Results 1 to 10 of about 13,391 (192)

Alternative splicing of METTL3 explains apparently METTL3-independent m6A modifications in mRNA

PLoS Biology, 2022
N6-methyladenosine (m6A) is a highly prevalent mRNA modification that promotes degradation of transcripts encoding proteins that have roles in cell development, differentiation, and other pathways. METTL3 is the major methyltransferase that catalyzes the
Hui Xian Poh, Aashiq H. Mirza, Brian F. Pickering, Samie R. Jaffrey   +3 more
doaj   +5 more sources

Regulation of Methylase METTL3 on Fat Deposition

Diabetes, Metabolic Syndrome and Obesity, 2021
Gang Luo, Jialing Chen, Zhanjun Ren College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, People’s Republic of ChinaCorrespondence: Zhanjun RenCollege of Animal Science and Technology, Northwest A&F University ...
Luo G, Chen J, Ren Z
doaj   +4 more sources

RNA Modifications in Tumor Microenvironment: A New Dimension for Cancer Treatment. [PDF]

MedComm (2020)
Tumor initiation and progression depend on a supportive and highly heterogeneous tumor microenvironment (TME). RNA modifications regulate signaling pathways and cytokine networks that shape TME dynamics, facilitating interactions between cancer cells and noncancerous stromal cells, and ultimately promoting immune evasion and tumor progression ...
Li Q, Sun Y, Lin S, Yuan Q.
europepmc   +2 more sources

METTL3 Affects Spinal Cord Neuronal Apoptosis by Regulating Bcl-2 m6A Modifications After Spinal Cord Injury [PDF]

Neurospine, 2023
Objective Spinal cord injury (SCI) is a severe type of neurological trauma. N6-methyladenosine (m6A) modification is one of the most common internal modifications of RNA.
Shengyu Guo, Taotao Lin, Gang Chen, Zhitao Shangguan, Linquan Zhou, Zhi Chen, Tengbin Shi, Dehui Chen, Zhenyu Wang, Wenge Liu   +9 more
doaj   +1 more source

A cleaved METTL3 potentiates the METTL3–WTAP interaction and breast cancer progression

eLife, 2023
N 6 -methyladenosine (m 6 A) methylation of RNA by the methyltransferase complex (MTC), with core components including METTL3–METTL14 heterodimers and Wilms’ tumor 1-associated protein (WTAP), contributes to ...
Chaojun Yan, Jingjing Xiong, Zirui Zhou, Qifang Li, Chuan Gao, Mengyao Zhang, Liya Yu, Jinpeng Li, Ming-Ming Hu, Chen-Song Zhang, Cheguo Cai, Haojian Zhang, Jing Zhang   +12 more
openaire   +3 more sources

TBK1-METTL3 Axis Facilitates Antiviral Immunity [PDF]

SSRN Electronic Journal, 2021
mRNA m6A modification is heavily involved in modulation of immune responses. However, its function in antiviral immunity is controversial, and how immune responses regulate m6A modification remains elusive. We here find TBK1, a key kinase of antiviral pathways, phosphorylates the core m6A methyltransferase METTL3 at serine 67. The phosphorylated METTL3
Jingxuan, Chen, Xuemei, Wei, Xiao, Wang, Tong, Liu, Yingchi, Zhao, Luoying, Chen, Yujie, Luo, Hongqiang, Du, Yunfei, Li, Tongtong, Liu, Lili, Cao, Zhe, Zhou, Zeming, Zhang, Ling, Liang, Lu, Li, Xuhui, Yan, Xuehui, Zhang, Xuliang, Deng, Guang, Yang, Ping, Yin, Jianlei, Hao, Zhinan, Yin, Fuping, You   +22 more
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METTL3 promotes glycolysis and cholangiocarcinoma progression by mediating the m6A modification of AKR1B10

Cancer Cell International, 2022
Objective N6-methyladenosine (m6A) RNA methylation is involved in governing the mechanism of tumor progression. We aimed to excavate the biological role and mechanism of the m6A methyltransferase METTL3 in cholangiocarcinoma (CCA).
Jingli Cai, Zheng Cui, Jingyi Zhou, Bosen Zhang, Ruiqi Lu, Youcheng Ding, Hai Hu   +6 more
doaj   +1 more source

7SK methylation by METTL3 promotes transcriptional activity [PDF]

Science Advances, 2023
A fundamental feature of cell signaling is the conversion of extracellular signals into adaptive transcriptional responses. The role of RNA modifications in this process is poorly understood. The small nuclear RNA 7SK prevents transcriptional elongation by sequestering the cyclin dependent kinase 9/cyclin T1 (CDK9/CCNT1) positive ...
Marcelo Perez-Pepe, Anthony W. Desotell, Hengyi Li, Wenxue Li, Bing Han, Qishan Lin, Daryl E. Klein, Yansheng Liu, Hani Goodarzi, Claudio R. Alarcón   +9 more
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METTL3 Regulates the Senescence of Stem Cells From the Apical Papilla by Mediating the m⁶A Modification of E2F3. [PDF]

Int Dent J
Introduction and aims: We aimed to investigate whether N6-methyladenosine (m⁶A) methylation modification mediated by METTL3 regulates the senescence of SCAPs, and to elucidate the underlying molecular mechanisms.
Sun C, Fang Y, Li Z, Li W.
europepmc   +2 more sources

METTL3 regulates WTAP protein homeostasis [PDF]

Cell Death & Disease, 2018
AbstractThe Wilms tumor 1 (WT1)-associated protein (WTAP) is upregulated in many tumors, including, acute myeloid leukemia (AML), where it plays an oncogenic role by interacting with different proteins involved in RNA processing and cell proliferation.
Sorci, Melissa, Ianniello, Zaira, Cruciani, Sonia, Larivera, Simone, Ginistrelli, Lavinia Ceci, Capuano, Ernestina, Marchioni, Marcella, Fazi, Francesco, Fatica, Alessandro   +8 more
openaire   +3 more sources