Results 41 to 50 of about 46,730 (259)
Liver-specific Mettl3 ablation delays liver regeneration in mice
Genes and Diseases, 2022 This study investigated the role of N6-methyladenosine RNA methylation in liver regeneration following partial hepatectomy in mice. We created a liver-specific knockout mouse model by the deletion of Mettl3, a key component of the N6-methyladenosine ...
Jiaxiang Meng +3 more
doaj +1 more source
Role of N6-methyladenosine modification in cancer
Current Opinion in Genetics & Development, 2018 As the most abundant internal modification in eukaryotic messenger RNAs identified, N6-methyladenosine (m6A) has been shown recently to play essential roles in various normal bioprocesses. Evidence is emerging that m6A modification and its regulatory proteins also play critical roles in various cancers including leukemia, brain tumor, breast cancer and
Xiaolan, Deng +4 more
openaire +3 more sources
, 2021 The role of N6-methyladenosine (m6A)-modifying proteins in cancer progression depends on the cell type and mRNA affected. However, the biological role and underlying mechanism of m6A in kidney cancer is limited. Here, we discovered the variability in m6A
Zijuan Xin (11472439) +7 more
core +1 more source
The N6-Methyladenosine RNA modification in pluripotency and reprogramming [PDF]
Current Opinion in Genetics & Development, 2017 Chemical modifications of RNA provide a direct and rapid way to manipulate the existing transcriptome, allowing rapid responses to the changing environment further enriching the regulatory capacity of RNA. N6-Methyladenosine (m6A) has been identified as the most abundant internal modification of messenger RNA in eukaryotes, linking external stimuli to ...
Francesca, Aguilo, Martin J, Walsh
openaire +2 more sources
, 2021 The role of N6-methyladenosine (m6A)-modifying proteins in cancer progression depends on the cell type and mRNA affected. However, the biological role and underlying mechanism of m6A in kidney cancer is limited. Here, we discovered the variability in m6A
Zijuan Xin (11472439) +7 more
core +1 more source
N6-Methyladenosine Role in Acute Myeloid Leukaemia [PDF]
International Journal of Molecular Sciences, 2018 We are currently assisting in the explosion of epitranscriptomics, which studies the functional role of chemical modifications into RNA molecules. Among more than 100 RNA modifications, the N6-methyladenosine (m6A), in particular, has attracted the interest of researchers all around the world.
Ianniello, Zaira, Fatica, Alessandro
openaire +3 more sources
Chinese Medicine, 2021 Background Epimedin C, one of the main active ingredients of Epimedium, has been reported to have potential hepatotoxicity. However, the mechanism of Epimedin C-induced liver injury has not been studied.
Zhizhen Song +4 more
doaj +1 more source
, 2022 N6-methyladenosine (m6a)-related mRNAs and lncRNAs have been explored for their functions in several cancers. The present study aimed to identify potential signatures of m6a-related lncRNAs in hepatocellular carcinoma (HCC).
Zhejun Deng (12791090) +8 more
core +1 more source
FTO-mediated cytoplasmic m6Am demethylation adjusts stem-like properties in colorectal cancer cell
Nature Communications, 2021 The demethylase FTO was shown to remove on N6-methyladenosine (m6A) and N6, 2’-O-dimethyladenosine (m6Am) modifications on RNAs. Here the authors show that FTO impedes cancer stem cell-like abilities in colorectal cancer cells through its m6Am ...
Sébastien Relier +21 more
doaj +1 more source
RNA Sequencing Reveals the Regulation of Betaine on Chicken Myogenesis
Animals, 2022 Betaine is trimethylglycine and a universal methyl donor which could provide methyl and glycine for cells and animals. As a new star in epigenetics, N6-Methyladenosine has been reported to regulate multiple biological activities, but the regulatory ...
Zhijun Wang +6 more
doaj +1 more source