Results 1 to 10 of about 16,538 (257)

Alternative splicing of METTL3 explains apparently METTL3-independent m6A modifications in mRNA

PLoS Biology, 2022
N6-methyladenosine (m6A) is a highly prevalent mRNA modification that promotes degradation of transcripts encoding proteins that have roles in cell development, differentiation, and other pathways. METTL3 is the major methyltransferase that catalyzes the
Hui Xian Poh, Aashiq H. Mirza, Brian F. Pickering, Samie R. Jaffrey   +3 more
doaj   +6 more sources

Mutant KRAS-m⁶A Epitranscriptome Axis Promotes Colorectal Cancer and is a Therapeutic Target. [PDF]

Adv Sci (Weinh)
Mutant KRAS‐m6A axis promotes colorectal cancer (CRC) progression. Mutant KRAS stabilizes METTL3, leading to increased m6A‐modified BCL9L mRNA and translation of BCL9L protein. BCL9L in turn mediates TGF‐β secretion to induce differentiation of Treg and an immunosuppressive microenvironment.
Chen D, Huang P, Tao R, Ji F, Wei Q, Ko LH, Zhou L, Chen H, Cheung A, Kang W, To KF, Yu J, Wong CC.   +12 more
europepmc   +2 more sources

SEC Mediates m6A Deposition and Transcription Pause Release to Drive Cell Identity Transition [PDF]

Advanced science
The SEC promotes cell identity transitions by facilitating transcription pause release at key identity‐associated genes, including Klf4 and Myc during iPSC reprogramming and Nes and Tubb3 during ESC‐to‐neuroectodermal differentiation. During early iPSC reprogramming, this function additionally involves cooperation with METTL3‐associated m6A regulation.
Zhang Z, Xu J, Wu Y, Qu Y, Hu X, Sun Y, Wu Y, Liu Z, Wang J, Lei L.   +9 more
europepmc   +2 more sources

METTL3 Increases Temozolomide Resistance in MGMT-Negative Glioblastoma by Enhancing CBX5 mRNA Stability in an m⁶A-IGF2BP2-Dependent Manner. [PDF]

CNS Neurosci Ther
METTL3‐dependent m6A modification and IGF2BP2‐associated CBX5 mRNA stabilization help maintain CBX5 expression in MGMT‐negative glioblastoma. During temozolomide (TMZ) treatment, CBX5 contributes to ATM–RAD51‐associated signaling, limits persistent DNA damage and apoptosis, and thereby supports cell survival and TMZ resistance.
Deng H, Chen R, Qu D, Qu C, Shi J.
europepmc   +2 more sources

Restoration of m6A-Modified circPSMB1 Suppresses Chordoma Progression and Enables Local Nanotherapeutic Intervention. [PDF]

Adv Sci (Weinh)
An m6A‐modified circRNA, circPSMB1, is identified as a tumor suppressor in chordoma. METTL3‐dependent m6A promotes circPSMB1 interaction with HNRNPA2B1, limiting c‐MYC expression and malignant progression. An injectable HMnO2‐based nanohydrogel enables local circPSMB1 delivery and tumor microenvironment‐responsive therapy, offering a promising strategy
Tang Y, Qiu L, Ruan X, Shi Y, Wang Y, Li H, Zhang K, Chen K.   +7 more
europepmc   +2 more sources

METTL3 Alleviates Liver Abscess by Enhancing Macrophage Efferocytosis via m6A Methylation of Nrf2 mRNA [PDF]

Immun Inflamm Dis
ABSTRACT Background Persistent inflammation and impaired macrophage efferocytosis contribute to liver injury during bacterial liver abscesses (BLA). This study was conducted to investigate whether METTL3 alleviates BLA by promoting macrophage efferocytosis through m6A methylation of Nrf2 mRNA. Materials and Methods METTL3 was overexpressed in the liver
Wang G, Luo D, Pang Y, Gao C, Jin D, Wang Q.   +5 more
europepmc   +2 more sources

WTAP-mediated m6A RNA methylation promotes diabetic foot ulcer healing under negative pressure wound therapy. [PDF]

J Diabetes Investig
NPWT significantly increases the suppressed WTAP and m6A levels in DFU patients, correlating directly with better 4‐week healing outcomes. In vitro, negative pressure reverses high‐glucose‐induced WTAP downregulation, restoring the cell proliferation and migration necessary for wound repair.
Li Y, Chen W, Lu J, Lin X, Tang Y, Li J, Chen M.   +6 more
europepmc   +2 more sources

METTL3 Affects Spinal Cord Neuronal Apoptosis by Regulating Bcl-2 m6A Modifications After Spinal Cord Injury [PDF]

Neurospine, 2023
Objective Spinal cord injury (SCI) is a severe type of neurological trauma. N6-methyladenosine (m6A) modification is one of the most common internal modifications of RNA.
Shengyu Guo, Taotao Lin, Gang Chen, Zhitao Shangguan, Linquan Zhou, Zhi Chen, Tengbin Shi, Dehui Chen, Zhenyu Wang, Wenge Liu   +9 more
doaj   +1 more source

Comprehensive analysis of m6A methylomes in idiopathic pulmonary arterial hypertension

Epigenetics, 2023
Idiopathic pulmonary arterial hypertension (IPAH) is a serious and fatal disease. Recently, m6A has been reported to play an important role in the lungs of IPAH patients and experimental pulmonary hypertension models. However, the meaning of m6A mRNAs in
Ting Huang, Yunhong Zeng, Yao Yang, Haoqin Fan, Youcai Deng, Wenjuan Chen, Jinqiao Liu, Fan Yang, Wenfeng Li, Yunbin Xiao   +9 more
doaj   +1 more source

The requirement of Mettl3-promoted MyoD mRNA maintenance in proliferative myoblasts for skeletal muscle differentiation [PDF]

Open Biology, 2017
Myogenic progenitor/stem cells retain their skeletal muscle differentiation potential by maintaining myogenic transcription factors such as MyoD. However, the mechanism of how MyoD expression is maintained in proliferative progenitor cells has not been ...
Kensuke Kudou, Tetsuro Komatsu, Jumpei Nogami, Kazumitsu Maehara, Akihito Harada, Hiroshi Saeki, Eiji Oki, Yoshihiko Maehara, Yasuyuki Ohkawa   +8 more
doaj   +1 more source