Results 71 to 80 of about 2,478 (156)

RNA Modifications: Current Understandings and Future Perspectives

MedComm, Volume 7, Issue 5, May 2026.
Types of RNA modification. We have summarized the currently common types of RNA modifications, including ac4C, m6A, m1A, m5C, m3C, m7G, and ψ, and visually characterized their features through structural formulas. The characteristic structures are marked with a background color different from the background color.
Shiyu Xiao, Tingwen Xiang, Chuan Yang, Xiaohua Wang, Gang Huang, Fei Luo, Zhao Xie, Yueqi Chen   +7 more
wiley   +1 more source

Interplay of RNA m6A/m1A/m5C/m7G/ψ Regulators Predicting the Prognosis of Pancreatic Cancer

FASEB BioAdvances, Volume 8, Issue 5, May 2026.
In this study, we comprehensively analyze the 64 RNA modification regulators, including 24 m6A regulators, 13 m1A regulators, 12 m5C regulators, 9 m7G regulators, and 12 pseudouridine regulators in pancreatic cancer in TCGA, GTEx, and HPA databases. We investigate their RNA and protein expression, their association with patients' clinical significance,
Shiyin Chen, Jiawei Mao, Lin Xu, Linbei Lu, Yajuan Hao   +4 more
wiley   +1 more source

NSUN2 mediates distinct pathways to regulate enterovirus 71 replication

Virologica Sinica
Increasing evidences suggest that the methyltransferase NSUN2 catalyzes 5-methylcytosine (m5C) modifications on viral RNAs, which are essential for the replication of various viruses. Despite the function of m5C deposition is well characterized, other potential roles of NSUN2 in regulating viral replication remain largely unknown.
Liu, Lishi, Chen, Zhen, Zhang, Kui, Hao, Haojie, Ma, Li, Liu, Haizhou, Yu, Baocheng, Ding, Shuang, Zhang, Xueyan, Zhu, Miao, Guo, Xiang, Liu, Yi, Liu, Haibin, Huang, Fang, Peng, Ke, Guan, Wuxiang   +15 more
openaire   +2 more sources

The 5‐Methylcytosine RNA Modification in Hepatitis B Virus‐Negative Hepatocellular Carcinoma: Insights From Long‐Read Nanopore Sequencing

Molecular Carcinogenesis, Volume 65, Issue 4, Page 397-406, April 2026.
ABSTRACT 5‐Methylcytosine (m5C) RNA modification contributes to tumor initiation and progression. However, its transcriptome‐wide distribution patterns and biological implications in hepatitis B virus (HBV)‐negative hepatocellular carcinoma (HCC) remain poorly understood.
Tianhan Sun, Liying Zhou, XiaoQing Li, Ryan Xiao, Gaoyuan Sun, Lili Zhang, Yifei Li, Wei Huang, Yayu Li, Lu Kuai, Xuanmei Luo, Hongyuan Cui, Meng Chen   +12 more
wiley   +1 more source

NSUN2 rs13181449 variant decreases the risk of oral cancer development

International Journal of Medical Sciences
NOP2/Sun RNA methyltransferase 2 (NSUN2), encoded by the NSUN2 gene, is a nuclear RNA methyltransferase that catalyzes the methylation of cytosine to 5-methylcytosine (m5C). Although RNA modification has been widely discussed in cancer development and prognosis, the role of the NSUN2 gene in oral cavity squamous cell carcinoma (OCSCC) is unclear.
Hung, Li-Chung, Huang, Cheng-Chen, Lu, Yen-Ting, Su, Chun-Wen, Lin, Chiao-Wen, Chu, Hsiao-Ju, Yang, Shun-Fa, Lu, Hsueh-Ju   +7 more
openaire   +2 more sources

NSUN2-mediated RNA m5C modification drives multiple myeloma progression by enhancing the stability of HIP1 mRNA

Scientific Reports
RNA 5-methylcytosine (m5C) modification is a crucial epigenetic regulation, and aberrant m5C methylation is associated with the pathogenesis of certain cancers.
Yang Jiang, Jing Sun, Yuyan Chen, Lin Cheng, Saran Feng, Yan Wang, Congcong Sun   +6 more
doaj   +1 more source

The RNA M5C methyltransferase NSUN2 promotes progression of hepatocellular carcinoma by enhancing PKM2-mediated glycolysis

Cell Death and Disease
Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. The 5-methylcytosine (m5C) RNA methyltransferase NSUN2 is involved in cell proliferation and metastasis and is upregulated in a variety of cancers.
Qin Qi, Rui Zhong, Yan Huang, Yong Tang, Xiao-wen Zhang, Chang Liu, Chun-fang Gao, Lin Zhou, Jian Yu, Lu-yi Wu   +9 more
doaj   +1 more source

Expression profiles of long noncoding RNAs associated with the NSUN2 gene in HepG2 cells

Molecular Medicine Reports, 2019
NOP2/Sun domain family member 2 (NSUN2) is upregulated in numerous types of tumors and may be implicated in multiple biological processes, including cell proliferation, migration and human tumorigenesis. However, little is known about how NSUN2 serves a role in these processes.
Sun, Zhen, Xue, Shonglei, Xu, Hui, Hu, Xuming, Chen, Shihao, Yang, Zhe, Yang, Yu, Ouyang, Juan, Cui, Hengmi   +8 more
openaire   +3 more sources

NSUN2 Promotes Head and Neck Squamous Cell Carcinoma Progression by Targeting EMT-Related Gene LAMC2 in an m⁵C-YBX1-Dependent Manner

Biomedicines
Background/Objectives: Head and neck squamous cell carcinoma (HNSCC) is a prevalent and aggressive cancer with high rates of metastasis and poor prognosis. Recent research highlights the role of 5-methylcytosine (m5C) in cancer progression. NSUN2, an m5C
Shuojin Huang, Congyuan Cao, Dongxiao Tang, Yiwen Liu, Wanhang Zhou, Lianlian Liu, Xin Zheng, Qianting He, Anxun Wang   +8 more
doaj   +1 more source

Structural insights into the recognition and catalysis of tRNA by human NSUN2

Abstract The human RNA m 5 C methyltransferase NSUN2 catalyzes site-specific cytosine methylation across diverse RNA substrates and thereby regulates a wide range of biological and physiological processes.
Qian Hu, Wen Yang, Yunyun Yu, Ran Yi, Yutong Zhang, Leyuan Duan, Lei Wang, Fudong Li, Kaiming Zhang, Qingguo Gong, Shanshan Li   +10 more
openaire   +1 more source