Results 91 to 100 of about 2,920 (152)

Loss of NSUN2 triggers a shift of the metabolic state towards catabolism.

, 2019
(A, B) Detection of Nsun2 RNA in Nsun2+/+ and Nsun2−/− mouse skin in early (A) and late (B) anagen. Scale bar: 50 μm. (C-E) Transcriptional changes in skin of wild-type (Nsun2+/+) and Nsun2 knockout (Nsun2−/−) mice.
Sandra Blanco (34725), Martyna C. Popis (6843032), Abdulrahim A. Sajini (6843035), James A. West (462445), Michaela Frye (78179), Julian L. Griffin (152780), Susanne Bornelöv (189128), Cecilia Castro (538966), Matthias Heiß (6843029), Stefanie Kellner (430068), Anne E. Willis (361379), Sabine Dietmann (2388382), Nikoletta A. Gkatza (6843023), Joseph G. Gleeson (779314), Robert F. Harvey (6843026)   +14 more
core   +1 more source

Abstract 2387: Overexpression of NSUN2 by DNA hypomethylation is associated with metastatic progression in human breast cancer

, 2017
NSUN2 is a RNA methyltransferase that has been shown to be implicated in development of human cancer. However, the functional role of NSUN2, mechanism of NSUN2 overexpression and its association with clinicopathologic features in breast cancer remain ...
Zhuo Yang, Yingchun Xu, Jie Yi, Yu Chen, Ran Gao, Jinhua Wang   +5 more
core   +1 more source

NSUN2-mediated cytosine-5 methylation of FSP1 protects acute myeloid leukemia cells from ferroptosis

Molecular Cancer
RNA 5-methylcytosine (m5C), a prevalent epitranscriptomic modification that critically regulates gene expression and cellular homeostasis. While its roles in solid tumors have been increasingly recognized, the functional landscape of m5C in acute myeloid
Wenle Ye, Yanchun Zhao, Yutong Zhou, Jiansong Huang, Xiao He, Zhixin Ma, Xin Huang, Chao Hu, Fenglin Li, Qing Ling, Huafeng Wang, Hongyan Tong, Jie Sun, Jie Jin   +13 more
doaj   +1 more source

Enoxaparin alleviates preeclampsia by enhancing trophoblast function via the NSUN2-mediated m5C methylation of PAX3 mRNA

European Journal of Medical Research
Objective Preeclampsia (PE), a complex multisystem disorder, is a major contributor to maternal and perinatal morbidity and mortality. Enoxaparin, a low-molecular-weight heparin, has shown therapeutic efficacy in preventing various diseases.
Xuan Zhong, Danfeng Zeng
doaj   +1 more source

NSUN2 Negatively Regulates TP53 mRNA Stability to Promote the Malignant Progression of Nasopharyngeal Carcinoma

Background: Nasopharyngeal carcinoma (NPC) is a prevalent malignancy in China, often diagnosed at advanced stages. The 5-methylcytosine (m5C) RNA modification plays a crucial role in tumorigenesis, influencing cell proliferation, differentiation ...
Qingqing Wei, Chen, Shipeng, Deng, Hongyu, Changning Xue, Songqing Fan, Wei, Qingqing, Zhou, Ming, Xue, Changning, Fan, Songqing, Li, Xiaolong, Mengna Li, Xiong, Wei, Lemei Zheng, Ming Zhou, Wei, Jianxia, Zheng, Lemei, Jianxia Wei, Li, Mengna, Xiaolong Li, Shipeng Chen, Wei Xiong, Hongyu Deng   +21 more
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Epigenetically upregulated NSUN2 confers ferroptosis resistance in endometrial cancer via m5C modification of SLC7A11 mRNA

Redox Biology
Endometrial cancer (EC) is a prevalent gynecological malignancy worldwide, and 5-methylcytosine (m5C) modification of mRNA is a crucial epigenetic modification associated with the development and occurrence of several cancers.
Shuai-Jun Chen, Jun Zhang, Ting Zhou, Shan-Shan Rao, Qian Li, Ling-Yan Xiao, Si-Tian Wei, Hong-Feng Zhang   +7 more
doaj   +1 more source

The role of NSUN2-mediated mRNA 5-methylcytidine methylation in colorectal cancer initiation and progression [PDF]

Colorectal cancer (CRC), the second commonest cause of cancer mortality, initiates with the loss of the APC gene and progresses to cancer with additional mutations. APC is mutated in ~80% of CRC patients with Wnt signalling activation.
Bastem Akan, Aslıhan
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NSUN2 knockdown ameliorates hepatic glucose and lipid metabolism disorders in type 2 diabetes mellitus through the Inhibition of ACSL6 m5C methylation

Lipids in Health and Disease
Background Hyperglycemia and dyslipidemia characterize type 2 diabetes mellitus (T2DM). The impact of 5-methylcytosine (m5C) on liver glucose and lipid regulation in T2DM is unclear.
Xianshu Jiang, Xuelan Cheng, Qiu Wan
doaj   +1 more source

NSun2 delays replicative senescence by repressing p27 (KIP1) translation and elevating CDK1 translation

, 2015
A rise in the levels of the cyclin-dependent kinase (CDK) inhibitor p27(KIP1) is important for the growth arrest of senescent cells, but the mechanisms responsible for this increase are poorly understood.
Liu, Zhenyun, Fan, Xiuqin, Jiang, Bin, Gorospe, Myriam, Dou, Yali, Wang, Wengong, Tang, Hao, Xing, Junyue   +7 more
core  

A novel variant in NSUN2 causes intellectual disability in a Chinese family

NSUN2-intellectual disability syndrome, also known as intellectual disability type 5 (MRT5), is an autosomal recessive disorder that is characterized by intellectual disability (ID), postnatal growth retardation, dysmorphic facies, microcephaly, short ...
Jingsi Luo, Qiang Zhang, Shang Yi, Qi Yang, Zailong Qin   +4 more
core   +1 more source