Results 41 to 50 of about 3,656 (193)

Multi-omics analysis of expression and prognostic value of NSUN members in prostate cancer

Frontiers in Oncology, 2022
BackgroundProstate cancer is the most common tumor in men worldwide, seriously threatening the health of older men, and 5-methylcytosine (m5C) RNA modification has been shown to have a significant impact on the development and progression of various ...
Guangyu Sun, Shenfei Ma, Zhiwen Zheng, Xiaohua Wang, Shuaiqi Chen, Taihao Chang, Zhengxin Liang, Yuchen Jiang, Shengxian Xu, Ranlu Liu   +9 more
doaj   +1 more source

Mutations in NSUN2 Cause Autosomal- Recessive Intellectual Disability [PDF]

The American Journal of Human Genetics, 2012
With a prevalence between 1 and 3%, hereditary forms of intellectual disability (ID) are among the most important problems in health care. Particularly, autosomal-recessive forms of the disorder have a very heterogeneous molecular basis, and genes with an increased number of disease-causing mutations are not common.
Abbasi-Moheb, Lia, Mertel, Sara, Gonsior, Melanie, Nouri-Vahid, Leyla, Kahrizi, Kimia, Cirak, Sebahattin, Wieczorek, Dagmar, Motazacker, M. Mahdi, Esmaeeli-Nieh, Sahar, Cremer, Kirsten, Weißmann, Robert, Tzschach, Andreas, Garshasbi, Masoud, Abedini, Seyedeh S., Najmabadi, Hossein, Ropers, H. Hilger, Sigrist, Stephan J., Kuss, Andreas W.   +17 more
openaire   +4 more sources

RNA methyltransferase NSUN2 promotes growth of hepatocellular carcinoma cells by regulating fizzy‐related‐1 in vitro and in vivo

Kaohsiung Journal of Medical Sciences, 2021
The aim of the study was to investigate the role of NSUN2 (NOP2/Sun RNA Methyltransferase Family Member 2) in hepatocellular carcinoma (HCC). The expressions of NSUN2 and FZR1 were measured. Cell viability, proliferation, and apoptosis were assessed. HCC
Chun‐Tao Zhai, Yi‐Cheng Tian, Zu‐Xiong Tang, Long‐Jiang Shao   +3 more
doaj   +1 more source

The RNA Methyltransferase NSUN2 and Its Potential Roles in Cancer [PDF]

Cells, 2020
5-methylcytosine is often associated as an epigenetic modifier in DNA. However, it is also found increasingly in a plethora of RNA species, predominantly transfer RNAs, but increasingly found in cytoplasmic and mitochondrial ribosomal RNAs, enhancer RNAs, and a number of long noncoding RNAs.
Anitha Chellamuthu, Steven G. Gray
openaire   +3 more sources

The Effect of Methyltransferase NSUN2 in Stroke

, 2021
Abstract Stroke is one of the most important diseases that seriously threaten the health and public health of elderly patients.NSUN2 refers to the predominant methyltransferase for RNA m5C methylation, contributing to increased RNA stability, translocation and translation, and playing an important role in the physiopathology.
Xuqing Ni, Xia Liu, Xinyu Yao, Shan Li, Yurun Zhu, Ye Zhu, Yunchang Mo, Qinxue Dai, Junlu Wang   +8 more
openaire   +1 more source

Deficient methylation and formylation of mt-tRNA(Met) wobble cytosine in a patient carrying mutations in NSUN3. [PDF]

, 2016
Epitranscriptome modifications are required for structure and function of RNA and defects in these pathways have been associated with human disease.
Blanco, Sandra, Dietmann, Sabine, Durbin, Richard, Frye, Michaela, Hoffmann, Georg F, Hussain, Shobbir, Kolb-Kokocinski, Anja, Kotzaeridou, Urania, Kremer, Laura, Lantaff, Rebecca, Mayr, Johannes A, Memari, Yasin, Minczuk, Michal, Pearce, Sarah F, Powell, Christopher A, Prokisch, Holger, Rorbach, Joanna, Sauer, Sascha, Van Haute, Lindsey   +18 more
core   +9 more sources

NSUN2 promotes osteosarcoma progression by enhancing the stability of FABP5 mRNA via m5C methylation

Cell Death and Disease, 2023
5-methylcytosine (m5C) modification, which is mainly induced by the RNA methyltransferase NSUN2 (NOP2/Sun domain family, member 2), is an important chemical posttranscriptional modification in mRNA and has been proven to play important roles in the ...
Min Yang, Renxiong Wei, Sheng Zhang, Sang Hu, Xiaoxiao Liang, Zhiqiang Yang, Chong Zhang, Yufeng Zhang, Lin Cai, Yuanlong Xie   +9 more
doaj   +1 more source

The nucleolar RNA methyltransferase Misu (NSun2) is required for mitotic spindle stability [PDF]

, 2009
Myc-induced SUN domain–containing protein (Misu or NSun2) is a nucleolar RNA methyltransferase important for c-Myc–induced proliferation in skin, but the mechanisms by which Misu contributes to cell cycle progression are unknown.
Shobbir Hussain, Sandra Blanco Benavente, Elisabete Nascimento, Ilaria Dragoni, Agata Kurowski, Astrid Gillich, Peter Humphreys, Michaela Frye, Agris, Agris, Albee, Andersen, Andrews, Arnold, Blower, Blower, Boisvert, Brzezicha, Bujnicki, Clarke, Dephoure, Eliscovich, Frye, Frye, Gautier, Goshima, Greasley, Grosjean, Gruss, King, Liau, Ma, Nachury, Obara, Oeffinger, Raemaekers, Ribbeck, Rogakou, Sakita-Suto, Sato, Schmit, Schug, Taylor, Trieselmann, Tsai, Tscherne, Waikel, Watt, Wiese, Wu   +49 more
core   +1 more source

The biogenesis pathway of tRNA-derived piRNAs in Bombyx germ cells. [PDF]

, 2017
Transfer RNAs (tRNAs) function in translational machinery and further serves as a source of short non-coding RNAs (ncRNAs). tRNA-derived ncRNAs show differential expression profiles and play roles in many biological processes beyond translation ...
Honda, Shozo, Kawamura, Takuya, Kirino, PhD, Yohei, Loher, Phillipe, Morichika, Keisuke, Rigoutsos, Isidore   +5 more
core   +2 more sources

Stem cell function and stress response are controlled by protein synthesis. [PDF]

, 2016
Whether protein synthesis and cellular stress response pathways interact to control stem cell function is currently unknown. Here we show that mouse skin stem cells synthesize less protein than their immediate progenitors in vivo, even when forced to ...
A Sobala, Abdulrahim Sajini, AL Means, B Schwanhäusser, CS Trempus, D Ruggero, DB Longley, DE Weinberg, DM Owens, DR Morris, E Fuchs, E Fuchs, F Tuorto, FJ Martinez, H Tang, HC Lin, Hinal Tanna, I Malanchi, J Gebetsberger, J Xing, Jelena Aleksic, JL Hintze, KA Spriggs, KK Youssef, KM Braun, L Abbasi-Moheb, L Madisen, M Egeblad, M Frye, M Frye, M Schaefer, M Schaefer, M Schober, M Sibilia, MA Khan, Martyna Popis, Michaela Frye, MV Gerashchenko, MV Plikus, N Atsumi, N Barker, Nikoletta Gkatza, NT Ingolia, NT Ingolia, NT Ingolia, NT Ingolia, P Ivanov, Patrick Lombard, PD Lu, PV Baranov, RA Signer, Roberto Bandiera, Rosana Cortés-Garrido, RS Joshi, RY Kao, S Blanco, S Blanco, S Hussain, S Hussain, S Hussain, S Hussain, S Müller-Röver, S Schleich, Sabine Dietmann, Sandra Blanco, SE Calvo, Shobbir Hussain, T Schneider-Poetsch, V Jaks, V Khoddami, X Zhang, Y Hirai   +71 more
core   +2 more sources