NSUN2 promoted tumor growth and metastatic via m5C-regulation of YAP through ALYREF/YBX1 axis in NSCLC [PDF]
Cell Death and DiseaseNSUN2-dependent RNA m5C methylation is essential for RNA stability, cellular metabolism, and intracellular transport. Aberrant YAP expression is closely associated with tumorigenesis and progression in human cancers.
Rui Li, Dan Jin, Shuang Shao, Jiwei Guo
doaj +2 more sources
Multi-omics analysis reveals that ALYREF-mediated m5C modification promotes platinum resistance in ovarian cancer via the NSUN2/ALYREF/LGR4 axis [PDF]
Cell Death and DiseasePlatinum resistance remains a major obstacle to effective treatment and improved prognosis in ovarian cancer. Although 5-methylcytosine (m5C) RNA modification has been implicated in chemoresistance, its precise functional role in ovarian cancer remains ...
Shimin Yang +5 more
doaj +2 more sources
Upregulation of TTYH3 by lncRNA LUCAT1 through interacting with ALYREF facilitates the metastasis in non-small cell lung cancer [PDF]
Cancer Biology & TherapyMetastasis is the predominant culprit of cancer-associated mortality in non-small cell lung cancer (NSCLC). Tweety homolog 3 (TTYH3) reportedly functions vitally in the development of diverse cancers, including NSCLC; nevertheless, its role in NSCLC ...
Fang Fang +9 more
doaj +2 more sources
Electronic Journal of BiotechnologyBackground: Colon cancer is a prevalent malignancy causing significant global morbidity and mortality. The RNA methyltransferase Aly/REF export factor (ALYREF), which binds 5-methylcytosine (m5C)-modified messenger RNA, represents a potential diagnostic ...
Dian Yin
exaly +3 more sources
Hypoxia Triggers ALYREF‐Mediated m5C Methylation of KIF20A to Activate KIF20A/BUB1 for Generating Ferroptosis Resistance in Cervical Cancer Cells [PDF]
Kaohsiung Journal of Medical SciencesFerroptosis resistance is a key player in cervical cancer (CC) development. Hypoxia is a negative factor affecting CC treatment by inducing ferroptosis resistance.
Yan Gao, Ting Zou
doaj +2 more sources
Scientific ReportsFerroptosis is of great significance in carcinogenesis as it interconnects with a multiplicity of biological processes. Meanwhile, its function and regulatory role in lung cancer remains ambiguous.
Yanni Chen, Han Weili
exaly +2 more sources
NSUN2/ALYREF axis-driven m5C methylation enhances PD-L1 expression and facilitates immune evasion in non-small-cell lung cancer [PDF]
Cancer Immunology, ImmunotherapyNon-small-cell lung cancer (NSCLC) represents a highly prevalent form of malignancy. 5-methylcytosine (m5C) methylation functions as a key post-transcriptional regulatory mechanism linked to cancer progression. The persistent expression of PD-L1 in tumor
Yiran Yang +11 more
doaj +2 more sources
ALYREF enhances breast cancer progression by regulating EZH2
HeliyonBreast cancer is one of the most common malignant tumors in women worldwide. Similarly, Canine mammary tumors (CMTs) are mostly diagnosed as spontaneous diseases in female dogs.
Je-Yoel Cho
exaly +3 more sources
NSUN2 promotes colorectal cancer progression by stabilizing PHGDH mRNA to promote serine metabolism reprogramming [PDF]
Cancer & MetabolismPurpose Cancer cells rely on serine biosynthesis for growth, but its regulation in colorectal cancer (CRC) remains not well understood. This study identifies the m5C methyltransferase NSUN2 (NOP2/Sun domain family, member 2) as a key regulator of serine ...
Hao Li +7 more
doaj +2 more sources
Phototriggered Morphological and Compositional Change of UGGAA Repeat RNA Foci by Photoswitchable RNA-Binding Ligand. [PDF]
Angew Chem Int Ed EnglWe here developed a molecular tool for the optical control of UGGAA repeat RNA foci, a pathological hallmark of spinocerebellar ataxia type 31 (SCA31). The photoswitchable RNA‐binding ligand enabled reversible control of the RNA foci. UV irradiation induced the growth of the RNA foci, while subsequent visible light irradiation dissolved the structure ...
Fujiwara Y, Shibata T, Dohno C.
europepmc +3 more sources