LINC02159 promotes non-small cell lung cancer progression via ALYREF/YAP1 signaling
Molecular Cancer, 2023 Lung cancer is the leading cause of cancer-related deaths worldwide. Long non-coding RNAs (lncRNAs) have emerged as key regulators of cancer development and progression, and as promising biomarkers for the diagnosis and prognosis of cancer. In this study,
Qiurong Yang +9 more
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An ALYREF-MYCN coactivator complex drives neuroblastoma tumorigenesis through effects on USP3 and MYCN stability [PDF]
Nature Communications, 2021 Neuroblastoma (NB) is often driven by MYCN amplification. Here, the authors show that the most frequent genetic lesion, gain of 17q21-ter in NB leads to overexpression of ALYREF, which forms a complex with MYCN, regulating MYCN stability via the ...
Janith Ananda Seneviratne +2 more
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Hypoxia Triggers ALYREF‐Mediated m5C Methylation of KIF20A to Activate KIF20A/BUB1 for Generating Ferroptosis Resistance in Cervical Cancer Cells [PDF]
Kaohsiung Journal of Medical SciencesFerroptosis resistance is a key player in cervical cancer (CC) development. Hypoxia is a negative factor affecting CC treatment by inducing ferroptosis resistance.
Yan Gao, Ting Zou
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Npj Precision OncologyALYREF can recognize 5-methylcytosine (m5C) decoration throughout RNAs to regulate RNA metabolism. However, its implications in cancer and precise regulatory mechanisms remain largely elusive. Here, we demonstrated that ALYREF supported colorectal cancer
Longhua Zhong +6 more
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Cell Death and DiseaseApproximately 70% of treatment failures in nasopharyngeal carcinoma (NPC) patients are attributed to distant metastasis, yet the underlying mechanisms remain unclear.
Ya-Nan Jin
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ALYREF mediates RNA m5C modification to promote hepatocellular carcinoma progression
Signal Transduction and Targeted Therapy, 2023 Chen Xue +9 more
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RNA binding protein ALYREF regulates ferroptosis to facilitate LUAD growth and metastasis via promoting SLC7A11 mRNA stability [PDF]
Scientific ReportsFerroptosis is of great significance in carcinogenesis as it interconnects with a multiplicity of biological processes. Meanwhile, its function and regulatory role in lung cancer remains ambiguous.
Yanni Chen +4 more
doaj +4 more sources
ALYREF associated with immune infiltration is a prognostic biomarker in hepatocellular carcinoma
Translational Oncology, 2022 Background: Although ALYREF has been demonstrated to have a role in a number of malignancies, its role in hepatocellular carcinoma (HCC) has received little attention.
Zhen-Zhen Wang +10 more
doaj +3 more sources
Incomplete activation of Alyref and Gabpb1 leads to preimplantation arrest in cloned mouse embryos
Life Science Alliance, 2023 This study shows that failed activation of developmentally required Alyref and Gabpb1 genes leads to the arrest of cloned mouse embryos. Differentiated cell nuclei can be reprogrammed after nuclear transfer (NT) to oocytes and the produced NT embryos can
Shunya Ihashi +16 more
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ALYREF inhibits ferroptosis in vascular endothelial cells and improves atherosclerosis by epigenetic modification of CISD1 [PDF]
Clinical EpigeneticsBackground Atherosclerosis (AS) is a disease marked by lipid metabolism dysfunction. Methylation of 5-methylcytosine (m5C) mRNA can regulate AS progression. We investigated the role and mechanism of m5C reader ALYREF in AS. Methods ApoE−/− mice AS models
Jinghai Hua +7 more
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