Results 121 to 130 of about 3,656 (193)

Trans-m5C:A transformer-based model for predicting 5-methylcytosine (m5C) sites [PDF]

5-Methylcytosine (m5C) plays a pivotal role in various RNA metabolic processes, including RNA localization, stability, and translation. Current high-throughput sequencing technologies for m5C site identification are resource-intensive in terms of cost ...
Ding, Zewen, Fu, Haitao, Wang, Wen
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NSUN2/ALYREF axis-driven m5C methylation enhances PD-L1 expression and facilitates immune evasion in non-small-cell lung cancer

Cancer Immunology, Immunotherapy
Non-small-cell lung cancer (NSCLC) represents a highly prevalent form of malignancy. 5-methylcytosine (m5C) methylation functions as a key post-transcriptional regulatory mechanism linked to cancer progression. The persistent expression of PD-L1 in tumor
Yiran Yang, Leiqun Cao, Xin Xu, Dan Li, Yiran Deng, Lan Li, Bingjie Zeng, Haixia Jiang, Liang Shan, Yiwen Huang, Yunhua Xu, Lifang Ma   +11 more
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DNA methyltransferase 1 modulates mitochondrial function through bridging m5C RNA methylation [PDF]

DNA methyltransferase 1 (DNMT1) is an enzyme known for DNA methylation maintenance. Point mutations in its replication focus targeting sequence (RFTS) domain lead to late-onset neurodegeneration, such as autosomal dominant cerebellar ataxia-deafness and ...
Bahn, Jae Hoon, Chen, Linzhi, Deng, Xiaoqian, Fan, Guoping, Hu, Ganlu, Jian, Tianshen, Lee, Ryan, Li, Zhehao, Lim, Sin Yee, Liu, Huoyuan, Liu, Yizhi, Reue, Karen, Vergnes, Laurent, Wang, Jing, Xiao, Xinshu, Yin, Shanshan, Zhu, Xianmin   +16 more
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NSUN2 knockdown ameliorates hepatic glucose and lipid metabolism disorders in type 2 diabetes mellitus through the Inhibition of ACSL6 m5C methylation

Lipids in Health and Disease
Background Hyperglycemia and dyslipidemia characterize type 2 diabetes mellitus (T2DM). The impact of 5-methylcytosine (m5C) on liver glucose and lipid regulation in T2DM is unclear.
Xianshu Jiang, Xuelan Cheng, Qiu Wan
doaj   +1 more source

多細胞生物におけるrRNAのm1A修飾に関する研究 [PDF]

, 2018
この博士論文は内容の要約のみの公開（または一部非公開）になっています筑波大学 (University of Tsukuba ...
YOKOYAMA Wataru, 横山 航
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NSUN2 as an emerging epigenetic regulator in cancer: from biomarker to therapeutic target

RNA Biology
NOL1/NOP2/SUN domain family member 2 (NSUN2), a member of the RNA methyltransferase family responsible for catalysing 5-methylcytosine (m5 C) modifications, has been increasingly recognized as a key regulatory factor in the initiation and progression of ...
Yukun Wei, Wenjian Xu, Yueyang Bi, Qingqun Guo, Pengzhao Song, Yahui Sun, Fengli Guo, Pengfei Gu, Yong Han   +8 more
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Eye manifestations in the NSUN2 intellectual disability syndrome.

International journal of molecular epidemiology and genetics
The NSUN2-intellectual disability syndrome is a rare disorder of the cellular transcriptome that prevents proper t-RNA splicing. This disorder interrupts cellular function and leads to an accumulation of RNA fragments, producing a constellation of symptoms including dysmorphic facies, hypotonia, microcephaly, and short stature.
Graham, Pingree, Amy, Harper, Jordan, Snajczuk, Natario L, Couser   +3 more
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NSUN2 rs13181449 variant decreases the risk of oral cancer development

International Journal of Medical Sciences
NOP2/Sun RNA methyltransferase 2 (NSUN2), encoded by the NSUN2 gene, is a nuclear RNA methyltransferase that catalyzes the methylation of cytosine to 5-methylcytosine (m5C). Although RNA modification has been widely discussed in cancer development and prognosis, the role of the NSUN2 gene in oral cavity squamous cell carcinoma (OCSCC) is unclear.
Hung, Li-Chung, Huang, Cheng-Chen, Lu, Yen-Ting, Su, Chun-Wen, Lin, Chiao-Wen, Chu, Hsiao-Ju, Yang, Shun-Fa, Lu, Hsueh-Ju   +7 more
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NSUN2/YBX1 promotes the progression of breast cancer by enhancing HGH1 mRNA stability through m5C methylation

Breast Cancer Research
Background RNA m5C methylation has been extensively implicated in the occurrence and development of tumors. As the main methyltransferase, NSUN2 plays a crucial regulatory role across diverse tumor types. However, the precise impact of NSUN2-mediated m5C
Xuran Zhang, Ke An, Xin Ge, Yuanyuan Sun, Jingyao Wei, Weihong Ren, Han Wang, Yueqin Wang, Yue Du, Lulu He, Ouwen Li, Shaoxuan Zhou, Yong Shi, Tong Ren, Yun-gui Yang, Quancheng Kan, Xin Tian   +16 more
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FOXA1-dependent NSUN2 facilitates the advancement of prostate cancer by preserving TRIM28 mRNA stability in a m5C-dependent manner

npj Precision Oncology
RNA epigenetics is gaining increased attention for its role in the initiation, metastasis, and drug resistance of tumors. These studies have primarily focused on m6A modification. However, despite being the second most abundant modification found in RNA,
Zhenda Wang, Abudurexiti Mierxiati, Wenkai Zhu, Tian Li, Hua Xu, Fangning Wan, Dingwei Ye   +6 more
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