NSUN2 introduces 5-methylcytosines in mammalian mitochondrial tRNAs [PDF]
Nucleic Acids Research, 2019 Expression of human mitochondrial DNA is indispensable for proper function of the oxidative phosphorylation machinery. The mitochondrial genome encodes 22 tRNAs, 2 rRNAs and 11 mRNAs and their post-transcriptional modification constitutes one of the key ...
Lindsey Van Haute +2 more
exaly +8 more sources
NSUN2 alleviates doxorubicin-induced myocardial injury through Nrf2-mediated antioxidant stress
Cell Death Discovery, 2023 Doxorubicin (DOX) is a commonly used antitumor drug, but its application has been limited because of its strong cardiac damage. This study aims to explore the role of NSUN2 in DOX-induced heart injury.
Yi Wang +13 more
doaj +3 more sources
NSUN2 stimulates tumor progression via enhancing TIAM2 mRNA stability in pancreatic cancer
Cell Death Discovery, 2023 NSUN2 is a nuclear RNA methyltransferase which catalyzes 5-methylcytosine (m5C), a posttranscriptional RNA modification. Aberrant m5C modification has been implicated in the development of multiple malignancies. However, its function in pancreatic cancer
Guizhen Zhang +9 more
doaj +3 more sources
NSUN2 Promotes Tumor Progression and Regulates Immune Infiltration in Nasopharyngeal Carcinoma
Frontiers in Oncology, 2022 Nasopharyngeal carcinoma (NPC) is one of the most common malignancies in the head and neck with a complex etiology, such as environmental factors, genetic factors, and Epstein–Barr virus infection.
Xinya Tong +10 more
doaj +3 more sources
Distinct Roles of m5C RNA Methyltransferase NSUN2 in Major Gynecologic Cancers [PDF]
Frontiers in Oncology, 2022 RNA methylation has recently emerged as an important category of epigenetic modifications, which plays diverse physiopathological roles in various cancers.
Lingfang Wang +13 more
doaj +3 more sources
NSUN2 restrains gastric cancer cell apoptosis and ferroptosis by promoting the m5C modification of EPYC. [PDF]
HereditasBackground Epiphycan (EPYC) has been confirmed to play an oncogenic role in many cancers. However, its role and mechanism in gastric cancer (GC) progression has not been explored.
Wu L, Chen B, Cheng S, Fang X, Zhou F.
europepmc +2 more sources
Redox BiologyLactate-mediated lactylation on target proteins is recently identified as the novel posttranslational modification with profound biological functions.
Zixiang Chen
exaly +3 more sources
Lactylation-Boosted m<sup>5</sup>C RNA Modification Drives Choroidal Neovascularization. [PDF]
Research (Wash D C)As a prevalent posttranscriptional RNA modification, N5-methylcytosine (m5C) plays a crucial role in a multitude of cellular responses and processes that govern RNA metabolism.
Zuo S +10 more
europepmc +2 more sources
NSUN2 Promotes Cardiac Hypertrophy by Activating LARP1–GATA4 Axis
EngineeringPathological cardiac hypertrophy contributes to the development of heart failure (HF). NOL1/NOP2/Sun domain family member 2 (NSUN2) is implicated in pathophysiological processes of many diseases.
Yingqi Liu +25 more
doaj +2 more sources
NSUN2-mediated mRNA m5C Modification Regulates the Progression of Hepatocellular Carcinoma
Genomics, Proteomics & Bioinformatics, 2023 RNA modifications affect many biological processes and physiological diseases. The 5-methylcytosine (m5C) modification regulates the progression of multiple tumors.
Dan Song +9 more
doaj +3 more sources