Mitomycin C binding to poly[d(G-m5C)] [PDF]
, 1995 6 pages, 5 figures, 1 table.-- PMID: 7864808 [PubMed].-- PMCID: PMC1136499.Poly[d(G-m5C)] was modified by reductively activated mitomycin C, an anti-tumour drug, under buffer conditions which are known to favour either the B or the Z conformations of DNA.
Sánchez Baeza, Francisco J. +1 more
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RNA m5C methylation mediated by Ybx1 ensures hematopoietic stem and progenitor cell expansion
Cell ReportsHematopoietic stem and progenitor cells (HSPCs) undergo rapid transcriptional transitions among distinct cell states and functional properties during development, but the underlying molecular mechanism is largely unknown. Here, we characterize the mRNA m5C landscape of developing HSPCs in zebrafish and found that m5C modification is essential for HSPC ...
Fan Liu +12 more
openaire +2 more sources
Advances in research on RNA methylation and cancer radiotherapy resistance
Frontiers in OncologyRNA methylation is a type of reversible chemical modification in epitranscriptomics that influences gene expression by dynamically regulating RNA functions.
Hui Liu +5 more
doaj +1 more source
Elevating RNA m5C methylation provides a promising strategy for crop productivity
Abstract RNA 5-methylcytidine (m5C) has been identified as a key epi-transcriptomic modification of mRNAs involved in regulating multiple post-transcriptional processes. Here, we found that knockout of the RNA m5C demethylase, OsNOP2, results in elevated m5C levels and positively influences numerous agronomic traits in rice.
Xiaofeng Gu +9 more
openaire +1 more source
Transcription influences repair-induced DNA methylation [PDF]
, 2008 This work is aimed at the dissection of the molecular mechanism(s) linking DNA damage and gene silencing. To this end, we have developed a genetic system that allows a rapid assessment of homologous-directed repair (HR) of an unique DNA double strand ...
Morano, Annalisa
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Cancer ControlBackground The aim of this retrospective research was to develop an immune-related genes significantly associated with m5C methylation methylation (m5C-IRGs)-related signature associated with lung adenocarainoma (LUAD).
Xiong Cao +4 more
doaj +1 more source
Functional Analysis of DNA Methylation in Development and Disease [PDF]
, 2006 The genome of mammals harbors chemical modifications at some cytosine residues in the form of a methyl group. These modified residues, termed 5’-methylcytosines, have been discovered more than 50 years ago (Hotchkiss 1948) and have since been shown to ...
Gaudet, François
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Comprehensive analysis of m6a and m5c RNA methylation profiles in gliomas
Gliomas are aggressive primary brain tumors with high morbidity and mortality [1]. Despite advances in oncology, their complex biology limits effective treatment options, making gliomas a key focus of cancer research. Epigenetic modifications, including RNA methylation (m6A and 5mC), have been implicated in tumor progression, yet their specific roles ...
Tamašuitytė, Samanta +1 more
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Identification and validation of novel prognostic signatures based on m5C methylation patterns and tumor EMT profiles in head and neck squamous cell carcinoma. [PDF]
Sci Rep, 2023 Zhu G +8 more
europepmc +1 more source
Hypoxia-Induced Lactylation of NSUN3 Promotes m5C Methylation of SETD2 to Regulate Peripheral Nerve Injury Repair. [PDF]
J Peripher Nerv SystAn S +5 more
europepmc +1 more source