Results 71 to 80 of about 2,920 (152)

How Epitranscriptomic Machinery Senses Environmental Cues

Advanced Biology, Volume 10, Issue 9, September 2026.
Exogenous exposures, microenvironmental signals, and intracellular metabolic or redox states can alter RNA‐modification machinery through catalytic chemistry, signaling‐dependent PTMs, compartmental redistribution, or changes in abundance and composition.
Shayan Jalali, Ehsan Pashay Ahi
wiley   +1 more source

Unveiling the potential impact of RNA m5C methyltransferases NSUN2 and NSUN6 on cellular aging

Frontiers in Genetics
NSUN2 and NSUN6, two family members of NOL1/NSUN protein, are mainly responsible for catalyzing the formation of 5-methylcytosine (m5C) in RNA and highly involved in the physiological and pathological processes of many diseases.
Jiale Zhou, Jiale Zhou, Yang Han, Fuxi Ji, Renquan Zhang, Yuru Liang, Xudong Zhao, Ruizhe Hou   +7 more
doaj   +1 more source

NSUN4‐dependent m5C modification facilitates mitochondrial fission to accelerate diabetic nephropathy process via regulating SMURF1/CAMK1 axis

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
NSUN4‐mediated upregulation of SMURF1 promoted mitochondrial fission and inhibited mitochondrial fusion to accelerate DN progression via increasing CAMK1 ubiquitination. Abstract Background NOP2/Sun RNA methyltransferase family member 4 (NSUN4)‐mediated 5‐methylcytosine (m5C) modification has been implicated in diabetes‐related diseases.
Danyi Yang, Yinyin Chen, Hao Li, Guoyong Liu, Yang Gao, Liyu He   +5 more
wiley   +1 more source

NSUN2 positively regulates HBV expression and replication in vivo.

, 2023
(A-F) Three groups of C57BL/6JGpt-Nsun2+/+ mice (six in each group) and one group of C57BL/6JGpt-Nsun2+/- mice were prepared for in vivo experiments.
Xianying Chen (11248785), Cong Zeng (145162), Miao He (148269), Jiangpeng Feng (9287738), Tianmo Xu (11029548), Chengbao Ma (17549768), Shimin Yang (440641), Peipei Yao (17549765), Li Zhou (54356), Jiali Li (436886), Yu Chen (29959), Hongyun Wang (225359), Jiejie Liu (388856), Kun Yan (300887), Yuchen Xia (9287840), Zaichao Xu (15877593), Huan Yan (445452)   +16 more
core   +1 more source

RNA m5C modification upregulates E2F1 expression in a manner dependent on YBX1 phase separation and promotes tumor progression in ovarian cancer

Experimental and Molecular Medicine
5-Methylcytosine (m5C) is a common RNA modification that modulates gene expression at the posttranscriptional level, but the crosstalk between m5C RNA modification and biomolecule condensation, as well as transcription factor-mediated transcriptional ...
Xiaoyi Liu, Qinglv Wei, Chenyue Yang, Hongyan Zhao, Jie Xu, Youchaou Mobet, Qingya Luo, Dan Yang, Xinzhao Zuo, Ningxuan Chen, Yu Yang, Li Li, Wei Wang, Jianhua Yu, Jing Xu, Tao Liu, Ping Yi   +16 more
doaj   +1 more source

Ferroptosis: Newly Emerged Regulator for Human Disease

MedComm, Volume 7, Issue 9, September 2026.
Ferroptosis is a key regulated cell death pathway closely involved in cancers, neurodegenerative disorders, acute organ injuries, and cardiovascular and chronic metabolic diseases, representing a promising therapeutic target for diverse human illnesses.
Dandan Xiao, Lin Ye, Tianqi Jiang, Mengyuan Liu, Yuxia Zhou   +4 more
wiley   +1 more source

Mutations in NSUN2 Cause Autosomal- Recessive Intellectual Disability [PDF]

, 2012
With a prevalence between 1 and 3%, hereditary forms of intellectual disability (ID) are among the most important problems in health care. Particularly, autosomal-recessive forms of the disorder have a very heterogeneous molecular basis, and genes with ...
Kahrizi, Kimia, Motazacker, M. Mahdi, Garshasbi, Masoud, Mertel, Sara, Tzschach, Andreas, Ropers, H. Hilger, Wieczorek, Dagmar, Kuss, Andreas W., Abedini, Seyedeh S., Abbasi-Moheb, Lia, Gonsior, Melanie, Esmaeeli-Nieh, Sahar, Najmabadi, Hossein, Cirak, Sebahattin, Nouri-Vahid, Leyla, Sigrist, Stephan J., Cremer, Kirsten, Weißmann, Robert   +17 more
core   +3 more sources

RNA–Protein Reciprocity and the Limits of RBP Buffering

WIREs RNA, Volume 17, Issue 5, September/October 2026.
Effective transcript demand (D) reflects accessible binding sites weighted by affinity; usable RBP supply (S) is the protein available to bind them in the same compartment. The load ratio L = D/S describes their balance, which can influence regulatory reserve and target regulation.
Epaminondas Doxakis
wiley   +1 more source

NSUN2 mediated-aberrant 5-methylcytosine methylation regulates autophagy-related ferroptosis in oral squamous cell carcinoma progression

Cell Death and Disease
Oral squamous cell carcinoma (OSCC) is a common malignant tumor with high metastasis rates and poor prognosis. This study investigated the role of NOP2/Sun RNA methyltransferase family member 2 (NSUN2), a key 5-methylcytosine (m5C) methyltransferase, and
Yunyang Lu, Runze Li, Weidong Du, Jie Wu, Yi He, Lingyu Yuan, Xun Chen, Shiyu Lv, Fangyang Shi, Jiajun Hu, Wei Zhao, Dongsheng Yu   +11 more
doaj   +1 more source

Apigenin Alleviates Pyroptosis in Lung Adenocarcinoma Cells by Modulating TNF‐α/NF‐κB Signaling and AIM2 Inflammasome Activation

Thoracic Cancer, Volume 17, Issue 17, September 2026.
Apigenin attenuated CCCP/FeSO4‐induced injury and pyroptosis‐associated molecular changes in A549 cells by suppressing TNF‐α/NF‐κB signaling and reducing AIM2/ASC‐associated protein expression. Integrated network pharmacology, molecular docking, molecular dynamics simulations, and LUAD transcriptomic analyses further prioritized TNF and AIM2 as ...
Kairui Zhu, Yulong Mu, Zhenguo Su, Zhen Yue, Dongyang Wu, Guiwu Qu, Chenyang Jiang, Qing Li, Youjie Li, Ning Xie   +9 more
wiley   +1 more source