Results 21 to 30 of about 814,114 (202)

NSUN2‐mediated m5C methylation modification regulates trophoblast cell proliferation, apoptosis, and autophagy in gestational diabetes mellitus

Journal of Diabetes Investigation
Introduction Gestational diabetes mellitus (GDM) represents one of the most prevalent medical complications during pregnancy. Emerging evidence has implicated NOL1/NOP2/SUN domain (NSUN)2‐mediated 5‐methylcytosine (m5C) methylation modifications in ...
Jiujiu Liu, Yingjun Chen, Dapeng Wang, Zhaozhao Li   +3 more
doaj   +2 more sources

m5C-Atlas: a comprehensive database for decoding and annotating the 5-methylcytosine (m5C) epitranscriptome. [PDF]

, 2021
5-Methylcytosine (m5C) is one of the most prevalent covalent modifications on RNA. It is known to regulate a broad variety of RNA functions, including nuclear export, RNA stability and translation. Here, we present m5C-Atlas, a database for comprehensive
Huang, Daiyun, de Magalhães, João Pedro, Meng, Jia, Ma, Jiongming, Song, Bowen, Rigden, Daniel J, Zhang, Yuxin, Su, Jionglong, Chen, Kunqi, Wei, Zhen, Yuxin Zhang, Jiongming Ma, Kunqi Chen, Jionglong Su, João Pedro de Magalhães, Daniel J Rigden, Bowen Song, Zhen Wei, Daiyun Huang, Jia Meng   +19 more
core   +1 more source

m6A and m5C modification of GPX4 facilitates anticancer immunity via STING activation. [PDF]

Cell Death Dis, 2023
AbstractCancer immunotherapy is arguably the most rapidly advancing realm of cancer treatment. Glutathione peroxidase 4 (GPX4) has emerged as the vital enzyme to prevent lipid peroxidation and maintain cellular redox homeostasis. However, the mechanism of GPX4 in the regulation of cancer immunotherapy of colon adenocarcinoma (COAD) are incompletely ...
Chen B, Hong Y, Zhai X, Deng Y, Hu H, Tian S, Zhang Y, Ren X, Zhao J, Jiang C.   +9 more
europepmc   +4 more sources

The Emerging Roles of Cytosine-5 Methylation in mRNAs [PDF]

, 2021
Recent studies have unequivocally confirmed the presence of 5-methylcytosine (m5C) in mammalian mRNAs while indicating significant functional roles for this internal base modification type.
Hussain, Shobbir, Shobbir Hussain
core   +1 more source

RNF115 upregulation by YBX1-dependent m5C modification promotes hepatocellular carcinoma progression. [PDF]

NPJ Precis Oncol
5-methylcytosine (m5C) RNA modification plays critical roles in post-transcriptional regulation and cancer progression. However, the downstream effectors of the m5C reader protein YBX1 and their mechanistic contribution to hepatocellular carcinoma (HCC) remain largely undefined.
Li J, Chen H, Bai L, Tang H.
europepmc   +3 more sources

The lncRNA epigenetics: The significance of m6A and m5C lncRNA modifications in cancer

Frontiers in Oncology, 2023
Most of our transcribed RNAs are represented by non-coding sequences. Long non-coding RNAs (lncRNAs) are transcripts with no or very limited protein coding ability and a length >200nt. They can be epigenetically modified. N6-methyladenosine (m6A), N1-methyladenosine (m1A), 5-methylcytosine (m5C), 7-methylguanosine (m7G) and 2’-O-methylation (Nm)
Vincenza Ylenia Cusenza, Annalisa Tameni, Antonino Neri, Raffaele Frazzi   +3 more
openaire   +3 more sources

m5C Regulator-mediated methylation modification clusters contribute to the immune microenvironment regulation of multiple myeloma

Frontiers in Genetics, 2022
Background: Multiple myeloma (MM) is a hematological malignancy in which plasma cells proliferate abnormally. 5-methylcytosine (m5C) methylation modification is the primary epigenetic modification and is involved in regulating the occurrence, development,
Hefei Ren, Chang Liu, Hongkun Wu, Zhenhua Wang, Sai Chen, Xiaomin Zhang, Jigang Ren, Huiying Qiu, Lin Zhou   +8 more
doaj   +1 more source

Prediction of m5C Modifications in RNA Sequences by Combining Multiple Sequence Features [PDF]

Molecular Therapy Nucleic Acids, 2020
5-Methylcytosine (m5C) is a well-known post-transcriptional modification that plays significant roles in biological processes, such as RNA metabolism, tRNA recognition, and stress responses. Traditional high-throughput techniques on identification of m5C sites are usually time consuming and expensive.
Lijun Dou, Xiaoling Li, Hui Ding, Lei Xu, Huaikun Xiang   +4 more
openaire   +3 more sources

Advances in RNA cytosine-5 methylation: detection, regulatory mechanisms, biological functions and links to cancer

Biomarker Research, 2020
As an important posttranscriptional modification of RNA, 5-methylcytosine (m5C) has attracted increasing interest recently, with accumulating evidence suggesting the involvement of RNA m5C modification in multiple cellular processes as well as ...
Chen Xue, Yalei Zhao, Lanjuan Li
doaj   +1 more source

m5C Regulator-Mediated Methylation Modification Patterns and Tumor Microenvironment Infiltration Characterization in Papillary Thyroid Carcinoma

Frontiers in Oncology, 2021
Recently, immune response modulation at the epigenetic level is illustrated in studies, but the possible function of RNA 5-methylcytosine (m5C) modification in cell infiltration within the tumor microenvironment (TME) is still unclear.
Fei Li, Qingmei Deng, Xiaoxi Pang, Shan Huang, Jingmiao Zhang, Xiaxia Zhu, Hong Chen, Xiuxia Liu   +7 more
doaj   +1 more source