The nucleolar RNA methyltransferase Misu (NSun2) is required for mitotic spindle stability [PDF]
, 2009 Myc-induced SUN domain–containing protein (Misu or NSun2) is a nucleolar RNA methyltransferase important for c-Myc–induced proliferation in skin, but the mechanisms by which Misu contributes to cell cycle progression are unknown.
Shobbir Hussain +49 more
core +1 more source
Complete genome sequence of the Clostridium difficile laboratory strain 630Δerm reveals differences from strain 630, including translocation of the mobile element CTn5 [PDF]
, 2015 Molecular Technology and Informatics for Personalised Medicine and ...
Adam P Roberts +7 more
core +1 more source
CIGAR‐seq, a CRISPR/Cas‐based method for unbiased screening of novel mRNA modification regulators
Molecular Systems Biology, 2020 Cellular RNA is decorated with over 170 types of chemical modifications. Many modifications in mRNA, including m6A and m5C, have been associated with critical cellular functions under physiological and/or pathological conditions.
Liang Fang +16 more
doaj +1 more source
Methylation at position 32 of tRNA catalyzed by TrmJ alters oxidative stress response in Pseudomonas aeruginosa [PDF]
, 2016 Bacteria respond to environmental stresses using a variety of signaling and gene expression pathways, with translational mechanisms being the least well understood.
Atichartpongkul, Sopapan +12 more
core +2 more sources
Cell Death and DiseaseHepatocellular carcinoma (HCC) is one of the most common cancers worldwide. The 5-methylcytosine (m5C) RNA methyltransferase NSUN2 is involved in cell proliferation and metastasis and is upregulated in a variety of cancers.
Qin Qi +9 more
doaj +1 more source
A human tRNA methyltransferase 9-like protein prevents tumour growth by regulating LIN9 and HIF1-α [PDF]
, 2012 Emerging evidence points to aberrant regulation of translation as a driver of cell transformation in cancer. Given the direct control of translation by tRNA modifications, tRNA modifying enzymes may function as regulators of cancer progression.
Aguirre-Ghiso, Julio A. +10 more
core +1 more source
Identification and Validation of a m5C RNA Modification-Related Gene Signature for Predicting Prognosis and Immunotherapeutic Efficiency of Gastric Cancer [PDF]
, 2023 Li Song +5 more
openalex +1 more source
The Reverse Transcription Signature of N-\u3csub\u3e1\u3c/sub\u3e-Methyladenosine in RNA-Seq is Sequence Dependent [PDF]
, 2015 The combination of Reverse Transcription (RT) and high-throughput sequencing has emerged as a powerful combination to detect modified nucleotides in RNA via analysis of either abortive RT-products or of the incorporation of mismatched dNTPs into cDNA ...
Alfonzo, Juan +14 more
core +1 more source
NSUN2‐Mediated m5C Methylation and METTL3/METTL14‐Mediated m6A Methylation Cooperatively Enhance p21 Translation [PDF]
, 2017 N6‐methyladenosine (m6A) and m5C methylation are two major types of RNA methylation, but the impact of joint modifications on the same mRNA is unknown.
Dou, Yali +6 more
core +1 more source
M5C regulator-mediated methylation modification patterns and tumor microenvironment infiltration characterization in lung adenocarcinoma [PDF]
, 2021 Hui Chen +9 more
openalex +1 more source