Results 61 to 70 of about 1,624 (115)

Kaposi's sarcoma-associated herpesvirus ORF57 protein protects viral transcripts from specific nuclear RNA decay pathways by preventing hMTR4 recruitment.

PLoS Pathogens, 2019
Nuclear RNAs are subject to a number of RNA decay pathways that serve quality control and regulatory functions. As a result, any virus that expresses its genes in the nucleus must have evolved mechanisms that avoid these pathways, but the how viruses ...
Julio C Ruiz, Olga V Hunter, Nicholas K Conrad   +2 more
doaj   +1 more source

NSUN2 relies on ALYREF to regulate Nrf2-mediated oxidative stress and alleviate Dox-induced liver injury

Biology Direct
Background Doxorubicin (Dox) is associated with various liver injuries, limiting its clinical utility. This study investigates whether NSUN2 participates in Dox-induced liver injury and the associated molecular mechanism.
Yingying Huang, Xiao Li, Lin Wei, Shinan Ma, Liming Ma, Yuxin Zan, Xiju He, Yijun Tang, Yan Ding   +8 more
doaj   +1 more source

NSUN2 affects diabetic retinopathy progression by regulating MUC1 expression through RNA m5C methylation

Journal of Translational Medicine
Background Diabetic retinopathy (DR) is the leading cause of blinding eye disease among working adults and is primarily attributed to the excessive proliferation of microvessels, which leads to vitreous hemorrhage and retinal traction, thereby ...
Runze Wang, Wei Xue, Feifei Kan, Huiying Zhang, Di Wang, Lei Wang, Jianwen Wang   +6 more
doaj   +1 more source

Proteomic analysis reveals chromatin remodeling as a potential therapeutical target in neuroblastoma

Journal of Translational Medicine
Background Neuroblastoma (NB) is the most common solid tumor in children, characterized by high recurrence rates, drug resistance, and significant mortality.
Zan Liu, Zitong Zhao, Longlong Xie, Zhenghui Xiao, Ming Li, Yong Li, Ting Luo   +6 more
doaj   +1 more source

NOP2 facilitates EZH2-mediated epithelial–mesenchymal transition by enhancing EZH2 mRNA stability via m5C methylation in lung cancer progression

Cell Death and Disease
NOP2, a member of the NOL1/NOP2/SUN domain (NSUN) family, is responsible for catalyzing the posttranscriptional modification of RNA through 5-methylcytosine (m5C). Dysregulation of m5C modification has been linked to the pathogenesis of various malignant
Ying Yang, Hongzhao Fan, Hongyang Liu, Xueling Lou, Nan Xiao, Chenxing Zhang, Huanxiang Chen, Shuangshuang Chen, Huihui Gu, Hongchun Liu, Junhu Wan   +10 more
doaj   +1 more source

Dysregulation of RNA modification systems in clinical populations with neurocognitive disorders

Neural Regeneration Research
The study of modified RNA known as epitranscriptomics has become increasingly relevant in our understanding of disease-modifying mechanisms. Methylation of N6 adenosine (m6A) and C5 cytosine (m5C) bases occur on mRNAs, tRNA, mt-tRNA, and rRNA species as ...
Helen M Knight, Merve Demirbugen Öz, Adriana PerezGrovas-Saltijeral   +2 more
doaj   +1 more source

NSUN6-mediated 5-methylcytosine modification of NDRG1 mRNA promotes radioresistance in cervical cancer

Molecular Cancer
Background Radioresistance is the leading cause of death in advanced cervical cancer (CC). Dysregulation of RNA modification has recently emerged as a regulatory mechanism in radiation and drug resistance.
Min Yu, Mengdong Ni, Fei Xu, Chaohua Liu, Lihua Chen, Jiana Li, Siyu Xia, Yixin Diao, Jiaxin Chen, Jun Zhu, Xiaohua Wu, Min Tang, Jiajia Li, Guihao Ke   +13 more
doaj   +1 more source

OTUB2/ALYREF axis modulates the docetaxel resistance of castration-resistant prostate cancer via upregulating ABCG4-mediated drug efflux. [PDF]

Int J Biol Sci
Ke ZB, Chen JY, Lin B, Chen CR, Xue YT, Sun JB, Yan ZH, Zhao YX, Liu MX, Wang Z, Xue XY, Zheng QS, Wei Y, Xu N.   +13 more
europepmc   +1 more source

m⁵C RNA modification in gastrointestinal cancers: a comprehensive review from molecular mechanism to clinical implication. [PDF]

Biol Direct
Xu C, Ye Q, Wang H, Yu Y.
europepmc   +1 more source

5-Methylcytidine RNA Epitranscriptomics in Women's Health and Disease: Mechanisms and Clinical Implications. [PDF]

Cells
Yang Q, Salih SM, Wu R, Arora I, Mousa M, Al-Hendy A, Boyer TG.   +6 more
europepmc   +1 more source