Results 91 to 100 of about 5,895 (158)

Identification of the m6A/m5C/m1A methylation modification genes in Alzheimer’s disease based on bioinformatic analysis

Aging
As a progressive neurodegenerative disease, the comprehensive understanding of the pathogenesis of Alzheimer's disease (AD) is yet to be clarified. Modifications in RNA, including m6A/m5C/m1A, affect the onset and progression of many diseases. Consequently, this study focuses on the role of methylation modification in the pathogenesis of AD.Three AD ...
Tan, Qifa, Zhou, Desheng, Guo, Yuan, Chen, Haijun, Xie, Peng   +4 more
openaire   +2 more sources

NSUN2‐mediated m5C methylation modification regulates trophoblast cell proliferation, apoptosis, and autophagy in gestational diabetes mellitus

Journal of Diabetes Investigation
Introduction Gestational diabetes mellitus (GDM) represents one of the most prevalent medical complications during pregnancy. Emerging evidence has implicated NOL1/NOP2/SUN domain (NSUN)2‐mediated 5‐methylcytosine (m5C) methylation modifications in ...
Jiujiu Liu, Yingjun Chen, Dapeng Wang, Zhaozhao Li   +3 more
doaj   +1 more source

Epitranscriptomic Modifications (m6A, m5C) as Emerging Regulators of Drug Response and Resistance

Background: Epitranscriptomics—the study of chemical modifications on RNA—has emerged as a pivotal layer of gene expression regulation. Among the most prevalent modifications are N6-methyladenosine (m6A) and 5-methylcytosine (m5C), which govern RNA stability, splicing, translation, and nuclear export. Disruptions in these modifications are increasingly
openaire   +2 more sources

NSUN2 as a potential prognostic as well as therapeutic target in cancer by regulating m5C modification

m5C modification is a type of RNA methylation modification, and its major methyltransferase, NSUN2, catalyzes m5C modification. NSUN2 is overexpressed in a variety of cancers, and it affects the metabolism of RNA from target genes by affecting the level of m5C modification in cancer cells, which in turn promotes the development of cancers and is ...
He, Zifang, Yang, Longtao, Ma, Peiyao
openaire   +2 more sources

ALYREF promotes the metastasis of nasopharyngeal carcinoma by increasing the stability of NOTCH1 mRNA

Cell Death and Disease
Approximately 70% of treatment failures in nasopharyngeal carcinoma (NPC) patients are attributed to distant metastasis, yet the underlying mechanisms remain unclear.
Yanan Jin, Jijin Yao, Jianchang Fu, Qitao Huang, Yilin Luo, Yafei You, Wangjian Zhang, Qian Zhong, Tianliang Xia, Liangping Xia   +9 more
doaj   +1 more source

m5C-modified circRREB1 promotes lung cancer progression by inducing mitophagy

Journal of Experimental & Clinical Cancer Research
Background Lung cancer is the most common malignant tumour and the leading cause of cancer-related death. circular RNAs (circRNAs) have important biological functions and are closely related to tumour development.
Dunyu Cai, Xingcai Chen, Haotian Xu, Qingyun Zhao, Xiaodong Zhou, Jiaxi Wu, Shengyi Yuan, Yihong Gao, Deqing Li, Ruirui Zhang, Wenyi Peng, Gang Li, Aruo Nan   +12 more
doaj   +1 more source

CDK13 promotes lipid deposition and prostate cancer progression by stimulating NSUN5-mediated m5C modification of ACC1 mRNA. [PDF]

Cell Death Differ, 2023
Zhang Y, Chen XN, Zhang H, Wen JK, Gao HT, Shi B, Wang DD, Han ZW, Gu JF, Zhao CM, Xue WY, Zhang YP, Qu CB, Yang Z.   +13 more
europepmc   +1 more source

CASC19 stabilization by ALYREF via m5C modification and its impact on SCD in colorectal cancer cell aggressiveness and stemness. [PDF]

Cell Biosci
Zhao L, Xie R, Li L, Lu X, Wang L, Wang H, Liu L.   +6 more
europepmc   +1 more source

NOP2-mediated m5C Modification of c-Myc in an EIF3A-Dependent Manner to Reprogram Glucose Metabolism and Promote Hepatocellular Carcinoma Progression. [PDF]

Research (Wash D C), 2023
Zhang H, Zhai X, Liu Y, Xia Z, Xia T, Du G, Zhou H, Franziska Strohmer D, Bazhin AV, Li Z, Wang X, Jin B, Guo D.   +12 more
europepmc   +1 more source

LncRNA SLC16A1-AS1 cooperates with NSUN2 to stabilize GRP78 mRNA via m5C modification in gastric cancer. [PDF]

iScience
Zheng B, Zhao W, Jin Y, Sun W, Li Y, Zhang Q, Li Y, Wang J, Chen D, Ren K, Zhang W, Chen Y, Yuan L, Wang XJ, Yang F, Chen J.   +15 more
europepmc   +1 more source