Results 61 to 70 of about 2,471 (170)

Site Specific Modification of Adeno-Associated Virus Enables Both Fluorescent Imaging of Viral Particles and Characterization of the Capsid Interactome [PDF]

, 2017
Adeno-associated viruses (AAVs) are attractive gene therapy vectors due to their low toxicity, high stability, and rare integration into the host genome.
A Asokan, A Bayes, A Burgess, A Wistuba, AA Scheel, AM Tintaru, B Akache, BR Martin, C Holscher, C Naro, C Pan, C Summerford, CA Schreiber, CF Valori, CT Chang, CY Yu, DM McCarty, EB Lee, G Murlidharan, GS Arnold, H Buning, J Chu, J Cox, J Cox, J Du, J Qiu, J Rappsilber, JL Ronan, JS Johnson, K Varadi, KD Foust, KH Warrington Jr, L Geng, L Lisowski, L Shkreta, M Akerman, M Hohl, M Mano, M Mielcarek, M Monici, MA DiMattia, MA Kotterman, MD Stachler, N Déglon, N Majdzadeh, P Wu, R Weigert, RB Tunnicliffe, RD Dayton, RE Kelemen, S Michelfelder, S Shen, SA Nicklin, SJ Gray, SR Adams, T Kashima, T Okada, TA Bolger, TW Loo, V Basile, W Fischle, X Li, Y Liu, Y Zheng, YS Tseng   +64 more
core   +2 more sources

NCBP3 positively impacts mRNA biogenesis [PDF]

, 2020
The nuclear Cap-Binding Complex (CBC), consisting of Nuclear Cap-Binding Protein 1 (NCBP1) and 2 (NCBP2), associates with the nascent 5' cap of RNA polymerase II transcripts and impacts RNA fate decisions.
Barbosa, Isabelle, Cusack, Stephen, Dou, Yuhui, Iasillo, Claudia, Jensen, Torben Heick, Jiang, Hua, LaCava, John, Le Hir, Herve, Molloy, Kelly R., Schmid, Manfred, Schulze, Wiebke Manuela   +10 more
core   +4 more sources

Integration of protein phosphorylation, acetylation, and methylation data sets to outline lung cancer signaling networks [PDF]

, 2018
Integrated multiomics network analysis reveals signaling profiles in lung cancer.
Clark, Neil R., Comb, Michael, Cook, William, Foltz, Lauren, Gaiser, Jeremiah, Grimes, Mark, Hall, Benjamin, Hornbeck, Peter, Lachmann, Alexander, Levy, Tyler, Ma’ayan, Avi, Rikova, Klarisa, Smirnova, Ekaterina, Wheeler, Travis, Zhang, Bin   +14 more
core   +1 more source

Stealing the Show: KSHV Hijacks Host RNA Regulatory Pathways to Promote Infection [PDF]

, 2020
Kaposi’s sarcoma-associated herpesvirus (KSHV) induces life-long infections and has evolved many ways to exert extensive control over its host’s transcriptional and post-transcriptional machinery to gain better access to resources and dampened immune ...
Macveigh-Fierro, Daniel, Miles, Jacob, Muller, Mandy, Rodriguez, William   +3 more
core   +2 more sources

The comprehensive interactomes of human adenosine RNA methyltransferases and demethylases reveal distinct functional and regulatory features [PDF]

, 2021
N6-methyladenosine (m(6)A) and N6,2 '-O-dimethyladenosine (m(6)Am) are two abundant modifications found in mRNAs and ncRNAs that can regulate multiple aspects of RNA biology.
Covelo-Molares, Helena, Dohnalkova, Michaela, Ganji, Ranjani, Gawriyski, Lisa, Gregorova, Pavlina, Obrdlik, Ales, Postulkova, Ivana, Potesil, David, Vanacova, Stepanka, Varjosalo, Markku   +9 more
core   +2 more sources

A Comprehensive Analysis for Expression, Diagnosis, and Prognosis of m5C Regulator in Breast Cancer and Its ncRNA–mRNA Regulatory Mechanism

Frontiers in Genetics, 2022
Recent studies have well demonstrated that 5-methylcytosine (m5C) regulators play pivotal roles in pathological conditions, including cancer. This study first tried to identify potential 5-methylcytosine (m5C) regulators in breast cancer by combination ...
Jingxing Liu, Shuyuan Xiao, Jing Chen, Weiyang Lou, Xu Chen   +4 more
doaj   +1 more source

Kaposi's sarcoma-associated herpesvirus ORF57 protein: exploiting all stages of viral mRNA processing [PDF]

, 2013
Nuclear mRNA export is a highly complex and regulated process in cells. Cellular transcripts must undergo successful maturation processes, including splicing, 5'-, and 3'-end processing, which are essential for assembly of an export competent ...
Adrian Whitehouse, Ambroziak, Belinda Baquero-Perez, Bello, Bray, Brennan, Brian Jackson, Chang, Folco, Goodwin, Hakata, Hautbergue, Hiriart, Jackson, Kang, Kieff, Kudo, Massimelli, Moore, Nakano, Penn, Semmes, Sophie Schumann, Soulier, Staskus   +24 more
core   +3 more sources

Pan-cancer analysis of RNA 5-methylcytosine reader (ALYREF)

Oncology Research
The increasing interest in RNA modifications has significantly advanced epigenomic and epitranscriptomic technologies. This study focuses on the immuno-oncological impact of ALYREF in human cancer through a pan-cancer analysis, enhancing understanding of this gene's role in cancer.
YE, XING, TUO, ZHOUTING, CHEN, KAI, WU, RUICHENG, WANG, JIE, YU, QINGXIN, YE, LUXIA, MIYAMOTO, AKIRA, YOO, KOO HAN, ZHANG, CHI, WEI, WURAN, LI, DENGXIONG, FENG, DECHAO   +12 more
openaire   +2 more sources

Engineering exosomal cargo loading via endogenous molecular pathways: Strategies to enhance therapeutic potential

Interdisciplinary Medicine, EarlyView.
This review illustrates how scientists engineer exosomes by hijacking the cell's own cargo‐sorting machinery. These strategies efficiently load therapeutic molecules into natural vesicles, creating powerful next‐generation drug delivery systems (Created with BioGDP.com).
Huanrong Zhu, Chenning Zhang, Shihan Ma, Zhanxue Xu, Cailing Liang, Fang Cheng, Hongbo Chen   +6 more
wiley   +1 more source

NSUN2‐mediated m5C RNA methylation dictates retinoblastoma progression through promoting PFAS mRNA stability and expression

Clinical and Translational Medicine, 2023
Background The precise temporal and spatial regulation of N5‐methylcytosine (m5C) RNA modification plays essential roles in RNA metabolism, and is necessary for the maintenance of epigenome homeostasis.
Sipeng Zuo, Lin Li, Xuyang Wen, Xiang Gu, Ai Zhuang, Rui Li, Fuxiang Ye, Shengfang Ge, Xianqun Fan, Jiayan Fan, Peiwei Chai, Linna Lu   +11 more
doaj   +1 more source