Results 51 to 60 of about 2,920 (152)

NSUN2 promotes leukemogenesis by ferritin heavy chain 1-mediated anti-ferroptosis and enhancing global protein synthesis in an m5C-dependent manner in B-acute lymphoblastic leukemia

Clinical Epigenetics
Background NOP2/Sun RNA methyltransferase family member 2 (NSUN2) catalyzes 5-methylcytosine (m5C) modifications in tRNA, rRNA, and mRNA, playing critical roles in various malignancies.
Yigang Yuan, Min Li, Xuanyu Yu, Chen Meng, Shirui Yu, Xinyao Chen, Shixin Zhang, Liuzhi Shi, Xiaoyi Qin, Ziyang Huang, Chongyun Xing, Shanhu Qian, Bin Zhou, Shenmeng Gao   +13 more
doaj   +1 more source

Methylation-dependent and -independent functions of NSUN2.

, 2019
(A) Schematic representation of NSUN2-methylated tRNA sites in the anticodon loop (C34) and the VL (C46, C47). (B, C) Number of m5C per tRNA in all tRNAs (B) or tRNA leucine (C) quantified by mass spectrometry in NSUN2−/ cells reexpressing NSUN2, the ...
Sandra Blanco (34725), Martyna C. Popis (6843032), Abdulrahim A. Sajini (6843035), James A. West (462445), Michaela Frye (78179), Julian L. Griffin (152780), Susanne Bornelöv (189128), Cecilia Castro (538966), Matthias Heiß (6843029), Stefanie Kellner (430068), Anne E. Willis (361379), Sabine Dietmann (2388382), Nikoletta A. Gkatza (6843023), Joseph G. Gleeson (779314), Robert F. Harvey (6843026)   +14 more
core   +1 more source

DataSheet_1_Distinct Roles of m5C RNA Methyltransferase NSUN2 in Major Gynecologic Cancers.pdf

, 2022
RNA methylation has recently emerged as an important category of epigenetic modifications, which plays diverse physiopathological roles in various cancers.
Yasen Maimaitiyiming (1637338), Fenfen Wang (690916), Shizhen Shen (12135822), Chih-Hung Hsu (171225), Lingfang Wang (1588774), Yingfeng Su (12135816), Siqi Yang (1678081), Shitong Lin (8539239), Guankai Zhan (12135825), Zhangjin Shen (12135819), Jian Zhang (1682), Xiaodong Cheng (8947)   +11 more
core   +1 more source

NSUN2 Promotes Tumor Progression and Regulates Immune Infiltration in Nasopharyngeal Carcinoma

Frontiers in Oncology, 2022
Nasopharyngeal carcinoma (NPC) is one of the most common malignancies in the head and neck with a complex etiology, such as environmental factors, genetic factors, and Epstein–Barr virus infection.
Xinya Tong, Yilan Xiang, Yuanbo Hu, Yuanbo Hu, Yingying Hu, Yingying Hu, He Li, Huilin Wang, Kong-Nan Zhao, Xiangyang Xue, Shanli Zhu   +10 more
doaj   +1 more source

FTSJ3‐Mediated 2′‐O‐Methylation of HSPA5 mRNA Stabilizes BOP1 via SUMOylation to Drive DRP1‐Dependent Mitochondrial Fission and Fatty Acid Oxidation in Lung Squamous Cell Carcinoma

Advanced Science, EarlyView.
The RNA methyltransferase FTSJ3 drives lung squamous cell carcinoma progression by catalyzing 2′‐O‐methylation of HSPA5 mRNA, which stabilizes BOP1 through SUMOylation and activates DRP1/SREBP1‐mediated mitochondrial fission and fatty acid oxidation. Targeting this axis with liposomal siRNA potently suppresses tumor growth and metastasis ABSTRACT Lung ...
Qin Hu, Jiaheng Lin, Yifei Zhu, Ying Liu, Guoren Zhou   +4 more
wiley   +1 more source

The subcellular localization and functions of NSUN2 in LIHC, LUAD and HNSC.

, 2023
(A) The subcellular localization of NSUN2 in HepG2, A549 and 5-8F cells. (B) Detection of the overexpression efficiency of NSUN2 in cell lines. (C) The effect of NSUN2 overexpression on cell proliferation was tested by CCK-8 assay in HepG2, A549 and 5-8F
Wei Xiong (58411), Mengna Li (4987769), Hongyu Deng (104622), Ming Zhou (73279), Faqing Tang (326220), Changning Xue (17061040), Lemei Zheng (17061034), Yumei Duan (7040045), Kelin She (11412944), Jianxia Wei (17061037), Shipeng Chen (693094), Guiyuan Li (129719)   +11 more
core   +1 more source

NSUN3‐Associated m5C Modification of tRF5‐GlyTCC Suppresses Colorectal Cancer Progression via RPL23‐Linked Nucleolar Stress and p53‐Associated Autophagy and Enhances 5‐FU Sensitivity

Advanced Science, EarlyView.
This study identifies that NSUN3‐mediated m5C modification stabilizes tRF5‐GlyTCC, linking ribosomal homeostasis, nucleolar stress responses, and p53 signaling changes. This regulatory axis suppresses colorectal cancer and enhances chemotherapy response to 5‐FU, positioning tRF5‐GlyTCC as a potential therapeutic target for improving drug sensitivity in
Xinhui Lv, Can Tang, Feiyang Song, Yu Wu, Yafang Chen, Sicong Liu, Ziwen Yuan, Guihua Wang, Xudong Wang   +8 more
wiley   +1 more source

The relationships between the expression levels of NSUN2 and TILs or immune-related gene.

, 2023
(A) Expression analysis between NSUN2 and TILs including B cells, CD4+ T cells, CD8+ T cells, neutrophils, macrophages and dendritic cells. (B) The correlation between the expression levels of NSUN2 and neutrophils.
Wei Xiong (58411), Mengna Li (4987769), Hongyu Deng (104622), Ming Zhou (73279), Faqing Tang (326220), Changning Xue (17061040), Lemei Zheng (17061034), Yumei Duan (7040045), Kelin She (11412944), Jianxia Wei (17061037), Shipeng Chen (693094), Guiyuan Li (129719)   +11 more
core   +1 more source

NSUN2 relies on ALYREF to regulate Nrf2-mediated oxidative stress and alleviate Dox-induced liver injury

Biology Direct
Background Doxorubicin (Dox) is associated with various liver injuries, limiting its clinical utility. This study investigates whether NSUN2 participates in Dox-induced liver injury and the associated molecular mechanism.
Yingying Huang, Xiao Li, Lin Wei, Shinan Ma, Liming Ma, Yuxin Zan, Xiju He, Yijun Tang, Yan Ding   +8 more
doaj   +1 more source

Epigenomic Cascades Across Organs in Metabolic Dysfunction–Associated Steatotic Liver Disease: New Therapeutic Horizons

Obesity Reviews, EarlyView.
ABSTRACT Metabolic dysfunction–associated steatotic liver disease (MASLD) is the most common chronic liver disorder worldwide, affecting approximately one‐third of the population and increasing the risk of severe hepatic and cardiovascular complications.
Shurui Yang, Zhongyu Huang, Sanchun Tan, Fengxia Liang, Li Chen   +4 more
wiley   +1 more source