Results 21 to 30 of about 7,166 (173)

Characterization of BisI Homologs

Frontiers in Microbiology, 2021
BisI is a sequence-specific and 5-methylcytosine (m5C)-dependent restriction endonuclease (REase), that cleaves the modified DNA sequence Gm5CNGC (G indicates that the cytosine opposite to G is modified).
Shuang-yong Xu, Elena V. Zemlyanskaya, Danila A. Gonchar, Zhiyi Sun, Peter Weigele, Alexey Fomenkov, Sergey Kh Degtyarev, Richard J. Roberts   +7 more
doaj   +1 more source

m5C: Novel Diagnostic and Drug Repurposing Targets for Nonalcoholic Steatohepatitis. [PDF]

Int J Genomics
Background Epigenetic medication, such as RNA 5‐methylcytosine (m5C), is well‐recognized as a key regulator in hepatic metabolism and immune responses. However, m5C regulatory mechanisms in NASH pathogenesis have not yet been clearly elucidated. Methods
Chen S, Duan R, Qiu J, Lei Z, Chen W, Li X.   +5 more
europepmc   +3 more sources

m5C regulator-mediated modification patterns and tumor microenvironment infiltration characterization in colorectal cancer: One step closer to precision medicine

Frontiers in Immunology, 2022
BackgroundThe RNA modification 5-methylcytosine (m5C) is one of the most prevalent post-transcriptional modifications, with increasing evidence demonstrating its extensive involvement in the tumorigenesis and progression of various cancers.
Baoxiang Chen, Baoxiang Chen, Baoxiang Chen, Yiqing Xi, Jianhong Zhao, Jianhong Zhao, Yuntian Hong, Yuntian Hong, Yuntian Hong, Shunhua Tian, Shunhua Tian, Shunhua Tian, Xiang Zhai, Xiang Zhai, Xiang Zhai, Quanjiao Chen, Xianghai Ren, Xianghai Ren, Xianghai Ren, Lifang Fan, Xiaoyu Xie, Xiaoyu Xie, Xiaoyu Xie, Congqing Jiang, Congqing Jiang, Congqing Jiang   +25 more
doaj   +1 more source

Advances in RNA cytosine-5 methylation: detection, regulatory mechanisms, biological functions and links to cancer

Biomarker Research, 2020
As an important posttranscriptional modification of RNA, 5-methylcytosine (m5C) has attracted increasing interest recently, with accumulating evidence suggesting the involvement of RNA m5C modification in multiple cellular processes as well as ...
Chen Xue, Yalei Zhao, Lanjuan Li
doaj   +1 more source

Diagnostic and prognostic value of m5C regulatory genes in hepatocellular carcinoma

Frontiers in Genetics, 2022
Background: A high mortality rate makes hepatocellular carcinoma (HCC) one of the most common types of cancer globally. 5-methylcytosine (m5C) is an epigenetic modification that contributes to the prognosis of several cancers, but its relevance to HCC remains unknown. We sought to determine if the m5C-related regulators had any diagnostic or prognostic
Xiawei Yang, Feng Yang, Liugen Lan, Liugen Lan, Liugen Lan, Liugen Lan, Ning Wen, Ning Wen, Ning Wen, Ning Wen, Haibin Li, Haibin Li, Haibin Li, Haibin Li, Xuyong Sun, Xuyong Sun, Xuyong Sun, Xuyong Sun, Xuyong Sun   +18 more
openaire   +3 more sources

5-Methylcytosine (m5C) modification in peripheral blood immune cells is a novel non-invasive biomarker for colorectal cancer diagnosis

Frontiers in Immunology, 2022
Current non-invasive tumor biomarkers failed to accurately identify patients with colorectal cancer (CRC), delaying CRC diagnosis and thus leading to poor prognosis.
Haofan Yin, Haofan Yin, Zhijian Huang, Zhijian Huang, Shiqiong Niu, Liang Ming, Hongbo Jiang, Liang Gu, Liang Gu, Weibin Huang, Weibin Huang, Jinye Xie, Yulong He, Yulong He, Changhua Zhang, Changhua Zhang   +15 more
doaj   +1 more source

Overview of distinct 5-methylcytosine profiles of messenger RNA in normal and knock-down NSUN2 colorectal cancer cells

Frontiers in Genetics, 2023
Background: Colorectal cancer (CRC) is a harmful cancer with high morbidity and poor prognosis. There is growing evidence that RNA methylation is closely related to the occurrence of cancer and its malignant biological behavior.
Yu Lin, Yu Lin, Yu Lin, Zhifang Zhao, Wenqiang Nie, Manting Huang, Jiazhong Cai, Yadong Wang, Hesong Wang, Yongmei Huang, Yang Bai, Yang Bai   +11 more
doaj   +1 more source

Overview of distinct 5-methylcytosine profiles of messenger RNA in human hepatocellular carcinoma and paired adjacent non-tumor tissues

Journal of Translational Medicine, 2020
Background Post-transcriptional methylation modifications, including 5-methylcytosine (m5C) modification, are closely related to the tumorigenesis of cancers.
Qiyao Zhang, Qingyuan Zheng, Xiao Yu, Yuting He, Wenzhi Guo   +4 more
doaj   +1 more source

An Enzymatic Platform for Late‐Stage (Radio)isotope Labelling of Oligonucleotides With Methyltransferases

Angewandte Chemie, EarlyView.
State‐of‐the‐art synthesis of radiolabelled oligonucleotides involves multi‐step synthesis with high costs, extended timelines and significant radioactive waste generation. Herein, a dual‐methyltransferase platform enables late‐stage, site‐specific labelling, overcoming these limitations through reduced costs, faster turnaround and minimal radioactive ...
Christopher R. B. Swanson, Ulrich Kauhl, Martin R. Edelmann, Florian P. Seebeck   +3 more
wiley   +2 more sources

5-Methylcytosine profiles in mouse transcriptomes suggest the randomness of m5C formation catalyzed by RNA methyltransferase

BMC Research Notes, 2022
Objective 5-Methylcytosine (m5C) is a type of chemical modification on the nucleotides and is widespread in both DNA and RNA. Although the DNA m5C has been extensively studied over the past years, the distribution and biological function of RNA m5C still
Junfeng Liu
doaj   +1 more source