Results 131 to 140 of about 2,478 (156)

mRNA turnover dynamics are affected by cell differentiation and loss of the cytosine methyltransferase Nsun2. [PDF]

Nucleic Acids Res
Delazer I, Bauer I, Rummel T, Nykiel K, Rieder D, Fickl M, Tumler V, Razkova A, Schaefer MR, Scheed T, Erlacher MD, Erhard F, Micura R, Lusser A.   +13 more
europepmc   +1 more source

Recent research advances in RNA m5C methylation modification in liver diseases. [PDF]

Front Mol Biosci
Chen W, Zhang L, Gu X, Liu Y, Zhang S, Hu X, Li P.   +6 more
europepmc   +1 more source

Reorganization of the Landscape of Translated mRNAs in NSUN2-Deficient Cells and Specific Features of NSUN2 Target mRNAs

International Journal of Molecular Sciences, 2022
The RNA cytosine C5 methyltransferase NSUN2 has a variety of RNA substrates and plays an important role in mRNA metabolism. NSUN2 binds to specific sequences enriched in exosomal mRNAs, suggesting its possible involvement in the sorting of mRNAs into exosomes.
Alexander V Gopanenko, Alexey E Tupikin, Marsel R Kabilov   +2 more
exaly   +3 more sources

NSun2 promotes cell migration through methylating autotaxin mRNA [PDF]

Journal of Biological Chemistry, 2020
NSun2 is an RNA methyltransferase introducing 5-methylcytosine into tRNAs, mRNAs, and noncoding RNAs, thereby influencing the levels or function of these RNAs. Autotaxin (ATX) is a secreted glycoprotein and is recognized as a key factor in converting lysophosphatidylcholine into lysophosphatidic acid (LPA).
Xin Xu, Junjie Zhang
exaly   +6 more sources

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NSUN2 gene rs13181449 C>T polymorphism reduces neuroblastoma risk

Gene, 2023
Neuroblastoma is the most common tumor in infants. RNA m5C modification regulates the survival, differentiation, and migration of cells affecting RNA function. However, the effects of the m5C modification methyltransferase gene NSUN2 polymorphism on neuroblastoma susceptibility have not been reported.
Lei, Lin, Changmi, Deng, Chunlei, Zhou, Xinxin, Zhang, Jinhong, Zhu, Jiabin, Liu, Haiyan, Wu, Jing, He   +7 more
openaire   +2 more sources

mRNA methylation by NSUN2 in cell proliferation

WIREs RNA, 2016
Methylation is a prevalent post‐transcriptional modification that occurs in almost all RNA species. NSUN2, a nucleolar RNA methyltransferase, has been shown to methylate mRNAs encoding factors that control cell division and growth arrest, thereby affecting their stability and/or translation.
openaire   +2 more sources

NSUN2-Mediated m5C Methylation Impairs Endometrial Receptivity

Laboratory Investigation
Impaired endometrial decidualization is the primary cause of recurrent implantation failure (RIF). RNA methylation modification, especially NSUN family mediated m5C, is crucial for various physiological events, such as maternal-to-zygotic transition, gametogenesis, embryonic development, organismal lifespan, and cell cycle.
Jiafeng Lu, Ming Zhang, Zhenxing Liu, Ling Guo, Peng Huang, Wenjuan Xia, Jincheng Li, Jinghuan Lv, Hoi-Hung Cheung, Chenyue Ding, Hong Li, Boxian Huang   +11 more
openaire   +2 more sources

ETV4/NSUN2 Axis modulates aerobic glycolysis and malignancy in HSCC

Human Molecular Genetics
Abstract This study delves into the molecular intricacies of hypopharyngeal squamous cell carcinoma (HSCC), specifically focusing on the pivotal role played by ETS translocation variant 4 (ETV4) in aerobic glycolysis. The objective is to uncover new targets for early diagnosis and treatment of HSCC.
Xiaoxu Ding, Xueyan Zhang, Panxia Fang, Weiliang Bai   +3 more
openaire   +2 more sources

NSUN2 is critical for mouse oocyte meiosis and early embryonic development

Reproduction
  In brief The mechanism by which the NSUN2 mutation causes female infertility is still unclear. This study reveals the role and potential mechanism of NSUN2 in mouse oocyte maturation and early embryonic development, and provides a resource for elucidating female infertility with NSUN2 ...
Tengteng Xu, Min Gao, Ling Zhang, Tianqi Cao, Yanling Qiu, Simiao Liu, Wenlian Wu, Yitong Zhou, Haiying Liu, Rui Zhang, Xiaohong Ruan, Junjiu Huang   +11 more
openaire   +2 more sources

NSun2 regulates aneurysm formation by promoting autotaxin expression and T cell recruitment

Cellular and Molecular Life Sciences, 2020
Abdominal aortic aneurysm (AAA) is characterized by inflammatory cell infiltration and aggravated by hyperhomocysteinemia (HHcy). It is unknown whether the homocysteine (Hcy)-activated RNA methyltransferase NOP2/Sun domain family member 2 (NSun2) is associated with AAA.
Yutong Miao, Yang Zhao, Lulu Han, Xiaolong Ma, Jiacheng Deng, Juan Yang, Silin Lü, Fangyu Shao, Wei Kong, Wengong Wang, Qingbo Xu, Xian Wang, Juan Feng   +12 more
openaire   +3 more sources