Results 31 to 40 of about 5,895 (158)

m5C regulator-mediated methylation modification phenotypes characterized by distinct tumor microenvironment immune heterogenicity in colorectal cancer

Scientific Reports, 2023
The RNA 5-methylcytosine (m5C) modification has been demonstrated to be an important epigenetic regulator and to impact colorectal cancer (CRC) progression.
Zhihua Chen, Quanfa Li, Yilin Lin, Suyong Lin, Ji Gao, Shaoqin Chen   +5 more
doaj   +1 more source

m5C modification of LINC01082 inhibits osteosarcoma progression by modulating the miR-543-TNRC6A axis. [PDF]

Transl Oncol
Osteosarcoma (OS) is a highly malignant bone tumor primarily affecting children and adolescents, with a significant portion of patients developing metastasis, leading to poor prognosis. Recent studies have identified long noncoding RNAs (lncRNAs) as critical regulators in cancer progression.
Hu Y, Wu J, Zeng H, Zhou J, Gong M, Guo Z, Zhang W, Zhang N, Zhang H.   +8 more
europepmc   +4 more sources

RNA m5C regulator-mediated modification patterns and the cross-talk between tumor microenvironment infiltration in gastric cancer

Frontiers in Immunology, 2022
The effect of immunotherapy strategy has been affirmed in the treatment of various tumors. Nevertheless, the latent role of RNA 5-methylcytosine (m5C) modification in gastric cancer (GC) tumor microenvironment (TME) cell infiltration is still unclear. We
Qiang Zhang, Qiang Zhang, Xiangfei Sun, Jianyi Sun, Jiangshen Lu, Xiaodong Gao, Kuntang Shen, Xinyu Qin   +7 more
doaj   +1 more source

Identification of Expression Patterns and Potential Prognostic Significance of m5C-Related Regulators in Head and Neck Squamous Cell Carcinoma

Frontiers in Oncology, 2021
5-Methylcytosine (m5C) methylation is a major epigenetic technique of RNA modification and is dynamically mediated by m5C “writers,” “erasers,” and “readers.” m5C RNA modification and its regulators are implicated in the onset and development of many ...
Zhenyuan Han, Zhenyuan Han, Biao Yang, Yu Wang, Yu Wang, Xiuxia Zeng, Zhen Tian   +6 more
doaj   +1 more source

Identification of m5C-related molecular subtypes and prediction models in the prognosis and tumor microenvironment infiltration of soft tissue sarcoma

Heliyon, 2023
Background: The epigenetic regulator in cancer progression and immune response has been demonstrated recently. However, the potential implications of 5-methylcytosine (m5C) in soft tissue sarcoma (STS) are unclear.
Xianfeng Wang, Yicheng Mao, Hanlu Xu, Jiyang Chen, Xiao chen   +4 more
doaj   +1 more source

Lactylation-driven <i>NSUN2</i>-mediated RNA m5C modification promotes perineural invasion in pancreatic cancer. [PDF]

Theranostics
Background: Perineural invasion (PNI) is a key biological feature underpinning the high malignancy and poor prognosis of pancreatic ductal adenocarcinoma (PDAC). Lysine lactylation (Kla), a metabolite-stress-induced post-translational modification, plays crucial regulatory roles in diverse biological processes.
Huang T, Hu C, Chen H, Jiang H, Li T, Tian Q, He R, Yuan Y, Jiang Y, Zhou Y, Lin Q, Li Z, Xiao M, Wei X, Chen R, Zheng S.   +15 more
europepmc   +3 more sources

Developmental mRNA m5C landscape and regulatory innovations of massive m5C modification of maternal mRNAs in animals

Nature Communications, 2022
Abstractm5C is one of the longest-known RNA modifications, however, its developmental dynamics, functions, and evolution in mRNAs remain largely unknown. Here, we generate quantitative mRNA m5C maps at different stages of development in 6 vertebrate and invertebrate species and find convergent and unexpected massive methylation of maternal mRNAs ...
Jianheng Liu, Tao Huang, Wanying Chen, Chenhui Ding, Tianxuan Zhao, Xueni Zhao, Bing Cai, Yusen Zhang, Song Li, Ling Zhang, Maoguang Xue, Xiuju He, Wanzhong Ge, Canquan Zhou, Yanwen Xu, Rui Zhang   +15 more
openaire   +3 more sources

CX3CL1 promotes M1 macrophage polarization and osteoclast differentiation via NSUN5-mediated m5C modification. [PDF]

Sci Rep
Bone homeostasis refers to a dynamic equilibrium maintained between osteogenesis and osteoclastic bone resorption within the skeletal system. CX3CL1 (Fractalkine) is a chemokine that plays a significant regulatory role in bone homeostasis. This study aimed to investigate the mechanisms by which CX3CL1 regulates bone homeostasis.
Deng Z, Zhong W.
europepmc   +3 more sources

Aberrant m5C hypermethylation mediates intrinsic resistance to gefitinib through NSUN2/YBX1/QSOX1 axis in EGFR-mutant non-small-cell lung cancer

Molecular Cancer, 2023
Background RNA 5-methylcytosine (m5C) modification plays critical roles in the pathogenesis of various tumors. However, the function and molecular mechanism of RNA m5C modification in tumor drug resistance remain unclear.
Yueqin Wang, Jingyao Wei, Luyao Feng, Ouwen Li, Lan Huang, Shaoxuan Zhou, Yingjie Xu, Ke An, Yu Zhang, Ruiying Chen, Lulu He, Qiming Wang, Han Wang, Yue Du, Ruijuan Liu, Chunmin Huang, Xiaojian Zhang, Yun-gui Yang, Quancheng Kan, Xin Tian   +19 more
doaj   +1 more source

Molecular Characterization and Clinical Characteristics of m5C-Based RNA Methylation in Spinal Cord Injury: Validated by qPCR

International Journal of Genomics, 2022
Aberrant patterns of 5-methylcytosine (m5C)-based ribonucleic acid (RNA) methylation have critical roles in various human diseases, but their importance in spinal cord injury (SCI) is largely unknown.
Liang Cao, Wen Jun Pi, Qiang Zhang, Qing Li   +3 more
doaj   +1 more source