Results 91 to 100 of about 814,114 (202)

Identification and analysis of RNA-5-methylcytosine-related key genes in osteoarthritis

BMC Genomics, 2023
Background 5-methylcytosine (m5C) modification is widely associated with many biological and pathological processes. However, knowledge of m5C modification in osteoarthritis (OA) remains lacking.
Yang Yu, Shitao Lu, Xiaoming Liu, Yu Li, Jianzhong Xu   +4 more
doaj   +1 more source

Lactate metabolism and protein lactylation in programmed cell death: From novel mechanism to therapeutic strategies in human diseases

Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.
This review highlights protein lactylation as a metabolic‐epigenetic regulator linking lactate reprogramming to programmed cell death. By modulating histone and non‐histone targets, lactylation reshapes cell fate decisions and represents a promising biomarker and therapeutic target in human diseases.
Yue Chen, Xiwen Wang, Xiuping Wang, Na Lin, Wenjie Wang, Ruiqi Fu, Yutong Wu, Yi Liu, Hengwei Liu   +8 more
wiley   +1 more source

Image_1_5-Methylcytosine (m5C) modification in peripheral blood immune cells is a novel non-invasive biomarker for colorectal cancer diagnosis.tif

, 2022
Current non-invasive tumor biomarkers failed to accurately identify patients with colorectal cancer (CRC), delaying CRC diagnosis and thus leading to poor prognosis.
Shiqiong Niu (13835683), Jinye Xie (11504809), Zhijian Huang (1649578), Liang Gu (573034), Liang Ming (280713), Haofan Yin (11504815), Hongbo Jiang (501149), Weibin Huang (9157199), Yulong He (3452147), Changhua Zhang (157463)   +9 more
core   +1 more source

CNSC-28. THE IMPORTANCE OF M5C RNA MODIFICATIONS IN EPITRANSCRIPTOMICS FOR GLIOBLASTOMA

Neuro-Oncology
Abstract Glioblastoma is the most aggressive brain tumor in adults. Despite surgical resection, chemo- and radiotherapies, patients have a median overall survival of less than 2 years. Recently DNA analysis has been developed and defined the characteristics of glioma. Accordingly, the m5C modification on DNA are well reported.
Yamamoto, Takahiro, Matsuura, Jin, Kuroda, Jun-ichiro, Shinojima, Naoki, Nagayoshi, Yu, Chujo, Takeshi, Tomizawa, Kazuhito, Mukasa, Akitake   +7 more
openaire   +1 more source

NSUN2/YBX1 promotes the progression of breast cancer by enhancing HGH1 mRNA stability through m5C methylation

Breast Cancer Research
Background RNA m5C methylation has been extensively implicated in the occurrence and development of tumors. As the main methyltransferase, NSUN2 plays a crucial regulatory role across diverse tumor types. However, the precise impact of NSUN2-mediated m5C
Xuran Zhang, Ke An, Xin Ge, Yuanyuan Sun, Jingyao Wei, Weihong Ren, Han Wang, Yueqin Wang, Yue Du, Lulu He, Ouwen Li, Shaoxuan Zhou, Yong Shi, Tong Ren, Yun-gui Yang, Quancheng Kan, Xin Tian   +16 more
doaj   +1 more source

Interrogating the Escherichia coli Epitranscriptome Via CRISPR Interference and Nanopore Native RNA Sequencing

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
Epitranscriptomics is understudied in bacteria but has the ability to modulate antimicrobial resistance, virulence and pathogenicity. Pitt et al. implement two cutting‐edge techniques: CRISPR interference and Nanopore direct RNA sequencing along with functional assays to study RNA modifications in Escherichia coli.
Miranda E. Pitt, Jianshu Zhang, An N. T. Nguyen, Michael B. Hall, Leila Jebeli, Leo A. Featherstone, Garry S. A. Myers, Nichollas E. Scott, Lachlan J. M. Coin   +8 more
wiley   +1 more source

Image_2_5-Methylcytosine (m5C) modification in peripheral blood immune cells is a novel non-invasive biomarker for colorectal cancer diagnosis.tif

, 2022
Current non-invasive tumor biomarkers failed to accurately identify patients with colorectal cancer (CRC), delaying CRC diagnosis and thus leading to poor prognosis.
Shiqiong Niu (13835683), Jinye Xie (11504809), Zhijian Huang (1649578), Liang Gu (573034), Liang Ming (280713), Haofan Yin (11504815), Hongbo Jiang (501149), Weibin Huang (9157199), Yulong He (3452147), Changhua Zhang (157463)   +9 more
core   +1 more source

Extracellular Vesicles: Classification, Biological Functions, Diseases, and Therapeutic Opportunities

MedComm, Volume 7, Issue 10, October 2026.
• EV content maintains cellular homeostasis and is involved in several disease onset and progression. • miRNA export in EVs depends on: RNA‐binding proteins recognizing motif sequences and on epitranscriptomic modifications. • The disclosure of delivery mechanisms is crucial for developing personalized EV‐based therapeutic tools. ABSTRACT Extracellular
Sabrina Garbo, Francesco Marocco, Clemens Zwergel, Marco Tripodi, Cecilia Battistelli   +4 more
wiley   +1 more source

Roles of m5C RNA modification patterns in biochemical recurrence and tumor microenvironment characterization of prostate cancer

, 2022
The datasets included in the manuscript 'Roles of m5C RNA modification patterns in biochemical recurrence and tumor microenvironment characterization of prostate ...
Zhipeng, Xu
core   +1 more source

A Hypertrophic Stimulus Drives Age‐Dependent Transcript Isoform Switching With and Without Differential Gene Expression in Skeletal Muscle

Aging Cell, Volume 25, Issue 10, October 2026.
A combined analysis of short‐read and long‐read RNA‐seq demonstrates reduced isoform switching after an acute hypertrophic stimulus in aged muscle and identifies age‐dependent isoforms that may not be detected with total gene‐level analyses. ABSTRACT Aged skeletal muscle has a reduced ability to adapt to hypertrophic stimuli concomitant with ...
Pieter J. Koopmans, Abbey L. Stokes, Christopher E. Nelson, Yuan Wen, Ahmed Ismaeel, Kevin A. Murach   +5 more
wiley   +1 more source