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Results 41 to 50 of about 2,920 (152)

NSUN2 depletion in HepG2 negatively regulates HBV expression and replication.

, 2023
(A-D) pHBV1.3 and pSV-β-gal were transfected into HepG2 and HepG2-NSUN2-KO cells. At 48 hours later, supernatant was collected for ELISA. Cells were harvested for RNA or rcDNA extraction. β-galactosidase activity in cell lysates was measured to normalize
Xianying Chen (11248785) +16 more
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HBV expression positively regulates expression of endogenous NSUN2.

, 2023
(A) Western blot (left) and gray degree analysis (right) of endogenous NSUN2 in HepG2 after pHBV1.3 gradient transfection. Relative levels of NSUN2 protein to GAPDH were quantified using Quantity One.
Xianying Chen (11248785) +16 more
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RNA modification and expression of NSUN2 in immune cells.

, 2023
(A) Analysis between NSUN2 and RNA modification-related genes. (B) Protein expression of NSUN2 in different seven cells or tissue types. (C) Expression of NSUN2 in immune cells. (TIF)
Wei Xiong (58411) +11 more
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Coexpression genes analysis of NSUN2 in LIHC, LUAD and HNSC based on the LinkedOmics website.

, 2023
(A) Genes related to NSUN2 based on the Pearson test in LIHC cohorts. (B) The top 50 positively related genes of NSUN2 in LIHC. (C) The top 50 negatively related genes of NSUN2 in LIHC. (D) Genes related to NSUN2 in LUAD cohorts.
Wei Xiong (58411) +11 more
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Distinct Roles of m5C RNA Methyltransferase NSUN2 in Major Gynecologic Cancers

Frontiers in Oncology, 2022
RNA methylation has recently emerged as an important category of epigenetic modifications, which plays diverse physiopathological roles in various cancers.
Lingfang Wang +13 more
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NSUN2-mediated tRNA methylation is dynamic and site-specific.

, 2019
(A, B) Volcano plot depicting the significant methylation changes when NSUN2 was reexpressed in NSUN2−/− cells compared to empty (‘E.’) vector (A) or K190M controls (B).
Sandra Blanco (34725) +14 more
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Aberrant m5C hypermethylation mediates intrinsic resistance to gefitinib through NSUN2/YBX1/QSOX1 axis in EGFR-mutant non-small-cell lung cancer

Molecular Cancer, 2023
Background RNA 5-methylcytosine (m5C) modification plays critical roles in the pathogenesis of various tumors. However, the function and molecular mechanism of RNA m5C modification in tumor drug resistance remain unclear.
Yueqin Wang +19 more
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Coexpression analysis of NSUN2-related genes in LIHC, LUAD and HNSC, and analysis between NSUN2 expression and the levels of immune cells.

, 2023
(A-C) KEGG pathway analysis of NSUN2-related gene in LIHC, LUAD and HNSC cohorts. (D) Expression analysis between NSUN2 and TILs including B cells, CD8+ T cells, CD4+ T cells, macrophages, neutrophils and dendritic cells based on the TIMER database.
Wei Xiong (58411) +11 more
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NSUN2 introduces 5-methylcytosines in mammalian mitochondrial tRNAs. [PDF]

, 2019
Expression of human mitochondrial DNA is indispensable for proper function of the oxidative phosphorylation machinery. The mitochondrial genome encodes 22 tRNAs, 2 rRNAs and 11 mRNAs and their post-transcriptional modification constitutes one of the key ...
Miska, EA +39 more
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Schematic diagram of regulation between NSUN2 and HBV.

, 2023
NSUN2-mediated m5C methylation positively regulates expression and replication of HBV during which TET2 plays the opposite role with demethylation; in turn, HBV expression or HBcAg affects endogenous NSUN2 expression.
Xianying Chen (11248785) +16 more
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ferroptosis
m5c
5-methylcytosine

colorectal cancer
m5c modification
cytology

ybx1
neoplasms
tumors