Results 1 to 10 of about 53,902 (279)

N6-methyladenosine methylation in kidney injury

Clinical Epigenetics, 2023
Multiple mechanisms are involved in kidney damage, among which the role of epigenetic modifications in the occurrence and development of kidney diseases is constantly being revealed.
Qimeng Wang, Xiaoting Fan, Qinghao Sheng, Meilin Yang, Ping Zhou, Shangwei Lu, Ying Gao, Zhijuan Kong, Ning Shen, Zhimei Lv, Rong Wang   +10 more
doaj   +4 more sources

Benchmark data for identifying N6-methyladenosine sites in the Saccharomyces cerevisiae genome [PDF]

Data in Brief, 2015
This data article contains the benchmark dataset for training and testing iRNA-Methyl, a web-server predictor for identifying N6-methyladenosine sites in RNA (Chen et al., 2015 [15]).
Wei Chen, Pengmian Feng, Hui Ding, Hao Lin, Kuo-Chen Chou   +4 more
doaj   +2 more sources

Roles and implications of mRNA N6-methyladenosine in cancer

Cancer Communications, 2023
RNA N6‐methyladenosine modification is the most prevalent internal modification of eukaryotic RNAs and has emerged as a novel field of RNA epigenetics, garnering increased attention.
Jian Zheng, Jialiang Zhang, Lingxing Zeng   +2 more
exaly   +2 more sources

Multigenerational paternal obesity enhances the susceptibility to male subfertility in offspring via Wt1 N6-methyladenosine modification

Nature Communications
There is strong evidence that obesity is a risk factor for poor semen quality. However, the effects of multigenerational paternal obesity on the susceptibility to cadmium (a reproductive toxicant)-induced spermatogenesis disorders in offspring remain ...
Yong-Wei Xiong, Hua-Long Zhu, Jin Zhang, Hao Geng, Lu-Lu Tan, Xin-Mei Zheng, Hao Li, Long-Long Fan, Xin-Run Wang, Xu-Dong Zhang, Kai-Wen Wang, Wei Chang, Yu-Feng Zhang, Zhi Yuan, Zong-Liu Duan, Yun-Xia Cao, Xiao-Jin He, De-Xiang Xu, Hua Wang   +18 more
doaj   +2 more sources

N6-methyladenosine RNA methylation: From regulatory mechanisms to potential clinical applications

Frontiers in Cell and Developmental Biology, 2022
Epitranscriptomics has emerged as another level of epigenetic regulation similar to DNA and histone modifications. N6-methyladenosine (m6A) is one of the most prevalent and abundant posttranscriptional modifications, widely distributed in many biological
Peipei Li, Peipei Li, Yuntao Wang, Yiwen Sun, Sanjie Jiang, Jingjing Li   +5 more
doaj   +1 more source

One Stone, Two Birds: N6-Methyladenosine RNA Modification in Leukemia Stem Cells and the Tumor Immune Microenvironment in Acute Myeloid Leukemia

Frontiers in Immunology, 2022
Acute myeloid leukemia is the most common acute leukemia in adults, with accumulation of abundant blasts and impairment of hematogenic function. Despite great advances in diagnosis and therapy, the overall survival of patients with acute myeloid leukemia
Xianfeng Ouyang, Xianfeng Ouyang, Yuping Gong   +2 more
doaj   +1 more source

RNA methylation in vascular disease: a systematic review

Journal of Cardiothoracic Surgery, 2022
Despite the rise in morbidity and mortality associated with vascular diseases, the underlying pathophysiological molecular mechanisms are still unclear.
Yue Shu, Yilong Guo, Yin Zheng, Shuwu He, Zhensu Shi   +4 more
doaj   +1 more source

Acetaminophen changes the RNA m6A levels and m6A-related proteins expression in IL-1β-treated chondrocyte cells

BMC Molecular and Cell Biology, 2022
Background Acetaminophen is commonly recommended for the early analgesia of osteoarthritis. However, the molecular mechanism by which it acts remains unknown.
Jie Gao, Yan Li, Zijin Liu, Dong Wang, Huawu Zhang   +4 more
doaj   +1 more source

RNA N6-methyladenosine: a promising molecular target in metabolic diseases

Cell & Bioscience, 2020
N6-methyladenosine is a prevalent and abundant transcriptome modification, and its methylation regulates the various aspects of RNAs, including transcription, translation, processing and metabolism.
Yan Li, Jiawen Wang, Chunyan Huang, Meng Shen, Huakui Zhan, Keyang Xu   +5 more
doaj   +1 more source

N6-methyladenosine-induced SVIL antisense RNA 1 restrains lung adenocarcinoma cell proliferation by destabilizing E2F1

, 2022
Accumulating evidence indicates that N6-methyladenosine (m6A) and long noncoding RNAs (lncRNAs) play crucial roles in cancer development. However, the biological roles of m6A and lncRNAs in lung cancer tumorigenesis are largely unknown.
Liang Zhu (172992), Zedong Hu (480092), Yilin Zhang (1463938), Bing Chen (32669)   +3 more
core   +1 more source