Temporal-iCLIP captures co-transcriptional RNA-protein interactions [PDF]
, 2023 Dynamic RNA-protein interactions govern the co-transcriptional packaging of RNA polymerase II (RNAPII)-derived transcripts. Yet, our current understanding of this process in vivo primarily stems from steady state analysis. To remedy this, we here conduct
Bugai, Andrii +5 more
core +2 more sources
The 5-Methylcytosine RNA Modification in Hepatitis B Virus-Negative Hepatocellular Carcinoma: Insights From Long-Read Nanopore Sequencing. [PDF]
Mol CarcinogABSTRACT 5‐Methylcytosine (m5C) RNA modification contributes to tumor initiation and progression. However, its transcriptome‐wide distribution patterns and biological implications in hepatitis B virus (HBV)‐negative hepatocellular carcinoma (HCC) remain poorly understood.
Sun T +12 more
europepmc +2 more sources
A short conserved motif in ALYREF directs cap- and EJC-dependent assembly of export complexes on spliced mRNAs. [PDF]
, 2016 The export of messenger RNAs (mRNAs) is the final of several nuclear posttranscriptional steps of gene expression. The formation of export-competent mRNPs involves the recruitment of export factors that are assumed to facilitate transport of the mature ...
Gehring, NH +4 more
core +1 more source
SRSF1-dependent nuclear export of C9ORF72 repeat-transcripts: targeting toxic gain-of-functions induced by protein sequestration as a selective therapeutic strategy for neuroprotection [PDF]
, 2018 Microsatellite repeat expansions cause several incurable and lethal neurodegenerative disorders including ataxias, myotonic dystrophy, Huntington's disease and C9ORF72-linked amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD ...
Azzouz, M. +8 more
core +1 more source
Impact of Asp/Glu-ADP-ribosylation on protein-protein interaction and protein function. [PDF]
, 2022 PARylation plays critical role in regulating multiple cellular processes such as DNA damage response and repair, transcription, RNA processing, and stress response.
Cong, Qian +5 more
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RNA Nuclear Export: From Neurological Disorders to Cancer [PDF]
, 2017 The presence of a nuclear envelope, also known as nuclear membrane, defines the structural framework of all eukaryotic cells by separating the nucleus, which contains the genetic material, from the cytoplasm where the synthesis of proteins takes place ...
Hautbergue, G.M.
core +1 more source
Interactomic analysis of REST/NRSF and implications of its functional links with the transcription suppressor TRIM28 during neuronal differentiation [PDF]
, 2019 RE-1 silencing transcription factor (REST) is a transcriptional repressor that regulates gene expression by binding to repressor element 1. However, despite its critical function in physiology, little is known about its interaction proteins.
CHOI, KWAN YONG +6 more
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Luzp4 defines a new mRNA export pathway in cancer cells [PDF]
, 2015 Cancer testis antigens (CTAs) represented a poorly characterized group of proteins whose expression is normally restricted to testis but are frequently up-regulated in cancer cells. Here we show that one CTA, Luzp4, is an mRNA export adaptor.
Bachi +48 more
core +1 more source
The EMBO Journal, 2019 The RNA-binding protein ALYREF plays key roles in nuclear export and also 3'-end processing of polyadenylated mRNAs, but whether such regulation also extends to non-polyadenylated RNAs is unknown. Replication-dependent (RD)-histone mRNAs are not polyadenylated, but instead end in a stem-loop (SL) structure.
Jing Fan +15 more
openaire +2 more sources
The role of TREX in gene expression and disease [PDF]
, 2016 TRanscription and EXport (TREX) is a conserved multisubunit complex essential for embryogenesis, organogenesis and cellular differentiation throughout life.
Heath, C.G., Viphakone, N., Wilson, S.A.
core +3 more sources