Results 91 to 100 of about 2,471 (170)

The association of circular RNAs with hypertension [PDF]

, 2022
This thesis contains six chapters in total with chapter 1 being a literature overview and chapter 2 being a summary of material and methods. The three results chapters contain all my own work unless stated otherwise and lastly chapter 6 is discussion and
Woods, Bradley
core   +2 more sources

Label-free tissue proteomics can classify oral squamous cell carcinoma from healthy tissue in a stage-specific manner [PDF]

, 2018
Objectives: No prognostic or predictive biomarkers for oral squamous cell carcinoma (OSCC) exist. We aimed to discover novel proteins, altered in OSCC, to be further investigated as potential biomarkers, and to improve understanding about pathways ...
Dickinson, Amy, Haglund, Caj, Hagström, Jaana, Joenväärä, Sakari, Mäkitie, Antti, Saraswat, Mayank, Silen, Robert, Silen, Suvi   +7 more
core   +1 more source

Alternative Splicing: Molecular Mechanisms, Biological Functions, Diseases, and Potential Therapeutic Targets

MedComm, Volume 6, Issue 12, December 2025.
Alternative splicing (AS) expands proteomic diversity and functional complexity in eukaryotes, regulated by spliceosomal components, RNA elements, and epigenetic modifications. Dysregulated AS contributes to diseases, including cancer, neurodegenerative disorders, and cardiovascular conditions, among others. Therapeutic interventions, such as antisense
Zhi‐Min Zhu, Xiao‐Mei Wu, Yan Hu, Xiao‐Lan Bian, Ya‐Qin Wang, Qiong‐Ni Zhu   +5 more
wiley   +1 more source

KLF1 Promotes Non‐Small Cell Lung Cancer Cell Proliferation and Invasion by Upregulating the LINC02159/DYNC1H1 Pathway

The Kaohsiung Journal of Medical Sciences, Volume 41, Issue 11, November 2025.
ABSTRACT Non‐small cell lung cancer (NSCLC) is a common and fatal malignancy. This study aimed to elucidate the mechanism of Kruppel‐like factor (KLF1) in NSCLC progression. Clinical samples were collected, after which the expression levels of KLF1, LINC02159, and dynein cytoplasmic 1 heavy chain 1 (DYNC1H1) in tissues and cells were initially detected,
Han Yang
wiley   +1 more source

Molecular mechanisms of neurodegeneration related to C9orf72 hexanucleotide repeat expansion [PDF]

, 2019
Two clinically distinct diseases, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), have recently been classified as two extremes of the FTD/ALS spectrum.
Hof Patrick R., Hortobágyi Tibor, Kirincich Jason, Leko Mirjana Babić, Smilović Dinko, Šimić Goran, Župunski Vera   +6 more
core   +3 more sources

ALYREF facilitates the proliferation of hepatocellular carcinoma via MAZ-mediated p53-dependent cell cycle promotion

, 2023
Abstract Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide, with poor prognosis and high mortality. Increasing evidence suggests that m5C binding protein ALYREF plays an important role in HCC progression. However, further research is required to understand its mechanism.The mechanism of ALYREF in HCC was ...
Yuying Ma, Ting Liu, Fan Rong, Abid Naeem, Bin Jiang, Qiong Wang, Yahong Yuan, Yan Ding, Zhongji Meng, Xingrong Guo, Xiaoli Wang   +10 more
openaire   +1 more source

Aging-declined RNA exportation impairs hematopoietic stem cells by inducing R-loop

Haematologica
Aging-related accumulation of DNA damage adversely affects hematopoietic stem cell (HSC). However, the mechanisms underlying this accumulation and strategies for its elimination to rejuvenate aged HSCs remain largely obscure.
Ruiqing Chen, Qiongye Dong, Lihong Zhou, Hanqing He, Yingxue Du, Qianwen Sun, Toshio Suda, Tao Cheng, Jianwei Wang   +8 more
doaj   +1 more source

Co-transcriptional Loading of RNA Export Factors Shapes the Human Transcriptome [PDF]

, 2019
During gene expression, RNA export factors are mainly known for driving nucleo-cytoplasmic transport. While early studies suggested that the exon junction complex (EJC) provides a binding platform for them, subsequent work proposed that they are only ...
Andersen, Andersen, Baejen, Boehm, Boutz, Braun, Brody, Broughton, Catherine G. Heath, Chang, Cheng, Chi, Chi, Choe, Choudhury, Chu, Cohen, Custódio, David Sims, Derti, Dias, Eckmann, Fan, Fanis, Fong, Gatfield, Gebhardt, Gromadzka, Gruber, Hauer, Hautbergue, Hautbergue, Heath, Huang, Ian Sudbery, Izumikawa, Jung, Kaida, Katahira, Katahira, König, Le Hir, Le Hir, Li, Llorian, Llywelyn Griffith, Martin, Masamha, Mauger, Meola, Middleton, Millevoi, Müller-McNicoll, Nicolas Viphakone, Ohno, Pabis, Pandya-Jones, Qu, Romeo, Rot, Ruepp, Schlackow, Shi, Singh, Singh, Smith, Strässer, Stuart A. Wilson, Stubbs, Stutz, Sultan, Tian, Tilgner, Viphakone, Viphakone, Wang, Werner, Windhager, Yao, Yoshimoto, Zhang, Zhu, Zolotukhin, Änkö   +83 more
core   +1 more source

RNA methyltransferase NSUN2-mediated m5C methylation promotes Cr(VI)-induced malignant transformation and lung cancer by accelerating metabolism reprogramming

Environment International
Hexavalent chromium [Cr(VI)], one common environmental contaminant, has long been recognized as a carcinogen associated with lung cancer, but roles and mechanisms of Cr(VI)-induced epigenetic dysregulations in carcinogenesis remain to be investigated. In
Rui-Ke Zhang, Yan Li, Fan-Li Sun, Zhi-Hao Zhou, Yun-Xia Xie, Wen-Jing Liu, Wei Wang, Jian-Ge Qiu, Bing-Hua Jiang, Lin Wang   +9 more
doaj   +1 more source

Kaposi's sarcoma-associated herpesvirus ORF57 protein protects viral transcripts from specific nuclear RNA decay pathways by preventing hMTR4 recruitment.

PLoS Pathogens, 2019
Nuclear RNAs are subject to a number of RNA decay pathways that serve quality control and regulatory functions. As a result, any virus that expresses its genes in the nucleus must have evolved mechanisms that avoid these pathways, but the how viruses ...
Julio C Ruiz, Olga V Hunter, Nicholas K Conrad   +2 more
doaj   +1 more source