Results 51 to 60 of about 5,562 (124)

Artesunate Ameliorates APAP‐induced Liver Injury by Promoting NEDD4L‐Mediated Ubiquitination and Degradation of TXNIP

Advanced Science, Volume 13, Issue 27, 13 May 2026.
ABSTRACT Liver injury can lead to severe acute liver failure and even death in patients. Artesunate (ART), which is a derivative of artemisinin that has been approved by the FDA for the treatment of malaria, has significant regulatory effects on cell death and inflammation.
Zhe Zhang, Hongyi Zhang, Haixiang Guo, Xiwen Zhang, Yidan Wang, Baoyin Wang, Tong Wang, Guokun Zhao, Qing Zhang, Fei Gao, Shuang Liang, Hao Jiang, Yu Ding, Xiliang Du, Jiabao Zhang, Yi Zheng, Xinwei Li, Bao Yuan   +17 more
wiley   +1 more source

Tumor‐Derived Exosomal TAGLN2 Promotes Metastasis by Inducing Vascular Permeability and Angiogenesis via the NRP1/SEMA4D/YAP Axis

Advanced Science, Volume 13, Issue 29, 22 May 2026.
Gastric cancer‐derived exosomal TAGLN2 is identified as a key mediator of vascular reprogramming, with significantly elevated levels detected in patient serum. Independent of canonical SEMA4D signaling, it nucleates a cytoplasmic TAGLN2/NRP1/SEMA4D ternary complex that dually activates YAP, promoting angiogenesis, vascular dysfunction, and metastasis ...
Shuqi Yu, Jiajia Zhuo, Xiaoquan Hong, Shihao Rao, Yafang Ye, Dandan Kang, Huifang Peng, Huiqin Zhuo   +7 more
wiley   +1 more source

The RNA‐ and DNA‐Binding Protein Y‐Box Binding Protein 1 (YB‐1) Regulates iNKT Cell Development

European Journal of Immunology, Volume 56, Issue 5, May 2026.
YB‐1 is essential for invariant NKT cell development, integrating TCR, co‐stimulatory, and IL‐15 signaling to control maturation, subset differentiation, and survival. Its loss at the double‐positive thymocyte stage causes ∼80% iNKT cell depletion, maturation arrest, impaired cytokine production, and increased apoptosis.
Silvia Schulze, Laura Knop, Nouria Jantz‐Naeem, Vladyslava Dovhan, Stephan Fricke, Sascha Kahlfuß, Thomas Schüler, Ursula Bommhardt   +7 more
wiley   +1 more source

YBX1: an RNA/DNA-binding protein that affects disease progression

Frontiers in Oncology
YBX1 is a member of the Y-box transcription factor family and is a multifunctional RNA/DNA-binding protein characterized by a highly conserved cold shock domain (CSD).
Xifeng Zheng, Xifeng Zheng, Feng Zeng, Yan Lei, Yanling Li, Jun Deng, Gengqiu Luo, Qian He, Yanhong Zhou   +8 more
doaj   +1 more source

In silico analysis of overall survival with YBX1 in male and female solid tumours

Scientific Reports
The Y-box binding protein-1 (YBX1) gene codes for a multifunctional oncoprotein that is increasingly being linked to the regulations of many aspects of cancer cell biology.
David Robert Grimes, Treewut Rassamegevanon, Laure Marignol   +2 more
doaj   +1 more source

YBX1-LDHB axis orchestrates pyruvate production from lactate to promote ICC initiation and development

Pharmacological Research
Previous work from our group established that Y-box binding protein 1 (YBX1) plays a pivotal role in the initiation and progression of intrahepatic cholangiocarcinoma (ICC); however, its specific biological functions and underlying regulatory mechanisms ...
Yong Liu, Fei Wang, Mi Zhang, Xiabing Shi, Lei Li, Tingjie Wang, Haifeng Zhang, Zhongyu Cheng, Xiangpan Li, Juan Chen, Chuanrui Xu   +10 more
doaj   +1 more source

New Insights into the Role of Inflammatory Pathways and Immune Cell Infiltration in Sleep Deprivation-Induced Atrial Fibrillation: An Integrated Bioinformatics and Experimental Study

Journal of Inflammation Research
Junqing Liang,1,2 Baopeng Tang,1,2 Jun Shen,1,2 Manzeremu Rejiepu,1,2 Yankai Guo,1,2 Xiaoyan Wang,1,2 Shijie Shao,1,2 Fei Guo,3 Qin Wang,4 Ling Zhang1 1Xinjiang Key Laboratory of Cardiac Electrophysiology and Cardiac Remodeling, The First Affiliated ...
Liang J, Tang B, Shen J, Rejiepu M, Guo Y, Wang X, Shao S, Guo F, Wang Q, Zhang L   +9 more
doaj  

Multi-omic analyses of m5C readers reveal their characteristics and immunotherapeutic proficiency

Scientific Reports
5-methylcytosine (m5C) is a post-transcriptional RNA modification identified, m5C readers can specifically identify and bind to m5C. ALYREF and YBX1 as members of m5C readers that have garnered increasing attention in cancer research.
Rui Xu, Yue Wang, Ye Kuang
doaj   +1 more source

YBX1 promotes type H vessel–dependent bone formation in an m5C-dependent manner

JCI Insight
RNA-binding proteins (RBPs) interact with RNA and ubiquitously regulate RNA transcripts during their life cycle, playing a fundamental role in the progression of angiogenesis-related diseases. In the skeletal system, endothelium-dependent angiogenesis is
Yu-Jue Li, Qi Guo, Ming-Sheng Ye, GuangPing Cai, Wen-Feng Xiao, Sheng Deng, Ye Xiao   +6 more
doaj   +1 more source

MDM1 overexpression promotes p53 expression and cell apoptosis to enhance therapeutic sensitivity to chemoradiotherapy in patients with colorectal cancer

Cancer Biology & Medicine
Objective: Identifying biomarkers that predict the efficacy and prognosis of chemoradiotherapy is important for individualized clinical treatment. We previously reported that high murine double minute 1 (MDM1) expression in patients with rectal cancer is
Ningxin Ren, Hongxia Chen, Ying Huang, Jing Jin, Shaosen Zhang, Ruoqing Yan, Mengjie Li, Linlin Zheng, Shuangmei Zou, Yexiong Li, Wen Tan, Dongxin Lin   +11 more
doaj   +1 more source