Results 111 to 120 of about 8,203 (227)
Aging Cell, Volume 25, Issue 5, May 2026.Organ‐specific aging clocks integrating genomics, epigenomics, transcriptomics, proteomics, and metabolomics offer a more accurate assessment of biological aging than single‐omics approaches. This review proposes a multi‐omics framework emphasizing tissue data, longitudinal study designs, and clinically meaningful training outcomes to advance the ...
Maria Vasileiou +3 more
wiley +1 more source
Recent Results from the L3 Experiment [PDF]
, 2000 A data sample corresponding to an integrated luminosity of 232pb^-1 was collected in 1997 and 1998 by the L3 experiment at LEP in e+e- collisions at centre-of-mass energies between 181.7GeV and 188.7GeV.
Mele, Salvatore
core +1 more source
RNA:(guanine-N2) methyltransferases RsmC/RsmD and their homologs revisited – bioinformatic analysis and prediction of the active site based on the uncharacterized Mj0882 protein structure [PDF]
, 2002 Background Escherichia coli guanine-N2 (m2G) methyltransferases (MTases) RsmC and RsmD modify nucleosides G1207 and G966 of 16S rRNA. They possess a common MTase domain in the C-terminus and a variable region in the N-terminus. Their C-terminal domain is
Rychlewski Leszek, Bujnicki Janusz M
core +1 more source
Cancer Science, Volume 117, Issue 5, Page 1362-1379, May 2026.Our findings identify circ‐0030167/IGF2BP1/HMOX1 axis as a critical regulatory factor targeting mitochondria‐mediated ferroptosis, thereby presenting a novel therapeutic target for PC combination therapies. ABSTRACT Pancreatic cancer (PC) represents a highly aggressive malignancy characterized by a 5 year survival rate of less than 12%.
Qun Zhao +6 more
wiley +1 more source
Cancer MedicineABSTRACTBackgroundColorectal cancer (CRC) is a leading cause of cancer‐related mortality globally, yet current therapies exhibit suboptimal efficacy with limited prognostic improvement. RNA 5‐methylcytosine (m5C), a posttranscriptional modification, has been implicated in tumorigenesis and progression across malignancies. In our previous study, the m5C
Jinling Bi +3 more
openaire +3 more sources
多細胞生物におけるrRNAのm1A修飾に関する研究 [PDF]
, 2018 この博士論文は内容の要約のみの公開（または一部非公開）になっています筑波大学 (University of Tsukuba ...
YOKOYAMA Wataru, 横山 航
core +1 more source
A structural snapshot of base-pair opening in DNA [PDF]
, 1999 The response of double-helical DNA to torsional stress may be a driving force for many processes acting on DNA. The 1.55-A crystal structure of a duplex DNA oligonucleotide d(CCAGGCCTGG)(2) with an engineered crosslink in the minor groove between the ...
Erlanson, D. A. +3 more
core +1 more source
Cancer Science, Volume 117, Issue 5, Page 1322-1332, May 2026.We performed the first transcriptome‐wide profiling of m5C modifications in osteosarcoma, analyzing four pairs of tumor and adjacent normal tissues. We revealed that NSUN2 suppresses apoptosis in osteosarcoma cells by promoting GPRC5B m5C modification and expression.
Zhenyi Chen +10 more
wiley +1 more source
Recent research advances in RNA m5C methylation modification in liver diseases
Frontiers in Molecular BiosciencesRNA m5C methylation refers to the process wherein the 5th carbon atom of cytosine in RNA molecules is methylated by the action of methyltransferase, thus forming 5-methylcytosine (m5C). This crucial epigenetic modification significantly impacts gene expression and various biological processes.
Wenjuan Chen +6 more
openaire +1 more source
Detection, molecular function and mechanisms of m5C in cancer
Clinical and Translational MedicineInterest in RNA posttranscriptional modifications, particularly 5‐methylcytosine (m5C), has surged in recent years. Studies have shown that m5C plays a key role in cellular processes and is closely linked to tumourigenesis.
Linhui Zhang +6 more
doaj +1 more source