Results 1 to 10 of about 2,471 (170)

Preservation of ALYREF Phase Separation Mitigates Doxorubicin‐Induced Cardiomyocyte DNA Damage and Cardiotoxicity [PDF]

Advanced Science
The clinical utility of the anticancer agent doxorubicin (DOX) is limited by its dose‐dependent cardiotoxicity. ALYREF, a nuclear protein that preserves genomic stability through interactions with intranuclear components or as an m⁵C‐binding regulator of
Xinlu Gao, Yifu Shen, Zhihui Xiao, Zhenbo Han, Xu Liu, Ao Cai, Yanan Tian, Guang Lian, Wenya Ma, Yining Liu, Rui Gong, Hanjing Li, Xiuxiu Wang, Zhongyu Ren, Naufal Zagidullin, Lei Yu, Ye Tian, Yu Liu, Zhenwei Pan, Baofeng Yang, Benzhi Cai   +20 more
doaj   +4 more sources

RNF31 induces paclitaxel resistance by sustaining ALYREF cytoplasmic–nuclear shuttling in human triple‐negative breast cancer [PDF]

Clinical and Translational Medicine
Background Resistance to paclitaxel‐based chemotherapy is the major obstacle in triple‐negative breast cancer (TNBC) treatment. However, overcoming paclitaxel resistance remains an unsolved problem. The present study aimed to determine whether paclitaxel
Boyu Chen, lingzhi kong, Weidong Wei
exaly   +5 more sources

Multi-Omic Analyses of the m5C Regulator ALYREF Reveal Its Essential Roles in Hepatocellular Carcinoma [PDF]

Frontiers in Oncology, 2021
The ALYREF protein acts as a crucial epigenetic regulator in several cancers. However, the specific expression levels and functional roles of ALYREF in cancers are largely unknown, including for hepatocellular carcinoma (HCC).
Yalei Zhao
exaly   +6 more sources

Competitive and cooperative interactions mediate RNA transfer from herpesvirus saimiri ORF57 to the mammalian export adaptor ALYREF. [PDF]

PLoS Pathogens, 2014
The essential herpesvirus adaptor protein HVS ORF57, which has homologs in all other herpesviruses, promotes viral mRNA export by utilizing the cellular mRNA export machinery.
Richard B Tunnicliffe, Guillaume M Hautbergue, Stuart A Wilson, Priti Kalra, Alexander P Golovanov   +4 more
doaj   +12 more sources

ETV4/ALYREF-mediated glycolytic metabolism through PKM2 enhances resistance to ferroptosis and promotes the development of intrahepatic cholangiocarcinoma [PDF]

Cancer & Metabolism
Background Intrahepatic cholangiocarcinoma (ICC) is the second most common primary hepatocellular cancer. This study investigated whether ETV4, ALYREF, and PKM2 affect glycolytic metabolism and ferroptosis, thereby potentially influencing ICC.
Xiaohui Wang, Wenbin Duan, Zhongzhi Ma, Haoquan Wen, Xianhai Mao, Changjun Liu   +5 more
exaly   +3 more sources

The role of the HIF‐1α/ALYREF/PKM2 axis in glycolysis and tumorigenesis of bladder cancer [PDF]

Cancer Communications, 2021
Background As a rate‐limiting enzyme of glycolysis, pyruvate kinase muscle isozyme M2 (PKM2) participates in tumor metabolism and growth. The regulatory network of PKM2 in cancer is complex and has not been fully studied in bladder cancer.
Xiao Yang, Jie Han, Xiao Yang
exaly   +4 more sources

Comprehensive analysis of ALYREF gene expression and its correlation with immunotherapy efficacy and circulating tumor cells in bladder cancer [PDF]

Scientific Reports
Bladder cancer (BCa) presents a significant clinical challenge, with a pressing need for biomarkers to predict prognosis and guide immunotherapy. Aly/REF export factor (ALYREF) is a key regulator in various cancers, but its role in bladder cancer (BCa ...
Zhen Tang, Jiao Peng, Zhengshu Wei, Shangxin Wu, Gangyun Guan, Fengyao Lu, Baode Lu, Siping Zeng   +7 more
doaj   +2 more sources

Identification of ALYREF in pan cancer as a novel cancer prognostic biomarker and potential regulatory mechanism in gastric cancer [PDF]

Scientific Reports
ALYREF is considered as a specific mRNA m5C-binding protein which recognizes m5C sites in RNA and facilitates the export of RNA from the nucleus to the cytoplasm.
Yujie Yuan, Yiyang Fan, Wenqing Tang, Hui Sun, Jinghan Sun, Hongmeng Su, Hong Fan   +6 more
doaj   +3 more sources

CASC19 stabilization by ALYREF via m5C modification and its impact on SCD in colorectal cancer cell aggressiveness and stemness [PDF]

Cell & Bioscience
The progression of colorectal cancer (CRC) is closely associated with aberrant epigenetic regulation. As a key regulator of m5C modification, the role and mechanism of Aly/REF export factor (ALYREF) in CRC remain unclear. This study aims to elucidate the
Li Zhao, Rongjun Xie, Li Li, Xianzhou Lu, Li Wang, Hui Wang, Longfei Liu   +6 more
doaj   +2 more sources

ALYREF condensation stabilizes m5C-modified PARP10 mRNA and promotes PI3K-AKT signaling in ovarian cancer [PDF]

The EMBO Journal
The role of epigenetic regulation of RNAs in the tumorigenesis remains incompletely understood. This study uncovers a critical function of the 5-methylcytosine (m5C) RNA modification reader protein ALYREF (also termed, ALY; BEF) in ovarian cancer. ALYREF
Hongyan Zhao, Qinglv Wei, Zhi Luo, Xiaoyi Liu, Chenyue Yang, Ningxuan Chen, Yuan Wang, Xin Luo, Xinzhao Zuo, Qingya Luo, Yu Yang, Yang Zhou, Jiaqi Liu, Te Zhang, Dan Yang, Yingfei Long, Youchaou Mobet, Jing Xu, Wei Wang, Tao Liu, Ping Yi   +20 more
doaj   +2 more sources