Results 61 to 70 of about 5,418 (159)

Single‐Cell Profiling Reveals RAB13+ Endothelial Cells and Profibrotic Mesenchymal Cells in Aged Human Bone Marrow

Aging Cell, Volume 25, Issue 4, April 2026.
Integrated single‐cell, spatial transcriptomic, and immunofluorescence analyses reveal profound aging‐associated remodeling of the non‐immune human bone marrow niche. Aging is marked by endothelial dysfunction, emergence of RAB13+ arterial endothelial cells, and expansion of profibrotic THY1+ mesenchymal cells, identifying potential cellular targets ...
Itziar Cenzano, Miguel Cócera, Ana Rosa Lopez‐Perez, Lorea Campos‐Dopazo, Javier Ruiz, Ignacio Sancho, Patxi San Martin‐Uriz, Paula Aguirre‐Ruiz, Sarai Sarvide, Amaia Vilas‐Zornoza, Purificacion Ripalda‐Cemborain, Diego Alignani, Aitziber Lopez, Marta Miñana Barrios, Delia Quilez Agreda, Jin Ye, Robert Lehmann, Laura Sudupe, Marta Abengozar‐Muela, Álvaro Lopez‐Janeiro, Luis‐Esteban Tamariz‐Amador, Emma Muiños‐López, Borja Saez, Jesper Tegner, Isabel A. Calvo, David Gomez‐Cabrero, Felipe Prosper   +26 more
wiley   +1 more source

YBX1 promotes tumor growth by elevating glycolysis in human bladder cancer

Oncotarget, 2017
Aerobic glycolysis, also known as Warburg effect, is a key hallmark of cancers. The Y-box-binding protein 1 (YBX1) is a well-known oncoprotein implicated in multiple malignant phenotypes of cancers. Meanwhile, little is known about the oncogenic functions and mechanisms of YBX1 in bladder cancer.
Xu, Liuyu, Li, Hongyun, Wu, Longchao, Huang, Shiming   +3 more
openaire   +3 more sources

The RNA-binding protein YBX1 regulates epidermal progenitors at a posttranscriptional level [PDF]

Nature Communications, 2018
AbstractThe integrity of stratified epithelia depends on the ability of progenitor cells to maintain a balance between proliferation and differentiation. While much is known about the transcriptional pathways underlying progenitor cells’ behavior in the epidermis, the role of posttranscriptional regulation by mRNA binding proteins—a rate-limiting step ...
Kwon, Eunjeong, Todorova, Kristina, Wang, Jun, Neel, Victor, Lee, Sam, Mandinova, Anna, Horos, Rastislav, Lee, Kevin K., Negri, Gian Luca, Sorensen, Poul H., Hentze, Matthias W.   +10 more
openaire   +4 more sources

Targeting Ferroptosis With Natural Products for the Treatment of Skeletal System Disease: An Updated Review

Journal of Cellular and Molecular Medicine, Volume 30, Issue 7, April 2026.
ABSTRACT Skeletal system diseases, encompassing chronic disorders of the skeletal system which commonly include osteoarthritis, rheumatoid arthritis, osteoporosis and osteosarcoma. Their incidence rates have been increasing in recent years, resulting in significant social and economic burdens.
Qian Yi, Jinye Li, Guotian Luo, Jiachen Li, Dahang Yang, Wei Sun, Weichao Sun, Wei You, Lei Yang   +8 more
wiley   +1 more source

An essential role for maternal control of Nodal signaling

eLife, 2013
Growth factor signaling is essential for pattern formation, growth, differentiation, and maintenance of stem cell pluripotency. Nodal-related signaling factors are required for axis formation and germ layer specification from sea urchins to mammals ...
Pooja Kumari, Patrick C Gilligan, Shimin Lim, Long Duc Tran, Sylke Winkler, Robin Philp, Karuna Sampath   +6 more
doaj   +1 more source

Selective sorting and secretion of hY4 RNA fragments into extracellular vesicles mediated by methylated YBX1 to promote lung cancer progression

Journal of Experimental & Clinical Cancer Research, 2022
Background Extracellular vesicles (EVs) are emerging mediators of intercellular communication that have been shown to play important roles in tumor progression.
Chuang Li, Wei Wang, Yuting Sun, Yifan Ni, Fang Qin, Xiaolu Li, Tao Wang, Mingxiong Guo, Guihong Sun   +8 more
doaj   +1 more source

Export of miRNAs from activated macrophages is cooperative and HuR‐dependent

FEBS Letters, Volume 600, Issue 5, Page 693-709, March 2026.
This study uncovers a new mechanism for miRNA export regulation in mammalian cells, driven by the RNA‐binding protein HuR. In macrophages, HuR cooperatively binds with miRNAs to export both low‐ and high‐affinity substrates, thereby influencing macrophage activation.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

CircSMAD3 represses SMAD3 phosphorylation and ameliorates cardiac remodeling by recruiting YBX1

iScience
Circular RNA (circRNA) has emerged as potential therapeutic targets for cardiovascular diseases. Given the central role of the TGFβ signaling pathway in cardiac remodeling and its potential as a therapeutic target, we hypothesized that a circRNA from this pathway could modulate cardiac remodeling and serve as a heart failure treatment.
Shuai Mei, Xiaozhu Ma, Li Zhou, Qidamugai Wuyun, Jing Wang, Qianqian Xiao, Man Wang, Kaiyue Zhang, Chen Chen, Jiangtao Yan, Hu Ding   +10 more
openaire   +4 more sources

Disrupting the Formation of YAP Condensates Promotes the Activation of AMPKα to Inhibit the Progression of Primary Liver Cancer

Advanced Science, Volume 13, Issue 14, 9 March 2026.
This study systematically investigates the function and molecular mechanisms of YAP phase separation in multiple primary liver cancers. These findings provide novel insights into phase separation‐mediated primary liver cancer development and validate targeted disruption of this process as an effective therapeutic strategy for primary liver cancer ...
Shuang‐Zhou Peng, Jia‐Jia Liang, Yun‐Feng Zhan, Wei‐Xun Wu, Wan‐Li Xu, Xiao‐Kun Zhang, Li‐Jun Cai, Fu‐Quan Jiang   +7 more
wiley   +1 more source

KAT7-acetylated YBX1 promotes hepatocellular carcinoma proliferation by reprogramming nucleotide metabolism

BMC Cancer
Lysine acetylation is a critical post-translational modification regulating tumor initiation and progression. Lysine acetyltransferase 7 (KAT7)-mediated lysine acetylation is frequently dysregulated in cancer. However, the role of KAT7-mediated lysine acetylation in hepatocellular carcinoma (HCC) progression remains unclear.Bioinformatic analysis was ...
He Huang, Longfei Ren, Yongqiang Zhou, Pengyu Chen, Haixia Zhao, Shang Li, Haiping Wang, Xun Li   +7 more
openaire   +3 more sources