The molecular chaperone ALYREF promotes R-loop resolution and maintains genome stability [PDF]
Journal of Biological ChemistryUnscheduled R-loops usually cause DNA damage and replication stress, and are therefore a major threat to genome stability. Several RNA processing factors, including the conserved THO complex and its associated RNA and DNA-RNA helicase UAP56, prevent R-loop accumulation in cells.
Andres Aguilera +2 more
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Cryo-EM structure of the CBC-ALYREF complex
eLife, 2023 In eukaryotes, RNAs transcribed by RNA Pol II are modified at the 5′ end with a 7-methylguanosine (m7G) cap, which is recognized by the nuclear cap binding complex (CBC). The CBC plays multiple important roles in mRNA metabolism, including transcription,
Bradley P Clarke +5 more
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NSUN2 promoted tumor growth and metastatic via m5C-regulation of YAP through ALYREF/YBX1 axis in NSCLC [PDF]
Cell Death and DiseaseNSUN2-dependent RNA m5C methylation is essential for RNA stability, cellular metabolism, and intracellular transport. Aberrant YAP expression is closely associated with tumorigenesis and progression in human cancers.
Rui Li, Dan Jin, Shuang Shao, Jiwei Guo
doaj +2 more sources
Multi-omics analysis reveals that ALYREF-mediated m5C modification promotes platinum resistance in ovarian cancer via the NSUN2/ALYREF/LGR4 axis [PDF]
Cell Death and DiseasePlatinum resistance remains a major obstacle to effective treatment and improved prognosis in ovarian cancer. Although 5-methylcytosine (m5C) RNA modification has been implicated in chemoresistance, its precise functional role in ovarian cancer remains ...
Shimin Yang +5 more
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Cell Death and Disease, 2023 The significance of 5-methylcytosine (m5C) methylation in human malignancies has become an increasing focus of investigation. Here, we show that m5C regulators including writers, readers and erasers, are predominantly upregulated in urothelial carcinoma ...
Wensu Wei, Zhaohui Zhou, Yunlin Ye
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Identification of putative reader proteins of 5-methylcytosine and its derivatives in Caenorhabditis elegans RNA [version 1; peer review: 1 approved, 2 approved with reservations] [PDF]
Wellcome Open Research, 2022 Background: Methylation of carbon-5 of cytosines (m5C) is a conserved post-transcriptional nucleotide modification of RNA with widespread distribution across organisms. It can be further modified to yield 5-hydroxymethylcytidine (hm5C), 5-formylcytidine (
IC Navarro +6 more
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Mapping interactions between mRNA export factors in living cells. [PDF]
PLoS ONE, 2013 The TREX complex couples nuclear mRNA processing events with subsequent export to the cytoplasm. TREX also acts as a binding platform for the mRNA export receptor Nxf1.
I-Fang Teng, Stuart A Wilson
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Drosophila Ref1/ALYREF regulates transcription and toxicity associated with ALS/FTD disease etiologies [PDF]
Acta Neuropathologica Communications, 2019 RNA-binding proteins (RBPs) are associated with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), but the underlying disease mechanisms remain unclear.
Amit Berson +7 more
doaj +3 more sources
ALYREF enhances breast cancer progression by regulating EZH2
HeliyonBreast cancer is one of the most common malignant tumors in women worldwide. Similarly, Canine mammary tumors (CMTs) are mostly diagnosed as spontaneous diseases in female dogs.
Su-Jin Jeong, Ji Hoon Oh, Je-Yoel Cho
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Upregulation of TTYH3 by lncRNA LUCAT1 through interacting with ALYREF facilitates the metastasis in non-small cell lung cancer [PDF]
Cancer Biology & TherapyMetastasis is the predominant culprit of cancer-associated mortality in non-small cell lung cancer (NSCLC). Tweety homolog 3 (TTYH3) reportedly functions vitally in the development of diverse cancers, including NSCLC; nevertheless, its role in NSCLC ...
Fang Fang +9 more
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