Results 111 to 120 of about 814,114 (202)

The RNA M5C methyltransferase NSUN2 promotes progression of hepatocellular carcinoma by enhancing PKM2-mediated glycolysis

Cell Death and Disease
Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. The 5-methylcytosine (m5C) RNA methyltransferase NSUN2 is involved in cell proliferation and metastasis and is upregulated in a variety of cancers.
Qin Qi, Rui Zhong, Yan Huang, Yong Tang, Xiao-wen Zhang, Chang Liu, Chun-fang Gao, Lin Zhou, Jian Yu, Lu-yi Wu   +9 more
doaj   +1 more source

Distinct 5-methylcytosine profiles in poly(A) RNA from mouse embryonic stem cells and brain [PDF]

, 2017
Background Recent work has identified and mapped a range of posttranscriptional modifications in mRNA, including methylation of the N6 and N1 positions in adenine, pseudouridylation, and methylation of carbon 5 in cytosine (m5C ...
Wille, Alexandra, Xi-Yu Jia, Trixl, Lukas, Thomas Amort, Lusser, Alexandra, Lukas Trixl, Khokhlova-Cubberley, Daria, Alexandra Wille, Rieder, Dietmar, Amort, Thomas, Riml, Christian, Jia, Xi-Yu, Dietmar Rieder, Daria Khokhlova-Cubberley, Alexandra Lusser, Christian Riml, Ronald Micura, Micura, Ronald   +17 more
core   +1 more source

Table_3_Uncovering the Association Between m5C Regulator-Mediated Methylation Modification Patterns and Tumour Microenvironment Infiltration Characteristics in Hepatocellular Carcinoma.xlsx

, 2021
Background: 5-Methylcytosine (m5C) plays essential roles in hepatocellular carcinoma (HCC), but the association between m5C regulation and immune cell infiltration in HCC has not yet been clarified.Methods: In this study, we analysed 371 patients with ...
Jing Wang (6206297), Haihong Zhu (269409), Haibo Zhou (575077), Qiuxian Zheng (9948220), Xinyu Gu (382878), Qingfei Chu (11424061)   +5 more
core   +1 more source

NSUN6-mediated 5-methylcytosine modification of NDRG1 mRNA promotes radioresistance in cervical cancer

Molecular Cancer
Background Radioresistance is the leading cause of death in advanced cervical cancer (CC). Dysregulation of RNA modification has recently emerged as a regulatory mechanism in radiation and drug resistance.
Min Yu, Mengdong Ni, Fei Xu, Chaohua Liu, Lihua Chen, Jiana Li, Siyu Xia, Yixin Diao, Jiaxin Chen, Jun Zhu, Xiaohua Wu, Min Tang, Jiajia Li, Guihao Ke   +13 more
doaj   +1 more source

NCAPG confers ferroptosis resistance of hepatocellular carcinoma through NSUN2-mediated m5C modification

Cellular Signalling
Ferroptosis is considered as a promising strategy for treatment of hepatocellular carcinoma (HCC) due to its susceptibility. However, ferroptosis-based treatment is rarely discussed in clinical application, which is closely correlated with insufficient exploration toward the upstream mechanisms of ferroptosis and corresponding biomarkers.
Zhihao, Huang, Jiakun, Wang, Aoxiao, He, Qian, Feng, Jun, Yang, Linquan, Wu, Wenjun, Liao   +6 more
openaire   +2 more sources

An orphan DNA (cytosine-5-)-methyltransferase in Vibrio cholerae

, 2006
5-Methyl cytosine (m5C) was detected in genomic DNA of the enteric pathogen Vibrio cholerae by HPLC analysis and immunoblotting with m5C-specific antibody.
Chowdhury, Rukhsana, Banerjee, Sanjib
core   +1 more source

Comprehensive Analysis of Differentially Expressed Profiles of mRNA 5-Methylcytosine Modification in Metabolic Dysfunction-Associated Steatotic Liver Disease

Current Issues in Molecular Biology
RNA methylation plays a critical role in regulating all aspects of RNA function, which are implicated in the pathogenesis of various human diseases.
Yueying Yang, E Wang, Bing Zhou, Yan Lu, Xiaoying Ding, Yao Li   +5 more
doaj   +1 more source

SURVEY AND SUMMARY 5-methylcytosine in RNA: detection, enzymatic formation and biological functions

, 2009
The nucleobase modification 5-methylcytosine (m5C) is widespread both in DNA and different cellular RNAs. The functions and enzymatic mecha-nisms of DNA m5C-methylation were extensively studied during the last decades.
Frank Lyko, Mark Helm, Yuri Motorin
core  

NOP2-mediated m5C methylation impairs mitophagy and aggravates acute lung injury by targeting PINK1

Scientific Reports
Sepsis-induced acute lung injury (ALI) involves complex pathological mechanisms. 5-methylcytosine (m5C) RNA modification, catalyzed by methyltransferases like NOP2, plays a crucial role in regulating inflammation and cellular processes. However, the role
Xiaoyuan Chen, Rui Zhao, Hong Zhu, Yang Lu   +3 more
doaj   +1 more source

Epigenetic addition of m5C to HBV transcripts promotes viral replication and evasion of innate antiviral responses

Cell Death and Disease
Eukaryotic five-methylcytosine (m5C) is an important regulator of viral RNA splicing, stability, and translation. However, its role in HBV replication remains largely unknown.
Shuang Ding, Haibin Liu, Lijuan Liu, Li Ma, Zhen Chen, Miao Zhu, Lishi Liu, Xueyan Zhang, Haojie Hao, Li Zuo, Jingwen Yang, Xiulin Wu, Ping Zhou, Fang Huang, Fan Zhu, Wuxiang Guan   +15 more
doaj   +1 more source