Results 51 to 60 of about 8,203 (227)
The lncRNA epigenetics: The significance of m6A and m5C lncRNA modifications in cancer
Frontiers in Oncology, 2023 Most of our transcribed RNAs are represented by non-coding sequences. Long non-coding RNAs (lncRNAs) are transcripts with no or very limited protein coding ability and a length >200nt. They can be epigenetically modified. N6-methyladenosine (m6A), N1-methyladenosine (m1A), 5-methylcytosine (m5C), 7-methylguanosine (m7G) and 2’-O-methylation (Nm)
Vincenza Ylenia Cusenza +3 more
openaire +3 more sources
Post-transcriptional modifications to tRNA--a response to the genetic code degeneracy. [PDF]
, 2015 tRNA is essential for translation and decoding of the proteome. The yeast proteome responds to stress and tRNA biosynthesis contributes in this response by repression of tRNA transcription and alterations of tRNA modification.
,, Hou, Ya-Ming, Yang, Wei
core +6 more sources
Codon-biased translation can be regulated by wobble-base tRNA modification systems during cellular stress responses [PDF]
, 2014 tRNA (tRNA) is a key molecule used for protein synthesis, with multiple points of stress-induced regulation that can include transcription, transcript processing, localization and ribonucleoside base modification.
Begley, Thomas J. +2 more
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Heliyon, 2023 Background: The epigenetic regulator in cancer progression and immune response has been demonstrated recently. However, the potential implications of 5-methylcytosine (m5C) in soft tissue sarcoma (STS) are unclear.
Xianfeng Wang +4 more
doaj +1 more source
The sequence specificity domain of cytosine-C5 methylases [PDF]
, 1991 Prokaryotic DNA[cytosine-C5]methyltransferases (m5C-methylases) share a common architectural arrangement of ten conserved sequence motifs. A series of eleven hybrids have been constructed between the HpaII (recognition sequence: Cm5CGG) and HhaI ...
Klimasauskas, S. +2 more
core +1 more source
Formation and abundance of 5-hydroxymethylcytosine in RNA. [PDF]
, 2015 RNA methylation is emerging as a regulatory RNA modification that could have important roles in the control and coordination of gene transcription and protein translation. Herein, we describe an in vivo isotope-tracing methodology to demonstrate that the
Bachman, Martin +7 more
core +2 more sources
DNA methylation and DNA methyltransferases [PDF]
, 2017 The prevailing views as to the form, function, and regulation of genomic methylation patterns have their origin many years in the past, at a time when the structure of the mammalian genome was only dimly perceived, when the number of protein-encoding ...
Bestor, Timothy H +3 more
core +3 more sources
A System of RNA Modifications and Biased Codon Use Controls Cellular Stress Response at the Level of Translation [PDF]
, 2014 Cells respond to environmental stressors and xenobiotic exposures using regulatory networks to control gene expression, and there is an emerging appreciation for the role of numerous postsynthetic chemical modifications of DNA, RNA, and proteins in ...
Begley, Thomas J., Dedon, Peter C
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Insights into DNA platination within unusual structural settings [PDF]
, 2011 2D [1H, 15N] HSQC NMR spectroscopy has been used to monitor reaction and product formation between [Pt(15NH3)2I2] and nucleic acids possessing irregular topologies and containing site specific phosphorothioate substitution in the phosphodiester backbone.
Harvie, Stephanie +2 more
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Cloning and characterization of the HpaII methylase gene [PDF]
, 1990 The HpaII restriction-modification system from Haemophilus parainfluenzae recognizes the DNA sequence CCGG. The gene for the HpaII methylase has been cloned into E. coli and its nucleotide sequence has been determined.
Card, C. O. +5 more
core +1 more source