coding RNA Research
Breast cancer brain metastasis (BCBM) remains fatal with elusive mechanisms. Here, we unveil the first circRNA m5C methylation landscape in BCBM through MeRIP-seq (methylated RNA immunoprecipitation next-generation sequencing) identifying 7465 BCBM ...
Min Li, Jiawei Li, Hongbo Wen, Jun Li, Song Wang, Jianran Guo, Dongyan Zhang, Anqi Zhang, Chuanyou Cui, Rong Fu, Meng An, Wei Zhang, Bo Fu   +12 more
doaj   +1 more source