Results 71 to 80 of about 5,895 (158)

NSUN2/YBX1 promotes the progression of breast cancer by enhancing HGH1 mRNA stability through m5C methylation

Breast Cancer Research
Background RNA m5C methylation has been extensively implicated in the occurrence and development of tumors. As the main methyltransferase, NSUN2 plays a crucial regulatory role across diverse tumor types. However, the precise impact of NSUN2-mediated m5C
Xuran Zhang, Ke An, Xin Ge, Yuanyuan Sun, Jingyao Wei, Weihong Ren, Han Wang, Yueqin Wang, Yue Du, Lulu He, Ouwen Li, Shaoxuan Zhou, Yong Shi, Tong Ren, Yun-gui Yang, Quancheng Kan, Xin Tian   +16 more
doaj   +1 more source

RNA Modifications in Tumor Microenvironment: A New Dimension for Cancer Treatment

MedComm, Volume 7, Issue 7, July 2026.
Tumor initiation and progression depend on a supportive and highly heterogeneous tumor microenvironment (TME). RNA modifications regulate signaling pathways and cytokine networks that shape TME dynamics, facilitating interactions between cancer cells and noncancerous stromal cells, and ultimately promoting immune evasion and tumor progression ...
Qiwen Li, Yating Sun, Shuibin Lin, Quan Yuan   +3 more
wiley   +1 more source

Topological Characterization of Human and Mouse m5C Epitranscriptome Revealed by Bisulfite Sequencing

International Journal of Genomics, 2018
Background. Compared with the well-studied 5-methylcytosine (m5C) in DNA, the role and topology of epitranscriptome m5C remain insufficiently characterized. Results.
Zhen Wei, Subbarayalu Panneerdoss, Santosh Timilsina, Jingting Zhu, Tabrez A. Mohammad, Zhi-Liang Lu, João Pedro de Magalhães, Yidong Chen, Rong Rong, Yufei Huang, Manjeet K. Rao, Jia Meng   +11 more
doaj   +1 more source

Salt Stress Adaptations in Soybean Involve Alterations in Pre‐mRNA Processing

Plant, Cell &Environment, Volume 49, Issue 7, Page 4000-4014, July 2026.
ABSTRACT Salt stress can seriously affect plant survival. To adapt to salt stress, plants can alter gene expressions and/or pre‐mRNA processing patterns, or both. Previous studies could not comprehensively profile stress‐responsive pre‐mRNA processing patterns due to limitations in traditional sequencing technologies.
Shoudong Zhang, Zhixia Xiao, Ailin Liu, Dongpeng Ren, Shengjie Chen, Hanxue Zhang, Li Zhang, Zhili Wang, Jun Yang, Hon‐Ming Lam   +9 more
wiley   +1 more source

NSUN5 Attenuates Renal Injury and Ferroptosis in Hyperuricaemic Nephropathy Through YBX2‐Dependent Stabilisation of SCD1 m5C Methylation

Advanced Science, Volume 13, Issue 34, 19 June 2026.
NSUN5 is downregulated in hyperuricaemic nephropathy. Overexpression of NSUN5 enhances the stability of SCD1 mRNA through the m5C reader YBX2, ultimately inhibiting ferroptosis in renal tubular epithelial cells. Additionally, this axis suppresses the NF‐κB signaling pathway to alleviate inflammation and upregulates ABCG2 to promote uric acid excretion,
Xiu‐xiu Song, Xiao‐guo Suo, Yue Yu, Kuo Zhang, Chen‐ao Li, Jie Wang, Hui‐xia Xu, Si‐yu Niu, Dong‐xue Lv, Zi‐hao He, Feng‐he Li, Xiao‐ming Meng, Juan Jin   +12 more
wiley   +1 more source

Ribozymes for RNA‐Catalyzed RNA Methylation and Labeling

Angewandte Chemie International Edition, Volume 65, Issue 23, 1 June 2026.
Ribozymes are powerful tools for site‐specific RNA modification. Their activities range from installing tags and fluorophores to generating natural RNA methylations, making them valuable tools to uncover the many functions that RNA plays in nature.
Carolin P. M. Scheitl, Claudia Höbartner   +1 more
wiley   +1 more source

5‐Methylcytosine Analysis of miRNAs in Minimal Change Disease

Biotechnology and Applied Biochemistry, Volume 73, Issue 3, Page 1137-1150, June 2026.
ABSTRACT Minimal change disease (MCD) is a glomerular disorder, which is the most common cause of nephrotic syndrome in children. Additionally, the prevalence of MCD in adults has been increasing in recent years. During protein synthesis, noncoding RNAs can be regulated through a variety of modifications, which helps preserve biological diversity and ...
Huiyi Zeng, Dandan Li, Yunyi Li, Chen Yun, Xinzhou Zhang, Wenyu Gong, Mengyun Xiao, Haitao Li, Zhipeng Zeng, Ruqi Tan, Yishen Yang, Shaodong Luan, Yong Dai, Lianghong Yin, Donge Tang   +14 more
wiley   +1 more source

Detection, molecular function and mechanisms of m5C in cancer

Clinical and Translational Medicine
Interest in RNA posttranscriptional modifications, particularly 5‐methylcytosine (m5C), has surged in recent years. Studies have shown that m5C plays a key role in cellular processes and is closely linked to tumourigenesis.
Linhui Zhang, Yuelong Li, Liqing Li, Fei Yao, Maoping Cai, Dingwei Ye, Yuanyuan Qu   +6 more
doaj   +1 more source

CIGAR‐seq, a CRISPR/Cas‐based method for unbiased screening of novel mRNA modification regulators

Molecular Systems Biology, 2020
Cellular RNA is decorated with over 170 types of chemical modifications. Many modifications in mRNA, including m6A and m5C, have been associated with critical cellular functions under physiological and/or pathological conditions.
Liang Fang, Wen Wang, Guipeng Li, Li Zhang, Jun Li, Diwen Gan, Jiao Yang, Yisen Tang, Zewen Ding, Min Zhang, Wenhao Zhang, Daqi Deng, Zhengyu Song, Qionghua Zhu, Huanhuan Cui, Yuhui Hu, Wei Chen   +16 more
doaj   +1 more source

The RNA M5C methyltransferase NSUN2 promotes progression of hepatocellular carcinoma by enhancing PKM2-mediated glycolysis

Cell Death and Disease
Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. The 5-methylcytosine (m5C) RNA methyltransferase NSUN2 is involved in cell proliferation and metastasis and is upregulated in a variety of cancers.
Qin Qi, Rui Zhong, Yan Huang, Yong Tang, Xiao-wen Zhang, Chang Liu, Chun-fang Gao, Lin Zhou, Jian Yu, Lu-yi Wu   +9 more
doaj   +1 more source