Results 121 to 130 of about 814,114 (202)
Redox BiologyEndometrial cancer (EC) is a prevalent gynecological malignancy worldwide, and 5-methylcytosine (m5C) modification of mRNA is a crucial epigenetic modification associated with the development and occurrence of several cancers.
Shuai-Jun Chen +7 more
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5-Methylcytosine RNA modification and its roles in cancer and cancer chemotherapy resistance
Journal of Translational MedicineRecent advancements in cancer therapies have improved clinical outcomes, yet therapeutic resistance remains a significant challenge because of its complex mechanisms.
Fang Li +5 more
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Illustrating the Epitranscriptome at Nucleotide Resolution Using Methylation-iCLIP (miCLIP) [PDF]
, 2017 Next-generation sequencing technologies have enabled the transcriptome to be profiled at a previously unprecedented speed and depth. This yielded insights into fundamental transcriptomic processes such as gene transcription, RNA processing, and mRNA ...
George, H, Ule, J, Hussain, S
core
Deciphering the vital roles and mechanism of m5C modification on RNA in cancers.
American journal of cancer research5-methylcytosine (m5C modification) plays an essential role in tumors, which affects different types of RNA, the expression of downstream target genes, and downstream pathways, thus participating in the tumor process. However, the effect of m5C modification on RNA in tumors and the exact mechanism have not been systematically reviewed.
Lemei, Zheng +10 more
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Protocol for profiling RNA m5C methylation at base resolution using m5C-TAC-seq
Summary: RNA 5-methylcytosine (m5C) is a widespread modification and plays a crucial role in gene expression regulation. Here, we present a protocol for transcriptome-wide m5C methylome profiling at base resolution using bisulfite-free m5C detection ...
Xiaoyu Li +3 more
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AgingAs a progressive neurodegenerative disease, the comprehensive understanding of the pathogenesis of Alzheimer's disease (AD) is yet to be clarified. Modifications in RNA, including m6A/m5C/m1A, affect the onset and progression of many diseases. Consequently, this study focuses on the role of methylation modification in the pathogenesis of AD.Three AD ...
Tan, Qifa +4 more
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Engineering Reports5‐Methylcytosine (m5C) is a widely recognized epigenetic modification in ribonucleic acid (RNA), catalyzed by methyltransferases. This modification is crucial for various biological functions. While the role of m5C in deoxyribonucleic acid (DNA) has been
Shahid Qazi +6 more
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NOP2‐Mediated m5C Methylation Modification of LMNB2 mRNA Facilitates Colorectal Cancer Progression
Background Colorectal cancer (CRC) is a leading cause of cancer‐related mortality globally, yet current therapies exhibit suboptimal efficacy with limited prognostic improvement.
Yulong Liu +3 more
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Epitranscriptomic Modifications (m6A, m5C) as Emerging Regulators of Drug Response and Resistance
Background: Epitranscriptomics—the study of chemical modifications on RNA—has emerged as a pivotal layer of gene expression regulation. Among the most prevalent modifications are N6-methyladenosine (m6A) and 5-methylcytosine (m5C), which govern RNA stability, splicing, translation, and nuclear export. Disruptions in these modifications are increasingly
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Cell Death and DiseaseApproximately 70% of treatment failures in nasopharyngeal carcinoma (NPC) patients are attributed to distant metastasis, yet the underlying mechanisms remain unclear.
Yanan Jin +9 more
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