Results 91 to 100 of about 2,478 (156)

NSUN2 as an emerging epigenetic regulator in cancer: from biomarker to therapeutic target

RNA Biology
NOL1/NOP2/SUN domain family member 2 (NSUN2), a member of the RNA methyltransferase family responsible for catalysing 5-methylcytosine (m5 C) modifications, has been increasingly recognized as a key regulatory factor in the initiation and progression of ...
Yukun Wei, Wenjian Xu, Yueyang Bi, Qingqun Guo, Pengzhao Song, Yahui Sun, Fengli Guo, Pengfei Gu, Yong Han   +8 more
doaj   +1 more source

NSUN2/YBX1 promotes the progression of breast cancer by enhancing HGH1 mRNA stability through m5C methylation

Breast Cancer Research
Background RNA m5C methylation has been extensively implicated in the occurrence and development of tumors. As the main methyltransferase, NSUN2 plays a crucial regulatory role across diverse tumor types. However, the precise impact of NSUN2-mediated m5C
Xuran Zhang, Ke An, Xin Ge, Yuanyuan Sun, Jingyao Wei, Weihong Ren, Han Wang, Yueqin Wang, Yue Du, Lulu He, Ouwen Li, Shaoxuan Zhou, Yong Shi, Tong Ren, Yun-gui Yang, Quancheng Kan, Xin Tian   +16 more
doaj   +1 more source

FOXA1-dependent NSUN2 facilitates the advancement of prostate cancer by preserving TRIM28 mRNA stability in a m5C-dependent manner

npj Precision Oncology
RNA epigenetics is gaining increased attention for its role in the initiation, metastasis, and drug resistance of tumors. These studies have primarily focused on m6A modification. However, despite being the second most abundant modification found in RNA,
Zhenda Wang, Abudurexiti Mierxiati, Wenkai Zhu, Tian Li, Hua Xu, Fangning Wan, Dingwei Ye   +6 more
doaj   +1 more source

m5C and m6A cooperatively stabilize EPHB4 to drive lymphatic metastasis in gastric cancer. [PDF]

Front Genet
Zhang Y, He R, Lin X, Ye J.
europepmc   +1 more source

Role of RNA 5‑methylcytosine modification in cancer: Insights from coding and non‑coding RNAs (Review). [PDF]

Mol Med Rep
Jiang Q, Gong Y, Zhai M, Tang T, Liu S.
europepmc   +1 more source

A novel small-molecule inhibitor GSK-F1 confers radiosensitivity by inhibiting the NSUN2/TP53/RAD51 axis-mediated DNA homologous recombination repair in nasopharyngeal carcinoma. [PDF]

Int J Biol Sci
Zheng L, Li M, Li X, Wei J, Xue C, Wei Q, Duan Y, Xin H, Wu Z, Zeng T, Xiong W, Fan S, Zhou M, Deng H.   +13 more
europepmc   +1 more source

m⁵C RNA modification in gastrointestinal cancers: a comprehensive review from molecular mechanism to clinical implication. [PDF]

Biol Direct
Xu C, Ye Q, Wang H, Yu Y.
europepmc   +1 more source

Nanocarriers engineering for efficient NSUN2 silencing and immune responsive therapy in metastatic colorectal cancer. [PDF]

Mater Today Bio
Ali K, Li Y, Bi Q, Zhu X, Sun X, Zhu H, Zhang H, Huang L, Hu H, Yang X, Tang L, Wang J.   +11 more
europepmc   +1 more source

5-Methylcytidine RNA Epitranscriptomics in Women's Health and Disease: Mechanisms and Clinical Implications. [PDF]

Cells
Yang Q, Salih SM, Wu R, Arora I, Mousa M, Al-Hendy A, Boyer TG.   +6 more
europepmc   +1 more source

NSUN2 mediates intestinal stem cell expansion and colorectal tumour initiation via MAPK/ERK signalling. [PDF]

Cell Death Dis
Bastem Akan A, Billard CV, Chen SY, Huang PH, Cammareri P, Rajasekaran V, Hall AE, Preyzner P, Pohl SÖ, Farrington SM, Dunlop MG, Din FVN, Myant KB.   +12 more
europepmc   +1 more source