Results 31 to 40 of about 171,203 (189)

NSUN2-Mediated m⁵C Methylation in Human Disease: Mechanism and Therapeutic Implications. [PDF]

Int J Gen Med
Zheng X, Zhao S, Gu H, Jiang P, Zheng L.
europepmc   +2 more sources

m5C RNA Methylation Primarily Affects the ErbB and PI3K–Akt Signaling Pathways in Gastrointestinal Cancer

Frontiers in Molecular Biosciences, 2020
5-Methylcytosine (m5C) is a kind of methylation modification that occurs in both DNA and RNA and is present in the highly abundant tRNA and rRNA. It has an important impact on various human diseases including cancer.
Shixin Xiang, Shixin Xiang, Yongshun Ma, Yongshun Ma, Jing Shen, Jing Shen, Yueshui Zhao, Yueshui Zhao, Xu Wu, Xu Wu, Mingxing Li, Mingxing Li, Xiao Yang, Parham Jabbarzadeh Kaboli, Parham Jabbarzadeh Kaboli, Fukuan Du, Fukuan Du, Huijiao Ji, Huijiao Ji, Yuan Zheng, Xiang Li, Jing Li, Qinglian Wen, Zhangang Xiao, Zhangang Xiao   +24 more
doaj   +1 more source

Sequence- and structure-specific cytosine-5 mRNA methylation by NSUN6. [PDF]

, 2021
The highly abundant N6-methyladenosine (m6A) RNA modification affects most aspects of mRNA function, yet the precise function of the rarer 5-methylcytidine (m5C) remains largely unknown.
Hussain, Shobbir, Flad, Sophia, Kellner, Stefanie, Selmi, Tommaso, Dennison, Rebecca, Bornelöv, Susanne, Borland, Kayla, Dietmann, Sabine, Frye, Michaela, Huang, Ya-Lin, Heiß, Matthias, Carter, Jean-Michel, Hussain S., Carter J. -M., Kellner S., Dennison R., DIetmann S., Heiss M., Selmi T., Flad S., Borland K., Huang Y. -L., Frye M., Bornelov S.   +23 more
core   +2 more sources

Elevating RNA m⁵C methylation provides a promising strategy for crop productivity. [PDF]

Natl Sci Rev
ABSTRACT RNA 5-methylcytidine (m5C) has been identified as a key epitranscriptomic modification of mRNAs involved in regulating multiple post-transcriptional processes. Here, we found that knockout of the RNA m5C demethylase, OsNOP2, results in elevated m5C levels and positively influences numerous agronomic traits in rice.
Li X, Li C, Wang X, Yang L, Guo W, Mao Y, Liu H, Li D, Yan S, Zhang Y, Gu X, Pu L.   +11 more
europepmc   +2 more sources

Molecular features, biological behaviors and clinical implications of m5C RNA methylation modification regulators in gastrointestinal cancers

Cancer Biology & Therapy, 2023
Epitranscriptome studies have shown that critical RNA modifications drive tumorigenicity; however, the role of 5-methylcytosine (m5C) RNA methylation remains poorly understood.
Mengyao Zhan, Huan Song, Dan Tian, Qin Wen, Xinling Shi, Yuting Wang, Xuhua Mao, Jianming Wang   +7 more
doaj   +1 more source

Is DNA methylation modulated by wounding-induced oxidative burst in maize? [PDF]

, 2014
Plants respond to environmental changes by modifying gene expression. One of the mechanisms regulating gene expression is methylation of cytosine to 5-methylcytosine (m5C) which modulates gene expression by changing chromatin structure.
Barciszewski, Jan, Barciszewska, Mirosława, Lewandowska-Gnatowska, Elżbieta, Polkowska-Kowalczyk, Lidia, Szczegielniak, Jadwiga, Muszyńska, Grażyna   +5 more
core   +1 more source

m5C Regulator-mediated methylation modification clusters contribute to the immune microenvironment regulation of multiple myeloma

Frontiers in Genetics, 2022
Background: Multiple myeloma (MM) is a hematological malignancy in which plasma cells proliferate abnormally. 5-methylcytosine (m5C) methylation modification is the primary epigenetic modification and is involved in regulating the occurrence, development,
Hefei Ren, Chang Liu, Hongkun Wu, Zhenhua Wang, Sai Chen, Xiaomin Zhang, Jigang Ren, Huiying Qiu, Lin Zhou   +8 more
doaj   +1 more source

Cytosine-to-Uracil Deamination by SssI DNA Methyltransferase [PDF]

, 2013
The prokaryotic DNA(cytosine-5)methyltransferase M.SssI shares the specificity of eukaryotic DNA methyltransferases (CG) and is an important model and experimental tool in the study of eukaryotic DNA methylation.
Stier, Ildikó, Antal Kiss (474840), Ildikó Stier, Antal Kiss, Kiss, Antal, Ildikó Stier (474839)   +5 more
core   +2 more sources

Overview of distinct 5-methylcytosine profiles of messenger RNA in human hepatocellular carcinoma and paired adjacent non-tumor tissues

Journal of Translational Medicine, 2020
Background Post-transcriptional methylation modifications, including 5-methylcytosine (m5C) modification, are closely related to the tumorigenesis of cancers.
Qiyao Zhang, Qingyuan Zheng, Xiao Yu, Yuting He, Wenzhi Guo   +4 more
doaj   +1 more source

RNA 5‐Methylcytosine Modification Regulates Vegetative Development Associated with H3K27 Trimethylation in Arabidopsis

Advanced Science, 2023
Methylating RNA post‐transcriptionally is emerging as a significant mechanism of gene regulation in eukaryotes. The crosstalk between RNA methylation and histone modification is critical for chromatin state and gene expression in mammals.
Daolei Zhang, Weijun Guo, Ting Wang, Yifan Wang, Liang Le, Fan Xu, Yue Wu, Hada Wuriyanghan, Zinmay Renee Sung, Li Pu   +9 more
doaj   +1 more source