Results 71 to 80 of about 2,471 (170)

Mapping arginine methylation in the human body and cardiac disease [PDF]

, 2016
Purpose Arginine methylation (ArgMe) is one of the most ubiquitous post-translational modifications, and hundreds of proteins undergo ArgMe in e.g. brain. However, the scope of ArgMe in many tissues, including the heart, is currently under explored. Here,
Beltran-Alvarez, Pedro, Cawthorne, Chris, Cawthorne, Christopher, Onwuli, Donatus, Onwuli, Donatus O., Rigau-Roca, Laura   +5 more
core   +1 more source

Identification and verification of an ALYREF-involved 5-methylcytosine based signature for stratification of prostate cancer patients and prediction of clinical outcome and response to therapies

Discover Oncology, 2023
Objectives Due to the heterogeneity of PCa, the clinical indicators used for PCa can't satisfy risk prognostication and personalized treatment.
Xiao Tan, Zhouda Cai, Guo Chen, Chao Cai, Jiahong Chen, Yingke Liang, Yangjia Zhuo, Jianming Liu, Liangliang Huang, Bin Ouyang, Yanni Wei, Zhenyu Jia, Junhong Deng, Weide Zhong, Jianming Lu   +14 more
doaj   +1 more source

GPRC5B Identified by m5C meRIP‐Seq Suppresses Apoptosis in Osteosarcoma Through NSUN2‐Mediated RNA Methylation

Cancer Science, Volume 117, Issue 5, Page 1322-1332, May 2026.
We performed the first transcriptome‐wide profiling of m5C modifications in osteosarcoma, analyzing four pairs of tumor and adjacent normal tissues. We revealed that NSUN2 suppresses apoptosis in osteosarcoma cells by promoting GPRC5B m5C modification and expression.
Zhenyi Chen, Min Yang, Xiaoxiao Liang, Zhiqiang Yang, Wulan Mai, Yuyang Wang, Yushen Lu, Ruimin Wang, Yuanhang Han, Yuanlong Xie, Lin Cai   +10 more
wiley   +1 more source

ALYREF-mediated RNA 5-methylcytosine modification promotes laryngeal cancer progression via stabilizing DDX11 mRNA

Scientific Reports
Laryngeal cancer (LC) is one of the malignant tumors affecting the head and neck region. 5-methylcytosine (m5C) is a common RNA modification that contributes to the carcinogenesis process.
Shanyan Bian, Rui Li, Yingwei Guo, Yingtao Wu, Jianqi Zhao, Zhiyuan Wang, Jiancong Huang   +6 more
doaj   +1 more source

Structure of the human core transcription-export complex reveals a hub for multivalent interactions

eLife, 2020
The export of mRNA from nucleus to cytoplasm requires the conserved and essential transcription and export (TREX) complex (THO–UAP56/DDX39B–ALYREF). TREX selectively binds mRNA maturation marks and licenses mRNA for nuclear export by loading the export ...
Thomas Pühringer, Ulrich Hohmann, Laura Fin, Belén Pacheco-Fiallos, Ulla Schellhaas, Julius Brennecke, Clemens Plaschka   +6 more
doaj   +1 more source

Identification of a novel 5-methylcytosine-related signature for prognostic prediction of kidney renal papillary cell carcinoma and a Putative target for drug repurposing

Translational Oncology, 2023
Background: Many studies have demonstrated the crucial roles of 5-methylcytosine (m5C) RNA methylation in cancer pathogenesis. Methods: Two datasets, including TCGA-KIRP and ICGC, and related clinical information were downloaded, where the expression of ...
Zhen Zhang, Chunhua Cao, Chun-Li Zhou, Xilong Li, Changhong Miao, Li Shen, Rajeev K. Singla, Xihua Lu   +7 more
doaj   +1 more source

SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits [PDF]

, 2017
Hexanucleotide repeat expansions in the C9ORF72 gene are the commonest known genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia.
Alam, Sarah M, Sanchez-Martinez, Alvaro, Whitworth, Alex   +2 more
core   +1 more source

Identification of Key Genes Involved in Lactic Acid Metabolism in Periodontitis Based on Bioinformatics Analysis

Journal of Cellular and Molecular Medicine, Volume 30, Issue 8, April 2026.
ABSTRACT Lactic acid metabolism correlates with periodontitis progression. Using machine learning (LASSO and SVM‐RFE) on GSE16134 and GSE173078 datasets, CFI and COQ2 were identified as key genes, with good diagnostic performance (AUC > 0.75). GSEA linked these genes to MAPK signalling, endocytosis, and ubiquitin‐mediated proteolysis.
Bijun Zhu, Shi Xu, Mingyue Cheng, Leiying Miao   +3 more
wiley   +1 more source

Export of miRNAs from activated macrophages is cooperative and HuR‐dependent

FEBS Letters, Volume 600, Issue 5, Page 693-709, March 2026.
This study uncovers a new mechanism for miRNA export regulation in mammalian cells, driven by the RNA‐binding protein HuR. In macrophages, HuR cooperatively binds with miRNAs to export both low‐ and high‐affinity substrates, thereby influencing macrophage activation.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Small Nucleolar RNA Snord17 Promotes Self‐Renewal of Intestinal Stem Cells through Yy2 mRNA Export and Tead4 Activation

Advanced Science, Volume 13, Issue 13, 3 March 2026.
Snord17, through interaction with Thoc3, promotes nuclear export and translation of Yy2 mRNA in Snord17+/+ ISCs. The Yy2 protein subsequently binds the Tead4 promoter to promote its transcription, activating Hippo signaling, which is essential for ISC maintenance.
Peikang Zhang, Yuwei Xu, Yufei Lan, Zhen Xiong, Zhibin Yi, Runyuan Wu, Cunzhen Li, Ying Du, Hui Guo, Yingchi Yang, Zusen Fan   +10 more
wiley   +1 more source