Results 131 to 140 of about 814,114 (202)

NSUN2 as a potential prognostic as well as therapeutic target in cancer by regulating m5C modification

m5C modification is a type of RNA methylation modification, and its major methyltransferase, NSUN2, catalyzes m5C modification. NSUN2 is overexpressed in a variety of cancers, and it affects the metabolism of RNA from target genes by affecting the level of m5C modification in cancer cells, which in turn promotes the development of cancers and is ...
He, Zifang, Yang, Longtao, Ma, Peiyao
openaire   +2 more sources

m5C related-regulator-mediated methylation modification patterns and prognostic significance in breast cancer

5-Methylcytosine (m5C) is closely associated with cancer. However, the role of m5C in breast cancer(BC)remains unclear. This study combined single-cell RNA sequencing (scRNA-Seq) and transcriptomics datasets to screen m5C regulators associated with BC ...
Shiming Wang, Chen Cheng, Wendi Guo, Xinpei Wu, Jie Hou, Yinyi Luo, Fucheng Wang, Guangwen Zhang, Sanyuan Zhang, Zhe Wang, Chenquan Li, Wei Wang, Jinpeng Li   +12 more
core   +1 more source

NSUN2 regulates PARP9 progression through m5C modification to mediate breast cancer progression. [PDF]

Cell Div
Li X, Yan C, Yi J, Yun J, Cui F, Xu X, Li Y, Xu X.   +7 more
europepmc   +1 more source

NSUN4-dependent m5C modification facilitates mitochondrial fission to accelerate diabetic nephropathy process via regulating SMURF1/CAMK1 axis. [PDF]

Clin Transl Med
Yang D, Chen Y, Li H, Liu G, Gao Y, He L.   +5 more
europepmc   +1 more source

NSUN2-mediated m5C modification of E2F1 promotes lung adenocarcinoma progression via the RAD54L signaling axis. [PDF]

Respir Res
Li Y, Chen C, Liu H, Zhang Z, Wang C.
europepmc   +1 more source

TAF15-mediated m5C modification of MTHFD2 RNA reveals a novel therapeutic target for IDH mutant gliomas. [PDF]

Biomark Res
Wu R, Zhang L, Wong PJ, Sun C, Feng Y, Wang X, Fu M, Zhang J, Qiu F, Chen X, Fan Z, Shu M, Hua W.   +12 more
europepmc   +1 more source

ALYREF stabilizes MZF1 via m5C modification to exacerbate cardiac remodeling and atrial fibrillation in heart failure. [PDF]

Cell Mol Life Sci
Nian S, Zhao L, He X, Xia P, Liu Y, Hua B, Li J, Zhang H.   +7 more
europepmc   +1 more source

Programmable aging function-related mitochondrial DNA 5-methylcytosine (m5C) modification with a TALE-directed methyltransferase. [PDF]

Cell Commun Signal
Li G, Zhou X, Zhu G, Cheng Y, Pan Y, Guo X, Liao G, Li X, Hu X, Yao Y, Gu Z, Jiang W.   +11 more
europepmc   +1 more source

CASC19 stabilization by ALYREF via m5C modification and its impact on SCD in colorectal cancer cell aggressiveness and stemness. [PDF]

Cell Biosci
Zhao L, Xie R, Li L, Lu X, Wang L, Wang H, Liu L.   +6 more
europepmc   +1 more source

CDK13 promotes lipid deposition and prostate cancer progression by stimulating NSUN5-mediated m5C modification of ACC1 mRNA. [PDF]

Cell Death Differ, 2023
Zhang Y, Chen XN, Zhang H, Wen JK, Gao HT, Shi B, Wang DD, Han ZW, Gu JF, Zhao CM, Xue WY, Zhang YP, Qu CB, Yang Z.   +13 more
europepmc   +1 more source