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Scientific Reports5-Methylcytosine (m5C) is closely associated with cancer. However, the role of m5C in breast cancer(BC)remains unclear. This study combined single-cell RNA sequencing (scRNA-Seq) and transcriptomics datasets to screen m5C regulators associated with BC ...
Zhe Wang +12 more
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Engineering Reports5‐Methylcytosine (m5C) is a widely recognized epigenetic modification in ribonucleic acid (RNA), catalyzed by methyltransferases. This modification is crucial for various biological functions. While the role of m5C in deoxyribonucleic acid (DNA) has been
Shahid Qazi +6 more
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The role of m5C methyltransferases in cardiovascular diseases
Frontiers in Cardiovascular Medicine, 2023 The global leading cause of death is cardiovascular disease (CVD). Although advances in prevention and treatment have been made, the role of RNA epigenetics in CVD is not fully understood. Studies have found that RNA modifications regulate gene expression in mammalian cells, and m5C (5-methylcytosine) is a recently discovered RNA modification that ...
Yan-Yue Wang +6 more
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Cell Host & Microbe, 2019 In this issue of Cell Host & Microbe, Courtney et al. (2019a) find that HIV-1 genomic RNA has much more m5C than cellular mRNA. Deleting the m5C "writer" NSUN2 decreases HIV-1 m5C levels, promotes translation of the HIV-1 5' gag gene, and alters splicing at the A2 site.
Shelby, Winans, Karen, Beemon
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A CNN based m5c RNA methylation predictor
Scientific Reports, 2023 AbstractPost-transcriptional modifications of RNA play a key role in performing a variety of biological processes, such as stability and immune tolerance, RNA splicing, protein translation and RNA degradation. One of these RNA modifications is m5c which participates in various cellular functions like RNA structural stability and translation efficiency,
Irum Aslam +6 more
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The potential regulatory role of RNA methylation in ovarian cancer
RNA Biology, 2023 Updates in whole genome sequencing technologies have revealed various RNA modifications in cancer, among which RNA methylation is a frequent posttranscriptional modification.
Shijie Zhao +5 more
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Frontiers in Oncology, 2022 PurposeStudies reported that 5-methylcytosine (m5C) RNA transferase alters tumor progression; however, studies of m5C-related lncRNA remain lacking. This article intends to study the lncRNA modified by m5C RNA transferase in hepatocellular carcinoma ...
Qi Pan, Caiyu Yi, Yijie Zhang
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Predictive value of m5C regulatory gene expression in pancreatic adenocarcinoma [PDF]
Scientific Reports, 2021 Abstract Pancreatic adenocarcinoma (PAAD) is the most malignant digestive tumor. The global incidence of pancreatic cancer has been rapidly trending upwards, necessitating an exploration of potential prognostic biomarkers and mechanisms of disease development.
Xiao Yu +6 more
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Mitomycin C binding to poly[d(G-m5C)] [PDF]
Biochemical Journal, 1995 Poly[d(G-m5C)] was modified by reductively activated mitomycin C, an anti-tumour drug, under buffer conditions which are known to favour either the B or the Z conformations of DNA. C.d. and 31P-n.m.r. were used to characterize the poly[d(G-m5C)]-mitomycin cross-linked complexes, as well as the effects on the equilibrium between the B and Z forms of the
Portugal, José +1 more
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m5CPred-SVM: A Novel Method for Predicting m5C Sites of RNA [PDF]
BMC Bioinformatics, 2020 Abstract Background: As one of the most common post-transcriptional modifications (PTCM) in RNA, 5-cytosine-methylation plays important roles in many biological functionssuch as RNA metabolism and cell fate decision. Through accurate identification of 5-methylcytosine (m5C) sites on RNA,researcherscanbetter understandthe exact role of 5 ...
Xiao Chen +5 more
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