Results 21 to 30 of about 6,571 (196)

White adipose remodeling during browning in mice involves YBX1 to drive thermogenic commitment [PDF]

Molecular Metabolism, 2021
Objective: Increasing adaptive thermogenesis by stimulating browning in white adipose tissue is a promising method of improving metabolic health. However, the molecular mechanisms underlying this transition remain elusive.
Atefeh Rabiee, Kaja Plucińska, Marie Sophie Isidor, Erin Louise Brown, Marco Tozzi, Simone Sidoli, Patricia Stephanie S. Petersen, Marina Agueda-Oyarzabal, Silje Bøen Torsetnes, Galal Nazih Chehabi, Morten Lundh, Ali Altıntaş, Romain Barrès, Ole Nørregaard Jensen, Zachary Gerhart-Hines, Brice Emanuelli   +15 more
doaj   +2 more sources

CircEPHB4 binds to YBX1 to upregulate MRPS16 and promotes glioma progression

Cellular and Molecular Life Sciences
Background Glioma is the most frequently diagnosed brain tumor in adults worldwide which is associated with unfavorable prognosis and survival time. However, the understanding of glioma progression remains limited.
Yuxiang Liao, Bo Liu, Zhiping Zhang, Qian Zhang, Mingyong Xiang, Chen Jin   +5 more
doaj   +3 more sources

YBX1: an RNA/DNA-binding protein that affects disease progression

Frontiers in Oncology
YBX1 is a member of the Y-box transcription factor family and is a multifunctional RNA/DNA-binding protein characterized by a highly conserved cold shock domain (CSD).
Xifeng Zheng, Xifeng Zheng, Feng Zeng, Yan Lei, Yanling Li, Jun Deng, Gengqiu Luo, Qian He, Yanhong Zhou   +8 more
doaj   +4 more sources

YBX1 Expression and Function in Early Hematopoiesis and Leukemic Cells

Immunogenetics, 2011
Hematopoietic transcription factors play a critical role in directing the commitment and differentiation of hematopoietic stem cells along a particular lineage.
Bhullar, Jasjeet, Sollars, Vincent E.
core   +3 more sources

In silico analysis of overall survival with YBX1 in male and female solid tumours

Scientific Reports
The Y-box binding protein-1 (YBX1) gene codes for a multifunctional oncoprotein that is increasingly being linked to the regulations of many aspects of cancer cell biology.
David Robert Grimes, Treewut Rassamegevanon, Laure Marignol   +2 more
doaj   +5 more sources

Unveiling the immunological functions of the RNA m5C reader YBX1 in cancer

Frontiers in Immunology
Y-box binding protein 1 (YBX1) is a multifunctional RNA-binding protein that plays a central role in cancer progression across diverse tumor types. Mechanistically, YBX1 promotes tumorigenesis through multiple pathways, including interactions with long ...
Chunhong Li, Yixiao Yuan, Xiulin Jiang, Qiang Wang   +3 more
doaj   +3 more sources

Nuclear IDH3A Drives Transcriptional Programs in Melanoma via the YBX1-JUN/FOS Axis. [PDF]

Adv Sci (Weinh)
Genomic amplification drives aberrant nuclear localization of IDH3A in melanoma. Independent of its canonical metabolic activity, nuclear IDH3A cooperates with YBX1 to activate the c‐JUN/c‐FOS transcriptional program, while NONO facilitates its nuclear localization.
Ran J, Fang Y, Ruan S, Wang J, Liu S, Mao Y, Hou D, Wang Y, Ye Z, Li Q, Zhang D.   +10 more
europepmc   +2 more sources

YBX1 Promotes Malignant Progression of HNSCC via Stabilizing NSUN2-m5C Modified ATF4 mRNA. [PDF]

Cancer Sci
The diagram depicts the core axis and the key finding: “Targeting YBX1/NSUN2 abrogates HNSCC progression”. Within left‐sided HNSCC cells, NSUN2 mediates m5C methylation on the CDS of ATF4 mRNA; YBX1 then specifically recognizes and binds this modified site, augmenting ATF4 mRNA stability, which ultimately promotes cancer cell proliferation, migration ...
Li Y, Li S, Li Y, Pan Z.
europepmc   +2 more sources

NSUN2-Mediated m⁵C Modification of TGFB1 in Trophoblasts Remodels Macrophage Function to Prevent URSA. [PDF]

Adv Sci (Weinh)
NSUN2 and m5C decline in URSA villous tissues. Trophoblast Nsun2 ablation disrupts macrophage‐mediated maternal‐fetal tolerance and triggers embryo resorption. Mechanistically, NSUN2‐YBX1 axis stabilizes m5C‐modified TGFB1 mRNA to maintain TGF‐β1 secretion and M2 polarization, and restoring this signaling rescues maternal‐fetal immune tolerance to ...
Zhu X, Liu X, Yu X, Han Q, Shi F, Song W, Liu L, Chu C, Shen C, Zhang Z, Li X.   +10 more
europepmc   +2 more sources

YBX1 regulates RNA polymerase III transcripts to prevent inflammation. [PDF]

Proc Natl Acad Sci U S A
Tolerance of endogenous nucleic acids is crucial for cellular homeostasis and when perturbed can lead to immune dysregulation. RNA-binding proteins (RBPs) bind, modify, and compartmentalize endogenous RNAs to prevent their recognition by the innate ...
Strilets TI, Dremel SE, Garcia-Blanco MA.   +2 more
europepmc   +2 more sources