Results 81 to 90 of about 5,895 (158)

Lactylation-Boosted m5C RNA Modification Drives Choroidal Neovascularization

Research
As a prevalent posttranscriptional RNA modification, N5-methylcytosine (m5C) plays a crucial role in a multitude of cellular responses and processes that govern RNA metabolism.
Sipeng Zuo, Lin Li, Jieling Tang, Fuxiang Ye, Sok, Yan Liu, Shengfang Ge, Renbing Jia, Xianqun Fan, Peiwei Chai, Linna Lu   +10 more
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NSUN6-mediated 5-methylcytosine modification of NDRG1 mRNA promotes radioresistance in cervical cancer

Molecular Cancer
Background Radioresistance is the leading cause of death in advanced cervical cancer (CC). Dysregulation of RNA modification has recently emerged as a regulatory mechanism in radiation and drug resistance.
Min Yu, Mengdong Ni, Fei Xu, Chaohua Liu, Lihua Chen, Jiana Li, Siyu Xia, Yixin Diao, Jiaxin Chen, Jun Zhu, Xiaohua Wu, Min Tang, Jiajia Li, Guihao Ke   +13 more
doaj   +1 more source

NCAPG confers ferroptosis resistance of hepatocellular carcinoma through NSUN2-mediated m5C modification

Cellular Signalling
Ferroptosis is considered as a promising strategy for treatment of hepatocellular carcinoma (HCC) due to its susceptibility. However, ferroptosis-based treatment is rarely discussed in clinical application, which is closely correlated with insufficient exploration toward the upstream mechanisms of ferroptosis and corresponding biomarkers.
Zhihao, Huang, Jiakun, Wang, Aoxiao, He, Qian, Feng, Jun, Yang, Linquan, Wu, Wenjun, Liao   +6 more
openaire   +2 more sources

Comprehensive Analysis of Differentially Expressed Profiles of mRNA 5-Methylcytosine Modification in Metabolic Dysfunction-Associated Steatotic Liver Disease

Current Issues in Molecular Biology
RNA methylation plays a critical role in regulating all aspects of RNA function, which are implicated in the pathogenesis of various human diseases.
Yueying Yang, E Wang, Bing Zhou, Yan Lu, Xiaoying Ding, Yao Li   +5 more
doaj   +1 more source

Epigenetic addition of m5C to HBV transcripts promotes viral replication and evasion of innate antiviral responses

Cell Death and Disease
Eukaryotic five-methylcytosine (m5C) is an important regulator of viral RNA splicing, stability, and translation. However, its role in HBV replication remains largely unknown.
Shuang Ding, Haibin Liu, Lijuan Liu, Li Ma, Zhen Chen, Miao Zhu, Lishi Liu, Xueyan Zhang, Haojie Hao, Li Zuo, Jingwen Yang, Xiulin Wu, Ping Zhou, Fang Huang, Fan Zhu, Wuxiang Guan   +15 more
doaj   +1 more source

5-Methylcytosine RNA modification and its roles in cancer and cancer chemotherapy resistance

Journal of Translational Medicine
Recent advancements in cancer therapies have improved clinical outcomes, yet therapeutic resistance remains a significant challenge because of its complex mechanisms.
Fang Li, Tingting Liu, Yajing Dong, Qianqian Gao, Rongzhu Lu, Zhiyong Deng   +5 more
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Correction to “[NSUN2 promotes colorectal cancer progression and increases lapatinib sensitivity by enhancing CUL4B/ErbB‐STAT3 signalling in a non‐m5C manner]”

Clinical and Translational Medicine, Volume 16, Issue 7, July 2026.
wiley   +1 more source

Deciphering the vital roles and mechanism of m5C modification on RNA in cancers.

American journal of cancer research
5-methylcytosine (m5C modification) plays an essential role in tumors, which affects different types of RNA, the expression of downstream target genes, and downstream pathways, thus participating in the tumor process. However, the effect of m5C modification on RNA in tumors and the exact mechanism have not been systematically reviewed.
Lemei, Zheng, Yumei, Duan, Mengna, Li, Jianxia, Wei, Changning, Xue, Shipeng, Chen, Qingqing, Wei, Faqing, Tang, Wei, Xiong, Ming, Zhou, Hongyu, Deng   +10 more
openaire   +1 more source

m5C‐TNKmer: Identification of 5‐Methylated Base Cytosine of Ribonucleic Acid Using Supervised Machine Learning Techniques

Engineering Reports
5‐Methylcytosine (m5C) is a widely recognized epigenetic modification in ribonucleic acid (RNA), catalyzed by methyltransferases. This modification is crucial for various biological functions. While the role of m5C in deoxyribonucleic acid (DNA) has been
Shahid Qazi, Dilawar Shah, Mohammad Asmat Ullah Khan, Shujaat Ali, Mohammad Abrar, Asfandyar Khan, Muhammad Tahir   +6 more
doaj   +1 more source

Epitranscriptomic profiling of m5C RNA methylation reveals a dynamic response to TSWV infection in tomato

Frontiers in Plant Science
Cytosine-5 methylation (m5C) is a crucial epitranscriptomic mark in eukaryotes that modulates RNA stability and gene expression. While the roles of m5C are partially understood in model plants, its function in horticultural crops under biotic stress ...
Xinyi Zhao, Yanwei Gong, Yubing Jiao, Wanhong Zhang, Dong An, Yingwen Wang, Binna Lv, Ying Li, Lili Shen, Jinguang Yang   +9 more
doaj   +1 more source