Results 81 to 90 of about 2,471 (170)

Novel Gene-Based Analysis of ASD GWAS: Insight Into the Biological Role of Associated Genes [PDF]

, 2019
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by its significant social impact and high heritability. The latest meta-analysis of ASD GWAS (genome-wide association studies) has revealed the association of several SNPs ...
Alonso González, Aitana, Calaza Cabanas, Manuel, Carracedo Álvarez, Ángel María, Rodríguez Fontenla, María Cristina   +3 more
core   +1 more source

Multi-omic analyses of m5C readers reveal their characteristics and immunotherapeutic proficiency

Scientific Reports
5-methylcytosine (m5C) is a post-transcriptional RNA modification identified, m5C readers can specifically identify and bind to m5C. ALYREF and YBX1 as members of m5C readers that have garnered increasing attention in cancer research.
Rui Xu, Yue Wang, Ye Kuang
doaj   +1 more source

RNA Regulatory Networks: Key Hubs in the Panorama of Cancer and Emerging Therapeutic Targets

MedComm, Volume 7, Issue 3, March 2026.
RNA regulatory networks play a crucial role in the initiation and progression of cancer through various modes of RNA interactions. Notably, circulating RNAs have emerged as potential biomarkers, while targeted interventions in RNA regulatory networks facilitate precise therapeutic strategies. ABSTRACT Cancer is a global health challenge. The initiation
Xuan Yin, Zengkan Du, Shuya Jiang, Yan Liao, Changli Wang, Jiaqi Li, Haoling Zhang, Ting‐Ting Wei, Wangzheqi Zhang, Zui Zou   +9 more
wiley   +1 more source

Inflammation and Cancer: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Chronic inflammation fuels tumorigenesis via “internal drivers” and “external attractions.” Targeting these core mechanisms with combined therapies/novel deliveries enables precise, potent anti‐inflammatory–antitumor treatment. ABSTRACT Inflammation is a core pathological factor regulating tumor initiation, progression, and therapeutic resistance, and ...
Xiaodie Liu, Ziyuan Wang, Huirong Zhu, Yicun Han, Qing Ji   +4 more
wiley   +1 more source

Accelerate the Highly Efficient Development of mRNA Vaccines Through Advanced Computational Methods

MedComm, Volume 7, Issue 2, February 2026.
This review explores the recent advancements in applying computational methods to optimize mRNA vaccines, with a primary focus on improvements in sequence design and delivery systems. ABSTRACT mRNA medicine is an emerging therapeutic approach that utilizes messenger RNA to synthesize functional proteins directly within target cells.
Ruichu Gu, Duanmiao Si, Dingwei Lei, Xiaoxue Xie, Yongge Li, Han Wen   +5 more
wiley   +1 more source

Transcriptome dynamics of CD4⁺ T cells during malaria maps gradual transit from effector to memory [PDF]

, 2020
The dynamics of CD4⁺ T cell memory development remain to be examined at genome scale. In malaria-endemic regions, antimalarial chemoprevention protects long after its cessation and associates with effects on CD4⁺ T cells.
Belz, Gabrielle T., Bramhall, Michael, Chen, Xi, Clarke, Lachlan S., Davenport, Miles P., Engel, Jessica A., Engwerda, Christian R., Haldar, Rohit N., Haque, Ashraful, James, Kylie R., Khoury, David S., Koufariotis, Lambros T., Lane, Steven W., Lansink, Lianne I. M., Laohamonthonkul, Pawat, Lee, Hyun Jae, Lönnberg, Tapio, Moreira, Marcela L., Pernold, Clara P. S., Soon, Megan S. F., Straube, Jasmin, Svensson, Valentine, Teichmann, Sarah A., Thomas, Bryce S., Williams, Cameron G., Wood, Scott   +25 more
core   +2 more sources

NSUN5 as a Prognostic Biomarker Correlates with Malignant Phenotype and Therapeutic Target in Glioma

Brain and Behavior, Volume 16, Issue 1, January 2026.
This study systematically analyzed the expression levels, clinical features, prognostic value, immune‐related roles, drug sensitivity, and biological functions of NSUN5 in glioma based on the CGGA and TCGA databases. Finally, a machine learning‐based prognostic model was constructed, and the function of NSUN5 was validated through in vitro experiments.
Ye Wenhao, Wu Huan, Zou Xiaoyun, Yang Yuanyuan, Bi Junlei, Liu Changqing, Zhao Mengyi, Zhang Yuyuan, Lu Jin, Wen Hebao, Ma Caiyun   +10 more
wiley   +1 more source

Semi-quantitative mass spectrometry in AML cells identifies new non-genomic targets of the EZH2 methyltransferase [PDF]

, 2017
Alterations to the gene encoding the EZH2 (KMT6A) methyltransferase, including both gain-of-function and loss-of-function, have been linked to a variety of haematological malignancies and solid tumours, suggesting a complex, context-dependent role of ...
Bhamra, Amandeep, Gil, Veronica, Kwok, Colin, Petrie, Kevin, Sbirkov, Yordan, Thompson, Andrew J, Zelent, Arthur   +6 more
core   +2 more sources

Genetic screening and molecular characterisation of biomarkers in hepatocellular carcinoma [PDF]

, 2021
Hepatocellular carcinoma (HCC) is the most common type of liver cancer that accounts for 4.7% of the total number of new cases of cancer worldwide every year.
Paradiso, Viola
core  

m5C: Novel Diagnostic and Drug Repurposing Targets for Nonalcoholic Steatohepatitis

International Journal of Genomics, Volume 2026, Issue 1, 2026.
Background Epigenetic medication, such as RNA 5‐methylcytosine (m5C), is well‐recognized as a key regulator in hepatic metabolism and immune responses. However, m5C regulatory mechanisms in NASH pathogenesis have not yet been clearly elucidated. Methods By utilizing three bulk profiles of NASH patients acquired from GEO and integrative bioinformatic ...
Shuxian Chen, Renquan Duan, Jingyi Qiu, Zhiyu Lei, Wei Chen, Xiumei Li, Zhenyu Gong   +6 more
wiley   +1 more source