Results 101 to 110 of about 2,471 (170)

ALYREF-Mediated Regulation of TBL1XR1 and KMT2E Synergistically Upregulates APOC1, Contributing to Oxaliplatin Resistance in Esophageal Cancer. [PDF]

Cancer Res Treat
Purpose Esophageal cancer (EC) is a rapidly progressing malignancy characterized by a low survival rate and limited treatment success, largely due to late-stage detection, frequent recurrence, and a high propensity for metastasis, despite ongoing advances in therapeutic strategies.
Hu J, Liu Q, Feng B, Lu Y, Chen K.
europepmc   +2 more sources

Antisense RNA foci in the motor neurons of C9ORF72-ALS patients are associated with TDP-43 proteinopathy [PDF]

, 2015
GGGGCC repeat expansions of C9ORF72 represent the most common genetic variant of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. We and others have proposed that RNA transcribed from the repeat sequence is toxic via sequestration of RNA ...
A Cruz-Migoni, Adrian Higginbottom, AE Renton, AP Golovanov, AR Haeusler, C Lagier-Tourenne, CJ Donnelly, D Sareen, DL Spector, GM Hautbergue, GM Hautbergue, Guillaume M. Hautbergue, HM Kaneb, I Kwon, IR Mackenzie, IR Mackenzie, J Cooper-Knock, J Cooper-Knock, J Cooper-Knock, J. Robin Highley, Janine Kirby, Johnathan Cooper-Knock, K Mori, K Mori, KP Smith, M DeJesus-Hernandez, M Neumann, Matthew J. Stopford, MM Phelan, Pamela J. Shaw, Paul G. Ince, R Bengoechea, S May, S Mizielinska, S Mizielinska, Stephen B. Wharton, Stuart Pickering-Brown, TF Gendron, YB Lee, YS Davidson   +39 more
core   +2 more sources

NSUN2 affects diabetic retinopathy progression by regulating MUC1 expression through RNA m5C methylation

Journal of Translational Medicine
Background Diabetic retinopathy (DR) is the leading cause of blinding eye disease among working adults and is primarily attributed to the excessive proliferation of microvessels, which leads to vitreous hemorrhage and retinal traction, thereby ...
Runze Wang, Wei Xue, Feifei Kan, Huiying Zhang, Di Wang, Lei Wang, Jianwen Wang   +6 more
doaj   +1 more source

mRNA recognition and packaging by the human transcription–export complex [PDF]

, 2023
Ayala, Farja I., Fin, Laura, O’Reilly, Francis J., Pacheco-Fiallos, Belén, Plaschka, Clemens, Rappsilber, Juri, Riabov-Bassat, Daria, Schellhaas, Ulla, Vorländer, Matthias K.   +8 more
core   +1 more source

Structural differences between the closely related RNA helicases, UAP56 and URH49, fashion distinct functional apo-complexes [PDF]

mRNAを核から細胞質へ輸送するバルクmRNA輸送体の構成因子を解明 がんの早期発見や予後の予測に役立つ可能性のある研究成果. 京都大学プレスリリース. 2024-01-16.mRNA export is an essential pathway for the regulation of gene expression.
Fujita, Ken-ichi, Fujiwara, Naoko, Harada, Kotaro, Ikeda, Yuya, Irie, Midori, Ito, Misa, Kojima, Masaki, Masuda, Seiji, Mayeda, Akila, Mikami, Bunzo, Yamazaki, Tomohiro, Yoshioka, Hanae   +11 more
core   +1 more source

ALYREF m5C RNA methylation reader predicts bladder cancer prognosis by regulating the tumor immune microenvironment

Medicine
Background: 5-Methylcytidine (m5C) methylation is a recently emerging epigenetic modification that is closely related to tumor proliferation, occurrence, and metastasis. This study aimed to investigate the clinicopathological characteristics and prognostic value of m5C regulators in bladder cancer (BLCA), and their correlation ...
Wengu Pan, Xiaoli Liu, Shuangde Liu
openaire   +2 more sources

Issue Information

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 1, January 2026.
wiley   +1 more source

Proteomic analysis reveals chromatin remodeling as a potential therapeutical target in neuroblastoma

Journal of Translational Medicine
Background Neuroblastoma (NB) is the most common solid tumor in children, characterized by high recurrence rates, drug resistance, and significant mortality.
Zan Liu, Zitong Zhao, Longlong Xie, Zhenghui Xiao, Ming Li, Yong Li, Ting Luo   +6 more
doaj   +1 more source

Dysregulation of RNA modification systems in clinical populations with neurocognitive disorders

Neural Regeneration Research
The study of modified RNA known as epitranscriptomics has become increasingly relevant in our understanding of disease-modifying mechanisms. Methylation of N6 adenosine (m6A) and C5 cytosine (m5C) bases occur on mRNAs, tRNA, mt-tRNA, and rRNA species as ...
Helen M Knight, Merve Demirbugen Öz, Adriana PerezGrovas-Saltijeral   +2 more
doaj   +1 more source

NOP2 facilitates EZH2-mediated epithelial–mesenchymal transition by enhancing EZH2 mRNA stability via m5C methylation in lung cancer progression

Cell Death and Disease
NOP2, a member of the NOL1/NOP2/SUN domain (NSUN) family, is responsible for catalyzing the posttranscriptional modification of RNA through 5-methylcytosine (m5C). Dysregulation of m5C modification has been linked to the pathogenesis of various malignant
Ying Yang, Hongzhao Fan, Hongyang Liu, Xueling Lou, Nan Xiao, Chenxing Zhang, Huanxiang Chen, Shuangshuang Chen, Huihui Gu, Hongchun Liu, Junhu Wan   +10 more
doaj   +1 more source