Results 81 to 90 of about 6,571 (196)

Overexpression of YBX1 Promotes Pancreatic Ductal Adenocarcinoma Growth via the GSK3B/Cyclin D1/Cyclin E1 Pathway

Molecular Therapy: Oncolytics, 2020
Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal cancers due to frequently late diagnosis and futile treatment. It is a crucial necessity to determine the mechanisms of PDAC.
Zhiqiang Liu, Yongfeng Li, Xiaogang Li, Jingyuan Zhao, Shihong Wu, Heshui Wu, Shanmiao Gou   +6 more
doaj   +1 more source

Long non‐coding RNAs at the crossroads of inflammation, cancer and angiogenesis: Molecular mechanisms and their potential as therapeutic targets

British Journal of Pharmacology, EarlyView.
Long non‐coding RNAs (lncRNAs), a broad class of non‐protein‐coding RNAs, are characterized as new regulators of gene expression at the epigenetic, transcriptional, and post‐transcriptional level. Thus, lncRNAs are involved in the regulation of physiological processes and the development of human diseases and cancer by modulating proinflammatory ...
Charlie Leboff, Pamela Calle‐Mendoza, Maria Hatziapostolou, Christos Polytarchou   +3 more
wiley   +1 more source

The m5C reader Ybx1 regulates embryonic cortical neurogenesis by promoting progenitor cell cycle progression.

PLoS Biology
The reversible epitranscriptomic mark, 5-methylcytosine (m5C) modification, is implicated in numerous cellular processes, but its role in neural development remains largely unexplored.
Jian Zhang, Pengfei Che, Zhuoxuan Yang, Pingrui Zhang, Yuxuan Shui, Xibin Lu, Jiuzhou Xu, Yuanchu She, Yanbo Zhang, Jun Yu, Sheng-Jian Ji   +10 more
doaj   +1 more source

YBX1 modulates humoral immunity through post-transcriptional regulation in B cells

Frontiers in Immunology
IntroductionY-box binding protein 1 (YBX1) is a multifunctional RNA- and DNA-binding protein implicated in transcriptional regulation, mRNA stabilization, and translation, as well as cell proliferation and stress responses.
Viktoria Kunz, Kathryn S. Bommert, Ralf Bargou, Kurt Bommert   +3 more
doaj   +1 more source

A Multicellular Coordinated Network Driving Lymphovascular Space Invasion in Endometrioid Endometrial Carcinoma

Cell Proliferation, EarlyView.
Single‐cell and spatial profiling reveal that lymphovascular space invasion in endometrioid endometrial carcinoma is driven by coordinated interactions among metastatic epithelium, fibroblasts, immune cells, and endothelium. This multicellular network promotes matrix remodelling, angiogenesis, and immune evasion, forming a pro‐metastatic niche that ...
Wendi Guo, Tianxiang Liu, Runling Ren, Na Li, Wenwen Zhang, Jingwen Si, Yongjun Piao, Yuanjing Hu   +7 more
wiley   +1 more source

YBX1 regulation of alveolar type II epithelial cells in idiopathic pulmonary fibrosis: mechanistic insights and small-molecule drug screening

Journal of Translational Medicine
Background This study aims to systematically elucidate the molecular mechanisms underlying idiopathic pulmonary fibrosis (IPF), with a specific focus on the regulatory role of the nucleic acid-binding protein Y-box binding protein 1 (YBX1) in alveolar ...
Yijie He, Jin Li, Yibo Xie, Yaming Wu, Li Wang, Jungang Ren, Zhiqiang Zhang, Tong Yu, Shuxia Jiang, Hongli Shan, Yun Wu, Yuhong Zhou   +11 more
doaj   +1 more source

Selective sorting and secretion of hY4 RNA fragments into extracellular vesicles mediated by methylated YBX1 to promote lung cancer progression

Journal of Experimental & Clinical Cancer Research, 2022
Background Extracellular vesicles (EVs) are emerging mediators of intercellular communication that have been shown to play important roles in tumor progression.
Chuang Li, Wei Wang, Yuting Sun, Yifan Ni, Fang Qin, Xiaolu Li, Tao Wang, Mingxiong Guo, Guihong Sun   +8 more
doaj   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, Volume 20, Issue 10, Page 2510-2532, October 2026.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

MIA/CD-RAP activates the p54^nrb promoter via the transcription factor YBX1.

, 2013
(A) YBX1 activity as measured using a reporter gene assay revealed a significant decrease in YBX1 promoter activity in MIA-/- mMSCs compared with WT mMSCs (III ...
Birgit Schittek (209307), Rainer Schmid (496848), Anja Katrin Bosserhoff (161850), Rainer Spang (21155), Katharina Meyer (496849)   +4 more
core   +1 more source

USP21/YBX1/HIF1-α promotes the progression of prostate cancer

Journal of Translational Medicine
Prostate cancer (PCa) is one of the prevalent cancers in men. Although deubiquitinating enzymes are implicated in tumorigenesis and progression, the specific role of ubiquitin specific peptidase 21 (USP21) in PCa remains unclear. This study provides the first comprehensive analysis of USP21 as a key oncogene driving PCa progression.Prognosis-related ...
Zhuoran Gu, Libin Zou, Cheng Jiang, Feng Qi, Dan Huang, Ji Liu, Yadong Guo, Shiyu Mao, Junfeng Zhang, Yue Zhang, Donghui Shi, Jiang Geng, Yifan Chen, Wentao Zhang, Xudong Yao   +14 more
openaire   +2 more sources