Results 61 to 70 of about 6,571 (196)

A broad role for YBX1 in defining the small non-coding RNA composition of exosomes [PDF]

Proceedings of the National Academy of Sciences, 2017
Abstract RNA is secreted from cells enclosed within extracellular vesicles (EVs). Defining the RNA composition of EVs is challenging due to their co-isolation with contaminants, a lack of knowledge of the mechanisms of RNA sorting into EVs and limitations of conventional RNA-seq methods.
Shurtleff, Matthew J., Yao, Jun, Qin, Yidan, Nottingham, Ryan M., Temoche-Diaz, Morayma, Schekman, Randy, Lambowitz, Alan M.   +6 more
openaire   +4 more sources

CircRNA-SORE mediates sorafenib resistance in hepatocellular carcinoma by stabilizing YBX1 [PDF]

Signal Transduction and Targeted Therapy, 2020
AbstractSorafenib is the first-line chemotherapeutic therapy for advanced hepatocellular carcinoma (HCC). However, sorafenib resistance significantly limits its therapeutic efficacy, and the mechanisms underlying resistance have not been fully clarified. Here we report that a circular RNA, circRNA-SORE (a circular RNA upregulated in sorafenib-resistant
Junjie Xu, Lin Ji, Yuelong Liang, Zhe Wan, Wei Zheng, Xiaomin Song, Kirill Gorshkov, Qiming Sun, Hui Lin, Xueyong Zheng, Jiang Chen, Ren-an Jin, Xiao Liang, Xiujun Cai   +13 more
openaire   +3 more sources

BOULE is Essential for the Dynamic Disassembly of Heat Shock Granules in Male Germ Cells

Advanced Science, EarlyView.
BOULE orchestrates stress granule disassembly in germ cells via a two‐pronged mechanism: it promotes G3BP1 ubiquitination by upregulating TRIM27, generating a signal for VCP/FAF2 recruitment, and it maintains G3BP1 and FAF2 protein levels. BOULE deficiency disrupts disassembly complex formation, leading to impaired heat shock granule clearance ...
Xin Li, Nana Zhang, Zexin Bian, Baobao Geng, Liyun Cao, Peipei Liu, Zengming Li, Yan Zhao, Jun Tan   +8 more
wiley   +1 more source

Melanoma inhibitory activity promotes melanoma development through activation of YBX1

, 2013
Melanoma inhibitory activity (MIA), a small soluble secreted protein, is functionally important for progression of malignant melanoma. We recently revealed that p54(nrb) acts as a mediator of MIA action. In this study, we characterize the transcriptional
Bosserhoff, Anja-Katrin, Spang, Rainer, Schittek, Birgit, Meyer, Katharina, Schmid, Rainer   +4 more
core   +1 more source

AL398, A Novel NSUN6 Inhibitor, Attenuates Epithelial‐Mesenchymal Transition and Metastasis in Endometrial Cancer by Abrogating m5C‐Dependent Stabilization of Snail mRNA

Advanced Science, EarlyView.
Proposed molecular mechanism: NSUN6 catalyzes m5C methylation on Snail mRNA to enhance its stability, leading to Snail upregulation and EMT promotion. The first‐in‐class inhibitor AL398 suppresses endometrial cancer metastasis by targeting the NSUN6‐m5C‐Snail. axis. ABSTRACT Endometrial cancer (EC) constitutes a leading gynecologic malignancy for which
Xiangzhuan Zhao, Linlin Yang, Huanxiang Chen, Chenfeng Guo, Hongshen Lu, Ying Zhu, Xuanzhi Wang, Yang Li, Ruike Zhang, Zichong Huang, Yifang Chen, Keyu Jin, Zeduo Xu, Lingxiu Meng, Longfeng Zhang, Yuanyuan Han, Yicong Yan, Qiaozhen Kang, Junhu Wan, Hongyang Liu   +19 more
wiley   +1 more source

C1QBP Negatively Regulates the Activation of Oncoprotein YBX1 in the Renal Cell Carcinoma As Revealed by Interactomics Analysis

, 2016
The Y-box-binding protein 1 (YBX1) plays a critical role in tumorigenesis by promoting cell proliferation, overriding cell-cycle check points, and enhancing genomic instability.
Ning Zhang (23771), Dan Yue (695973), Duxin Sun (501117), Yong Wang (12837), Yajing Chen (1556104), Ruibing Chen (1677394), Mingming Xiao (1677391), Can Qi (540350)   +7 more
core   +1 more source

The 5′-untranslated region of p16 INK4 a melanoma tumor suppressor acts as a cellular IRES, controlling mRNA translation under hypoxia through YBX1 binding [PDF]

, 2015
CDKN2A/p16INK4a is an essential tumor suppressor gene that controls cell cycle progression and replicative senescence. It is also the main melanoma susceptibility gene.
Latorre, Elisa, Paillerets, Brigitte Bressac-de, Harland, Mark, Andreotti, Virginia, Ghiorzo, Paola, Provenzani, Alessandro, Bisio, Alessandra, Inga, Alberto, BIANCHI, GIOVANNA, Bressac de Paillerets, Brigitte, Scarra, Giovanna Bianchi, Spitale, Robert C   +11 more
core   +1 more source

Y-box binding protein 1/cyclin A1 axis specifically promotes cell cycle progression at G2/M phase in ovarian cancer

Scientific Reports
Y-box binding protein 1 (YBX1) promotes oncogenic transformation and tumor growth. YBX1 plays a role in regulation of cell cycle promotion via upregulation of cell cycle-related genes.
Yuichi Murakami, Daisuke Katsuchi, Taichi Matsumoto, Kuon Kanazawa, Tomohiro Shibata, Akihiko Kawahara, Jun Akiba, Nozomu Yanaihara, Aikou Okamoto, Hiroaki Itamochi, Toru Sugiyama, Atsumu Terada, Shin Nishio, Naotake Tsuda, Kiyoko Kato, Mayumi Ono, Michihiko Kuwano   +16 more
doaj   +1 more source

The splicing factor YBX1 promotes the progression of osteosarcoma by upregulating VEGF165 and downregulating VEGF165b

Heliyon, 2023
VEGF165 and its isoform VEGF165b have the same length but opposite functions in cancer. Some studies have indicated the important role of VEGF165 in osteosarcoma (OS); however, VEGF165b has not been taken into consideration.
Bingxuan Quan, Zhigang Li, Hongbo Yang, Shuo Li, Xiuchun Yan, Yansong Wang   +5 more
doaj   +1 more source

Interaction network analysis of YBX1 for identification of therapeutic targets in adenocarcinomas

Journal of Biosciences, 2019
Human Y-box binding protein-1 (YBX1) is a member of highly conserved cold-shock domain protein family, which is involved in transcriptional as well as translational regulation of many genes. Nuclear localization of YBX1 has been observed in various cancer types and it's overexpression has been linked to adverse clinical outcome and poor therapy ...
Suriya Narayanan Murugesan, Birendra Singh Yadav, Pramod Kumar Maurya, Amit Chaudhary, Swati Singh, Ashutosh Mani   +5 more
openaire   +2 more sources