Results 101 to 110 of about 814,114 (202)

Polyphenism Through RNA Chemical Modifications

Molecular Ecology, Volume 35, Issue 19, October 2026.
ABSTRACT Polyphenism, the capacity of a single genotype to produce discrete phenotypes in response to environmental cues, has long served as a model for understanding developmental plasticity. While classical studies have highlighted hormonal signalling and transcription‐factor‐driven gene regulatory networks that mediate these environmentally induced ...
Ralf Schneider, Ehsan Pashay Ahi
wiley   +1 more source

Table2_Modification of m5C regulators in sarcoma can guide different immune infiltrations as well as immunotherapy.xls

, 2023
BackgroundRecent studies have found that 5-methylcytosine (m5C) modulators are associated with the prognosis and treatment of cancer. However, the relevance of m5C modulators in sarcoma prognosis and the tumour microenvironment is unclear.MethodsWe ...
Yangfan Zhou (10889385), Shusheng Wu (10889388), Mengge Li (3775978), Hao Shen (195461), Yifu He (5881085), Rixin Su (14337084)   +5 more
core   +1 more source

An Enzymatic Platform for Late‐Stage (Radio)isotope Labelling of Oligonucleotides With Methyltransferases

Angewandte Chemie, Volume 138, Issue 39, 21 September 2026.
State‐of‐the‐art synthesis of radiolabelled oligonucleotides involves multi‐step synthesis with high costs, extended timelines and significant radioactive waste generation. Herein, a dual‐methyltransferase platform enables late‐stage, site‐specific labelling, overcoming these limitations through reduced costs, faster turnaround and minimal radioactive ...
Christopher R. B. Swanson, Ulrich Kauhl, Martin R. Edelmann, Florian P. Seebeck   +3 more
wiley   +1 more source

Nanopore direct RNA sequencing reveals the m5C methylomes of tomato fruits in response to Botrytis cinerea

Plant Hormones
RNA methylation, particularly 5-methylcytosine (m5C) modification, has emerged as a pivotal regulatory layer governing plant development and stress responses.
Xinyao Cai, Baowen Huang, Yulin Cheng, Jianghua Cai, Hua Cassan-Wang, Guozheng Qin, Ying Gao, Leilei Zhou   +7 more
doaj   +1 more source

Image_4_5-Methylcytosine (m5C) modification in peripheral blood immune cells is a novel non-invasive biomarker for colorectal cancer diagnosis.tif

, 2022
Current non-invasive tumor biomarkers failed to accurately identify patients with colorectal cancer (CRC), delaying CRC diagnosis and thus leading to poor prognosis.
Shiqiong Niu (13835683), Jinye Xie (11504809), Zhijian Huang (1649578), Liang Gu (573034), Liang Ming (280713), Haofan Yin (11504815), Hongbo Jiang (501149), Weibin Huang (9157199), Yulong He (3452147), Changhua Zhang (157463)   +9 more
core   +1 more source

Image_3_5-Methylcytosine (m5C) modification in peripheral blood immune cells is a novel non-invasive biomarker for colorectal cancer diagnosis.tif

, 2022
Current non-invasive tumor biomarkers failed to accurately identify patients with colorectal cancer (CRC), delaying CRC diagnosis and thus leading to poor prognosis.
Shiqiong Niu (13835683), Jinye Xie (11504809), Zhijian Huang (1649578), Liang Gu (573034), Liang Ming (280713), Haofan Yin (11504815), Hongbo Jiang (501149), Weibin Huang (9157199), Yulong He (3452147), Changhua Zhang (157463)   +9 more
core   +1 more source

Detection, molecular function and mechanisms of m5C in cancer

Clinical and Translational Medicine
Interest in RNA posttranscriptional modifications, particularly 5‐methylcytosine (m5C), has surged in recent years. Studies have shown that m5C plays a key role in cellular processes and is closely linked to tumourigenesis.
Linhui Zhang, Yuelong Li, Liqing Li, Fei Yao, Maoping Cai, Dingwei Ye, Yuanyuan Qu   +6 more
doaj   +1 more source

CIGAR‐seq, a CRISPR/Cas‐based method for unbiased screening of novel mRNA modification regulators

Molecular Systems Biology, 2020
Cellular RNA is decorated with over 170 types of chemical modifications. Many modifications in mRNA, including m6A and m5C, have been associated with critical cellular functions under physiological and/or pathological conditions.
Liang Fang, Wen Wang, Guipeng Li, Li Zhang, Jun Li, Diwen Gan, Jiao Yang, Yisen Tang, Zewen Ding, Min Zhang, Wenhao Zhang, Daqi Deng, Zhengyu Song, Qionghua Zhu, Huanhuan Cui, Yuhui Hu, Wei Chen   +16 more
doaj   +1 more source

Transcriptome-wide Mapping of RNA 5-Methylcytosine in Arabidopsis mRNAs and non-coding RNAs

, 2017
Post-transcriptional methylation of RNA cytosine residues to 5-methylcytosine (m5C) is an important modification with diverse roles, such as regulating stress responses, stem cell proliferation, and RNA metabolism. Here, we used RNA bisulfite sequencing (
Parker, B., Pulsford, K., Searle, I., David, R., Sibbritt, T., Li, J., Burgess, A., Preiss, T.   +7 more
core   +1 more source

Table_4_Uncovering the Association Between m5C Regulator-Mediated Methylation Modification Patterns and Tumour Microenvironment Infiltration Characteristics in Hepatocellular Carcinoma.docx

, 2021
Background: 5-Methylcytosine (m5C) plays essential roles in hepatocellular carcinoma (HCC), but the association between m5C regulation and immune cell infiltration in HCC has not yet been clarified.Methods: In this study, we analysed 371 patients with ...
Jing Wang (6206297), Haihong Zhu (269409), Haibo Zhou (575077), Qiuxian Zheng (9948220), Xinyu Gu (382878), Qingfei Chu (11424061)   +5 more
core   +1 more source