Results 11 to 20 of about 2,411 (105)

Lactylation-Boosted m⁵C RNA Modification Drives Choroidal Neovascularization. [PDF]

Research (Wash D C)
As a prevalent posttranscriptional RNA modification, N5-methylcytosine (m5C) plays a crucial role in a multitude of cellular responses and processes that govern RNA metabolism.
Zuo S, Li L, Tang J, Ye F, Sok, Liu Y, Ge S, Jia R, Fan X, Chai P, Lu L.   +10 more
europepmc   +2 more sources

Metabolic Recoding of NSUN2‐Mediated m5C Modification Promotes the Progression of Colorectal Cancer via the NSUN2/YBX1/m5C‐ENO1 Positive Feedback Loop

Advanced Science
The RNA modification, 5‐methylcytosine (m5C), has recently gained prominence as a pivotal post‐transcriptional regulator of gene expression, intricately intertwined with various tumorigenic processes.
Congqing Jiang, Baoxiang Chen
exaly   +2 more sources

Epigenetically upregulated NSUN2 confers ferroptosis resistance in endometrial cancer via m5C modification of SLC7A11 mRNA

Redox Biology
Endometrial cancer (EC) is a prevalent gynecological malignancy worldwide, and 5-methylcytosine (m5C) modification of mRNA is a crucial epigenetic modification associated with the development and occurrence of several cancers.
Hongfeng Zhang, Shuai-Jun Chen
exaly   +3 more sources

Oncogenic and immunological roles of NSUN2 in triple negative breast cancer. [PDF]

Sci Rep
Immunotherapy have led to clinical remissions in many solid tumors. However, the efficacy of immunotherapeutic monotherapy in triple-negative breast cancer (TNBC) is not very satisfactory. NSUN2 functions as a proto-oncogene in various cancers, promoting
An N, Zeng YF, Tian ZW, Tian J, Xu LF, Yang YL, Zheng HM, Zhang JW, Xi YQ.   +8 more
europepmc   +2 more sources

Enoxaparin alleviates preeclampsia by enhancing trophoblast function via the NSUN2-mediated m⁵C methylation of PAX3 mRNA. [PDF]

Eur J Med Res
Objective Preeclampsia (PE), a complex multisystem disorder, is a major contributor to maternal and perinatal morbidity and mortality. Enoxaparin, a low-molecular-weight heparin, has shown therapeutic efficacy in preventing various diseases.
Zhong X, Zeng D.
europepmc   +2 more sources

NOP2/Sun RNA methyltransferase 2 is a potential pan-cancer prognostic biomarker and is related to immunity.

PLoS ONE, 2023
BackgroundNOP2/Sun RNA methyltransferase 2 (NSUN2), an important methyltransferase of m5C, has been poorly studied in cancers, and the relationship between NSUN2 and immunity remains largely unclear.
Lemei Zheng, Mengna Li, Jianxia Wei, Shipeng Chen, Changning Xue, Yumei Duan, Faqing Tang, Guiyuan Li, Wei Xiong, Kelin She, Hongyu Deng, Ming Zhou   +11 more
doaj   +1 more source

Multi-omics analysis of expression and prognostic value of NSUN members in prostate cancer

Frontiers in Oncology, 2022
BackgroundProstate cancer is the most common tumor in men worldwide, seriously threatening the health of older men, and 5-methylcytosine (m5C) RNA modification has been shown to have a significant impact on the development and progression of various ...
Guangyu Sun, Shenfei Ma, Zhiwen Zheng, Xiaohua Wang, Shuaiqi Chen, Taihao Chang, Zhengxin Liang, Yuchen Jiang, Shengxian Xu, Ranlu Liu   +9 more
doaj   +1 more source

Positive epigenetic regulation loop between AR and NSUN2 promotes prostate cancer progression

Clinical and Translational Medicine, 2022
Background Prostate cancer (PCa) is a major type of cancer in man worldwide. Androgen deprivation therapy (ADT) and the next‐generation androgen receptor (AR) pathway inhibitors have acquired great success in treating PCa.
Wenkai Zhu, Fangning Wan, Wenhao Xu, Zheng Liu, Junjie Wang, Hena Zhang, Shenglin Huang, Dingwei Ye   +7 more
doaj   +1 more source

NSUN2 stimulates tumor progression via enhancing TIAM2 mRNA stability in pancreatic cancer

Cell Death Discovery, 2023
NSUN2 is a nuclear RNA methyltransferase which catalyzes 5-methylcytosine (m5C), a posttranscriptional RNA modification. Aberrant m5C modification has been implicated in the development of multiple malignancies. However, its function in pancreatic cancer
Guizhen Zhang, Liwen Liu, Jianhao Li, Yu Chen, Yun Wang, Yize Zhang, Zihui Dong, Wenhua Xue, Ranran Sun, Guangying Cui   +9 more
doaj   +1 more source

NSUN2 alleviates doxorubicin-induced myocardial injury through Nrf2-mediated antioxidant stress

Cell Death Discovery, 2023
Doxorubicin (DOX) is a commonly used antitumor drug, but its application has been limited because of its strong cardiac damage. This study aims to explore the role of NSUN2 in DOX-induced heart injury.
Yi Wang, Yuxin Zan, Yingying Huang, Xiaoyun Peng, Shinan Ma, Ji Ren, Xiao Li, Lin Wei, Xiaoli Wang, Yahong Yuan, Junming Tang, Zhongqun Zhan, Zhixiao Wang, Yan Ding   +13 more
doaj   +1 more source