Results 81 to 90 of about 2,920 (152)

Association of tRNA methyltransferase NSUN2/IGF-II molecular signature with ovarian cancer survival

, 2017
Aim: To investigate the association between NSUN2/IGF-II signature and ovarian cancer survival. Methods: Using a publicly accessible dataset of RNA sequencing and clinical follow-up data, we performed Classification and Regression Tree and survival ...
Eric Risch, Huatian Huang, Chan Huang, Jia-cheng Yang, Meiqin Zhang, Lingeng Lu   +5 more
core   +1 more source

Targeting Dnmt3a/m5C/RelA Axis Attenuates Microglia Inflammatory Response and Improves Postoperative Recovery in Chronic Compressive Cervical Spinal Cord Injury

Advanced Science, Volume 13, Issue 48, 28 August 2026.
A pro‐inflammatory microglial subset persists after decompression in chronic compressive cervical spinal cord injury and shows enhanced Dnmt3a‐driven m5C signaling. By stabilizing RelA mRNA, this axis sustains NF‐κB activation and postoperative neuroinflammation.
Tianyu Qin, Yuan Jiang, Yongheng Xie, Huanwei Qu, Wenbin Yan, Jingle Chen, Yining Chen, Huayi Li, Naibo Feng, Jiajun Wu, Chao Zhang, Zhengqi Huang, Ming Shi, Zhihuai Deng, Guozhi Xiao, Houqing Long   +15 more
wiley   +1 more source

Über das Entwirren des Methylom, Interaktom und der Subzellulären Lokalisation von NSUN2 in Drosophila melanogaster

, 2019
NSUN2 ist eine stark konservierte, klinisch relevante (5-Cytosin) Methyltransferase, wobei der Verlust der Aktivität zu einer schwerwiegenden intellektuellen Beeinträchtigung führt.
Solano Mateos, Marta
core   +2 more sources

Aberrant KIF26B expression promotes bladder cancer progression through driving NSUN2 nuclear localization

Journal of Hematology & Oncology
Abnormal expression of kinesins has been observed in several types of cancer. The present study provided the first evidence that KIF26B could induce RNA m5C modification in bladder cancer (BCa).
Jia-Ming Wang, Hai-Yun Xie, Feng-Hao Zhang, Xuan Shu, Jin-Dan Luo, Li-Ping Xie, Jiang-Feng Li   +6 more
doaj   +1 more source

NSUN2 functions in the cell cycle to adapt dynamic protein synthesis in response to stress.

, 2019
(A) Schematic representation how oxidative stress modulates global and gene-specific translation. (B) Treatment regime using arsenite to induce stress and OP-puro to measure protein synthesis.
Sandra Blanco (34725), Martyna C. Popis (6843032), Abdulrahim A. Sajini (6843035), James A. West (462445), Michaela Frye (78179), Julian L. Griffin (152780), Susanne Bornelöv (189128), Cecilia Castro (538966), Matthias Heiß (6843029), Stefanie Kellner (430068), Anne E. Willis (361379), Sabine Dietmann (2388382), Nikoletta A. Gkatza (6843023), Joseph G. Gleeson (779314), Robert F. Harvey (6843026)   +14 more
core   +1 more source

NSUN2 positively regulates HBV expression and replication by maintaining RNA stability.

, 2023
(A-C) siRNAs were transfected into HepG2 followed by pHBV1.3 and pSV-β-gal transfection with an interval of 12 hours. Supernatant was collected for ELISA at 48 hours post-transfection. Cells were harvested for RNA extraction or lysis.
Xianying Chen (11248785), Cong Zeng (145162), Miao He (148269), Jiangpeng Feng (9287738), Tianmo Xu (11029548), Chengbao Ma (17549768), Shimin Yang (440641), Peipei Yao (17549765), Li Zhou (54356), Jiali Li (436886), Yu Chen (29959), Hongyun Wang (225359), Jiejie Liu (388856), Kun Yan (300887), Yuchen Xia (9287840), Zaichao Xu (15877593), Huan Yan (445452)   +16 more
core   +1 more source

NSUN2-mediated RNA m5C modification drives multiple myeloma progression by enhancing the stability of HIP1 mRNA

Scientific Reports
RNA 5-methylcytosine (m5C) modification is a crucial epigenetic regulation, and aberrant m5C methylation is associated with the pathogenesis of certain cancers.
Yang Jiang, Jing Sun, Yuyan Chen, Lin Cheng, Saran Feng, Yan Wang, Congcong Sun   +6 more
doaj   +1 more source

The RNA M5C methyltransferase NSUN2 promotes progression of hepatocellular carcinoma by enhancing PKM2-mediated glycolysis

Cell Death and Disease
Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. The 5-methylcytosine (m5C) RNA methyltransferase NSUN2 is involved in cell proliferation and metastasis and is upregulated in a variety of cancers.
Qin Qi, Rui Zhong, Yan Huang, Yong Tang, Xiao-wen Zhang, Chang Liu, Chun-fang Gao, Lin Zhou, Jian Yu, Lu-yi Wu   +9 more
doaj   +1 more source

Lactylation-Boosted m5C RNA Modification Drives Choroidal Neovascularization

Research
As a prevalent posttranscriptional RNA modification, N5-methylcytosine (m5C) plays a crucial role in a multitude of cellular responses and processes that govern RNA metabolism.
Sipeng Zuo, Lin Li, Jieling Tang, Fuxiang Ye, Sok, Yan Liu, Shengfang Ge, Renbing Jia, Xianqun Fan, Peiwei Chai, Linna Lu   +10 more
doaj   +1 more source

NSUN2 Promotes Head and Neck Squamous Cell Carcinoma Progression by Targeting EMT-Related Gene LAMC2 in an m⁵C-YBX1-Dependent Manner

Biomedicines
Background/Objectives: Head and neck squamous cell carcinoma (HNSCC) is a prevalent and aggressive cancer with high rates of metastasis and poor prognosis. Recent research highlights the role of 5-methylcytosine (m5C) in cancer progression. NSUN2, an m5C
Shuojin Huang, Congyuan Cao, Dongxiao Tang, Yiwen Liu, Wanhang Zhou, Lianlian Liu, Xin Zheng, Qianting He, Anxun Wang   +8 more
doaj   +1 more source