Results 31 to 40 of about 5,629 (182)

5-Methylcytosine profiles in mouse transcriptomes suggest the randomness of m5C formation catalyzed by RNA methyltransferase

BMC Research Notes, 2022
Objective 5-Methylcytosine (m5C) is a type of chemical modification on the nucleotides and is widespread in both DNA and RNA. Although the DNA m5C has been extensively studied over the past years, the distribution and biological function of RNA m5C still
Junfeng Liu
doaj   +1 more source

Overview of distinct 5-methylcytosine profiles of messenger RNA in normal and knock-down NSUN2 colorectal cancer cells

Frontiers in Genetics, 2023
Background: Colorectal cancer (CRC) is a harmful cancer with high morbidity and poor prognosis. There is growing evidence that RNA methylation is closely related to the occurrence of cancer and its malignant biological behavior.
Yu Lin, Yu Lin, Yu Lin, Zhifang Zhao, Wenqiang Nie, Manting Huang, Jiazhong Cai, Yadong Wang, Hesong Wang, Yongmei Huang, Yang Bai, Yang Bai   +11 more
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NSUN2-mediated M⁵c methylation of IRF3 mRNA negatively regulates type I interferon responses during various viral infections. [PDF]

Emerg Microbes Infect, 2023
5-Methylcytosine (m5C) is a widespread post-transcriptional RNA modification and is reported to be involved in manifold cellular responses and biological processes through regulating RNA metabolism.
Wang H, Feng J, Zeng C, Liu J, Fu Z, Wang D, Wang Y, Zhang L, Li J, Jiang A, He M, Cao Y, Yan K, Tang H, Guo D, Xu K, Zhou X, Zhou L, Lan K, Zhou Y, Chen Y.   +20 more
europepmc   +2 more sources

Folate regulates RNA m5C modification and translation in neural stem cells

BMC Biology, 2022
Background Folate is an essential B-group vitamin and a key methyl donor with important biological functions including DNA methylation regulation. Normal neurodevelopment and physiology are sensitive to the cellular folate levels.
Xiguang Xu, Zachary Johnson, Amanda Wang, Rachel L. Padget, James W. Smyth, Hehuang Xie   +5 more
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Elevating RNA m⁵C methylation provides a promising strategy for crop productivity. [PDF]

Natl Sci Rev
Abstract RNA 5-methylcytidine (m5C) has been identified as a key epi-transcriptomic modification of mRNAs involved in regulating multiple post-transcriptional processes. Here, we found that knockout of the RNA m5C demethylase, OsNOP2, results in elevated m5C levels and positively influences numerous agronomic traits in rice.
Li X, Li C, Wang X, Yang L, Guo W, Mao Y, Liu H, Li D, Yan S, Zhang Y, Gu X, Pu L.   +11 more
europepmc   +2 more sources

NSUN2-mediated m⁵C methylation modification regulates trophoblast cell proliferation, apoptosis, and autophagy in gestational diabetes mellitus. [PDF]

J Diabetes Investig
Introduction Gestational diabetes mellitus (GDM) represents one of the most prevalent medical complications during pregnancy. Emerging evidence has implicated NOL1/NOP2/SUN domain (NSUN)2‐mediated 5‐methylcytosine (m5C) methylation modifications in ...
Liu J, Chen Y, Wang D, Li Z.
europepmc   +2 more sources

m5C-Atlas: a comprehensive database for decoding and annotating the 5-methylcytosine (m5C) epitranscriptome. [PDF]

, 2022
5-Methylcytosine (m5C) is one of the most prevalent covalent modifications on RNA. It is known to regulate a broad variety of RNA functions, including nuclear export, RNA stability and translation. Here, we present m5C-Atlas, a database for comprehensive
Huang, Daiyun, de Magalhães, João Pedro, Meng, Jia, Ma, Jiongming, Song, Bowen, Rigden, Daniel J, Zhang, Yuxin, Su, Jionglong, Chen, Kunqi, Wei, Zhen   +9 more
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m5C Regulator-mediated methylation modification clusters contribute to the immune microenvironment regulation of multiple myeloma

Frontiers in Genetics, 2022
Background: Multiple myeloma (MM) is a hematological malignancy in which plasma cells proliferate abnormally. 5-methylcytosine (m5C) methylation modification is the primary epigenetic modification and is involved in regulating the occurrence, development,
Hefei Ren, Chang Liu, Hongkun Wu, Zhenhua Wang, Sai Chen, Xiaomin Zhang, Jigang Ren, Huiying Qiu, Lin Zhou   +8 more
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Molecular features, biological behaviors and clinical implications of m5C RNA methylation modification regulators in gastrointestinal cancers

Cancer Biology & Therapy, 2023
Epitranscriptome studies have shown that critical RNA modifications drive tumorigenicity; however, the role of 5-methylcytosine (m5C) RNA methylation remains poorly understood.
Mengyao Zhan, Huan Song, Dan Tian, Qin Wen, Xinling Shi, Yuting Wang, Xuhua Mao, Jianming Wang   +7 more
doaj   +1 more source

Table_2_Comprehensive Analysis of m5C Methylation Regulatory Genes and Tumor Microenvironment in Prostate Cancer.docx

, 2022
Background5-Methylcytidine (m5C) methylation is an emerging epigenetic modification in recent years, which is associated with the development and progression of various cancers.
Xin Gu (244758), Ming Zhan (27937), Jiahao Bao (12855575), Qing Yang (67856), Zhong Wang (132073), Yushan Liu (704070), Jiangyi Wang (6626843), Guopeng Yu (730431), Xinjuan Li (3599063), Bin Xu (10691), Shangqing Song (553292)   +10 more
core   +1 more source