Results 101 to 110 of about 3,656 (193)

NSUN5 as a Prognostic Biomarker Correlates with Malignant Phenotype and Therapeutic Target in Glioma

Brain and Behavior, Volume 16, Issue 1, January 2026.
This study systematically analyzed the expression levels, clinical features, prognostic value, immune‐related roles, drug sensitivity, and biological functions of NSUN5 in glioma based on the CGGA and TCGA databases. Finally, a machine learning‐based prognostic model was constructed, and the function of NSUN5 was validated through in vitro experiments.
Ye Wenhao, Wu Huan, Zou Xiaoyun, Yang Yuanyuan, Bi Junlei, Liu Changqing, Zhao Mengyi, Zhang Yuyuan, Lu Jin, Wen Hebao, Ma Caiyun   +10 more
wiley   +1 more source

Glucose binds and activates NSUN2 to promote translation and epidermal differentiation

Nucleic Acids Research
Abstract Elevations in intracellular glucose concentrations are essential for epithelial cell differentiation by mechanisms that are not fully understood. Glucose has recently been found to directly bind several proteins to alter their functions to enhance differentiation.
Weili Miao, Douglas F Porter, Ya Li, Lindsey M Meservey, Yen-Yu Yang, Chengjie Ma, Ian D Ferguson, Vivian B Tien, Timothy M Jack, Luca Ducoli, Vanessa Lopez-Pajares, Shiying Tao, Paul B Savage, Yinsheng Wang, Paul A Khavari   +14 more
openaire   +2 more sources

Loss of 5-methylcytosine alters the biogenesis of vault-derived small RNAs to coordinate epidermal differentiation. [PDF]

, 2019
The presence and absence of RNA modifications regulates RNA metabolism by modulating the binding of writer, reader, and eraser proteins. For 5-methylcytosine (m5C) however, it is largely unknown how it recruits or repels RNA-binding proteins.
Bornelöv, Susanne, Choudhury, Nila Roy, Dietmann, Sabine, Frye, Michaela, Michlewski, Gracjan, Rappsilber, Juri, Sajini, Abdulrahim A, Selmi, Tommaso, Spanos, Christos, Wagner, Rebecca E   +9 more
core   +2 more sources

Wnt Signaling Pathway: Biological Function, Diseases, and Therapeutic Interventions

MedComm, Volume 7, Issue 1, January 2026.
The Wnt signaling pathway is essential for development and tissue homeostasis, while its dysregulation drives diverse diseases. This review systematically outlines its components, functions, regulators, and preclinical models, highlighting secreted frizzled‐related proteins (SFRPs) as context‐dependent, biphasic modulators.
Xiaoyu Jin, Jiahui Wang, Runyi Cao, Dongsheng Jiang   +3 more
wiley   +1 more source

All‐Trans Retinoic Acid Suppresses Hepatocellular Carcinoma Progression via the CSTB/CYTB Axis

Journal of Cellular and Molecular Medicine, Volume 30, Issue 2, January 2026.
ABSTRACT Cystatin B (CSTB) is highly expressed in hepatocellular carcinoma (HCC) tissues and serum, indicating its potential as an early diagnostic biomarker. Given the known tumour‐suppressive effects of all‐trans retinoic acid (ATRA) in solid tumours, this study investigated whether ATRA inhibits HCC progression by modulating CSTB expression ...
Jing Sun, Jian Zheng, Weiyi Zhu, Yang Bi, Yun He   +4 more
wiley   +1 more source

RNA modifications regulating cell fate in cancer. [PDF]

, 2019
The deposition of chemical modifications into RNA is a crucial regulator of temporal and spatial gene expression programs during development. Accordingly, altered RNA modification patterns are widely linked to developmental diseases.
Delaunay, Sylvain, Frye, Michaela
core   +1 more source

Cytosine-5 RNA methylation links protein synthesis to cell metabolism. [PDF]

, 2019
Posttranscriptional modifications in transfer RNA (tRNA) are often critical for normal development because they adapt protein synthesis rates to a dynamically changing microenvironment.
Blanco, Sandra, Bornelöv, Susanne, Castro, Cecilia, Dietmann, Sabine, Frye, Michaela, Gkatza, Nikoletta A, Gleeson, Joseph G, Griffin, Julian L, Harvey, Robert F, Heiß, Matthias, Kellner, Stefanie, Popis, Martyna C, Sajini, Abdulrahim A, West, James A, Willis, Anne E   +14 more
core   +4 more sources

m5C: Novel Diagnostic and Drug Repurposing Targets for Nonalcoholic Steatohepatitis

International Journal of Genomics, Volume 2026, Issue 1, 2026.
Background Epigenetic medication, such as RNA 5‐methylcytosine (m5C), is well‐recognized as a key regulator in hepatic metabolism and immune responses. However, m5C regulatory mechanisms in NASH pathogenesis have not yet been clearly elucidated. Methods By utilizing three bulk profiles of NASH patients acquired from GEO and integrative bioinformatic ...
Shuxian Chen, Renquan Duan, Jingyi Qiu, Zhiyu Lei, Wei Chen, Xiumei Li, Zhenyu Gong   +6 more
wiley   +1 more source

The RNA M5C methyltransferase NSUN2 promotes progression of hepatocellular carcinoma by enhancing PKM2-mediated glycolysis

Cell Death and Disease
Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. The 5-methylcytosine (m5C) RNA methyltransferase NSUN2 is involved in cell proliferation and metastasis and is upregulated in a variety of cancers.
Qin Qi, Rui Zhong, Yan Huang, Yong Tang, Xiao-wen Zhang, Chang Liu, Chun-fang Gao, Lin Zhou, Jian Yu, Lu-yi Wu   +9 more
doaj   +1 more source

Widespread occurrence of 5-methylcytosine in human coding and non-coding RNA [PDF]

, 2012
The modified base 5-methylcytosine (m5C) is well studied in DNA, but investigations of its prevalence in cellular RNA have been largely confined to tRNA and rRNA.
Adams, Agris, Alexa, Anderson, Baer, Beilharz, Blanco, Bodi, Brian J. Parker, Brzezicha, Cantara, Catherine M. Suter, Chan, Chow, Clancy, Cokus, David T. Humphreys, Desrosiers, Dubin, Dubin, Dubin, Dubin, Esakova, Frommer, Frye, Furuichi, Goll, Gu, Hafner, Hardip R. Patel, Helm, Hotchkiss, Hubbard, Hussain, Jeffery, Jeffrey E. Squires, Jühling, Kozomara, Lavi, Li, Lister, Marco Nousch, Motorin, Motorin, Motorin, Okamoto, Ondov, Parker, Rai, Sakita-Suto, Salditt-Georgieff, Schaefer, Schaefer, Schaefer, Schaefer, Sommer, Squires, Suzuki, Tennille Sibbritt, Thomas Preiss, Thompson, Warren, Wen, Wyatt, Young   +64 more
core   +2 more sources