Results 111 to 120 of about 3,656 (193)

Proteomics reveals a switch in CDK1-associated proteins upon M-phase exit during the Xenopus laevis oocyte to embryo transition.

, 2012
International audienceCyclin-dependent kinase 1 (CDK1) is a major M-phase kinase which requires the binding to a regulatory protein, Cyclin B, to be active.
Borsuk, Ewa, Gagné, Jean-Philippe, Kubiak, Jacek, Marteil, Gaëlle, Poirier, Guy,, Richard-Parpaillon, Laurent   +5 more
core   +4 more sources

NAIL-MS Untersuchungen von RNA-Modifikationen in eukaryotischen Modellorganismen [PDF]

, 2021
In vielen Bereichen der Wissenschaft gewinnt die Dynamik der RNA-Modifikationen zu-nehmend an Bedeutung. So häufen sich die Nachweise von Korrelationen zwischen be-stimmten RNA-Modifikationen und Krankheitsbildern wie Krebs oder neurologischen Stö-rungen.
Heiß, Matthias
core  

Spatial regulation of NSUN2-mediated tRNA m5C installation in cognitive function

Nucleic Acids Research
Abstract Enzyme-mediated modifications of tRNA, such as 5-methylcytosine (m5C) installed by nuclear-enriched NOP2/Sun RNA methyltransferase 2 (NSUN2), play a critical role in neuronal development and function. However, our understanding of these modifications' spatial installation and biological functions remains incomplete.
Yulia Gonskikh, Christian Tirrito, Praneeth Bommisetti, Maria Saraí Mendoza-Figueroa, Julian Stoute, Joshua Kim, Qin Wang, Yuanquan Song, Kathy Fange Liu   +8 more
openaire   +2 more sources

NSUN2 Promotes Head and Neck Squamous Cell Carcinoma Progression by Targeting EMT-Related Gene LAMC2 in an m⁵C-YBX1-Dependent Manner

Biomedicines
Background/Objectives: Head and neck squamous cell carcinoma (HNSCC) is a prevalent and aggressive cancer with high rates of metastasis and poor prognosis. Recent research highlights the role of 5-methylcytosine (m5C) in cancer progression. NSUN2, an m5C
Shuojin Huang, Congyuan Cao, Dongxiao Tang, Yiwen Liu, Wanhang Zhou, Lianlian Liu, Xin Zheng, Qianting He, Anxun Wang   +8 more
doaj   +1 more source

A Thermodynamic-Based Interpretation of Protein Expression Heterogeneity in Different Glioblastoma Multiforme Tumors Identifies Tumor-Specific Unbalanced Processes [PDF]

, 2016
We describe a thermodynamic-motivated, information theoretic analysis of proteomic data collected from a series of 8 glioblastoma multiforme (GBM) tumors. GBMs are considered here as prototypes of heterogeneous cancers.
Heath, James R., Johnson, Hannah, Kravchenko-Balasha, Nataly, Levine, R. D., White, Forest M.   +4 more
core   +3 more sources

NSUN2-mediated m⁵C modification drives alternative splicing reprogramming and promotes multidrug resistance in anaplastic thyroid cancer through the NSUN2/SRSF6/UAP1 signaling axis

Theranostics
Rationale: Anaplastic thyroid carcinoma (ATC) is an extraordinarily aggressive form of thyroid cancer, frequently presenting with locally advanced infiltration or distant metastases at the time of initial diagnosis, thus missing the optimal window for surgical intervention.
Hou, Xiukun, Dong, Qiman, Hao, Jie, Liu, Min, Ning, Junya, Tao, Mei, Wang, Zhongyu, Guo, Fengli, Huang, Dongmei, Shi, Xianle, Gao, Ming, Li, Dapeng, Zheng, Xiangqian   +12 more
openaire   +2 more sources

Study on the expression and Functions of Nucleophosmin during the Apoptosis of the Human Hepatoma SMMC-7721 Cells

, 2015
为了建立在姜黄素诱导肿瘤细胞凋亡过程中以Nucleophosmin为中心的分子调控网络，阐明Nucleophosmin的表达和定位变化在肿瘤细胞诱导凋亡过程中的调控作用机制，本论文在成功制备Nucleophosmin兔多克隆抗体的基础上，运用Westernblot和免疫荧光标记技术（IF）分析Nucleophosmin在姜黄素诱导凋亡前后的人肝癌SMMC-7721细胞中的表达和定位变化，同时构建带有Flag标签的正常定位（pBobi-cmv-NPM）以及核仁定位信号突变（pBobi-cmv-NPM ...
李晓
core  

The m5C methyltransferase NSUN2 promotes progression of acute myeloid leukemia by regulating serine metabolism

Cell Reports
Summary: Acute myeloid leukemia (AML) is one of the most prevalent heterogeneous hematologic malignancies with a complicated etiology. RNA post-transcriptional modifications have been linked to the incidence and progression of AML, while the detailed ...
Songyu Li, Ya Liu, Xiang Wu, Minjia Pan, Hongxia Zhao, Yunguang Hong, Qinghua Zhang, Shushu Hu, Aorong Ouyang, Guangru Li, Minhui Wu, Shanshan Fan, Zhirong Jia, Shanchao Zhao, Guocai Wu, Xiangwei Gao, Zhigang Yang, Zhanghui Chen   +17 more
doaj   +1 more source

Nsun2 controls cardiac homeostasis and hypertrophic response by regulating PRKACA expression

Theranostics
Rationale: Internal modifications of mammalian RNA have been suggested to be essential for the maintenance of cardiac homeostasis. However, the role of RNA cytosine methylation (m5C) in the heart remains largely unknown. Methods: Bulk and single cell RNA sequencing data and tissues from the human hearts were exploited for analyzing the expression of ...
Jian, Dongdong, Cheng, Xiaolei, Qi, Datun, Wang, Shixing, Wang, Chenqiu, Shi, Yingchao, Li, Zhen, Jin, Shouyi, Jia, Zhen, Teng, Peng, Pei, Zhen, Gu, Xiaoping, Jian, Liguo, Wang, Wengong, Yi, Xia, Xing, Junyue, Tang, Hao   +16 more
openaire   +2 more sources

NSun2‐Mediated tsRNAs Alleviate Liver Fibrosis via FAK Dephosphorylation

Cell Proliferation
ABSTRACTSinusoidal capillarization – key symptoms of liver fibrosis progression – represents potential therapeutic targets. tRNA modification‐mediated tRNA‐derived small RNAs (tsRNAs) play a role in angiogenesis. NSun2, an RNA methyltransferase, generates a significant number of tsRNAs.
Pengcheng Li, Sunyang Ying, Yu Zou, Xin Wang, Runxue Zhang, Cheng Huang, Moyu Dai, Kai Xu, Guihai Feng, Xin Li, Haiping Jiang, Zhikun Li, Ying Zhang, Wei Li, Qi Zhou   +14 more
openaire   +2 more sources