Results 141 to 150 of about 8,203 (227)

Epigenetic addition of m5C to HBV transcripts promotes viral replication and evasion of innate antiviral responses

Cell Death and Disease
Eukaryotic five-methylcytosine (m5C) is an important regulator of viral RNA splicing, stability, and translation. However, its role in HBV replication remains largely unknown.
Shuang Ding, Haibin Liu, Lijuan Liu, Li Ma, Zhen Chen, Miao Zhu, Lishi Liu, Xueyan Zhang, Haojie Hao, Li Zuo, Jingwen Yang, Xiulin Wu, Ping Zhou, Fang Huang, Fan Zhu, Wuxiang Guan   +15 more
doaj   +1 more source

5-Methylcytosine RNA modification and its roles in cancer and cancer chemotherapy resistance

Journal of Translational Medicine
Recent advancements in cancer therapies have improved clinical outcomes, yet therapeutic resistance remains a significant challenge because of its complex mechanisms.
Fang Li, Tingting Liu, Yajing Dong, Qianqian Gao, Rongzhu Lu, Zhiyong Deng   +5 more
doaj   +1 more source

The role of m5C, m1A and m7G modifications in tumors of urinary system

Frontiers in Cell and Developmental Biology
Malignant tumors of the urinary system, such as kidney cancer, bladder cancer, and prostate cancer, remain a significant challenge despite the various treatment options available. Identifying therapeutic targets for urological tumors is crucial due to the potential for recurrence and metastasis.
Wei Xue, Yuanyuan Zhao, Gong Zhang, Zhiyuan Li, Jixin Li, Xiang Fei   +5 more
openaire   +3 more sources

Nuclear Surveillance and Degradation of Hypomodified Initiator tRNA\u3csup\u3eMet\u3c/sup\u3e in \u3cem\u3eS. cerevisiae\u3c/em\u3e [PDF]

, 2004
The tRNA m1A58 methyltransferase is composed of two subunits encoded by the essential genes TRM6 and TRM61 (formerly GCD10 and GCD14). The trm6-504 mutation results in a defective m1A methyltransferase (Mtase) and a temperature-sensitive growth phenotype
Anderson, James T., Hinnebusch, Alan G., Kadaba, Sujatha, Krecic, Annette M., Krueger, Anna, Trice, Tamyra   +5 more
core   +1 more source

Expanding the diversity of DNA base modifications with N 6-methyldeoxyadenosine [PDF]

, 2016
Kate D. Meyer, Samie R. Jaffrey
core   +1 more source

Epitranscriptomic profiling of m5C RNA methylation reveals a dynamic response to TSWV infection in tomato

Frontiers in Plant Science
Cytosine-5 methylation (m5C) is a crucial epitranscriptomic mark in eukaryotes that modulates RNA stability and gene expression. While the roles of m5C are partially understood in model plants, its function in horticultural crops under biotic stress ...
Xinyi Zhao, Yanwei Gong, Yubing Jiao, Wanhong Zhang, Dong An, Yingwen Wang, Binna Lv, Ying Li, Lili Shen, Jinguang Yang   +9 more
doaj   +1 more source

m5C‐TNKmer: Identification of 5‐Methylated Base Cytosine of Ribonucleic Acid Using Supervised Machine Learning Techniques

Engineering Reports
5‐Methylcytosine (m5C) is a widely recognized epigenetic modification in ribonucleic acid (RNA), catalyzed by methyltransferases. This modification is crucial for various biological functions. While the role of m5C in deoxyribonucleic acid (DNA) has been
Shahid Qazi, Dilawar Shah, Mohammad Asmat Ullah Khan, Shujaat Ali, Mohammad Abrar, Asfandyar Khan, Muhammad Tahir   +6 more
doaj   +1 more source

NSUN2‐mediated m5C methylation modification regulates trophoblast cell proliferation, apoptosis, and autophagy in gestational diabetes mellitus

Journal of Diabetes Investigation
Introduction Gestational diabetes mellitus (GDM) represents one of the most prevalent medical complications during pregnancy. Emerging evidence has implicated NOL1/NOP2/SUN domain (NSUN)2‐mediated 5‐methylcytosine (m5C) methylation modifications in ...
Jiujiu Liu, Yingjun Chen, Dapeng Wang, Zhaozhao Li   +3 more
doaj   +1 more source

Additional file 6 of Folate regulates RNA m5C modification and translation in neural stem cells

, 2022
Xiguang Xu, Zachary Johnson, Ying Wang, Rachel L. Padget, James W. Smyth, Hehuang Xie   +5 more
openalex   +1 more source

ALYREF promotes the metastasis of nasopharyngeal carcinoma by increasing the stability of NOTCH1 mRNA

Cell Death and Disease
Approximately 70% of treatment failures in nasopharyngeal carcinoma (NPC) patients are attributed to distant metastasis, yet the underlying mechanisms remain unclear.
Yanan Jin, Jijin Yao, Jianchang Fu, Qitao Huang, Yilin Luo, Yafei You, Wangjian Zhang, Qian Zhong, Tianliang Xia, Liangping Xia   +9 more
doaj   +1 more source