Results 71 to 80 of about 814,114 (202)

NSUN3‐Associated m5C Modification of tRF5‐GlyTCC Suppresses Colorectal Cancer Progression via RPL23‐Linked Nucleolar Stress and p53‐Associated Autophagy and Enhances 5‐FU Sensitivity

Advanced Science, EarlyView.
This study identifies that NSUN3‐mediated m5C modification stabilizes tRF5‐GlyTCC, linking ribosomal homeostasis, nucleolar stress responses, and p53 signaling changes. This regulatory axis suppresses colorectal cancer and enhances chemotherapy response to 5‐FU, positioning tRF5‐GlyTCC as a potential therapeutic target for improving drug sensitivity in
Xinhui Lv, Can Tang, Feiyang Song, Yu Wu, Yafang Chen, Sicong Liu, Ziwen Yuan, Guihua Wang, Xudong Wang   +8 more
wiley   +1 more source

Identification of tRNA nucleoside modification genes critical for stress response and development in rice and Arabidopsis

, 2017
Background Modification of nucleosides on transfer RNA (tRNA) is important either for correct mRNA decoding process or for tRNA structural stabilization.
Chaoqun Pang, Zhengyi Lv, Xukai Li, Zhen Hu, Bo Zheng, Peng Chen, Youmei Wang   +6 more
core   +1 more source

Deciphering transcriptome complexity via long‐read sequencing

iMeta, EarlyView.
Long‐read sequencing is transforming transcriptomics from gene‐level quantification to isoform‐resolved interpretation by directly resolving full‐length transcript structures, transcription in repetitive regions, and linked molecular features. This review provides an end‐to‐end roadmap covering sequencing platforms, library preparation strategies ...
Chuwen Xu, Jia Li, Chenxi Yin, Keying Li, Tian Wang, Shiwen Gao, Yue Yu, Cheng Chang, Ye Wang, Guoqing Tong, Liang Gong, Wen Hu, Guoliang Chai, Yilai Han, Qian Qin, Suoqin Jin, Xiufen Zou, Bo Li, Tianyuan Zhang, Ana Conesa, Yunhao Wang, Dingjie Wang   +21 more
wiley   +1 more source

Advances in mRNA 5-methylcytosine modifications: Detection, effectors, biological functions, and clinical relevance

Molecular Therapy: Nucleic Acids, 2021
5-methylcytosine (m5C) post-transcriptional modifications affect the maturation, stability, and translation of the mRNA molecule. These modifications play an important role in many physiological and pathological processes, including stress response ...
Gangqiang Guo, Kan Pan, Su Fang, Lele Ye, Xinya Tong, Zhibin Wang, Xiangyang Xue, Huidi Zhang   +7 more
doaj   +1 more source

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source

DataSheet_1_RNA m5C regulator-mediated modification patterns and the cross-talk between tumor microenvironment infiltration in gastric cancer.pdf

, 2022
The effect of immunotherapy strategy has been affirmed in the treatment of various tumors. Nevertheless, the latent role of RNA 5-methylcytosine (m5C) modification in gastric cancer (GC) tumor microenvironment (TME) cell infiltration is still unclear. We
Xiaodong Gao (353817), Kuntang Shen (3879946), Jianyi Sun (627104), Jiangshen Lu (14016135), Xiangfei Sun (8928503), Qiang Zhang (45005), Xinyu Qin (442493)   +6 more
core   +1 more source

m5C RNA modification in gastrointestinal cancers: a comprehensive review from molecular mechanism to clinical implication

Biology Direct
5-methylcytosine (m5C) modification has emerged as a novel epigenetic modification of ribonucleic acids (RNAs), encompassing messenger RNAs (mRNAs) and non- coding RNAs, in recent years.
Chao Xu, Qinwen Ye, Hao Wang, Yue Yu
doaj   +1 more source

ATP Citrate Lyase in Metabolic Disease: Mechanistic Insights and Clinical Potential

iNew Medicine, EarlyView.
ATP citrate lyase (ACLY) is a central metabolic hub that diverts mitochondrial citrate to fuel de novo lipogenesis, cholesterol biosynthesis, and protein acetylation. Given its robust correlation with pathological changes in multiple human diseases, ACLY inhibitors featuring distinct pharmacological strengths have been developed for therapeutic ...
Wenbiao Wang, Xinyan Li, Honglu Shi, Gaolei Song, Zhifu Xie, Jingya Li   +5 more
wiley   +1 more source

Mitomycin C binding to poly[d(G-m5C)] [PDF]

, 1995
6 pages, 5 figures, 1 table.-- PMID: 7864808 [PubMed].-- PMCID: PMC1136499.Poly[d(G-m5C)] was modified by reductively activated mitomycin C, an anti-tumour drug, under buffer conditions which are known to favour either the B or the Z conformations of DNA.
Sánchez Baeza, Francisco J., Portugal, José   +1 more
core  

Most m5C Modifications in Mammalian mRNAs are Nonadaptive

Molecular Biology and Evolution
Abstract 5-Methylation (m5C) on mRNA molecules is a prevalent internal posttranscriptional modification in eukaryotes. Although m5C modification has been reported to regulate some biological processes, whether most mRNA m5C modifications are functional is unknown.
Zheng Li, Kai Mi, Chuan Xu
openaire   +2 more sources