RNF115 upregulation by YBX1-dependent m5C modification promotes hepatocellular carcinoma progression [PDF]
npj Precision Oncology5-methylcytosine (m5C) RNA modification plays critical roles in post-transcriptional regulation and cancer progression. However, the downstream effectors of the m5C reader protein YBX1 and their mechanistic contribution to hepatocellular carcinoma (HCC ...
Jianhao Li +3 more
doaj +2 more sources
Unveiling the immunological functions of the RNA m5C reader YBX1 in cancer [PDF]
Frontiers in ImmunologyY-box binding protein 1 (YBX1) is a multifunctional RNA-binding protein that plays a central role in cancer progression across diverse tumor types. Mechanistically, YBX1 promotes tumorigenesis through multiple pathways, including interactions with long ...
Chunhong Li +3 more
doaj +2 more sources
ETV4 Improves Cerebral Ischemia-Reperfusion Injury by Restraining YBX1-GPX4-Ferroptosis Cascades. [PDF]
Brain BehavABSTRACT Background Cerebral ischemia‐reperfusion injury (CIRI) is a critical pathological process following ischemic stroke, with ferroptosis being increasingly recognized as a key contributor to neuronal damage. However, the regulatory mechanisms, particularly the role of specific transcription factors like E26 transformation‐specific variant 4 (ETV4)
Xu Q, Deng F, Yu D.
europepmc +2 more sources
YBX1: A Multifunctional Protein in Senescence and Immune Regulation
Current Issues in Molecular BiologyThe Y-box binding protein 1 (YBX1) is a multifunctional protein with a wide range of roles in cell biology. It plays a crucial role in immune modulation, senescence, and disease progression.
Zhe Zhao, Wanxia Wang
exaly +3 more sources
Advanced ScienceSpinal cord injury (SCI) is a severe injury to the central nervous system, and its treatment is always a major medical challenge. Proinflammatory cell death is considered an important factor affecting neuroinflammation and the prognosis after injury ...
Junsheng Lou +2 more
exaly +2 more sources
Expression of YBX1 and FOXA1 in Gastric Cancer and Their Clinicopathological Significance
Zhongliu Fangzhi Yanjiu, 2022 Objective To explore the expression levels of YBX1 and FOXA1 in gastric cancer tissues and determine their relationship with prognosis. Methods A total of 131 patients with gastric cancer were studied, and the corresponding adjacent normal tissues of ...
PEI Zhenghao +3 more
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YBX1 mediates alternative splicing and maternal mRNA decay during pre-implantation development
Cell & Bioscience, 2022 Background In mammals, maternal gene products decay and zygotic genome activation (ZGA) during maternal to zygotic transition (MZT) is critical for the early embryogenesis.
Mingtian Deng +6 more
doaj +1 more source
Knockdown of Y-box binding protein 1 induces autophagy in early porcine embryos
Frontiers in Cell and Developmental Biology, 2023 Y-box binding protein 1 (YBX1) plays important roles in RNA stabilization, translation, transcriptional regulation, and mitophagy. However, its effects on porcine preimplantation embryos remain unclear. In this study, we knocked down YBX1 in the one-cell
Wen-Jie Jiang +7 more
doaj +1 more source
Transcriptional and post-transcriptional control of autophagy and adipogenesis by YBX1
Cell Death and Disease, 2023 Obesity is strongly associated with metabolic diseases, which have become a global health problem. Exploring the underlying mechanism of adipogenesis is crucial for the treatment of excess white fat.
Ruifan Wu +9 more
doaj +1 more source
C1QBP Regulates YBX1 to Suppress the Androgen Receptor (AR)-Enhanced RCC Cell Invasion
Neoplasia: An International Journal for Oncology Research, 2017 Early studies suggested that the androgen receptor (AR) might play important roles to promote the renal cell carcinoma (RCC) progression; however, the detailed mechanisms remain unclear.
Dan Yue +4 more
doaj +1 more source