Results 81 to 90 of about 2,478 (156)

NSUN2 affects diabetic retinopathy progression by regulating MUC1 expression through RNA m5C methylation

Journal of Translational Medicine
Background Diabetic retinopathy (DR) is the leading cause of blinding eye disease among working adults and is primarily attributed to the excessive proliferation of microvessels, which leads to vitreous hemorrhage and retinal traction, thereby ...
Runze Wang, Wei Xue, Feifei Kan, Huiying Zhang, Di Wang, Lei Wang, Jianwen Wang   +6 more
doaj   +1 more source

Nsun2 controls cardiac homeostasis and hypertrophic response by regulating PRKACA expression

Theranostics
Rationale: Internal modifications of mammalian RNA have been suggested to be essential for the maintenance of cardiac homeostasis. However, the role of RNA cytosine methylation (m5C) in the heart remains largely unknown. Methods: Bulk and single cell RNA sequencing data and tissues from the human hearts were exploited for analyzing the expression of ...
Jian, Dongdong, Cheng, Xiaolei, Qi, Datun, Wang, Shixing, Wang, Chenqiu, Shi, Yingchao, Li, Zhen, Jin, Shouyi, Jia, Zhen, Teng, Peng, Pei, Zhen, Gu, Xiaoping, Jian, Liguo, Wang, Wengong, Yi, Xia, Xing, Junyue, Tang, Hao   +16 more
openaire   +2 more sources

Correction to “[NSUN2 promotes colorectal cancer progression and increases lapatinib sensitivity by enhancing CUL4B/ErbB‐STAT3 signalling in a non‐m5C manner]”

Clinical and Translational Medicine, Volume 16, Issue 7, July 2026.
wiley   +1 more source

The m5C methyltransferase NSUN2 promotes progression of acute myeloid leukemia by regulating serine metabolism

Cell Reports
Summary: Acute myeloid leukemia (AML) is one of the most prevalent heterogeneous hematologic malignancies with a complicated etiology. RNA post-transcriptional modifications have been linked to the incidence and progression of AML, while the detailed ...
Songyu Li, Ya Liu, Xiang Wu, Minjia Pan, Hongxia Zhao, Yunguang Hong, Qinghua Zhang, Shushu Hu, Aorong Ouyang, Guangru Li, Minhui Wu, Shanshan Fan, Zhirong Jia, Shanchao Zhao, Guocai Wu, Xiangwei Gao, Zhigang Yang, Zhanghui Chen   +17 more
doaj   +1 more source

NSUN2-mediated cytosine-5 methylation of FSP1 protects acute myeloid leukemia cells from ferroptosis

Molecular Cancer
RNA 5-methylcytosine (m5C), a prevalent epitranscriptomic modification that critically regulates gene expression and cellular homeostasis. While its roles in solid tumors have been increasingly recognized, the functional landscape of m5C in acute myeloid
Wenle Ye, Yanchun Zhao, Yutong Zhou, Jiansong Huang, Xiao He, Zhixin Ma, Xin Huang, Chao Hu, Fenglin Li, Qing Ling, Huafeng Wang, Hongyan Tong, Jie Sun, Jie Jin   +13 more
doaj   +1 more source

Eye manifestations in the NSUN2 intellectual disability syndrome.

International journal of molecular epidemiology and genetics
The NSUN2-intellectual disability syndrome is a rare disorder of the cellular transcriptome that prevents proper t-RNA splicing. This disorder interrupts cellular function and leads to an accumulation of RNA fragments, producing a constellation of symptoms including dysmorphic facies, hypotonia, microcephaly, and short stature.
Graham, Pingree, Amy, Harper, Jordan, Snajczuk, Natario L, Couser   +3 more
openaire   +1 more source

Spatial regulation of NSUN2-mediated tRNA m5C installation in cognitive function

Nucleic Acids Research
Abstract Enzyme-mediated modifications of tRNA, such as 5-methylcytosine (m5C) installed by nuclear-enriched NOP2/Sun RNA methyltransferase 2 (NSUN2), play a critical role in neuronal development and function. However, our understanding of these modifications' spatial installation and biological functions remains incomplete.
Yulia Gonskikh, Christian Tirrito, Praneeth Bommisetti, Maria Saraí Mendoza-Figueroa, Julian Stoute, Joshua Kim, Qin Wang, Yuanquan Song, Kathy Fange Liu   +8 more
openaire   +2 more sources

NSUN2-mediated m⁵C modification drives alternative splicing reprogramming and promotes multidrug resistance in anaplastic thyroid cancer through the NSUN2/SRSF6/UAP1 signaling axis

Theranostics
Rationale: Anaplastic thyroid carcinoma (ATC) is an extraordinarily aggressive form of thyroid cancer, frequently presenting with locally advanced infiltration or distant metastases at the time of initial diagnosis, thus missing the optimal window for surgical intervention.
Hou, Xiukun, Dong, Qiman, Hao, Jie, Liu, Min, Ning, Junya, Tao, Mei, Wang, Zhongyu, Guo, Fengli, Huang, Dongmei, Shi, Xianle, Gao, Ming, Li, Dapeng, Zheng, Xiangqian   +12 more
openaire   +2 more sources

NSUN2 knockdown ameliorates hepatic glucose and lipid metabolism disorders in type 2 diabetes mellitus through the Inhibition of ACSL6 m5C methylation

Lipids in Health and Disease
Background Hyperglycemia and dyslipidemia characterize type 2 diabetes mellitus (T2DM). The impact of 5-methylcytosine (m5C) on liver glucose and lipid regulation in T2DM is unclear.
Xianshu Jiang, Xuelan Cheng, Qiu Wan
doaj   +1 more source

NSUN2/ALYREF axis-driven m5C methylation enhances PD-L1 expression and facilitates immune evasion in non-small-cell lung cancer

Cancer Immunology, Immunotherapy
Non-small-cell lung cancer (NSCLC) represents a highly prevalent form of malignancy. 5-methylcytosine (m5C) methylation functions as a key post-transcriptional regulatory mechanism linked to cancer progression. The persistent expression of PD-L1 in tumor
Yiran Yang, Leiqun Cao, Xin Xu, Dan Li, Yiran Deng, Lan Li, Bingjie Zeng, Haixia Jiang, Liang Shan, Yiwen Huang, Yunhua Xu, Lifang Ma   +11 more
doaj   +1 more source