Results 41 to 50 of about 30,822 (300)

RNA Sequencing Reveals the Regulation of Betaine on Chicken Myogenesis

Animals, 2022
Betaine is trimethylglycine and a universal methyl donor which could provide methyl and glycine for cells and animals. As a new star in epigenetics, N6-Methyladenosine has been reported to regulate multiple biological activities, but the regulatory ...
Zhijun Wang, Danfeng Cai, Xing Ju, Kan Li, Sisi Liang, Meixia Fang, Qinghua Nie   +6 more
doaj   +1 more source

Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA binding factor Rbm15/Spenito to the m6A machinery component Wtap/Fl(2)d [PDF]

, 2018
N6-methyladenosine (m6A) is the most abundant mRNA modification in eukaryotes, playing crucial roles in multiple biological processes. m6A is catalyzed by the activity of Mettl3, which depends on additional proteins whose precise functions remain poorly ...
Andrade-Navarro, Miguel A., Biggiogera, Marco, Bühler, Marc, Carl, Sarah H., Hares, Tina, Haussmann, Irmgard, Helm, Mark, Hess, Daniel, Jacob, Dominik, Knuckles, Philip, Kreim, Nastasja, Lence, Tina, Masiello, Irene, Roignant, Jean-Yves, Soller, Matthias, Villaseñor, Rodrigo   +15 more
core   +4 more sources

FTO-mediated cytoplasmic m6Am demethylation adjusts stem-like properties in colorectal cancer cell

Nature Communications, 2021
The demethylase FTO was shown to remove on N6-methyladenosine (m6A) and N6, 2’-O-dimethyladenosine (m6Am) modifications on RNAs. Here the authors show that FTO impedes cancer stem cell-like abilities in colorectal cancer cells through its m6Am ...
Sébastien Relier, Julie Ripoll, Hélène Guillorit, Amandine Amalric, Cyrinne Achour, Florence Boissière, Jérôme Vialaret, Aurore Attina, Françoise Debart, Armelle Choquet, Françoise Macari, Virginie Marchand, Yuri Motorin, Emmanuelle Samalin, Jean-Jacques Vasseur, Julie Pannequin, Francesca Aguilo, Evelyne Lopez-Crapez, Christophe Hirtz, Eric Rivals, Amandine Bastide, Alexandre David   +21 more
doaj   +1 more source

The RNA m6A Reader YTHDF2 Is Essential for the Post-transcriptional Regulation of the Maternal Transcriptome and Oocyte Competence. [PDF]

, 2017
YTHDF2 binds and destabilizes N6-methyladenosine (m6A)-modified mRNA. The extent to which this branch of m6A RNA-regulatory pathway functions in vivo and contributes to mammalian development remains unknown.
Azzi, Chiara, Carrieri, Claudia, Di Giacomo, Monica, Enright, Anton J, Ivanova, Ivayla, Monahan, Jack, Moreira, Pedro N, Morgan, Marcos, Much, Christian, O'Carroll, Dónal   +9 more
core   +3 more sources

The importance of N6-methyladenosine modification in tumor immunity and immunotherapy

Experimental Hematology & Oncology, 2022
As the most common and abundant RNA modification in eukaryotic cells, N6-methyladenosine (m6A) modification plays an important role in different stages of tumor.
Ze Zhang, Furong Liu, Wei Chen, Zhibin Liao, Wanguang Zhang, Bixiang Zhang, Huifang Liang, Liang Chu, Zhanguo Zhang   +8 more
doaj   +1 more source

Control of box C/D snoRNP assembly by N⁶-methylation of adenine [PDF]

, 2017
N6-methyladenine is the most widespread mRNA modification. A sub-set of human box C/D snoRNA species have target GAC sequences that lead to formation of N6-methyladenine at a key trans Hoogsteen-sugar A•G basepair, of which half are methylated in vivo ...
Bokar JA, David MJ Lilley, Jia Wang, Lin Huang, Nicholas KB, Saira Ashraf   +5 more
core   +1 more source

N6-methyladenosine modification regulates cell death in cognitive impairment

Neural Regeneration Research
Neurodegenerative diseases are characterized by a decline in brain structure and function. Their pathology involves multiple cell death pathways, including ferroptosis, cuproptosis, and pyroptosis.
Yiqun Li, Yuxin Zhang, Yanzhen Wang, Ke Ye, Lulu Liu, Mengjie Tian, Xinyu Han, Xinyi Chen, Tianhu Zheng, Fuyuan Li, Xu Gao, Qing Xia, Dayong Wang   +12 more
doaj   +1 more source

EBV Exploits RNA m6A Modification to Promote Cell Survival and Progeny Virus Production During Lytic Cycle

Frontiers in Microbiology, 2022
N6-methyladenosine (m6A) mediates various biological processes by affecting RNA stability, splicing, and translational efficiency. The roles of m6A modification in Epstein-Barr virus (EBV) infection in the lytic phase are unclear.
Yusuke Yanagi, Takahiro Watanabe, Yuya Hara, Yoshitaka Sato, Hiroshi Kimura, Takayuki Murata, Takayuki Murata   +6 more
doaj   +1 more source

Role of FTO in adipocyte development and function: recent insights [PDF]

, 2015
In 2007, FTO was identified as the first genome-wide association study (GWAS) gene associated with obesity in humans. Since then, various animal models have served to establish the mechanistic basis behind this association.
Merkestein, Myrte, Sellayah, Dyan
core   +2 more sources

Neuromodulatory role and therapeutic potential of N6-methyladenosine RNA methylation in neurodegenerative diseases

Neural Regeneration Research
N6-methyladenosine RNA methylation, an essential post-transcriptional modification, dynamically regulates RNA metabolism and plays a crucial role in neuronal function.
Jinyu Zhang, Wenjing Ma, Ranxu Liu, Xiaoheng Li, Zengqiang Yuan, Jinbo Cheng   +5 more
doaj   +1 more source