Results 21 to 30 of about 8,203 (227)

Copy number amplification of TTPAL promotes cholesterol biosynthesis and esophageal squamous cell carcinoma progression via elevating NSUN2-mediated m5C modification of SREBP2 mRNA. [PDF]

J Exp Clin Cancer Res
Huang S, Liu Y, Zhao M, Wang T, Mao L, Wang T, Guo C, Huang W, Peng Z, Zhang Z, Jiang R, Ma X, Shen N, Rao J, Wang X, Zheng Z, Chen L.   +16 more
europepmc   +3 more sources

Epigenetically upregulated NSUN2 confers ferroptosis resistance in endometrial cancer via m5C modification of SLC7A11 mRNA [PDF]

Redox Biology
Endometrial cancer (EC) is a prevalent gynecological malignancy worldwide, and 5-methylcytosine (m5C) modification of mRNA is a crucial epigenetic modification associated with the development and occurrence of several cancers.
Shuai-Jun Chen, Jun Zhang, Ting Zhou, Shan-Shan Rao, Qian Li, Ling-Yan Xiao, Si-Tian Wei, Hong-Feng Zhang   +7 more
doaj   +2 more sources

Comprehensive analysis of key m5C modification-related genes in type 2 diabetes. [PDF]

Front Genet, 2022
Background: 5-methylcytosine (m5C) RNA methylation plays a significant role in several human diseases. However, the functional role of m5C in type 2 diabetes (T2D) remains unclear.Methods: The merged gene expression profiles from two Gene Expression Omnibus (GEO) datasets were used to identify m5C-related genes and T2D-related differentially expressed ...
Song Y, Jiang Y, Shi L, He C, Zhang W, Xu Z, Yang M, Xu Y.   +7 more
europepmc   +4 more sources

Aberrant NSUN2-mediated m5C modification of H19 lncRNA is associated with poor differentiation of hepatocellular carcinoma [PDF]

Oncogene, 2020
Zhen Sun, Songlei Xue, Meiying Zhang, Hui Xu, Xuming Hu, Shihao Chen, Yang Liu, Mingzhou Guo, Hengmi Cui   +8 more
openalex   +3 more sources

NSUN2 restrains gastric cancer cell apoptosis and ferroptosis by promoting the m5C modification of EPYC. [PDF]

Hereditas
Wu L, Chen B, Cheng S, Fang X, Zhou F.
europepmc   +2 more sources

The role of m5C RNA modification in cancer development and therapy

Heliyon
RNA modifications have been demonstrated to affect the function, stability, processing, and interactions of RNA, including pseudouridylation, acetylation and methylation. RNA methylation products, such as N6-methyladenosine (m6A), 5-methylcytidine (m5C), N7-methylguanosine (m7G), 2'-O-dimethyladenosine (m6Am), and N1-methyladenosine (m1A), have been ...
Li Yu, Hongen Xu, Hanchu Xiong, Chunju Yang, Ying Wu, Qiong Zhang   +5 more
openalex   +3 more sources

Multi-omics analysis reveals that ALYREF-mediated m⁵C modification promotes platinum resistance in ovarian cancer via the NSUN2/ALYREF/LGR4 axis. [PDF]

Cell Death Dis
Yang S, He P, Wang W, Xu X, Xi X, Li Y.
europepmc   +2 more sources

RNF115 upregulation by YBX1-dependent m5C modification promotes hepatocellular carcinoma progression. [PDF]

NPJ Precis Oncol
Li J, Chen H, Bai L, Tang H.
europepmc   +2 more sources

Isoimperatorin improves osteoporosis by increasing YBX1 expression to promote BGLAP m5C modification. [PDF]

Sci Rep
Osteoporosis is a chronic metabolic bone disease that is prone to fractures. Isoimperatorin (ISO) has been shown to alleviate the bone loss in ovariectomized (OVX) rats. The aim of this study was to investigate the effect and the mechanism of ISO on osteoporosis using animal study and cell experiments.
Hu G, Wen J, Yang H, Zhang K.
europepmc   +4 more sources

Uncovering the Association Between m5C Regulator-Mediated Methylation Modification Patterns and Tumour Microenvironment Infiltration Characteristics in Hepatocellular Carcinoma

Frontiers in Cell and Developmental Biology, 2021
Xinyu Gu, Haibo Zhou, Qingfei Chu, Qiuxian Zheng, Jing Wang, Haihong Zhu   +5 more
openalex   +3 more sources