Results 81 to 90 of about 5,418 (159)

Multi-omic analyses of m5C readers reveal their characteristics and immunotherapeutic proficiency

Scientific Reports
5-methylcytosine (m5C) is a post-transcriptional RNA modification identified, m5C readers can specifically identify and bind to m5C. ALYREF and YBX1 as members of m5C readers that have garnered increasing attention in cancer research.
Rui Xu, Yue Wang, Ye Kuang
doaj   +1 more source

YBX1 promotes type H vessel–dependent bone formation in an m5C-dependent manner

JCI Insight
RNA-binding proteins (RBPs) interact with RNA and ubiquitously regulate RNA transcripts during their life cycle, playing a fundamental role in the progression of angiogenesis-related diseases. In the skeletal system, endothelium-dependent angiogenesis is
Yu-Jue Li, Qi Guo, Ming-Sheng Ye, GuangPing Cai, Wen-Feng Xiao, Sheng Deng, Ye Xiao   +6 more
doaj   +1 more source

TAGLN2 induces resistance signature ISGs by activating AKT-YBX1 signal with dual pathways and mediates the IFN-related DNA damage resistance in gastric cancer

Cell Death and Disease
Recently, various cancer types have been identified to express a distinct subset of Interferon-stimulated genes (ISGs) that mediate therapy resistance.
Huiqin Zhuo, Jingjing Hou, Zhijun Hong, Shuqi Yu, Huifang Peng, Lihua Zhang, Wen Xie, Xuehui Hong   +7 more
doaj   +1 more source

MDM1 overexpression promotes p53 expression and cell apoptosis to enhance therapeutic sensitivity to chemoradiotherapy in patients with colorectal cancer

Cancer Biology & Medicine
Objective: Identifying biomarkers that predict the efficacy and prognosis of chemoradiotherapy is important for individualized clinical treatment. We previously reported that high murine double minute 1 (MDM1) expression in patients with rectal cancer is
Ningxin Ren, Hongxia Chen, Ying Huang, Jing Jin, Shaosen Zhang, Ruoqing Yan, Mengjie Li, Linlin Zheng, Shuangmei Zou, Yexiong Li, Wen Tan, Dongxin Lin   +11 more
doaj   +1 more source

5-methylcytosine regulated CCNL2 promotes tumorigenesis and cisplatin resistance of ovarian cancer with therapeutic implications

Journal of Ovarian Research
Backgroud Ovarian cancer (OC) is the most lethal gynecological tumor, primarily due to resistance to chemotherapy. Cyclin L2 (CCNL2) is a novel member of the cyclin family and mainly localized in nucleus.
Kai Zhang, Guiyun Cheng, Wenwen Jiang, Beihua Kong, Shu Yao, Xihan Liu   +5 more
doaj   +1 more source

PGC7 regulates maternal mRNA translation via AKT1-YBX1 interactions in mouse oocytes

Cell Communication and Signaling
Timely and accurate translation of maternal mRNA is essential for oocyte maturation and early embryonic development. Previous studies have highlighted the importance of Primordial Germ cell 7 (PGC7) as a maternal factor in maintaining DNA methylation of ...
Yingxiang Liu, Peiwen Feng, Xing Wei, Hongyu Xu, Mengying Yu, Lei Zhang, Weijie Hao, Zekun Guo   +7 more
doaj   +1 more source

CILP1 interacting with YBX1 promotes hypertrophic scar formation by suppressing PPARs transcription

Cell Death & Disease
Abstract Hypertrophic scar (HS) represents the most prevalent form of skin fibrosis, significantly impacting the quality of life. Despite this, the molecular mechanisms driving HS formation remain largely undefined, impeding the development of effective treatments.
Jianzhang Wang, Juan Du, Yajuan Song, Xiaoying Tan, Junzheng Wu, Tong Wang, Yi Shi, Xingbo Xu, Zhou Yu, Baoqiang Song   +9 more
openaire   +4 more sources

YBX1 Gene [PDF]

, 2020
openaire   +1 more source

YBX1 wt Allele [PDF]

, 2020
openaire   +1 more source

Integrated single-cell and spatial transcriptomic analysis reveals YBX1 drives immune regulation in GBM progression

Heliyon
The RNA modification 5-methylcytosine (m5C) is widespread across various RNA types, significantly impacting RNA stability and translational efficiency.
Yanshan Ge, Huiting Weng, Yingnan Sun, Minghua Wu   +3 more
doaj   +1 more source