Results 1 to 10 of about 15,062 (245)

Alternative splicing of METTL3 explains apparently METTL3-independent m6A modifications in mRNA [PDF]

PLoS Biology, 2022
N6-methyladenosine (m6A) is a highly prevalent mRNA modification that promotes degradation of transcripts encoding proteins that have roles in cell development, differentiation, and other pathways. METTL3 is the major methyltransferase that catalyzes the
Hui Xian Poh, Aashiq H. Mirza, Brian F. Pickering, Samie R. Jaffrey   +3 more
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A cleaved METTL3 potentiates the METTL3–WTAP interaction and breast cancer progression [PDF]

eLife, 2023
N 6 -methyladenosine (m 6 A) methylation of RNA by the methyltransferase complex (MTC), with core components including METTL3–METTL14 heterodimers and Wilms’ tumor 1-associated protein (WTAP), contributes to ...
Chaojun Yan, Jingjing Xiong, Zirui Zhou, Qifang Li, Chuan Gao, Mengyao Zhang, Liya Yu, Jinpeng Li, Ming-Ming Hu, Chen-Song Zhang, Cheguo Cai, Haojian Zhang, Jing Zhang   +12 more
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Regulation of Methylase METTL3 on Fat Deposition

Diabetes, Metabolic Syndrome and Obesity, 2021
Gang Luo, Jialing Chen, Zhanjun Ren College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, People’s Republic of ChinaCorrespondence: Zhanjun RenCollege of Animal Science and Technology, Northwest A&F University ...
Luo G, Chen J, Ren Z
doaj   +4 more sources

METTL3 Regulates the Senescence of Stem Cells From the Apical Papilla by Mediating the m6A Modification of E2F3 [PDF]

International Dental Journal
Introduction and aims: We aimed to investigate whether N6-methyladenosine (m⁶A) methylation modification mediated by METTL3 regulates the senescence of SCAPs, and to elucidate the underlying molecular mechanisms.
Cheng Sun, Yuxin Fang, Zehan Li, Wuli Li
doaj   +2 more sources

METTL3 expression is associated with glycolysis metabolism and sensitivity to glycolytic stress in hepatocellular carcinoma

Cancer Medicine, 2020
METTL3 is an RNA methyltransferase implicated in the control of cell differentiation and proliferation in embryonic development and cancer. The current study was aimed to explore the function and underlying mechanism of METTL3 in hepatocellular carcinoma
Xuewen Zhang, Xuewen Zhang
exaly   +2 more sources

METTL3 Affects Spinal Cord Neuronal Apoptosis by Regulating Bcl-2 m6A Modifications After Spinal Cord Injury [PDF]

Neurospine, 2023
Objective Spinal cord injury (SCI) is a severe type of neurological trauma. N6-methyladenosine (m6A) modification is one of the most common internal modifications of RNA.
Shengyu Guo, Taotao Lin, Gang Chen, Zhitao Shangguan, Linquan Zhou, Zhi Chen, Tengbin Shi, Dehui Chen, Zhenyu Wang, Wenge Liu   +9 more
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Comprehensive analysis of m6A methylomes in idiopathic pulmonary arterial hypertension

Epigenetics, 2023
Idiopathic pulmonary arterial hypertension (IPAH) is a serious and fatal disease. Recently, m6A has been reported to play an important role in the lungs of IPAH patients and experimental pulmonary hypertension models. However, the meaning of m6A mRNAs in
Ting Huang, Yunhong Zeng, Yao Yang, Haoqin Fan, Youcai Deng, Wenjuan Chen, Jinqiao Liu, Fan Yang, Wenfeng Li, Yunbin Xiao   +9 more
doaj   +1 more source

TBK1-METTL3 Axis Facilitates Antiviral Immunity [PDF]

SSRN Electronic Journal, 2021
mRNA m6A modification is heavily involved in modulation of immune responses. However, its function in antiviral immunity is controversial, and how immune responses regulate m6A modification remains elusive. We here find TBK1, a key kinase of antiviral pathways, phosphorylates the core m6A methyltransferase METTL3 at serine 67. The phosphorylated METTL3
Jingxuan, Chen, Xuemei, Wei, Xiao, Wang, Tong, Liu, Yingchi, Zhao, Luoying, Chen, Yujie, Luo, Hongqiang, Du, Yunfei, Li, Tongtong, Liu, Lili, Cao, Zhe, Zhou, Zeming, Zhang, Ling, Liang, Lu, Li, Xuhui, Yan, Xuehui, Zhang, Xuliang, Deng, Guang, Yang, Ping, Yin, Jianlei, Hao, Zhinan, Yin, Fuping, You   +22 more
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The requirement of Mettl3-promoted MyoD mRNA maintenance in proliferative myoblasts for skeletal muscle differentiation [PDF]

Open Biology, 2017
Myogenic progenitor/stem cells retain their skeletal muscle differentiation potential by maintaining myogenic transcription factors such as MyoD. However, the mechanism of how MyoD expression is maintained in proliferative progenitor cells has not been ...
Kensuke Kudou, Tetsuro Komatsu, Jumpei Nogami, Kazumitsu Maehara, Akihito Harada, Hiroshi Saeki, Eiji Oki, Yoshihiko Maehara, Yasuyuki Ohkawa   +8 more
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7SK methylation by METTL3 promotes transcriptional activity [PDF]

Science Advances, 2023
A fundamental feature of cell signaling is the conversion of extracellular signals into adaptive transcriptional responses. The role of RNA modifications in this process is poorly understood. The small nuclear RNA 7SK prevents transcriptional elongation by sequestering the cyclin dependent kinase 9/cyclin T1 (CDK9/CCNT1) positive ...
Marcelo Perez-Pepe, Anthony W. Desotell, Hengyi Li, Wenxue Li, Bing Han, Qishan Lin, Daryl E. Klein, Yansheng Liu, Hani Goodarzi, Claudio R. Alarcón   +9 more
openaire   +3 more sources