Results 31 to 40 of about 6,571 (196)

Selective sorting of microRNAs into exosomes by phase-separated YBX1 condensates [PDF]

eLife, 2021
Exosomes may mediate cell-to-cell communication by transporting various proteins and nucleic acids to neighboring cells. Some protein and RNA cargoes are significantly enriched in exosomes. How cells efficiently and selectively sort them into exosomes remains incompletely explored.
Xiao-Man Liu, Liang Ma, Randy Schekman
openaire   +5 more sources

Knockdown of Y-box binding protein 1 induces autophagy in early porcine embryos

Frontiers in Cell and Developmental Biology, 2023
Y-box binding protein 1 (YBX1) plays important roles in RNA stabilization, translation, transcriptional regulation, and mitophagy. However, its effects on porcine preimplantation embryos remain unclear. In this study, we knocked down YBX1 in the one-cell
Wen-Jie Jiang, Song-Hee Lee, Geun Heo, Hak Jae Chung, Eun Seok Cho, Soo Jin Sa, Shinichi Hochi, Xiang-Shun Cui   +7 more
doaj   +1 more source

YBX1 mediates alternative splicing and maternal mRNA decay during pre-implantation development

Cell & Bioscience, 2022
Background In mammals, maternal gene products decay and zygotic genome activation (ZGA) during maternal to zygotic transition (MZT) is critical for the early embryogenesis.
Mingtian Deng, Baobao Chen, Zifei Liu, Yongjie Wan, Dongxu Li, Yingnan Yang, Feng Wang   +6 more
doaj   +1 more source

YBX1 as an oncogenic factor in T-cell acute lymphoblastic leukemia

Blood Advances, 2023
Abstract Y-box-binding protein 1 (YBX1), a member of the RNA-binding protein family, is a critical regulator of cell survival in various solid tumors and acute myeloid leukemia. However, the function of YBX1 in T-cell acute lymphoblastic leukemia (T-ALL) remains elusive.
Huan Li, Danlan Zhang, Qiuxia Fu, Shang Wang, Zhongyuan Wang, Xin Zhang, Xin Chen, Xiaoyu Zhu, Na An, Yun Chen, Liang Zhou, Desheng Lu, Na Zhao   +12 more
openaire   +2 more sources

Critical role of phosphorylation of serine 165 of YBX1 on the activation of NF-κB in colon cancer [PDF]

, 2015
Y-box binding protein 1 [YBX1] is a multifunctional protein known to facilitate many of the hallmarks of cancer. Elevated levels of YBX1 protein are highly correlated with cancer progression, making it an excellent marker in cancer.
Matthew Martin, Wei, Han, Benlian Wang, Lakshmi Prabhu, Sandusky, George, Tao Lu, Hartley, Antja-Voy, Mundade, Rasika, Rasika Mundade, Antja-Voy Hartley, Kyle McElyea, Constance J. Temm, George Sandusky, Temm, Constance J., McElyea, Kyle, Han Wei, Prabhu, Lakshmi, Martin, Matthew, Liu, Yunlong, Wang, Benlian, Lu, Tao, Yunlong Liu   +21 more
core   +1 more source

YBX1 Indirectly Targets Heterochromatin-Repressed Inflammatory Response-Related Apoptosis Genes through Regulating CBX5 mRNA. [PDF]

, 2020
Medulloblastomas arise from undifferentiated precursor cells in the cerebellum and account for about 20% of all solid brain tumors during childhood; standard therapies include radiation and chemotherapy, which oftentimes come with severe impairment of ...
Duggimpudi, Sujitha, Remke, Marc, McHardy, Alice C, Borkhardt, Arndt, Klusmann, Jan-Henning, Schaal, Heiner, Hezaveh, Kebria, Kloetgen, Andreas, Schuschel, Konstantin, Picard, Daniel, Hoell, Jessica I   +10 more
core   +1 more source

PRMT5-mediated methylation of YBX1 regulates NF-κB activity in colorectal cancer

, 2020
The multifunctional protein Y-box binding protein 1 (YBX1), is a critical regulator of transcription and translation, and is widely recognized as an oncogenic driver in several solid tumors, including colorectal cancer (CRC).
Jiang, Guanglong, Wei, Han, Liu, Yunlong, Sun, Steven, Hartley, Antja-Voy, Wang, Benlian, Mundade, Rasika, Lu, Tao, Sun, Mengyao   +8 more
core   +1 more source

Dysregulated Expression of the MicroRNA miR-137 and Its Target YBX1 Contribute to the Invasive Characteristics of Malignant Pleural Mesothelioma [PDF]

, 2018
INTRODUCTION Malignant pleural mesothelioma (MPM) is an aggressive malignancy linked to asbestos exposure. On a genomic level, MPM is characterized by frequent chromosomal deletions of tumor suppressors, including microRNAs.
van Zandwijk, Nico, Kao, S, Marissa Williams, Brian C. McCaughan, Cheng, Yuen Y, Ruby C.Y. Lin, Schelch, Karin, Steven Kao, Anthony Linton, Glen Reid, Williams, Marissa, Linton, A, Yuen Y. Cheng, Nico van Zandwijk, Johnson, TG, Schelch, K, Reid, Glen, Sarun, Kadir H, Sonja Klebe, Kirschner, Michaela B, McCaughan, BC, Cheng, YY, Thomas G. Johnson, Annette Lasham, Johnson, Thomas G, Linton, Anthony, Lasham, Annette, Lasham, A, Kirschner, MB, Reid, G, Pirker, Christine, Kadir H. Sarun, Walter Berger, Pirker, C, Karin Schelch, Klebe, Sonja, van Zandwijk, N, Berger, Walter, Williams, M, Berger, W, Kao, Steven, Michaela B. Kirschner, Christine Pirker, Lin, Ruby C Y, Lin, RCY, McCaughan, Brian C, Klebe, S, Sarun, KH, Williams M, Schelch K, Berger W, Lin RCY, Klebe S, Pirker C, Lasham A, van Zandwijk N, McCaughan BC, Kao S, Sarun KH, Cheng YY, Linton A, Johnson TG, Reid G, Kirschner MB   +63 more
core   +1 more source

Phosphorylation of YBX1 in the Kidneys is Altered in Legumain Knockout-Mice. [PDF]

J Proteome Res
Abstract.
Sever T, Sinožić T, Kolarič M, Turk B, Fonović M.   +4 more
europepmc   +3 more sources

Additional file 1 of Hypoxia increases RCC stem cell phenotype via altering the androgen receptor (AR)-lncTCFL5-2-YBX1-SOX2 signaling axis

, 2022
Additional file 1: Figure S1. The expression of protein level related to AR.  (A) The AR protein level expression under hypoxia (H) and normoxia (N) in OSRC-2 and SW839 cells.
Bosen You (6741617), Junhua Zheng (500332), Dongkui Gong (5957279), Wei Zhai (1976914), Yin Sun (9092231), Chi-Ping Huang (616074), Chawnshang Chang (14139140), Changcheng Guo (500326), Xudong Yao (230241)   +8 more
core   +1 more source