Results 61 to 70 of about 5,895 (158)

Kaempferol Attenuates Myocardial Ischemia–Reperfusion Injury by Suppressing Ferroptosis via the KEAP1–Nrf2–GPX4 Axis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Myocardial ischemia/reperfusion (I/R) injury is characterized by cardiomyocyte death, excessive oxidative stress, inflammation, and ferroptosis, which collectively limit the efficacy of reperfusion therapy. In this study, we investigated whether kaempferol (KAE), a natural flavonol with antioxidative and antiinflammatory properties, could ...
Yan‐Bo Zhao, Ling‐Ling Sun, Xiao‐Hua Shen, Min Wang, Mei‐Hui Wang, Lu‐Lu Liu, Kai Zhang   +6 more
wiley   +1 more source

Recent research advances in RNA m5C methylation modification in liver diseases

Frontiers in Molecular Biosciences
RNA m5C methylation refers to the process wherein the 5th carbon atom of cytosine in RNA molecules is methylated by the action of methyltransferase, thus forming 5-methylcytosine (m5C). This crucial epigenetic modification significantly impacts gene expression and various biological processes.
Wenjuan, Chen, Lifan, Zhang, Xinyu, Gu, Yafeng, Liu, Shujun, Zhang, Xinjun, Hu, Penghui, Li   +6 more
openaire   +2 more sources

YBX1 Promotes Malignant Progression of HNSCC via Stabilizing NSUN2‐m5C Modified ATF4 mRNA

Cancer Science, EarlyView.
The diagram depicts the core axis and the key finding: “Targeting YBX1/NSUN2 abrogates HNSCC progression”. Within left‐sided HNSCC cells, NSUN2 mediates m5C methylation on the CDS of ATF4 mRNA; YBX1 then specifically recognizes and binds this modified site, augmenting ATF4 mRNA stability, which ultimately promotes cancer cell proliferation, migration ...
Yanwei Li, Shuang Li, Yang Li, Zhanyu Pan   +3 more
wiley   +1 more source

Lysine l‐Lactylation: Bridging Metabolism, Chromatin and Disease

Cell Proliferation, EarlyView.
Enzymatic regulation of KL‐la. The enzymatic regulation of KL‐la involves two distinct pathways for L‐lactate accumulation: intracellular production through glycolysis‐derived pyruvate conversion by lactate dehydrogenase (LDH) or direct cellular uptake via monocarboxylate transporters (MCTs). These L‐lactate pools fuel two distinct lactylation pathways—
Anoosha Malik, Muhammad Dilawar, Junguang Liao, Jie Zheng, Qitao Qian, Ming Xu, Sisi Lin, Xiaobo Zhu, Qiuwei Ge, Limin Jin, Guiqian Chen   +10 more
wiley   +1 more source

Identification and analysis of RNA-5-methylcytosine-related key genes in osteoarthritis

BMC Genomics, 2023
Background 5-methylcytosine (m5C) modification is widely associated with many biological and pathological processes. However, knowledge of m5C modification in osteoarthritis (OA) remains lacking.
Yang Yu, Shitao Lu, Xiaoming Liu, Yu Li, Jianzhong Xu   +4 more
doaj   +1 more source

Multilayer Proteome and Metabolome‐Based Validation Uncovers Combined Regulatory Roles and Predictive Values of 6 RNA Modifications and Cellular Senescence in Alzheimer's Disease

CNS Neuroscience &Therapeutics, Volume 32, Issue 7, July 2026.
This study integrated multi‐omics data to analyze the synergistic effects of cellular senescence and RNA modifications on AD pathology. Transcriptome and proteome data were used to validate the stability of machine learning‐screened proteins and the model, while metabolomics data further revealed metabolic alterations during the progression of AD ...
Mengjie Tian, Ke Ye, Xinyi Chen, Lulu Liu, Xinyu Han, Tianhu Zheng, Xu Gao, Qing Xia, Fuyuan Li, Dayong Wang   +9 more
wiley   +1 more source

CNSC-28. THE IMPORTANCE OF M5C RNA MODIFICATIONS IN EPITRANSCRIPTOMICS FOR GLIOBLASTOMA

Neuro-Oncology
Abstract Glioblastoma is the most aggressive brain tumor in adults. Despite surgical resection, chemo- and radiotherapies, patients have a median overall survival of less than 2 years. Recently DNA analysis has been developed and defined the characteristics of glioma. Accordingly, the m5C modification on DNA are well reported.
Yamamoto, Takahiro, Matsuura, Jin, Kuroda, Jun-ichiro, Shinojima, Naoki, Nagayoshi, Yu, Chujo, Takeshi, Tomizawa, Kazuhito, Mukasa, Akitake   +7 more
openaire   +1 more source

Bridging maternal effects and epitranscriptomics: A novel perspective in developmental biology

Developmental Dynamics, Volume 255, Issue 7, Page 628-645, July 2026.
Abstract Maternal effects, encompassing both genetic (maternally expressed gene products) and non‐genetic (maternal state) influences, are powerful determinants of offspring phenotype, yet their RNA‐level mechanisms remain incompletely resolved. In parallel, epitranscriptomics, an emerging field centered on chemical modifications to RNA, has revealed ...
Ehsan Pashay Ahi
wiley   +1 more source

Projecting future damage costs of non‐native species using combined dynamical and cost–density equations

Ecological Applications, Volume 36, Issue 5, July 2026.
Abstract Biological invasions threaten biodiversity, economic stability, and public health, exacerbated by intensive global trade and transport. The economic costs of these invasions have exceeded US$2 trillion globally and continue to increase. Although past invasion costs have been described across various contexts, there are few robust projections ...
Danish A. Ahmed, Corey J. A. Bradshaw, Noor Tahat, Emma J. Hudgins, Pierre Courtois, Philip E. Hulme, Yuya Watari, Ali Serhan Tarkan, Ismael Soto, Phillip J. Haubrock, Paride Balzani, Ross N. Cuthbert   +11 more
wiley   +1 more source

Impacts of glacier retreat, greening, and a changing sediment supply on debris flows in contrasting monsoon‐dominated Himalayan climates

Earth Surface Processes and Landforms, Volume 51, Issue 7, July 2026.
We modified the SedCas model to assess how glacier retreat, vegetation growth, and sediment availability and erosion timing affect debris flow activity in Langtang and Mustang, Nepal. Results reveal that landscape change reduces sediment supply and runoff response, making debris flows smaller and less seasonally concentrated under future conditions ...
Varvara O. Bazilova, Jacob Hirschberg, Leon Duurkoop, Tjalling de Haas, Walter Immerzeel   +4 more
wiley   +1 more source