N6-methyladenosine methylation in kidney injury
Clinical Epigenetics, 2023 Multiple mechanisms are involved in kidney damage, among which the role of epigenetic modifications in the occurrence and development of kidney diseases is constantly being revealed.
Qimeng Wang +10 more
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N6-methyladenosine in DNA promotes genome stability [PDF]
eLifeDNA base lesions, such as incorporation of uracil into DNA or base mismatches, can be mutagenic and toxic to replicating cells. To discover factors in repair of genomic uracil, we performed a CRISPR knockout screen in the presence of floxuridine, a ...
Brooke A Conti +15 more
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Epigenetic regulation of N6‐methyladenosine modifications in obesity [PDF]
Journal of Diabetes Investigation, 2021 Obesity is a serious health issue in the world and is related to a higher risk of suffering metabolic diseases. Understanding the molecular basis of obesity is critical to identify new targets to treat obesity and obesity‐associated metabolic diseases ...
Mingli Sun, Xinan Zhang
doaj +3 more sources
Benchmark data for identifying N6-methyladenosine sites in the Saccharomyces cerevisiae genome
Data in Brief, 2015 This data article contains the benchmark dataset for training and testing iRNA-Methyl, a web-server predictor for identifying N6-methyladenosine sites in RNA (Chen et al., 2015 [15]).
Wei Chen +4 more
doaj +2 more sources
Roles and implications of mRNA N 6 ‐methyladenosine in cancer
Cancer Communications, 2023 RNA N6‐methyladenosine modification is the most prevalent internal modification of eukaryotic RNAs and has emerged as a novel field of RNA epigenetics, garnering increased attention.
Lingxing Zeng +2 more
exaly +2 more sources
seed lectin inhibits oral squamous cell carcinoma tumorigenesis by suppressing N6-methyladenosine modification–mediated SRY-box transcription factor 2 expression [PDF]
Journal of International Medical ResearchObjective Studies have indicated that combining Maackia amurensis seed lectin with first-line chemotherapeutic agents enhances the efficacy of treatment for oral squamous cell carcinoma.
Yong Du +6 more
doaj +2 more sources
Nature CommunicationsThere is strong evidence that obesity is a risk factor for poor semen quality. However, the effects of multigenerational paternal obesity on the susceptibility to cadmium (a reproductive toxicant)-induced spermatogenesis disorders in offspring remain ...
Yong-Wei Xiong +18 more
doaj +2 more sources
The Role of N6‐Methyladenosine Modification in Health and Disease [PDF]
MedCommEmerging evidence highlights that N6‐methyladenosine (m6A), the most prevalent internal RNA modification in eukaryotes, serves as a critical epitranscriptomic regulator of RNA metabolism.
Linghuan Li +6 more
doaj +2 more sources
N6-Methyladenosine modification: a novel pharmacological target for anti-cancer drug development
Acta Pharmaceutica Sinica B, 2018 N6-Methyladenosine (m6A) modification is the most pervasive modification of human mRNA molecules. It is reversible via regulation of m6A modification methyltransferase, demethylase and proteins that preferentially recognize m6A modification as “writers”,
Xiongbin Lu, Guohui Wan
exaly +3 more sources
Function of N6-Methyladenosine Modification in Tumors [PDF]
Journal of Oncology, 2021 N6-Methyladenosine (m6A) modification is a dynamic and reversible methylation modification at the N6-position of adenosine. As one of the most prevalent posttranscriptional methylation modifications of RNA, m6A modification participates in several mRNA processes, including nuclear export, splicing, translation, and degradation.
Nan Zhang +3 more
openaire +2 more sources