Results 21 to 30 of about 1,624 (115)
Incomplete activation of Alyref and Gabpb1 leads to preimplantation arrest in cloned mouse embryos
Life Science Alliance, 2023 This study shows that failed activation of developmentally required Alyref and Gabpb1 genes leads to the arrest of cloned mouse embryos. Differentiated cell nuclei can be reprogrammed after nuclear transfer (NT) to oocytes and the produced NT embryos can
Shunya Ihashi +16 more
doaj +1 more source
ALYREF associated with immune infiltration is a prognostic biomarker in hepatocellular carcinoma
Translational Oncology, 2022 Background: Although ALYREF has been demonstrated to have a role in a number of malignancies, its role in hepatocellular carcinoma (HCC) has received little attention.
Zhen-Zhen Wang +10 more
doaj +1 more source
Competitive and cooperative interactions mediate RNA transfer from herpesvirus saimiri ORF57 to the mammalian export adaptor ALYREF. [PDF]
PLoS Pathogens, 2014 The essential herpesvirus adaptor protein HVS ORF57, which has homologs in all other herpesviruses, promotes viral mRNA export by utilizing the cellular mRNA export machinery.
Richard B Tunnicliffe +4 more
doaj +1 more source
ALYREF correlates with tumor progression and therapy resistance in localized and advanced prostate cancer [PDF]
Journal of Men's HealthBackground: Prostate cancer (PCa) is a leading malignancy in men, with a poor prognosis in the advanced stage. Aly/REF export factor (ALYREF), a 5-methylcytosine (m5C)-binding protein regulating RNA export, has been implicated in several cancers. This
Zhouda Cai +9 more
doaj +1 more source
Cell Death and Disease, 2023 The significance of 5-methylcytosine (m5C) methylation in human malignancies has become an increasing focus of investigation. Here, we show that m5C regulators including writers, readers and erasers, are predominantly upregulated in urothelial carcinoma ...
Ning Wang +13 more
doaj +1 more source
LINC02159 promotes non-small cell lung cancer progression via ALYREF/YAP1 signaling
Molecular Cancer, 2023 Lung cancer is the leading cause of cancer-related deaths worldwide. Long non-coding RNAs (lncRNAs) have emerged as key regulators of cancer development and progression, and as promising biomarkers for the diagnosis and prognosis of cancer. In this study,
Qiurong Yang +9 more
doaj +1 more source
Frontiers in Genetics, 2022 Recent studies have well demonstrated that 5-methylcytosine (m5C) regulators play pivotal roles in pathological conditions, including cancer. This study first tried to identify potential 5-methylcytosine (m5C) regulators in breast cancer by combination ...
Jingxing Liu +4 more
doaj +1 more source
Nature Communications, 2021 Neuroblastoma (NB) is often driven by MYCN amplification. Here, the authors show that the most frequent genetic lesion, gain of 17q21-ter in NB leads to overexpression of ALYREF, which forms a complex with MYCN, regulating MYCN stability via the ...
Zsuzsanna Nagy +15 more
doaj +1 more source
Cancer Science, EarlyView.CAFs could transfer EVs miR‐375 into endothelial cells with a low level of RASA1 and further promote EC angiogenesis. Plasma EVs miR‐375 have the potential values as a novel diagnostic and prognostic biomarker for HCC. ABSTRACT Cancer‐associated fibroblasts (CAFs) in the tumor microenvironment play an important role in cancer initiation and progression
Wei Qin +6 more
wiley +1 more source
Clinical and Translational Medicine, 2023 Background The precise temporal and spatial regulation of N5‐methylcytosine (m5C) RNA modification plays essential roles in RNA metabolism, and is necessary for the maintenance of epigenome homeostasis.
Sipeng Zuo +11 more
doaj +1 more source