Results 91 to 100 of about 3,656 (193)

NSUN2 mediates distinct pathways to regulate enterovirus 71 replication

Virologica Sinica
Increasing evidences suggest that the methyltransferase NSUN2 catalyzes 5-methylcytosine (m5C) modifications on viral RNAs, which are essential for the replication of various viruses. Despite the function of m5C deposition is well characterized, other potential roles of NSUN2 in regulating viral replication remain largely unknown.
Liu, Lishi, Chen, Zhen, Zhang, Kui, Hao, Haojie, Ma, Li, Liu, Haizhou, Yu, Baocheng, Ding, Shuang, Zhang, Xueyan, Zhu, Miao, Guo, Xiang, Liu, Yi, Liu, Haibin, Huang, Fang, Peng, Ke, Guan, Wuxiang   +15 more
openaire   +2 more sources

tRNA Thiolation Links Translation to Stress Responses in Saccharomyces cerevisiae [PDF]

, 2014
Although tRNA modifications have been well catalogued, the precise functions of many modifications and their roles in mediating gene expression are still being elucidated.
Damon, Jadyn Rose, Pincus, David, Ploegh, Hidde   +2 more
core   +1 more source

Epitranscriptomics as a Candidate Universal Modulator of Dormancy Transitions

Ecology and Evolution, Volume 16, Issue 2, February 2026.
Dormancy is presented as a conserved, reversible survival program in which epitranscriptomic RNA modifications are proposed to provide a rapid, energy‐efficient layer that establishes, maintains, and terminates the state by modulating mRNA stability, translation, and localization.
Ehsan Pashay Ahi
wiley   +1 more source

Unveiling the potential impact of RNA m5C methyltransferases NSUN2 and NSUN6 on cellular aging

Frontiers in Genetics
NSUN2 and NSUN6, two family members of NOL1/NSUN protein, are mainly responsible for catalyzing the formation of 5-methylcytosine (m5C) in RNA and highly involved in the physiological and pathological processes of many diseases.
Jiale Zhou, Jiale Zhou, Yang Han, Fuxi Ji, Renquan Zhang, Yuru Liang, Xudong Zhao, Ruizhe Hou   +7 more
doaj   +1 more source

Expanded carrier screening: A current perspective [PDF]

, 2018
Prenatal carrier screening has expanded to include a large number of genes offered to all couples considering pregnancy or with an ongoing pregnancy.
Al-Kouatly, Hb, Berghella, V, Carbone, Luigi, D'Alessandro, P, De Vivo, V, Esposito, G, Giuliani, Arduino, Maruotti, Gm, Mastantuoni, Enrica, Paternoster, M, Raffone, A, Saccone, G, Zullo, F.   +12 more
core   +1 more source

Microbial metabolites in tumor epigenetic regulation

iMeta, Volume 5, Issue 1, February 2026.
The gut microbiome modulates tumor epigenetic regulation through bioactive metabolites derived from dietary substrates. Microbiota‐produced SCFAs, secondary BAs, one‐carbon metabolites, and tryptophan‐derived ligands regulate histone acetylation, DNA methylation, and chromatin remodeling via HDAC, DNMT, AhR, and metabolic cofactor‐dependent pathways ...
Wangzheqi Zhang, Haoling Zhang, Yan Liao, Shuya Jiang, Haolong Zhang, Chenwei Huang, Zhijing Song, Rui Zhao, Ping Lu, Xiaohong Kang, Eryan Kong, Yalin Zhu, Wei Wang, Xuesong Liu, Yisheng Chen, Zhiwen Luo, Zhaoyu Li, Di Wang, Na Xing, Yadong Guo, Jingjing Zhang, Xiaojing Wang, Wenyi Wang, Mowaffaq Adam, Bakiah Shaharuddin, Muhamad Yusri Musa, Doblin Sandai, Chenglong Zhu, Aimin Jiang, Peng Luo, Zhijie Zhao, Zui Zou   +31 more
wiley   +1 more source

Inflammation and Cancer: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Chronic inflammation fuels tumorigenesis via “internal drivers” and “external attractions.” Targeting these core mechanisms with combined therapies/novel deliveries enables precise, potent anti‐inflammatory–antitumor treatment. ABSTRACT Inflammation is a core pathological factor regulating tumor initiation, progression, and therapeutic resistance, and ...
Xiaodie Liu, Ziyuan Wang, Huirong Zhu, Yicun Han, Qing Ji   +4 more
wiley   +1 more source

CypA Mediates Non‐Small Cell Lung Cancer Chemoresistance by Attenuating Ferroptosis via Stabilizing SLC7A11

Advanced Science, Volume 13, Issue 4, 19 January 2026.
Summary diagram for the role of CypA in chemoresistance in non‐small cell lung cancer (NSCLC). CypA is overexpressed in chemoresistance NSCLC and drives therapeutic evasion by competitively binding to the K37 site of SLC7A11, thereby blocking TRIM3 mediated K11‐linked ubiquitination and proteasomal degradation, ultimately inhibiting lipid peroxidation ...
Zhongcheng Wang, An Li, Ziwei Song, Xiangming Liu, Yong Ge, Zhiqiao Chen, Yuhui Liu, Boyu Zhang, Hao Zhang, Ting Lan   +9 more
wiley   +1 more source

RNA m5C modification upregulates E2F1 expression in a manner dependent on YBX1 phase separation and promotes tumor progression in ovarian cancer

Experimental and Molecular Medicine
5-Methylcytosine (m5C) is a common RNA modification that modulates gene expression at the posttranscriptional level, but the crosstalk between m5C RNA modification and biomolecule condensation, as well as transcription factor-mediated transcriptional ...
Xiaoyi Liu, Qinglv Wei, Chenyue Yang, Hongyan Zhao, Jie Xu, Youchaou Mobet, Qingya Luo, Dan Yang, Xinzhao Zuo, Ningxuan Chen, Yu Yang, Li Li, Wei Wang, Jianhua Yu, Jing Xu, Tao Liu, Ping Yi   +16 more
doaj   +1 more source

Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders. [PDF]

, 2014
Mutations in the cytosine-5 RNA methyltransferase NSun2 cause microcephaly and other neurological abnormalities in mice and human. How post-transcriptional methylation contributes to the human disease is currently unknown.
Becker, Lore, Blanco, Sandra, Dietmann, Sabine, Flores, Joana V, Frye, Michaela, Fuchs, Helmut, Gailus-Durner, Valerie, Garrett, Lillian, Gleeson, Joseph G, Helm, Mark, Hrabĕ de Angelis, Martin, Humphreys, Peter, Hussain, Shobbir, Hölter, Sabine M, Kellner, Stefanie, Klopstock, Thomas, Kutter, Claudia, Káradóttir, Ragnhildur T, Lombard, Patrick, Lukk, Margus, Odom, Duncan T, Popis, Martyna, Treps, Lucas, Ule, Jernej, Wurst, Wolfgang   +24 more
core   +1 more source