Results 31 to 40 of about 5,418 (159)

White adipose remodeling during browning in mice involves YBX1 to drive thermogenic commitment

Molecular Metabolism, 2021
Objective: Increasing adaptive thermogenesis by stimulating browning in white adipose tissue is a promising method of improving metabolic health. However, the molecular mechanisms underlying this transition remain elusive.
Atefeh Rabiee, Kaja Plucińska, Marie Sophie Isidor, Erin Louise Brown, Marco Tozzi, Simone Sidoli, Patricia Stephanie S. Petersen, Marina Agueda-Oyarzabal, Silje Bøen Torsetnes, Galal Nazih Chehabi, Morten Lundh, Ali Altıntaş, Romain Barrès, Ole Nørregaard Jensen, Zachary Gerhart-Hines, Brice Emanuelli   +15 more
doaj   +1 more source

Satellite RNAs promote pancreatic oncogenic processes via the dysfunction of YBX1 [PDF]

Nature Communications, 2016
AbstractHighly repetitive tandem arrays at the centromeric and pericentromeric regions in chromosomes, previously considered silent, are actively transcribed, particularly in cancer. This aberrant expression occurs even in K-ras-mutated pancreatic intraepithelial neoplasia (PanIN) tissues, which are precancerous lesions. To examine the biological roles
Takahiro Kishikawa, Motoyuki Otsuka, Takeshi Yoshikawa, Motoko Ohno, Hideaki Ijichi, Kazuhiko Koike   +5 more
openaire   +3 more sources

Long non-coding RNA KCND1 protects hearts from hypertrophy by targeting YBX1

Cell Death & Disease, 2022
Abstract Cardiac hypertrophy is a common structural remodeling in many cardiovascular diseases. Recently, long non-coding RNAs (lncRNAs) were found to be involved in the physiological and pathological processes of cardiac hypertrophy. In this study, we found that lncRNA KCND1 (LncKCND1) was downregulated in both transverse aortic constriction ...
Rui Yang, Liangliang Li, Yumeng Hou, Yingnan Li, Jing Zhang, Na Yang, Yuhan Zhang, Weihang Ji, Tong Yu, Lifang Lv, Haihai Liang, Xuelian Li, Tianyu Li, Hongli Shan   +13 more
openaire   +3 more sources

YBX1 Is a Modulator of MIA/CD-RAP-Dependent Chondrogenesis

PLoS ONE, 2013
MIA/CD-RAP is a small, secreted protein involved in cartilage differentiation and melanoma progression. We recently revealed that p54nrb acts as a mediator of MIA/CD-RAP action to promote chondrogenesis and the progression of malignant melanoma. As the molecular mechanism of MIA/CD-RAP action in cartilage has not been defined in detail until now, we ...
Schmid, Rainer, Meyer, Katharina, Spang, Rainer, Schittek, Birgit, Bosserhoff, Anja-Katrin   +4 more
openaire   +5 more sources

YBX1 mediates translation of oncogenic transcripts to control cell competition in AML [PDF]

Leukemia, 2021
AbstractPersistence of malignant clones is a major determinant of adverse outcome in patients with hematologic malignancies. Despite the fact that the majority of patients with acute myeloid leukemia (AML) achieve complete remission after chemotherapy, a large proportion of them relapse as a result of residual malignant cells.
Florian Perner, Tina M. Schnoeder, Yijun Xiong, Ashok Kumar Jayavelu, Nomusa Mashamba, Nuria Tubio Santamaria, Nicolas Huber, Kristina Todorova, Charles Hatton, Birgit Perner, Theresa Eifert, Ciara Murphy, Maximilian Hartmann, Jessica I. Hoell, Nicolas Schröder, Sabine Brandt, Andreas Hochhaus, Peter R. Mertens, Matthias Mann, Scott A. Armstrong, Anna Mandinova, Florian H. Heidel   +21 more
openaire   +6 more sources

DNMT2-m5C-ACLY Axis Promotes Lenvatinib Resistance in Hepatocellular Carcinoma Through Histone Acetylation-Mediated Notch Pathway. [PDF]

Adv Sci (Weinh)
Lenvatinib resistance poses a major challenge in advanced hepatocellular carcinoma (HCC). This study reveals that DNMT2 upregulation is a key driver, which stabilizes ACLY mRNA via m5C modification and activates the Notch signaling pathway. Crucially, combining ACLY inhibitors with lenvatinib overcomes resistance and suppresses tumors, offering a ...
Yang S, Li J, Mao S, Zhao X, Liu D, Chen J, Fu J, Bu Y, Wu X, Liu S, Yu Q, Dong Q, Tang Z, Fang Y, Shi Y.   +14 more
europepmc   +2 more sources

Ybx1 deficiency impairs spermatid development and male fertility without affecting meiosis in mice: insights into spermatogenesis

The Journal of Reproduction and Development
Spermatogenesis is a complex process that is required for sperm production. Multiple RNA-binding proteins participate in regulating spermatogenesis.
Yan HAN, Rui WU, Chaoqun DUAN, Jiemin CHEN, Xing DENG, Wei PENG, Buzhen TAN   +6 more
doaj   +1 more source

SENP1-mediated deSUMOylation of YBX1 promotes colorectal cancer development through the SENP1-YBX1-AKT signaling axis

Oncogene
Aberrant SUMOylation is associated with the progression of colorectal cancer (CRC). The SUMO-specific protease 1 (SENP1)-induced deSUMOylation of different target substrates plays specific roles in CRC. In this study, we dissected the SENP1-interacting protein complex by employing protein co-immunoprecipitation enrichment in combination with His6 ...
Zenghua Sheng, Shu Luo, Lan Huang, Ya-nan Deng, Nan Zhang, Yinheng Luo, Xinyu Zhao, Ying Chen, Qiu Li, Ruiwu Dai, Shufang Liang   +10 more
openaire   +2 more sources

YBX1 is required for assembly of viral replication complexes of chikungunya virus and replication of multiple alphaviruses

Journal of Virology
Chikungunya virus (CHIKV), an enveloped positive-sense RNA virus, is a member of the alphaviruses and cause fever and arthralgia in humans. We performed genome-wide CRISPR/Cas9-based screens and identified Y-box binding protein 1 (YBX1) as an essential ...
Zhen-Qi Li, Li-Xin Zhao, Su-Yun Wang, Chu-Yu Hu, Yan-Yi Wang, Yan Yang   +5 more
doaj   +1 more source

The splicing factor YBX1 promotes the progression of osteosarcoma by upregulating VEGF165 and downregulating VEGF165b

Heliyon, 2023
VEGF165 and its isoform VEGF165b have the same length but opposite functions in cancer. Some studies have indicated the important role of VEGF165 in osteosarcoma (OS); however, VEGF165b has not been taken into consideration.
Bingxuan Quan, Zhigang Li, Hongbo Yang, Shuo Li, Xiuchun Yan, Yansong Wang   +5 more
doaj   +1 more source