Results 141 to 150 of about 2,478 (156)

Pancancer Analysis of NSUN2 with a Focus on Prognostic and Immunological Roles in Endometrial Cancer

Reproductive Sciences
The significance of NSUN2 in carcinogenesis is gradually being recognized, yet a comprehensive analysis across pan-cancer remains a pivotal void in existing research. In our investigation, we capitalized on the UCSC Xena platform to evaluate NSUN2 expression levels and their prognostic implications across a range of cancer types.
Yuxin Zan, Yan Ding
openaire   +2 more sources

NSUN2-mediated RNA methylation: Molecular mechanisms and clinical relevance in cancer

Cellular Signalling
Cancer remains a leading cause of morbidity and mortality worldwide, necessitating the ongoing investigation of molecular targets for improved diagnosis, prognosis, and therapy. Among these targets, RNA modifications, particularly N5-methylcytosine (m5C) in RNA, have emerged as critical regulators of gene expression and cellular functions. NOP2/Sun RNA
Penghui, Li, Di, Huang
openaire   +2 more sources

Genomic gain of 5p15 leads to over-expression of Misu (NSUN2) in breast cancer

Cancer Letters, 2010
We have examined expression of the Myc target gene Misu (NSUN2) in breast cancer. There was extensive copy number gain, and increased mRNA and protein levels, of Misu in approximately one third of breast cancer cell lines and primary tumours examined, irrespective of tumour subtype.
Frye, Michaela, Dragoni, Ilaria, Chin, Suet-Feung, Spiteri, Immaculada, Kurowski, Agata, Provenzano, Elena, Green, Andrew, Ellis, Ian O, Grimmer, Donna, Teschendorff, Andrew, Zouboulis, Christos C, Caldas, Carlos, Watt, Fiona M   +12 more
openaire   +3 more sources

Mechanism of puerarin alleviating myocardial remodeling through NSUN2-mediated m5C methylation modification

Phytomedicine
Myocardial remodeling is a primary contributor to the development and progression of heart failure. Reversing this process is crucial for the prevention and treatment of heart failure. Puerarin (Pue), a traditional Chinese medicine, has been widely utilized in the management of cardiovascular diseases; however, its potential mechanisms for reversing ...
Yahua, Wu, Xiaomin, Huang, Yun, He, Junjie, Chang, Xiaoxia, Fang, Pengju, Kang, Na, Feng, Rui, Liu, Pingping, Xiao, Dandan, Shi, Qiufang, Zhang, Yan, Ding, Wenjun, Zhang, Xiju, He   +13 more
openaire   +2 more sources

NSUN2 is a glucose sensor suppressing cGAS/STING to maintain tumorigenesis and immunotherapy resistance

Cell Metabolism, 2023
Rajesh Kumar Manne, Hui-Kuan Lin
exaly  

RNA methyltransferase NSun2 deficiency promotes neurodegeneration through epitranscriptomic regulation of tau phosphorylation

Acta Neuropathologica, 2022
Yoon A Kim, Gunnar Hargus, Tohid Siddiqui   +2 more
exaly  

RNA methyltransferase NSUN2 promotes hypopharyngeal squamous cell carcinoma proliferation and migration by enhancing TEAD1 expression in an m5C-dependent manner

Experimental Cell Research, 2021
Lixiao Chen, Xinwei Chen, Ziwei Yu
exaly  

5-methylcytosine promotes mRNA export — NSUN2 as the methyltransferase and ALYREF as an m5C reader

Cell Research, 2017
Ying Yang, Yu-Sheng Chen, Ang Li
exaly  

Association of tRNA methyltransferase NSUN2/IGF-II molecular signature with ovarian cancer survival

Future Oncology, 2017
Meiqin Zhang, Chan Huang, Lingeng Lu
exaly  

NSun2 Deficiency Protects Endothelium From Inflammation via mRNA Methylation of ICAM-1

Circulation Research, 2016
Juan Feng, Qingbo Xu, Wengong Wang
exaly