Results 31 to 40 of about 814,114 (202)

Comprehensive analysis of key m5C modification-related genes in type 2 diabetes. [PDF]

Front Genet, 2022
Background: 5-methylcytosine (m5C) RNA methylation plays a significant role in several human diseases. However, the functional role of m5C in type 2 diabetes (T2D) remains unclear.Methods: The merged gene expression profiles from two Gene Expression Omnibus (GEO) datasets were used to identify m5C-related genes and T2D-related differentially expressed ...
Song Y, Jiang Y, Shi L, He C, Zhang W, Xu Z, Yang M, Xu Y.   +7 more
europepmc   +4 more sources

NSUN2 restrains gastric cancer cell apoptosis and ferroptosis by promoting the m5C modification of EPYC. [PDF]

Hereditas
Abstract Background Epiphycan (EPYC) has been confirmed to play an oncogenic role in many cancers. However, its role and mechanism in gastric cancer (GC) progression has not been explored. Methods
Wu L, Chen B, Cheng S, Fang X, Zhou F.
europepmc   +4 more sources

Identification of the Expression Patterns and Potential Prognostic Role of 5-Methylcytosine Regulators in Hepatocellular Carcinoma

Frontiers in Cell and Developmental Biology, 2022
Background: Hepatocellular carcinoma (HCC) is the most common primary liver cancer with a poor prognosis. 5-methylcytosine (m5C) modification plays a nonnegligible role in tumor pathogenesis and progression. However, little is known about the role of m5C
Yong Liu, Shunzhen Zheng, Tao Wang, Ziqi Fang, Junjie Kong, Junjie Kong, Jun Liu, Jun Liu   +7 more
doaj   +1 more source

NSUN2-mediated m5C modification of SOCS3 mRNA modulates macrophage polarization in bladder cancer. [PDF]

Cell Death Dis
Abstract Tumor-associated macrophages (TAMs) are pivotal in facilitating the progression of cancer cells. M1 and M2 are two polarization states of TAMs with opposite functions in tumor progression. While the regulatory role of N6-adenosine (m6A) methylation in macrophage polarization has been established, the function of 5 ...
Tang Y, Deng X, Wang Y, Zhou Q, Zhang C, Liu Z, Zheng R, Zeng J, Tan X, Wu Z, Yao K, Yuan G.   +11 more
europepmc   +4 more sources

Isoimperatorin improves osteoporosis by increasing YBX1 expression to promote BGLAP m5C modification. [PDF]

Sci Rep
Osteoporosis is a chronic metabolic bone disease that is prone to fractures. Isoimperatorin (ISO) has been shown to alleviate the bone loss in ovariectomized (OVX) rats. The aim of this study was to investigate the effect and the mechanism of ISO on osteoporosis using animal study and cell experiments.
Hu G, Wen J, Yang H, Zhang K.
europepmc   +4 more sources

The RNA Methylation Modification 5-Methylcytosine Impacts Immunity Characteristics, Prognosis and Progression of Oral Squamous Cell Carcinoma by Bioinformatics Analysis

Frontiers in Bioengineering and Biotechnology, 2021
Disorders pertaining to 5-methylcytosine (m5C) modifications are involved in the pathological process of many diseases. However, the effect of m5C on the tumorigenesis and progression of oral squamous cell carcinoma (OSCC) remains unclear. In this study,
Li Gao, Ru Chen, Masahiro Sugimoto, Masanobu Mizuta, Lei Zhou, Yo Kishimoto, Xinsheng Huang, Koichi Omori   +7 more
doaj   +1 more source

RNA m5C regulator-mediated modification patterns and the cross-talk between tumor microenvironment infiltration in gastric cancer

Frontiers in Immunology, 2022
The effect of immunotherapy strategy has been affirmed in the treatment of various tumors. Nevertheless, the latent role of RNA 5-methylcytosine (m5C) modification in gastric cancer (GC) tumor microenvironment (TME) cell infiltration is still unclear. We
Qiang Zhang, Qiang Zhang, Xiangfei Sun, Jianyi Sun, Jiangshen Lu, Xiaodong Gao, Kuntang Shen, Xinyu Qin   +7 more
doaj   +1 more source

5-methylcytidine has a complex, context-dependent role in RNA [PDF]

, 2016
Ribonucleic acid (RNA) metabolism processes and function are affected by specific RNA sequence motifs, the ability of RNA to form secondary structure and assemble into ribonucleoprotein (RNP) complexes (Dandekar & Bengert, 2002).
Shafik, Andrew Mark
core   +1 more source

Image_3_Roles of m5C RNA Modification Patterns in Biochemical Recurrence and Tumor Microenvironment Characterization of Prostate Adenocarcinoma.tif

, 2022
BackgroundProstate cancer is the second most common cancer with a high risk of biochemical recurrence (BCR) among men. Recently, 5-methylcytosine (m5C) modification has attracted more attention as a new layer of RNA post-transcriptional regulation. Hence,
Ruiji Liu (11975807), Zhipeng Xu (198453), Yuxi Zhang (212307), Ming Chen (115604), Shuqiu Chen (4595818)   +4 more
core   +1 more source

Identification of Expression Patterns and Potential Prognostic Significance of m5C-Related Regulators in Head and Neck Squamous Cell Carcinoma

Frontiers in Oncology, 2021
5-Methylcytosine (m5C) methylation is a major epigenetic technique of RNA modification and is dynamically mediated by m5C “writers,” “erasers,” and “readers.” m5C RNA modification and its regulators are implicated in the onset and development of many ...
Zhenyuan Han, Zhenyuan Han, Biao Yang, Yu Wang, Yu Wang, Xiuxia Zeng, Zhen Tian   +6 more
doaj   +1 more source