Results 71 to 80 of about 6,571 (196)

Transfer RNA‐Derived Small RNA‐5’tiRNAGln Drives HNRNPC Phase Separation to Promote Breast Cancer Bone Metastasis by Regulating IGF1R

Advanced Science, EarlyView.
This study reveals that 5'tiRNA‐Gln interacts with hnRNPC to promote IGF1R liquid‐liquid phase separation, which drives ERK1/2 signaling activation, EMT, and breast cancer bone metastasis. These findings highlight a novel mechanism of breast cancer bone metastasis and potential therapeutic target in metastatic breast cancer.
Bingnan Wang, Dongsong Liu, Xiaozhi Fan, Jiale Fan, Xuesi liu, Yu Wang, Zixin Wang, Mo Cheng, Ping Zhou, Wangjun Yan   +9 more
wiley   +1 more source

GDNF Signaling Regulates YBX1/mRNA Interactions in Mouse Spermatogonia [PDF]

, 2012
Spermatogenesis is a highly coordinated and productive process that maintains continuous sperm production in post-pubertal males. Spermatogonial stem cells (SSCs) are the basis of spermatogenesis and balance self-renewal with differentiation to maintain
Phillips, Bart
core  

Satellite RNAs promote pancreatic oncogenic processes via the dysfunction of YBX1 [PDF]

Nature Communications, 2016
AbstractHighly repetitive tandem arrays at the centromeric and pericentromeric regions in chromosomes, previously considered silent, are actively transcribed, particularly in cancer. This aberrant expression occurs even in K-ras-mutated pancreatic intraepithelial neoplasia (PanIN) tissues, which are precancerous lesions. To examine the biological roles
Takahiro Kishikawa, Motoyuki Otsuka, Takeshi Yoshikawa, Motoko Ohno, Hideaki Ijichi, Kazuhiko Koike   +5 more
openaire   +3 more sources

YBX1 orchestrates LDHA-mediated metabolic reprogramming and NF-κB activation to drive clear cell renal cell carcinoma progression

Cell Death and Disease
Renal cell carcinoma (RCC) is sometimes referred to as a “metabolic disease”, as nearly all types of RCC are associated with the reprogramming of glucose and lipid metabolism.
Yihan Dong, Aixin Qiu, Shuang Liu, Yuejing Pan, Tianyu Lin, Rui Wang, Ruibing Chen, Huamao Jiang, Yang Yu, Yong Wang, Dan Yue   +10 more
doaj   +1 more source

Engineered 3D Fibronectin‐Based Environments Modulate the Pathogenic Profile of Arthritic Synovial Fibroblasts

Advanced NanoBiomed Research, EarlyView.
Fibroblast behavior is shaped by the surrounding microenvironment, yet conventional culture systems often fail to capture disease‐relevant phenotypes. Here, platform‐dependent responses of healthy and arthritic synovial fibroblasts are examined across 2D and 3D culture systems. Distinct inflammatory and proliferative signatures emerge, highlighting how
Aneesah Khan, Piaopiao Pan, Yanling Lan, Çağlar Çi̇l, Julia Isakova, Yilin Wang, Theodora Rogkoti, Thanutchaporn Sartyoungkul, James F. C. Windmill, Jonathan William, Manuel Salmeron‐Sanchez, Margaret H. Harnett, Oana Dobre, Miguel A. Pineda   +13 more
wiley   +1 more source

Cross‐Species Single‐Cell Comparative Analysis Reveals Gluconeogenic Features of Hepatocytes in Ruminants

Animal Research and One Health, EarlyView.
In this study, we used cross‐species comparisons to identify ruminant hepatocyte features. We also identified potential genes and TFs involved in coordinating gluconeogenesis in ruminant hepatocytes. By integrating single‐cell data with population genetic analyses, we further identified candidate genetic variation in glucose metabolism and ...
Yaqi Zhou, Wuqiang Huo, Yingran Liu, Yihang Liu, Fei Wang, Tao Shi, Yu Jiang   +6 more
wiley   +1 more source

Elevated YBX1 expression distinguishes basal-like human breast cancer.

, 2022
Patients diagnosed with basal-like breast cancer face a more aggressive disease course and more dismal prognosis than patients diagnosed with luminal A and luminal B breast cancer molecular subtypes (1-4).
Shahan Mamoor
core   +1 more source

PANoptosis In Microglia and Neurons Following Traumatic CNS Injury: A Systematic Review of Pathological Features and Therapeutic Implications [PDF]

CNS Neurosci Ther
Following traumatic CNS injury, PANoptosis is activated in microglia and neurons, with microglia–neuron crosstalk serving as a key feature of this process. The PANoptosome sensors ZBP1 and NLRP12, together with the adaptor ASC, activate downstream executioner proteins to drive PANoptosis.
Feng Z, Fan Y, Du T, Huang P, Ye Y, Li J.   +5 more
europepmc   +2 more sources

Apigenin Protects Hypertensive Intracerebral Hemorrhage by Regulating Trx1 Through Binding to PRDX2

Phytotherapy Research, EarlyView.
ABSTRACT Intracerebral hemorrhage (ICH) remains the most severe stroke subtype with high mortality and disability rates. Although apigenin has shown cerebroprotective potential in preclinical studies, its mechanism of action, particularly in hypertensive ICH, remains poorly understood.
Hao‐chen Xu, Ming Liu, Ying‐ying Sun, Jie‐Dan Ping, Qing‐hua Cui, Jing‐zhou Chen, Hao Li   +6 more
wiley   +1 more source

Identification of Y-box binding protein 1 as a core regulator of MEK/ERK pathway-dependent gene signatures in colorectal cancer cells. [PDF]

, 2010
Transcriptional signatures are an indispensible source of correlative information on disease-related molecular alterations on a genome-wide level. Numerous candidate genes involved in disease and in factors of predictive, as well as of prognostic, value ...
Royer Hans-Dieter, Reinhold Schäfer, Friese Christian, Krech Till, Kuban Ralf-Jürgen, Schaefer, R., Krech, T., Szymon M. Kiełbasa, Nils Blüthgen, Lund Per, Juerchott, K., Walter Birchmeier, Royer, H.D., Ungethuem, U., Silke Sperling, Kuban, R.J., Knösel Thomas, Schlag Peter M., Herzel Hanspeter, Walther, W., Peter M. Schlag, Peter M Schlag, iełbasa, S., Kielbasa, S.M., Royer, H., Ungethüm, U., Schäfer, R., Sperling, S., Sers Christine, Morkel Markus, Karsten Jürchott, Ulrike Stein, Hanspeter Herzel, Wolfgang Walther, Birchmeier Walter, Krueger Tammo, Kuban, R., Fritzmann Johannes, Johannes Fritzmann, Jürchott Karsten, Till Krech, Sperling Silke, Lund, P., Knoesel, T., Birchmeier, W., Friese, C., Fritzmann, J., Sers, C., Hans-Dieter Royer, Christian Friese, Per Lund, Blüthgen Nils, Schlag, P.M., Krueger, T., Schäfer Reinhold, Ute Ungethüm, Stein, U., Schlag, P., Thomas Knösel, Kiełbasa Szymon M., Kemmner Wolfgang, Ungethüm Ute, Stein Ulrike, Walther Wolfgang, Herzel, H., Szymon M Kiełbasa, Ralf-Jürgen Kuban, Christine Sers, Blüthgen, N., Kemmner, W., Morkel, M., Markus Morkel, Jürchott, K., Wolfgang Kemmner, Tammo Krueger, Knösel, T.   +75 more
core   +1 more source