Results 21 to 30 of about 11,326 (215)

Predictive value of m5C regulatory gene expression in pancreatic adenocarcinoma [PDF]

Scientific Reports, 2021
Abstract Pancreatic adenocarcinoma (PAAD) is the most malignant digestive tumor. The global incidence of pancreatic cancer has been rapidly trending upwards, necessitating an exploration of potential prognostic biomarkers and mechanisms of disease development.
Xiao Yu, Qiyao Zhang, Fang Gao, Menggang Zhang, Qingyuan Zheng, Yuting He, Wenzhi Guo   +6 more
openaire   +3 more sources

The potential regulatory role of RNA methylation in ovarian cancer

RNA Biology, 2023
Updates in whole genome sequencing technologies have revealed various RNA modifications in cancer, among which RNA methylation is a frequent posttranscriptional modification.
Shijie Zhao, Mengxue Zhang, Xiaolan Zhu, Jie Xing, Jiaming Zhou, Xinming Yin   +5 more
doaj   +1 more source

Mitomycin C binding to poly[d(G-m5C)] [PDF]

Biochemical Journal, 1995
Poly[d(G-m5C)] was modified by reductively activated mitomycin C, an anti-tumour drug, under buffer conditions which are known to favour either the B or the Z conformations of DNA. C.d. and 31P-n.m.r. were used to characterize the poly[d(G-m5C)]-mitomycin cross-linked complexes, as well as the effects on the equilibrium between the B and Z forms of the
Portugal, José, Sánchez Baeza, Francisco J.   +1 more
openaire   +3 more sources

m5CPred-SVM:  A Novel Method for Predicting m5C Sites of RNA [PDF]

BMC Bioinformatics, 2020
Abstract Background: As one of the most common post-transcriptional modifications (PTCM) in RNA, 5-cytosine-methylation plays important roles in many biological functionssuch as RNA metabolism and cell fate decision. Through accurate identification of 5-methylcytosine (m5C) sites on RNA,researcherscanbetter understandthe exact role of 5 ...
Xiao Chen, Yi Xiong 0002, Yinbo Liu, Yuqing Chen, Shoudong Bi, Xiaolei Zhu 0001   +5 more
openaire   +3 more sources

Advances in RNA cytosine-5 methylation: detection, regulatory mechanisms, biological functions and links to cancer

Biomarker Research, 2020
As an important posttranscriptional modification of RNA, 5-methylcytosine (m5C) has attracted increasing interest recently, with accumulating evidence suggesting the involvement of RNA m5C modification in multiple cellular processes as well as ...
Chen Xue, Yalei Zhao, Lanjuan Li
doaj   +1 more source

Transcriptome-Wide Annotation of m5C RNA Modifications Using Machine Learning

Frontiers in Plant Science, 2018
The emergence of epitranscriptome opened a new chapter in gene regulation. 5-methylcytosine (m5C), as an important post-transcriptional modification, has been identified to be involved in a variety of biological processes such as subcellular localization
Jie Song, Jie Song, Jingjing Zhai, Enze Bian, Yujia Song, Jiantao Yu, Chuang Ma, Chuang Ma   +7 more
doaj   +1 more source

Cytosine-to-Uracil Deamination by SssI DNA Methyltransferase [PDF]

, 2013
The prokaryotic DNA(cytosine-5)methyltransferase M.SssI shares the specificity of eukaryotic DNA methyltransferases (CG) and is an important model and experimental tool in the study of eukaryotic DNA methylation.
A Beletskii, A Jeltsch, AN Sharath, Antal Kiss, AS Yang, B Bandaru, B Bandaru, B Chaikind, BM Hall, BTF van der Gun, DM Woodcock, EA Raleigh, EU Selker, EV Koudan, G Pósfai, GL Xu, H Gowher, I Stier, Ildikó Stier, J Sambrook, JC Shen, JC Shen, JC Shen, JM Zingg, JM Zingg, KM Reinisch, LA Frederico, LM Guzman, M Frommer, M Wyszynski, Martin G. Marinus, MH Sibley, P Rathert, P Renbaum, PA Waite-Rees, PM Warnecke, R Métivier, R Shapiro, RJ Roberts, RY-H Wang, S Kumar, SE Luria, T Durfee, TA Kunkel, UT Sankpal, WA Rosche, X Cheng, X Zhang   +47 more
core   +3 more sources

Characterization of BisI Homologs

Frontiers in Microbiology, 2021
BisI is a sequence-specific and 5-methylcytosine (m5C)-dependent restriction endonuclease (REase), that cleaves the modified DNA sequence Gm5CNGC (G indicates that the cytosine opposite to G is modified).
Shuang-yong Xu, Elena V. Zemlyanskaya, Danila A. Gonchar, Zhiyi Sun, Peter Weigele, Alexey Fomenkov, Sergey Kh Degtyarev, Richard J. Roberts   +7 more
doaj   +1 more source

Insights into the role of DNA methylation in diatoms by genome-wide profiling in Phaeodactylum tricornutum [PDF]

, 2013
DNA cytosine methylation is a widely conserved epigenetic mark in eukaryotes that appears to have critical roles in the regulation of genome structure and transcription.
Ahmed, Ikhlak, Allen, Andrew, Bhavsar, Jaysheel, Bondurant, Sandra Splinter, Bowler, Chris, Creasy, Todd, Crom, Stéphane Le, Farrant, Gregory K., Lin, Xin, Maumus, Florian, O'Brien, Kimberly, Olson, Sue A., Rabinowicz, Pablo D., Rayko, Edda, Rivarola, Maximo Lisandro, Sengamalay, Naomi A., Sgro, Jean-Yves, Smith, Andrew D., Sussman, Michael R., Tallon, Luke J., Tirichine, Leïla, Veluchamy, Alaguraj   +21 more
core   +3 more sources

m5C regulator-mediated modification patterns and tumor microenvironment infiltration characterization in colorectal cancer: One step closer to precision medicine

Frontiers in Immunology, 2022
BackgroundThe RNA modification 5-methylcytosine (m5C) is one of the most prevalent post-transcriptional modifications, with increasing evidence demonstrating its extensive involvement in the tumorigenesis and progression of various cancers.
Baoxiang Chen, Baoxiang Chen, Baoxiang Chen, Yiqing Xi, Jianhong Zhao, Jianhong Zhao, Yuntian Hong, Yuntian Hong, Yuntian Hong, Shunhua Tian, Shunhua Tian, Shunhua Tian, Xiang Zhai, Xiang Zhai, Xiang Zhai, Quanjiao Chen, Xianghai Ren, Xianghai Ren, Xianghai Ren, Lifang Fan, Xiaoyu Xie, Xiaoyu Xie, Xiaoyu Xie, Congqing Jiang, Congqing Jiang, Congqing Jiang   +25 more
doaj   +1 more source