Results 21 to 30 of about 7,626 (175)

Mitomycin C binding to poly[d(G-m5C)] [PDF]

Biochemical Journal, 1995
Poly[d(G-m5C)] was modified by reductively activated mitomycin C, an anti-tumour drug, under buffer conditions which are known to favour either the B or the Z conformations of DNA. C.d. and 31P-n.m.r. were used to characterize the poly[d(G-m5C)]-mitomycin cross-linked complexes, as well as the effects on the equilibrium between the B and Z forms of the
Portugal, José, Sánchez Baeza, Francisco J.   +1 more
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m5CPred-SVM:  A Novel Method for Predicting m5C Sites of RNA [PDF]

BMC Bioinformatics, 2020
Abstract Background: As one of the most common post-transcriptional modifications (PTCM) in RNA, 5-cytosine-methylation plays important roles in many biological functionssuch as RNA metabolism and cell fate decision. Through accurate identification of 5-methylcytosine (m5C) sites on RNA,researcherscanbetter understandthe exact role of 5 ...
Xiao Chen, Yi Xiong 0002, Yinbo Liu, Yuqing Chen, Shoudong Bi, Xiaolei Zhu 0001   +5 more
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Predictive value of m5C regulatory gene expression in pancreatic adenocarcinoma [PDF]

Scientific Reports, 2021
Abstract Pancreatic adenocarcinoma (PAAD) is the most malignant digestive tumor. The global incidence of pancreatic cancer has been rapidly trending upwards, necessitating an exploration of potential prognostic biomarkers and mechanisms of disease development.
Xiao Yu, Qiyao Zhang, Fang Gao, Menggang Zhang, Qingyuan Zheng, Yuting He, Wenzhi Guo   +6 more
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m5C regulator-mediated modification patterns and tumor microenvironment infiltration characterization in colorectal cancer: One step closer to precision medicine

Frontiers in Immunology, 2022
BackgroundThe RNA modification 5-methylcytosine (m5C) is one of the most prevalent post-transcriptional modifications, with increasing evidence demonstrating its extensive involvement in the tumorigenesis and progression of various cancers.
Baoxiang Chen, Baoxiang Chen, Baoxiang Chen, Yiqing Xi, Jianhong Zhao, Jianhong Zhao, Yuntian Hong, Yuntian Hong, Yuntian Hong, Shunhua Tian, Shunhua Tian, Shunhua Tian, Xiang Zhai, Xiang Zhai, Xiang Zhai, Quanjiao Chen, Xianghai Ren, Xianghai Ren, Xianghai Ren, Lifang Fan, Xiaoyu Xie, Xiaoyu Xie, Xiaoyu Xie, Congqing Jiang, Congqing Jiang, Congqing Jiang   +25 more
doaj   +1 more source

Advances in RNA cytosine-5 methylation: detection, regulatory mechanisms, biological functions and links to cancer

Biomarker Research, 2020
As an important posttranscriptional modification of RNA, 5-methylcytosine (m5C) has attracted increasing interest recently, with accumulating evidence suggesting the involvement of RNA m5C modification in multiple cellular processes as well as ...
Chen Xue, Yalei Zhao, Lanjuan Li
doaj   +1 more source

5-Methylcytosine (m5C) modification in peripheral blood immune cells is a novel non-invasive biomarker for colorectal cancer diagnosis

Frontiers in Immunology, 2022
Current non-invasive tumor biomarkers failed to accurately identify patients with colorectal cancer (CRC), delaying CRC diagnosis and thus leading to poor prognosis.
Haofan Yin, Haofan Yin, Zhijian Huang, Zhijian Huang, Shiqiong Niu, Liang Ming, Hongbo Jiang, Liang Gu, Liang Gu, Weibin Huang, Weibin Huang, Jinye Xie, Yulong He, Yulong He, Changhua Zhang, Changhua Zhang   +15 more
doaj   +1 more source

Diagnostic and prognostic value of m5C regulatory genes in hepatocellular carcinoma

Frontiers in Genetics, 2022
Background: A high mortality rate makes hepatocellular carcinoma (HCC) one of the most common types of cancer globally. 5-methylcytosine (m5C) is an epigenetic modification that contributes to the prognosis of several cancers, but its relevance to HCC remains unknown. We sought to determine if the m5C-related regulators had any diagnostic or prognostic
Xiawei Yang, Feng Yang, Liugen Lan, Liugen Lan, Liugen Lan, Liugen Lan, Ning Wen, Ning Wen, Ning Wen, Ning Wen, Haibin Li, Haibin Li, Haibin Li, Haibin Li, Xuyong Sun, Xuyong Sun, Xuyong Sun, Xuyong Sun, Xuyong Sun   +18 more
openaire   +3 more sources

Overview of distinct 5-methylcytosine profiles of messenger RNA in human hepatocellular carcinoma and paired adjacent non-tumor tissues

Journal of Translational Medicine, 2020
Background Post-transcriptional methylation modifications, including 5-methylcytosine (m5C) modification, are closely related to the tumorigenesis of cancers.
Qiyao Zhang, Qingyuan Zheng, Xiao Yu, Yuting He, Wenzhi Guo   +4 more
doaj   +1 more source

Overview of distinct 5-methylcytosine profiles of messenger RNA in normal and knock-down NSUN2 colorectal cancer cells

Frontiers in Genetics, 2023
Background: Colorectal cancer (CRC) is a harmful cancer with high morbidity and poor prognosis. There is growing evidence that RNA methylation is closely related to the occurrence of cancer and its malignant biological behavior.
Yu Lin, Yu Lin, Yu Lin, Zhifang Zhao, Wenqiang Nie, Manting Huang, Jiazhong Cai, Yadong Wang, Hesong Wang, Yongmei Huang, Yang Bai, Yang Bai   +11 more
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5-Methylcytosine profiles in mouse transcriptomes suggest the randomness of m5C formation catalyzed by RNA methyltransferase

BMC Research Notes, 2022
Objective 5-Methylcytosine (m5C) is a type of chemical modification on the nucleotides and is widespread in both DNA and RNA. Although the DNA m5C has been extensively studied over the past years, the distribution and biological function of RNA m5C still
Junfeng Liu
doaj   +1 more source