Results 101 to 110 of about 6,571 (196)

Methods of treatment and diagnosis of tumours [PDF]

, 2022
The invention relates to a method of treating a cartilage matrix-forming bone tumour and/or a metastatic cancer originating from a cartilage matrix-forming bone tumour, for example chondrosarcoma, in which one or more of an inhibitor of RUNX2 activity ...
Fraser, William, Green, Darrell
core  

MDB-35. Elucidating YBX1 as a dependency in pediatric medulloblastoma

Neuro-Oncology Pediatrics
Abstract Current standard of care treatment for medulloblastoma (MB) consists of maximal resection surgery followed by craniospinal irradiation and chemotherapy, with survivors experiencing diminished quality of life from intensive treatment regimens. The identification of novel targets is an unmet need and critical to enhance patient
Stephen Carney, John Hemenway, Kate Gadek, Christian Bonatto Paese, Sanjay Malhotra, Myron Evans II   +5 more
openaire   +1 more source

RNF115 upregulation by YBX1-dependent m5C modification promotes hepatocellular carcinoma progression

npj Precision Oncology
5-methylcytosine (m5C) RNA modification plays critical roles in post-transcriptional regulation and cancer progression. However, the downstream effectors of the m5C reader protein YBX1 and their mechanistic contribution to hepatocellular carcinoma (HCC ...
Jianhao Li, Han Chen, Lang Bai, Hong Tang   +3 more
doaj   +1 more source

CircSMAD3 represses SMAD3 phosphorylation and ameliorates cardiac remodeling by recruiting YBX1

iScience
Circular RNA (circRNA) has emerged as potential therapeutic targets for cardiovascular diseases. Given the central role of the TGFβ signaling pathway in cardiac remodeling and its potential as a therapeutic target, we hypothesized that a circRNA from this pathway could modulate cardiac remodeling and serve as a heart failure treatment.
Shuai Mei, Xiaozhu Ma, Li Zhou, Qidamugai Wuyun, Jing Wang, Qianqian Xiao, Man Wang, Kaiyue Zhang, Chen Chen, Jiangtao Yan, Hu Ding   +10 more
openaire   +4 more sources

New Insights into the Role of Inflammatory Pathways and Immune Cell Infiltration in Sleep Deprivation-Induced Atrial Fibrillation: An Integrated Bioinformatics and Experimental Study

Journal of Inflammation Research
Junqing Liang,1,2 Baopeng Tang,1,2 Jun Shen,1,2 Manzeremu Rejiepu,1,2 Yankai Guo,1,2 Xiaoyan Wang,1,2 Shijie Shao,1,2 Fei Guo,3 Qin Wang,4 Ling Zhang1 1Xinjiang Key Laboratory of Cardiac Electrophysiology and Cardiac Remodeling, The First Affiliated ...
Liang J, Tang B, Shen J, Rejiepu M, Guo Y, Wang X, Shao S, Guo F, Wang Q, Zhang L   +9 more
doaj  

YBX1-LDHB axis orchestrates pyruvate production from lactate to promote ICC initiation and development

Pharmacological Research
Previous work from our group established that Y-box binding protein 1 (YBX1) plays a pivotal role in the initiation and progression of intrahepatic cholangiocarcinoma (ICC); however, its specific biological functions and underlying regulatory mechanisms ...
Yong Liu, Fei Wang, Mi Zhang, Xiabing Shi, Lei Li, Tingjie Wang, Haifeng Zhang, Zhongyu Cheng, Xiangpan Li, Juan Chen, Chuanrui Xu   +10 more
doaj   +1 more source

Elevated nuclear YBX1 expression and the clinicopathological characteristics of patients with solid tumors: a meta-analysis

, 2019
Chunze Zhang,1,2,* Tingting Yin,3,* Ran Tao,4,* Bo Xiao,5,* Jing Chen,4 Zixuan Li,5 Xueyuan Miao,3 Qing Peng,3 Liu Sun,3 Weihua Zhang,1 Junxu Ren,4 Zhao Zhang,1 Ying Zhang,1 Xichuan Li,6 Wei Zhang51Department of Colorectal Surgery, Tianjin Union Medical ...
Yin T, Chen J, Sun L, Zhang W, Li X, Li Z, Zhang Z, Ren J, Zhang Y, Miao X, Tao R, Peng Q, Zhang C, Xiao B   +13 more
core  

CUHK electronic theses & dissertations collection

, 2015
A critical step in mammalian ovarian follicle development is the transition of gonadotropin-independent preantral follicles to the gonadotropin-dependent antral follicles.

core  

Additional file 2: of The interaction of YBX1 with G3BP1 promotes renal cell carcinoma cell metastasis via YBX1/G3BP1-SPP1- NF-κB signaling axis

, 2019
Figure S2. YBX1 regulates SPP1 to activate downstream NF-κB signaling pathway in RCC cells. (A) The genes regulated by YBX1 were enriched in sphingolipid metabolism, axon guidance, chemical carcinogenesis, cell adhesion molecules (CAMs), ECM-receptor ...
Yuanjie Niu (214916), Donghe Fu (7341953), Jing Su (23377), Qiqi Cui (7341956), Yiting Wang (169115), Justin Ideozu (6727145), Yixi Yu (7341959), Dan Yue (695973), Yong Wang (12837), Ruibing Chen (1677394), Hua Geng (197417), Chao Wang (146527)   +11 more
core   +1 more source

YBX1 promotes type H vessel–dependent bone formation in an m5C-dependent manner

JCI Insight
RNA-binding proteins (RBPs) interact with RNA and ubiquitously regulate RNA transcripts during their life cycle, playing a fundamental role in the progression of angiogenesis-related diseases. In the skeletal system, endothelium-dependent angiogenesis is
Yu-Jue Li, Qi Guo, Ming-Sheng Ye, GuangPing Cai, Wen-Feng Xiao, Sheng Deng, Ye Xiao   +6 more
doaj   +1 more source