Results 11 to 20 of about 2,920 (152)

NSUN2 lactylation drives cancer cell resistance to ferroptosis through enhancing GCLC-dependent glutathione synthesis

Redox Biology
Lactate-mediated lactylation on target proteins is recently identified as the novel posttranslational modification with profound biological functions.
Kaifeng Niu, Yong-Liang Zhao, Zixiang Chen   +2 more
exaly   +4 more sources

The m5C methyltransferase NSUN2 promotes progression of acute myeloid leukemia by regulating serine metabolism

Cell Reports
Summary: Acute myeloid leukemia (AML) is one of the most prevalent heterogeneous hematologic malignancies with a complicated etiology. RNA post-transcriptional modifications have been linked to the incidence and progression of AML, while the detailed ...
Zhang-Hui Chen, Guangru Li, Guocai Wu
exaly   +4 more sources

Targeting the NSUN2–DHODH axis reverses ferroptosis resistance and oxaliplatin resistance in colorectal cancer [PDF]

Frontiers in Pharmacology
BackgroundOxaliplatin (OXA) is a standard chemotherapy for advanced colorectal cancer (CRC), yet acquired resistance frequently limits its efficacy.
Junyi Zhang, Junxiao Shen, Tangye Zeng, Chang Gao, Biao Sheng, Junliang Li, Weiqi Zeng, Jieyi Shen, Chong Shen, Jiaojiao Wang, Jiaojiao Wang, Jiaojiao Wang, Jianwei Wang, Jianwei Wang   +13 more
doaj   +3 more sources

NSUN2 alleviates doxorubicin-induced myocardial injury through Nrf2-mediated antioxidant stress

Cell Death Discovery, 2023
Doxorubicin (DOX) is a commonly used antitumor drug, but its application has been limited because of its strong cardiac damage. This study aims to explore the role of NSUN2 in DOX-induced heart injury.
Yi Wang, Yuxin Zan, Yingying Huang, Xiaoyun Peng, Shinan Ma, Ji Ren, Xiao Li, Lin Wei, Xiaoli Wang, Yahong Yuan, Junming Tang, Zhongqun Zhan, Zhixiao Wang, Yan Ding   +13 more
doaj   +2 more sources

NSUN2-mediated m5C methylation of IRF3 mRNA negatively regulates type I interferon responses during various viral infections

Emerging Microbes and Infections, 2023
5-Methylcytosine (m5C) is a widespread post-transcriptional RNA modification and is reported to be involved in manifold cellular responses and biological processes through regulating RNA metabolism.
Hongyun Wang, Jiangpeng Feng, Cong Zeng, Jiejie Liu, Zhiying Fu, Dehe Wang, Yafen Wang, Lu Zhang, Jiali Li, Ao Jiang, Miao He, Yuanyuan Cao, Kun Yan, Hao Tang, Deyin Guo, Ke Xu, Xiang Zhou, Li Zhou, Ke Lan, Yu Zhou, Yu Chen   +20 more
doaj   +2 more sources

NSUN2 Promotes Cardiac Hypertrophy by Activating LARP1–GATA4 Axis

Engineering
Pathological cardiac hypertrophy contributes to the development of heart failure (HF). NOL1/NOP2/Sun domain family member 2 (NSUN2) is implicated in pathophysiological processes of many diseases.
Yingqi Liu, Fan Wu, Kuiwu Liu, Shuting Yu, Changhao Wang, Xin Li, Zhiyong Sun, Wanhong Li, Yi Zhang, Tiantian Ju, Qian Liu, Min Huang, Zhongting Mei, Zhezhe Qu, Meixi Lu, Xiaochen Pang, Yingqiong Jia, Jianhao Jiang, Shunkang Dou, Na Li, Yaozhi Zhang, Ying Li, Chuanhao Huang, Yuechao Dong, Baofeng Yang, Weijie Du   +25 more
doaj   +2 more sources

NSUN2–tRNAVal−CAC-axis-regulated codon-biased translation drives triple-negative breast cancer glycolysis and progression

Cellular & Molecular Biology Letters
Background Epitranscriptomic data indicate that aberrant tRNA modifications in malignant diseases can promote tumor growth by facilitating oncogene translation.
Wenlong Wang, Ying Ding, Haixi Zhao, Shouman Wang, Juan Huang, Lunquan Sun   +5 more
doaj   +2 more sources

Tumor cell-intrinsic NSUN2 deficiency reprograms macrophages to sensitize non-small cell lung cancer to EGFR inhibitors by reversing immune evasion [PDF]

Neoplasia: An International Journal for Oncology Research
Despite EGFR-tyrosine kinase inhibitors (EGFR-TKI) have improved outcomes in non-small cell lung cancer (NSCLC), acquired resistance remains a challenge.
Yueqin Wang, Jingyao Wei, Wenbin Xu, Yu Zhang, Luyao Feng, Lizhen Zhang, Shuaibing Liu, Xin Tian   +7 more
doaj   +2 more sources

NSUN2-mediated mRNA m5C Modification Regulates the Progression of Hepatocellular Carcinoma

Genomics, Proteomics & Bioinformatics, 2023
RNA modifications affect many biological processes and physiological diseases. The 5-methylcytosine (m5C) modification regulates the progression of multiple tumors.
Dan Song, Ke An, Wenlong Zhai, Luyao Feng, Yingjie Xu, Ran Sun, Yueqin Wang, Yun-Gui Yang, Quancheng Kan, Xin Tian   +9 more
doaj   +2 more sources

RNA methyltransferase NSUN2-mediated m5C methylation promotes Cr(VI)-induced malignant transformation and lung cancer by accelerating metabolism reprogramming

Environment International
Hexavalent chromium [Cr(VI)], one common environmental contaminant, has long been recognized as a carcinogen associated with lung cancer, but roles and mechanisms of Cr(VI)-induced epigenetic dysregulations in carcinogenesis remain to be investigated. In
Bing-Hua Jiang, Fan-Li Sun
exaly   +3 more sources