Results 1 to 10 of about 5,418 (159)

YBX1 promotes angiogenesis after myocardial infarction by stabilizing HIF1α mRNA via m6A signaling [PDF]

iScience
Summary: Angiogenesis is essential for myocardial repair after myocardial infarction (MI). While Y-box binding protein 1 (YBX1) is well-established in cancer biology, its role in post-MI angiogenesis remains unknown. Here, we show that YBX1 expression is
Fangfang Bi, Tong Yu, Hanyu Liu, Miao Cao, Yijie He, Jin Li, Haoshu Wang, Chengyu Kong, Hongwen Xiao, Hua Tian, Fu Liu, Yun Wu, Yuhong Zhou, Hongli Shan   +13 more
doaj   +2 more sources

YBX1 orchestrates LDHA-mediated metabolic reprogramming and NF-κB activation to drive clear cell renal cell carcinoma progression [PDF]

Cell Death and Disease
Renal cell carcinoma (RCC) is sometimes referred to as a “metabolic disease”, as nearly all types of RCC are associated with the reprogramming of glucose and lipid metabolism.
Yihan Dong, Aixin Qiu, Shuang Liu, Yuejing Pan, Tianyu Lin, Rui Wang, Ruibing Chen, Huamao Jiang, Yang Yu, Yong Wang, Dan Yue   +10 more
doaj   +2 more sources

Uridine metabolism promotes lung adenocarcinoma progression by activating FBL transcription via YBX1 [PDF]

Journal of Translational Medicine
Background Uridine metabolism serves as a critical compensatory metabolic pathway in tumor cells under glucose deprivation. However, the mechanistic role of uridine metabolism in tumorigenesis and progression has not been elucidated.
Xinyi Wang, Liang Chen, Yingge Li, Luojun Chen, Chunmei Hao, Qilu Yan, Shuyang Yu, Cai Zhang, Ruibin Li, Bin Xu, Yi Yao, Qibin Song   +11 more
doaj   +2 more sources

YBX1 Enhances Metastasis and Stemness by Transcriptionally Regulating MUC1 in Lung Adenocarcinoma

Frontiers in Oncology, 2021
Abnormal expression of the transcription factor Y-box-binding protein-1 (YBX1) is associated with the proliferation, migration, aggressiveness, and stem-like properties of various cancers.
Wei Guo, Wuguo Deng, Chundong Gu
exaly   +3 more sources

CircEPHB4 binds to YBX1 to upregulate MRPS16 and promotes glioma progression [PDF]

Cellular and Molecular Life Sciences
Background Glioma is the most frequently diagnosed brain tumor in adults worldwide which is associated with unfavorable prognosis and survival time. However, the understanding of glioma progression remains limited.
Yuxiang Liao, Bo Liu, Zhiping Zhang, Qian Zhang, Mingyong Xiang, Chen Jin   +5 more
doaj   +2 more sources

Computational Repurposing and Experimental Validation of YBX1 Inhibitors in Hepatocellular Carcinoma [PDF]

Biomedicines
Background/Objectives: Hepatocellular carcinoma (HCC) is the most common type of liver cancer worldwide. While early-stage HCC can often be treated with surgical resection, ablation, or liver transplantation, advanced disease typically relies on systemic
Omar Karkoutly, Veerababu Nagati, Subhash C. Chauhan, Manish Tripathi   +3 more
doaj   +2 more sources

YBX1 regulation of alveolar type II epithelial cells in idiopathic pulmonary fibrosis: mechanistic insights and small-molecule drug screening [PDF]

Journal of Translational Medicine
Background This study aims to systematically elucidate the molecular mechanisms underlying idiopathic pulmonary fibrosis (IPF), with a specific focus on the regulatory role of the nucleic acid-binding protein Y-box binding protein 1 (YBX1) in alveolar ...
Yijie He, Jin Li, Yibo Xie, Yaming Wu, Li Wang, Jungang Ren, Zhiqiang Zhang, Tong Yu, Shuxia Jiang, Hongli Shan, Yun Wu, Yuhong Zhou   +11 more
doaj   +2 more sources

RNF115 upregulation by YBX1-dependent m5C modification promotes hepatocellular carcinoma progression [PDF]

npj Precision Oncology
5-methylcytosine (m5C) RNA modification plays critical roles in post-transcriptional regulation and cancer progression. However, the downstream effectors of the m5C reader protein YBX1 and their mechanistic contribution to hepatocellular carcinoma (HCC ...
Jianhao Li, Han Chen, Lang Bai, Hong Tang   +3 more
doaj   +2 more sources

YBX1 modulates humoral immunity through post-transcriptional regulation in B cells [PDF]

Frontiers in Immunology
IntroductionY-box binding protein 1 (YBX1) is a multifunctional RNA- and DNA-binding protein implicated in transcriptional regulation, mRNA stabilization, and translation, as well as cell proliferation and stress responses.
Viktoria Kunz, Kathryn S. Bommert, Ralf Bargou, Kurt Bommert   +3 more
doaj   +2 more sources

Unveiling the immunological functions of the RNA m5C reader YBX1 in cancer [PDF]

Frontiers in Immunology
Y-box binding protein 1 (YBX1) is a multifunctional RNA-binding protein that plays a central role in cancer progression across diverse tumor types. Mechanistically, YBX1 promotes tumorigenesis through multiple pathways, including interactions with long ...
Chunhong Li, Yixiao Yuan, Xiulin Jiang, Qiang Wang   +3 more
doaj   +2 more sources