Results 1 to 10 of about 5,892 (110)
Age-Associated YBX1 Phosphorylation Regulates the Keratinocyte Senescence-Associated Secretory Phenotype Through Translational Control [PDF]
CellsSkin aging is characterized by epidermal atrophy, reduced keratinocyte proliferation, and the accumulation of senescent cells that sustain a chronic, low-grade inflammatory secretome known as the senescence-associated secretory phenotype (SASP).
Valdi Ven Japranata +8 more
doaj +2 more sources
Deletion of Ybx1 results in germ cell hypoplasia in mouse embryos [PDF]
The Journal of Reproduction and DevelopmentSeveral evolutionarily conserved genes have been reported to be involved in gametogenesis. Y-box binding proteins, which have a conserved nucleotide-binding cold-shock domain, have been reported in both vertebrates and ...
Shinya IKEDA +2 more
doaj +2 more sources
Long noncoding RNAs implicated in embryonic development in Ybx1 knockout zebrafish
FEBS Open Bio, 2021 Y‐box‐binding protein 1 (Ybx1, YB‐1), also known as Y‐box transcription factor, is involved in a variety of biological processes (BPs) and pathways, including embryogenesis, reproduction and development in vertebrates.
Xiaohua Douglas Zhang, Wei Ge
exaly +2 more sources
HDAC1 maintains metabolic homeostasis in nucleus pulposus cells via post-translational modification interactions with YBX1 [PDF]
Experimental and Molecular MedicineIntervertebral disc degeneration is characterized by the metabolic dysregulation of nucleus pulposus cells, which is regulated by complex post-translational modifications, manifesting as extracellular matrix remodeling and inflammatory microenvironment ...
Bohao Zhou +18 more
doaj +2 more sources
YBX1 Confers immunosuppressive bone metastatic traits in non-small cell lung cancer [PDF]
Nature CommunicationsThe spread of lung cancer to bone is a devastating complication often linked to resistance against immunotherapy, but the reasons for this connection are poorly understood.
Kai Zhang +12 more
doaj +2 more sources
Clinical and Translational MedicineBackground Lysine methyltransferase 2D (KMT2D) mediates mono‐methylation of histone H3 lysine 4 (H3K4me1) in mammals. H3K4me1 mark is involved in establishing an active chromatin structure to promote gene transcription.
Changyan Ma, Bing Yao, Mengying Xing
exaly +2 more sources
Uridine metabolism promotes lung adenocarcinoma progression by activating FBL transcription via YBX1 [PDF]
Journal of Translational MedicineBackground Uridine metabolism serves as a critical compensatory metabolic pathway in tumor cells under glucose deprivation. However, the mechanistic role of uridine metabolism in tumorigenesis and progression has not been elucidated.
Xinyi Wang +11 more
doaj +2 more sources
Advanced ScienceThe modification and recognition of 5‐methylcytosine (m5C) are involved in the initiation and progression of various tumor types. However, the precise role and potential mechanism of Y‐box‐binding protein 1 (YBX1) in esophageal squamous cell carcinoma ...
Ranran Sun, Yawen Zou
exaly +2 more sources
Computational Repurposing and Experimental Validation of YBX1 Inhibitors in Hepatocellular Carcinoma [PDF]
BiomedicinesBackground/Objectives: Hepatocellular carcinoma (HCC) is the most common type of liver cancer worldwide. While early-stage HCC can often be treated with surgical resection, ablation, or liver transplantation, advanced disease typically relies on systemic
Omar Karkoutly +3 more
doaj +2 more sources
Advanced ScienceSpinal cord injury (SCI) is a severe injury to the central nervous system, and its treatment is always a major medical challenge. Proinflammatory cell death is considered an important factor affecting neuroinflammation and the prognosis after injury ...
Junsong Wu, Honghao Shen, Junsheng Lou
exaly +2 more sources