Results 51 to 60 of about 6,571 (196)

Endogenous tRNA-Derived Fragments Suppress Breast Cancer Progression via YBX1 Displacement [PDF]

, 2015
SummaryUpon exposure to stress, tRNAs are enzymatically cleaved, yielding distinct classes of tRNA-derived fragments (tRFs). We identify a novel class of tRFs derived from tRNAGlu, tRNAAsp, tRNAGly, and tRNATyr that, upon induction, suppress the ...
Goodarzi, Hani, Zhang, Steven, Fish, Lisa, Liu, Xuhang, Tavazoie, Sohail F, Nguyen, Hoang CB   +5 more
core   +1 more source

YBX1 is required for assembly of viral replication complexes of chikungunya virus and replication of multiple alphaviruses

Journal of Virology
Chikungunya virus (CHIKV), an enveloped positive-sense RNA virus, is a member of the alphaviruses and cause fever and arthralgia in humans. We performed genome-wide CRISPR/Cas9-based screens and identified Y-box binding protein 1 (YBX1) as an essential ...
Zhen-Qi Li, Li-Xin Zhao, Su-Yun Wang, Chu-Yu Hu, Yan-Yi Wang, Yan Yang   +5 more
doaj   +1 more source

Long non-coding RNA aerrie controls DNA damage repair via YBX1 to maintain endothelial cell function

, 2021
Aging is accompanied by many physiological changes. These changes can progressively lead to many types of cardiovascular diseases. During this process blood vessels lose their ability to maintain vascular homeostasis, ultimately resulting in hypertension,
Bergen, Anke van, Matic, L,, Dimmeler, S, Pham, Tan Phát, Hedin, U,, Tran, Y, Leeuwen, Esmee van, Stanicek, L, Hedin, Ulf, Wittig, Ilka, Stanicek, Laura, Pham, TP, Bink, DI, van, Bergen A, Bink, Diewertje I., Dimmeler, Stefanie, van, Leeuwen E, Tran, Yvonne, Boon, Reinier, Wittig, I, Matic, Ljubica, Yvonne Tran, Tan Phát Pham, Ljubica Matic, Diewertje I. Bink, Ulf Hedin, Anke van Bergen, Reinier A. Boon, Ilka Wittig, Stefanie Dimmeler, Laura Stanicek, Esmee van Leeuwen   +31 more
core   +1 more source

circZNF148 Drives Glucose Metabolism Reprogramming to Enhance Metastasis and Immune Evasion via HK1 Stabilization in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
CircZNF148 stabilizes HK1 through deubiquitinase recruitment, thereby enhancing glycolysis and lactate production. Elevated lactate promotes PD‑L1 lactylation and membrane accumulation while suppressing CD8+ T‐cell cytotoxicity, collectively facilitating immune evasion and malignant progression in TNBC.
Yuhan Jin, Wenjing Zhao, Lei Wang, Jianing Wang, Keying Zhao, Dan Luo, Yifei Wang, Yuxia Yang, Jingze Yang, Yaming Li, Tong Chen, Dianwen Han, Zekun Wang, Xiaoyan Li, Bing Chen, Lijuan Wang, Yiran Liang, Qifeng Yang   +17 more
wiley   +1 more source

LNCAROD is stabilized by m6A methylation and promotes cancer progression via forming a ternary complex with HSPA1A and YBX1 in head and neck squamous cell carcinoma

Molecular Oncology, 2020
Head and neck squamous cell carcinoma (HNSCC) constitute approximately 4% of all cancers worldwide. In this study, we analyzed the expression profile of the long noncoding RNA (lncRNA) of 502 HNSCC patients from The Cancer Genome Atlas database.
Yuanyuan Ban, Pingqing Tan, Jing Cai, Junjun Li, Meng Hu, Ying Zhou, Yan Mei, Yixin Tan, Xiaoling Li, Zhaoyang Zeng, Wei Xiong, Guiyuan Li, Xiayu Li, Mei Yi, Bo Xiang   +14 more
doaj   +1 more source

Translational co-regulation of a ligand and inhibitor by a conserved RNA element [PDF]

, 2017
In many organisms, transcriptional and post-transcriptional regulation of components of pathways or processes has been reported. However, to date, there are few reports of translational co-regulation of multiple components of a developmental signaling ...
Jan Gorodkin, Cooper, L., Sampath, K., Gorodkin, J., Wang, Yin, Wang, Ying, Shruthi VijayKumar, Zaucker, Andreas, Andreas Zaucker, Yin Wang, Cooper, Ledean, Sivashanmugam, Lavanya, Brosens, Jan, Kumari, Pooja, Brosens, J., Nikolai Hecker, Jan Brosens, Zaucker, A., Sizhou Huang, Nagorska, A., Huang, S., Sivashanmugam, L., Agnieszka Nagorska, Sampath, Karuna, Hecker, Nikolai, Kumari, P., Huang, Sizhou, Hecker, N., Karuna Sampath, Nagorska, Agnieszka, Brosens, Jan J., Lavanya Sivashanmugam, Ledean Cooper, Gorodkin, Jan, Wang, Y., Pooja Kumari, Vijaykumar, Shruthi, VijayKumar, S.   +37 more
core   +1 more source

SENP1-mediated deSUMOylation of YBX1 promotes colorectal cancer development through the SENP1-YBX1-AKT signaling axis

Oncogene
Aberrant SUMOylation is associated with the progression of colorectal cancer (CRC). The SUMO-specific protease 1 (SENP1)-induced deSUMOylation of different target substrates plays specific roles in CRC. In this study, we dissected the SENP1-interacting protein complex by employing protein co-immunoprecipitation enrichment in combination with His6 ...
Zenghua Sheng, Shu Luo, Lan Huang, Ya-nan Deng, Nan Zhang, Yinheng Luo, Xinyu Zhao, Ying Chen, Qiu Li, Ruiwu Dai, Shufang Liang   +10 more
openaire   +2 more sources

Metabolic Reprogramming in Glioblastoma Stem Cells Promotes Radiation Resistance Through a H3K18la/USP30/MBOAT2 Axis

Advanced Science, EarlyView.
LDHA‐driven lactate production in mesenchymal glioma stem cells promotes p300‐dependent H3K18 lactylation, activates USP30 transcription, and stabilizes MBOAT2 to remodel phosphatidylethanolamines toward ferroptosis‐resistant PE‐MUFA species. Disrupting this metabolic–epigenetic–lipid circuit enhances ferroptosis and sensitizes glioblastoma to ...
Zong Miao, Wei Gu, Yimin Ren, Chenfei Lu, Wanzhi Cai, Junnan Lu, Zhongyuan Bao, Yanan Zhou, Rong Li, Ke Jin, Chao Chen, Hongxiang Wang, Lei Xu, Juxiang Chen   +13 more
wiley   +1 more source

YBX1 Modulates Drug Resistance in Liver Cancer [PDF]

, 2023
According to the Texas Cancer Registry, hepatocellular carcinoma (HCC) is the sixth most common cause of cancer death. In 2015, Texas had the country\u27s highest incidence rate and the fourth highest mortality rate.
Ayala Pazzi, Ana G.
core   +1 more source

A Multidimensional Engineering Strategy Reprograms Microglia via Targeted and Sustained‐Release Extracellular Vesicles for Spinal Cord Injury Repair

Advanced Science, EarlyView.
A multifunctional EV‐based nanoplatform (Ang‐TEVs@Gel) was engineered via preconditioning, surface targeting, and ROS‐responsive hydrogel encapsulation to reprogram microglia. This system restored autophagy via miR‐664a‐3p/PIK3CA axis, cleared myelin debris, resolved neuroinflammation, and promoted axon remyelination, ultimately achieving robust motor ...
Wu Xiong, Minhao Liu, Mingming Zheng, Jizhou Jia, Ziyan Zhu, Guang Kong, Jie Liu, Juan Wang, Wenbo Li, Qingyuan Wang, Qian Zhu, Peiran Chan, Tao Qin, Jiayang Wu, Yongjie Zhang, Chunming Tang, Cong Li, Jin Fan   +17 more
wiley   +1 more source