Results 21 to 30 of about 5,562 (124)

LncRNA HOXC-AS3 promotes non-small-cell lung cancer growth and metastasis through upregulation of YBX1

Cell Death and Disease, 2022
NSCLC is common and is the primary cause of cancer-related deaths due to a lack of early diagnosis and its propensity for metastasis. The pathogenesis of NSCLC is still unclear.
HongBo Su, GuanZhi Fan, Jin Huang, XueShan Qiu   +3 more
doaj   +1 more source

White adipose remodeling during browning in mice involves YBX1 to drive thermogenic commitment

Molecular Metabolism, 2021
Objective: Increasing adaptive thermogenesis by stimulating browning in white adipose tissue is a promising method of improving metabolic health. However, the molecular mechanisms underlying this transition remain elusive.
Atefeh Rabiee, Kaja Plucińska, Marie Sophie Isidor, Erin Louise Brown, Marco Tozzi, Simone Sidoli, Patricia Stephanie S. Petersen, Marina Agueda-Oyarzabal, Silje Bøen Torsetnes, Galal Nazih Chehabi, Morten Lundh, Ali Altıntaş, Romain Barrès, Ole Nørregaard Jensen, Zachary Gerhart-Hines, Brice Emanuelli   +15 more
doaj   +1 more source

Ybx1 deficiency impairs spermatid development and male fertility without affecting meiosis in mice: insights into spermatogenesis

The Journal of Reproduction and Development
Spermatogenesis is a complex process that is required for sperm production. Multiple RNA-binding proteins participate in regulating spermatogenesis.
Yan HAN, Rui WU, Chaoqun DUAN, Jiemin CHEN, Xing DENG, Wei PENG, Buzhen TAN   +6 more
doaj   +1 more source

YBX1 is required for assembly of viral replication complexes of chikungunya virus and replication of multiple alphaviruses

Journal of Virology
Chikungunya virus (CHIKV), an enveloped positive-sense RNA virus, is a member of the alphaviruses and cause fever and arthralgia in humans. We performed genome-wide CRISPR/Cas9-based screens and identified Y-box binding protein 1 (YBX1) as an essential ...
Zhen-Qi Li, Li-Xin Zhao, Su-Yun Wang, Chu-Yu Hu, Yan-Yi Wang, Yan Yang   +5 more
doaj   +1 more source

LNCAROD is stabilized by m6A methylation and promotes cancer progression via forming a ternary complex with HSPA1A and YBX1 in head and neck squamous cell carcinoma

Molecular Oncology, 2020
Head and neck squamous cell carcinoma (HNSCC) constitute approximately 4% of all cancers worldwide. In this study, we analyzed the expression profile of the long noncoding RNA (lncRNA) of 502 HNSCC patients from The Cancer Genome Atlas database.
Yuanyuan Ban, Pingqing Tan, Jing Cai, Junjun Li, Meng Hu, Ying Zhou, Yan Mei, Yixin Tan, Xiaoling Li, Zhaoyang Zeng, Wei Xiong, Guiyuan Li, Xiayu Li, Mei Yi, Bo Xiang   +14 more
doaj   +1 more source

The splicing factor YBX1 promotes the progression of osteosarcoma by upregulating VEGF165 and downregulating VEGF165b

Heliyon, 2023
VEGF165 and its isoform VEGF165b have the same length but opposite functions in cancer. Some studies have indicated the important role of VEGF165 in osteosarcoma (OS); however, VEGF165b has not been taken into consideration.
Bingxuan Quan, Zhigang Li, Hongbo Yang, Shuo Li, Xiuchun Yan, Yansong Wang   +5 more
doaj   +1 more source

The interaction of YBX1 with G3BP1 promotes renal cell carcinoma cell metastasis via YBX1/G3BP1-SPP1- NF-κB signaling axis

Journal of Experimental & Clinical Cancer Research, 2019
Background Renal cell carcinoma (RCC) is a deadly urological tumor that remains largely incurable. Our limited understanding of key molecular mechanisms underlying RCC invasion and metastasis has hampered efforts to identify molecular drivers with ...
Yong Wang, Jing Su, Yiting Wang, Donghe Fu, Justin E. Ideozu, Hua Geng, Qiqi Cui, Chao Wang, Ruibing Chen, Yixi Yu, Yuanjie Niu, Dan Yue   +11 more
doaj   +1 more source

PIWI-interacting RNA-YBX1 inhibits proliferation and metastasis by the MAPK signaling pathway via YBX1 in triple-negative breast cancer

Cell Death Discovery
Breast cancer is the second leading cause of death in women worldwide, with triple-negative breast cancer (TNBC) having the worst prognosis. Although there are numerous studies on TNBC, there is no effective treatment for it, and it is still a major ...
Linyu Wu, Shanshan Huang, Wenwen Tian, Peng Liu, Yi Xie, Yu Qiu, Xing Li, Yuhui Tang, Shaoquan Zheng, Yuying Sun, Hailin Tang, Wei Du, Weige Tan, Xinhua Xie   +13 more
doaj   +1 more source

UBE2O Drives Immune Evasion and Radioimmunotherapy Resistance in Lung Cancer by Degrading CDKL1 to Induce PD‐L1 Transcription

Advanced Science, EarlyView.
UBE2O targets CDKL1 for the degradation to upregulate PD‐L1 expression and promotes resistance to radioimmunotherapy in lung cancer, supporting the potential of targeting UBE2O as a promising therapeutic strategy. ABSTRACT Resistance to radioimmunotherapy is one of the primary causes of treatment failure in lung cancer patients; however, the underlying
Huichan Xue, Xiaohua Jie, Zhiwei Liu, Ruoxin Fang, Shuo Wu, Xiaorong Dong, Shuangbing Xu   +6 more
wiley   +1 more source

Unveiling the roles of extracellular vesicles in hematologic malignancies: Pathogenesis, diagnostic tools, and clinical translation

Interdisciplinary Medicine, EarlyView.
Extracellular vesicles play pivotal roles in both healthy hematopoiesis and hematologic malignancies. They not only regulate hematopoietic stem cell fitness but also drive cancer progression and drug resistance. Their clinical potential spans from serving as non‐invasive biomarkers to acting as innovative therapeutic platforms and drug delivery ...
Fengyu Chen, Zhiyuan Wu, Feng Zhang, Yuan Meng, Hongyan Liao, Tony Y. Hu   +5 more
wiley   +1 more source