Results 11 to 20 of about 2,478 (156)

Oncogenic and immunological roles of NSUN2 in triple negative breast cancer [PDF]

Scientific Reports
Immunotherapy have led to clinical remissions in many solid tumors. However, the efficacy of immunotherapeutic monotherapy in triple-negative breast cancer (TNBC) is not very satisfactory. NSUN2 functions as a proto-oncogene in various cancers, promoting
Ning An, Yi-Fan Zeng, Zhuo-wan Tian, Jie Tian, Ling-Feng Xu, Ya-Long Yang, Hong-Mei Zheng, Jing-Wei Zhang, Yi-qing Xi   +8 more
doaj   +4 more sources

Metabolic Recoding of NSUN2‐Mediated m5C Modification Promotes the Progression of Colorectal Cancer via the NSUN2/YBX1/m5C‐ENO1 Positive Feedback Loop

Advanced Science
The RNA modification, 5‐methylcytosine (m5C), has recently gained prominence as a pivotal post‐transcriptional regulator of gene expression, intricately intertwined with various tumorigenic processes.
Congqing Jiang, Lifang Fan, Baoxiang Chen   +2 more
exaly   +4 more sources

NSUN2 Promotes Tumor Progression and Regulates Immune Infiltration in Nasopharyngeal Carcinoma

Frontiers in Oncology, 2022
Nasopharyngeal carcinoma (NPC) is one of the most common malignancies in the head and neck with a complex etiology, such as environmental factors, genetic factors, and Epstein–Barr virus infection.
Xinya Tong, Yilan Xiang, Yuanbo Hu, Yuanbo Hu, Yingying Hu, Yingying Hu, He Li, Huilin Wang, Kong-Nan Zhao, Xiangyang Xue, Shanli Zhu   +10 more
doaj   +3 more sources

NSUN2 restrains gastric cancer cell apoptosis and ferroptosis by promoting the m5C modification of EPYC [PDF]

Hereditas
Background Epiphycan (EPYC) has been confirmed to play an oncogenic role in many cancers. However, its role and mechanism in gastric cancer (GC) progression has not been explored.
Lei Wu, Boxuan Chen, Si Cheng, Xiaofeng Fang, Fen Zhou   +4 more
doaj   +2 more sources

NSUN2 lactylation drives cancer cell resistance to ferroptosis through enhancing GCLC-dependent glutathione synthesis

Redox Biology
Lactate-mediated lactylation on target proteins is recently identified as the novel posttranslational modification with profound biological functions.
Zixiang Chen, Guannan Ma, Di Wei
exaly   +3 more sources

RNA methyltransferase NSUN2-mediated m5C methylation promotes Cr(VI)-induced malignant transformation and lung cancer by accelerating metabolism reprogramming

Environment International
Hexavalent chromium [Cr(VI)], one common environmental contaminant, has long been recognized as a carcinogen associated with lung cancer, but roles and mechanisms of Cr(VI)-induced epigenetic dysregulations in carcinogenesis remain to be investigated. In
Yun-Xia Xie, Jian-Ge Qiu, Bing-Hua Jiang   +2 more
exaly   +3 more sources

NSUN2-mediated mRNA m5C Modification Regulates the Progression of Hepatocellular Carcinoma

Genomics, Proteomics & Bioinformatics, 2023
RNA modifications affect many biological processes and physiological diseases. The 5-methylcytosine (m5C) modification regulates the progression of multiple tumors.
Dan Song, Ke An, Wenlong Zhai, Luyao Feng, Yingjie Xu, Ran Sun, Yueqin Wang, Yun-Gui Yang, Quancheng Kan, Xin Tian   +9 more
doaj   +3 more sources

Lactylation-Boosted m5C RNA Modification Drives Choroidal Neovascularization [PDF]

Research
As a prevalent posttranscriptional RNA modification, N5-methylcytosine (m5C) plays a crucial role in a multitude of cellular responses and processes that govern RNA metabolism.
Sipeng Zuo, Lin Li, Jieling Tang, Fuxiang Ye, Sok, Yan Liu, Shengfang Ge, Renbing Jia, Xianqun Fan, Peiwei Chai, Linna Lu   +10 more
doaj   +2 more sources

NSUN2 Promotes Cardiac Hypertrophy by Activating LARP1–GATA4 Axis

Engineering
Pathological cardiac hypertrophy contributes to the development of heart failure (HF). NOL1/NOP2/Sun domain family member 2 (NSUN2) is implicated in pathophysiological processes of many diseases.
Yingqi Liu, Fan Wu, Kuiwu Liu, Shuting Yu, Changhao Wang, Xin Li, Zhiyong Sun, Wanhong Li, Yi Zhang, Tiantian Ju, Qian Liu, Min Huang, Zhongting Mei, Zhezhe Qu, Meixi Lu, Xiaochen Pang, Yingqiong Jia, Jianhao Jiang, Shunkang Dou, Na Li, Yaozhi Zhang, Ying Li, Chuanhao Huang, Yuechao Dong, Baofeng Yang, Weijie Du   +25 more
doaj   +2 more sources

Enoxaparin alleviates preeclampsia by enhancing trophoblast function via the NSUN2-mediated m5C methylation of PAX3 mRNA [PDF]

European Journal of Medical Research
Objective Preeclampsia (PE), a complex multisystem disorder, is a major contributor to maternal and perinatal morbidity and mortality. Enoxaparin, a low-molecular-weight heparin, has shown therapeutic efficacy in preventing various diseases.
Xuan Zhong, Danfeng Zeng
doaj   +2 more sources